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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1836-1848页

作者： Wei Qian yanmin wu Bo Shen School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China College of Information Science and Technology Donghua UniversityShanghai 201620China

This article mainly investigates the fuzzy optimization robust control issue for nonlinear networked systems characterized by the interval type-2(IT2)fuzzy technique under a differential evolution *** provide a more reasonable utilization of the constrained communication channel,a novel adaptive memory event-triggered(AMET)mechanism is developed,where two event-triggered thresholds can be dynamically adjusted in the light of the current system information and the transmitted historical *** conditions with less conservative design of the fuzzy imperfect premise matching(IPM)controller are presented by introducing the Wirtinger-based integral inequality,the information of membership functions(MFs)and slack ***,under the IPM policy,a new MFs intelligent optimization technique that takes advantage of the differential evolution algorithm is first provided for IT2 TakagiSugeno(T-S)fuzzy systems to update the fuzzy controller MFs in real-time and achieve a better system control ***,simulation results demonstrate that the proposed control scheme can obtain better system performance in the case of using fewer communication resources.

关键词： Adaptive memory event-triggered(AMET) differential evolution algorithm fuzzy optimization robust control interval type-2(IT2)fuzzy technique.

Leakage of nuclear material powder from pressure container through a small orifice

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Particuology 2014年第3期12卷 117-123页

作者： Longbo Liu yanmin wu Yongyang Su Hanbing Tang Zhihong Zhang Ping Huang Lili Zhang Lixing Zhang Northwest Institute of Nuclear Technology

Because of the radioactivity and toxic nature of nuclear materials, their containment within oxide matrices, encased in sealed containers, has been proposed as a suitable means for storage and transportation. However, container failures because of cracks or small orifices present a major leakage risk for nuclear materials, consequently posing a significant hazard to the environment and human beings. In this study, terbium oxide powder was used as a nuclear material representative to examine the leakage of nuclear material powder through orifices located at the base of a pressure container. The dependence of the orifice diameter, the powder layer thickness, and the internal pressure of the container on the leakage mechanism and amount was examined. A simplified model correlating the dependence of the above-mentioned parameters to determine the utmost leakage amount was also developed based on the present results. The leakage of the nuclear material powder was assessed by measuring its concentration using an optical particle counter. The diameter of the orifice determined the powder leakage mechanism, which in turn influenced the amount of leakage produced. Comparison studies showed that unlike the changes in the differential pressure, the volume of the container has little effect on the leakage amount. Under sufficiently high internal pressures, the oxide powder can be released as a fine aerosol. The work is not only crucial from the nuclear safety aspect, but is also beneficial for the safe application of powder and nanoparticles.

关键词： Nuclear materials Powder Leakage Risk assessment

Changes of free radicals and digestive enzymes in saliva in cases with deficiency inspleen-yin syndrome

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The Journal of Biomedical Research 2010年第3期24卷 250-255页

作者： Muxin Wei yanmin wu Dezheng Chen Yuchun Gu Department of Traditional Chinese Medicine the First Affiliated Hospital with Nanjing Medical University Nanjing 210029 Jingsu Province China

Objective：To explore the nature of deficiency in spleen-yin syndrome,which could provide scientific theoretical support and practical guidance for clinical Traditional Chinese Medicine（TCM）syndrome differentiation based on biology,and had a strong clinical ***：Serum Cu and Zn were detected by atomic absorption spectrophotometer,serum vitamin E by high performance liquid chromatography,serum vitamin C by 2,4-Dinitrophenylhydrazine Colorimetry,total superoxide dismutase（SOD）and Cu and Zn- SOD by the xanthine oxidase method,and malondialdehyde（MDA）by the 2-thiobarbituric acid method（TBA）.Total antioxidant capacity was detected by a colorimetry *** Activity was detected by an automatic biochemical *** was detected by lysozyme detection plate,the diameter of bacteriolysis circle was measured and the corresponding content of lysozyme was obtained from a table of standard curve ***： No significant difference in total SOD and Cu,Zn-SOD was found between deficiency in spleen-yin group and normal ***,such factors in deficiency in kidney-yin group were significantly lower than the other groups（P〈0.05）.The MDA content in both deficiency in spleen-yin group and deficiency in kidney-yin group were significantly higher than that of normal group（P〈0.05）,while the total antioxidant capacity was significantly lower than normal group（P〈0.05）.The vitamin E content in deficiency in kidney-yin group was significantly lower than that in the other two groups（P〈0.05）.No significant difference in the contents of vitamin C,Cu and Zn were observed in these *** Zn/Cu level in deficiency in kidney-yin group and the vitamin E level in deficiency in spleen-yin group decreased,but with no significant *** activity in unit time in cases with deficiency in spleen-yin was lower than and had significant differences with that in normal cases,and higher than that in cases with deficiency in *** sectional velocity

关键词： deficiency in spleen-yin deficiency in kidney-yin digestive enzymes in saliva amylase salivary lysozyme salivary flow rate free radicals

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深度学习在口腔影像分析中的应用

中国组织工程研究 2025年第11期29卷 2385-2393页

作者：杨予萱谭静怡周鹂鹂边子睿陈伊凡吴燕岷浙江大学医学院附属第二医院牙周病专科浙江省杭州市310009

背景:近年来深度学习技术越来越多地被运用于口腔医学领域,提高了口腔影像分析的效率及准确率,推动了口腔智能医学的迅速发展。目的:基于口腔影像,阐述深度学习在口腔疾病诊断和治疗方案决策方面的研究现状、优势与局限性,探讨深度学习... 详细信息

背景:近年来深度学习技术越来越多地被运用于口腔医学领域,提高了口腔影像分析的效率及准确率,推动了口腔智能医学的迅速发展。目的:基于口腔影像,阐述深度学习在口腔疾病诊断和治疗方案决策方面的研究现状、优势与局限性,探讨深度学习技术背景下口腔医学变革的新方向。方法:应用计算机检索PubMed数据库中2017年1月至2024年1月发表的深度学习在口腔医学影像领域应用的相关文献,检索词为“deep learning,artificial intelligence,stomatology,oral medical imaging”等,按入组标准筛选后最终纳入80篇文献进行综述。结果与结论:(1)经典的深度学习模型包括人工神经网络、卷积神经网络、递归神经网络和生成对抗网络等,学者们以或竞争或联合的形式运用这些模型,实现更高效的对口腔医学影像的解释。(2)在口腔医学领域,疾病诊断和治疗方案的制定在很大程度上依赖医学影像资料的判读,而深度学习技术拥有强大的图像处理能力,无论是在辅助诊断龋齿、根尖周炎、牙根纵裂、牙周病、颌骨囊肿等疾病方面,还是在辅助第三磨牙拔除术、颈淋巴结清扫术等治疗操作的术前评估方面,深度学习都能帮助临床医生提高决策的准确率与效率。(3)尽管深度学习有望成为口腔疾病诊治的重要辅助工具,但它在模型技术、安全伦理、法律监管方面仍有一定的局限性,未来的研究应侧重于证明深度学习的可推广性、稳健性和临床实用性,寻找将深度学习自动化决策支持系统应用于常规临床工作流程中的最佳方式。

关键词：深度学习口腔医学口腔影像疾病诊断口腔智能医学

Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair

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Regenerative Biomaterials 2021年第2期8卷 118-128页

作者： Yi Chen Jiaping Huang Jiamei Liu Yingming Wei Xianyan Yang Lihong Lei Lili Chen yanmin wu Zhongru Gou Department of Stomotology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Zhejiang-California International Nanosystems Institute Zhejiang UniversityHangzhou 310058China

It is still a challenge to optimize the component distribution and microporous structures in scaffolds for tailoring biodegradation(ion releasing)and enhancing bone defect repair within an expected time ***,the core–shell-typed nonstoichiometric wollastonite(4%and 10%Mg-doping calcium silicate;CSiMg4,CSiMg10)macroporous scaffolds with microporous shells(adding~μ10 μm PS microspheres into shell-layer slurry)were fabricated via 3D *** initial mechanical properties and bio-dissolution(ion releasing)in vitro,and osteogenic capacity in vivo of the bioceramic scaffolds were evaluated *** was shown that endowing high-density micropores in the sparingly dissolvable CSiMg10 or dissolvable CSiMg4 shell layer inevitably led to nearly 30%reduction of compressive strength,but such micropores could readily tune the ion release behaviour of the scaffolds(CSiMg4@CSiMg10 ***4@CSiMg10-p;CSiMg10@CSiMg4 ***10@CSiMg4-p).Based on the in rabbit femoral bone defect repair model,the 3D μCT reconstruction and histological observation demonstrated that the CSiMg4@CSiMg10-p scaffolds displayed markedly higher osteogenic capability than the other scaffolds after 12weeks of *** demonstrated that core–shell bioceramic 3D printing technique can be developed to fabricate single-phase or biphasic bioactive ceramic scaffolds with accurately tailored filament biodegradation for promoting bone defect regeneration and repair in some specific pathological conditions.

关键词： core–shell-typed pore filament component distribution microporous structures controllable degradation 3D printing

MyD88 in macrophages protects against colitis via inhibiting the activation of NLRP3 inflammasome in epithelial cells

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Genes & Diseases 2023年第2期10卷 344-347页

作者： Shi Liu yanmin wu Haiqiang Chen Qi Yuan Shuang Ge Lishu Zhang Lingling Hou Tian Tian Jinhua Zhang College of Life Science and Bioengineering Beijing Jiaotong UniversityBeijing 100044China National Center for International Research of Bio-targeting Theranostics Guangxi Key Laboratory of Bio-targeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Talent Highland of Bio-targeting TheranosticsGuangxi Medical UniversityNanningGuangxi 530021China

The signal adaptor myeloid differentiation primary response 88(MyD88)of Toll-like receptor(TLR)signaling is universally expressed in immune cells and non-immune cells,and myeloid cells play a significant role in modulating *** are myeloid lineage cells which is important for maintaining intestinal homeostasis in inflammation.1 And macrophages can recognize invading pathogens through pattern recognition receptors(PRRs),such as TLRs and the nucleotide oligomerization domain(NOD)-like receptor family,pyrin domain-containing 3(NLRP3),and quickly infiltrate the injured site leading to inflammation.2 MyD88 expression in myeloid cells can rescue the intestinal injury induced by dextran sulfate sodium(DSS)in murine ***,the mechanism whereby MyD88 works in myeloid cells and influence the progress of the disease remain *** this study,we used DSS induced colitis mouse model and found Lysm-cre-MyD88fl/fl(MyD88ΔМΦ)mice were more susceptible to *** deficiency of MyD88 leads to up-regulation of S100A8,which activate NLRP3 inflammasome and their associated pyroptosis in intestinal epithelial cells in a RAGE dependent ***,MyD88 signaling in macrophages,which is necessary to maintain intestinal homeostasis,crucially prevents the development of *** results may shed new lights on potential targets that can be applied in colitis therapy.

关键词： NLRP3 colitis homeostasis

Single-cell RNA-seq of Lotus japonicus provide insights into identification and function of root cell types of legume

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Journal of Integrative Plant Biology 2023年第5期65卷 1147-1152页

作者： Zhanmin Sun Sanjie Jiang Dan Wang Linxia Li Boxin Liu Qifan Ran Lizhen Hu Junbo Xiong Yixiong Tang Xiaofeng Gu yanmin wu Zhe Liang Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijing 100081China BGl Genomics Shenzhen 518083China Key Laboratory of Southwest China Wildlife Resources Conservation China West Normal UniversityNanchong 637002China Chongqing Academy of Animal Sciences Chongqing 402460China Institute of Animal and Veterinary Science Jiangxi Academy of Agricultural SciencesNanchang 330200China Hubei Key Laboratory of Animal Embryo and Molecular Breeding Institute of Animal and Veterinary ScienceHubei Academy of Agricultural ScienceWuhan 430072China

The roots of legume plant play a crucial role in nitrogen fixation. However, the transcriptomes of different cell types of legume root and their functions remain largely unknown. Here, we performed single-cell RNA sequencing and profiled more than 22,000 single cells from root tips of Lotus japonicus, a model species of *** identified seven clusters corresponding to seven major cell types, which were validated by in situ hybridization. Further analysis revealed regulatory programs including phytohormone and nodulation associated with specific cell types, and revealed conserved and diverged features for the cell types. Our results represent the first single-cell resolution transcriptome for legume root tips and a valuable resource for studying the developmental and physiological functions of various cell types in legumes.

关键词： genome legume Lotus japonicus single-cell RNA-seq

The susceptibility of T5-TG12 of theCFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province,China

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The Journal of Biomedical Research 2012年第6期26卷 410-417页

作者： Ping Wang Satoru Naruse Hong Yin Zhongfang Yu Tianqu Zhuang Wei Ding yanmin wu Muxin Wei Department of Traditional Chinese Medicine the First Affiliated Hospital Nanjing Medical University Nanjing Jiangsu 210029 China Department of Internal Medicine the Miyoshi-City Hospital Nagoya 466-8550 Japan Department of Internal Medicine the Affiliated Yangzhou Hospital Traditional Chinese Medicine of the Nanjing University of Chinese Medicine Yangzhou Jiangsu 225009 China Department of Paediatries Yixing Hospital Traditional Chinese Medicine Yixing Jiangsu 214200 China Department of Andrology the Affiliated Suzhou Hospital Traditional Chinese Medicine of the Nanjing University of Chinese Medieine Suzhou Jiangsu 215003 China

Mutations in the cystic fibrosis transmembrane conductance regulator （CFTR） gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis pa- tients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism （RFLP）. We found that the fre- quency of TS-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects （0.01%） and bronchial asthma patients （0.04%）. Thus, the presence of the TS-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.

关键词： cystic fibrosis transmembrane conductance regulator (CFTR) T5-TG12 chronic bronchitis Chinesepopulation

现状与实效:国民政府时期救灾监督方式与效果研究——限于1927-1937年的考察

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山东师范大学学报（人文社会科学版） 2011年第3期56卷 78-81页

作者：武艳敏郑州大学马克思主义学院河南郑州450001

国民政府时期为提升救灾成效,政府采用因果报应、民间监督、常规视察、制度监督等一系列方式对官赈过程进行监督,民间则采用业报轮回、自身监督、官方监督、大众监督等方式以保证义赈的效果。但救灾成效平平,贪污盛行,监督低效。反思历... 详细信息

国民政府时期为提升救灾成效,政府采用因果报应、民间监督、常规视察、制度监督等一系列方式对官赈过程进行监督,民间则采用业报轮回、自身监督、官方监督、大众监督等方式以保证义赈的效果。但救灾成效平平,贪污盛行,监督低效。反思历史,应进一步激发和催生公民的社会意识和监督意识、健全社会和制度监督机制、加强对救灾过程的全程监督管理、提高救灾款物的公开性和透明度、加大宣传教育力度。

关键词：国民政府监督方式效果启示

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对我国当前宏观税负水平的经济学分析

税务研究 2018年第3期 10-16页

作者：武彦民温立洲天津财经大学经济学院

我国宏观税负水平问题一直受到质疑甚至诟病,指责我国宏观税负偏重的声音不绝于耳。本文以经过修正后的大口径宏观税负概念为基础,提出了宏观税负水平评价的理论标准和实践表达,并从需求和供给两个角度,利用大量数据资料对我国当前宏观... 详细信息

我国宏观税负水平问题一直受到质疑甚至诟病,指责我国宏观税负偏重的声音不绝于耳。本文以经过修正后的大口径宏观税负概念为基础,提出了宏观税负水平评价的理论标准和实践表达,并从需求和供给两个角度,利用大量数据资料对我国当前宏观税负水平进行比较严密的经济学分析,认为尽管还有许多需要完善之处,但我国当前34%左右的宏观税负水平是比较恰当和科学的,不存在较强的减税压力。

关键词：宏观税负政府职能强度税收供给能力