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Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC—Yunnan,China,2015 and 2021

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China CDC weekly 2024年第42期6卷 1080-1085页

作者： Min Chen Huichao Chen Shouxiong Lei Jie Dai yanling ma manhong Jia Yunnan Provincial Key Laboratory of Public Health and Biosafety&Health Laboratory Center Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Institute for AIDS/STD Control and Prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina Division for AIDS/STD Control and Prevention Zhaotong Center for Disease Control and PreventionZhaotong CityYunnan ProvinceChina Yunnan Provincial Key Laboratory of Public Health and Biosafety&Institute for AIDS/STD Control and Prevention Yunnan Center for Disease Control and PreventionKunming CityYunnan ProvinceChina

What is already known about this topic?Recombinant strains dominate the human immunodeficiency virus 1(HIV-1)epidemic in *** Province was the first region in China to report HIV-1 infections in *** long-term HIV-1 epidemic led to the generation of various recombinant *** the 47 circulating recombinant forms(CRFs)reported in China,more than 20 were first identified in Yunnan *** is added by this report?This study reported a previously unrecognized HIV-1 CRF(CRF142_BC)characterized by the insertion of four short subtype B fragments into the subtype C ***142_BC was estimated to have emerged in the mid-1990s,close to the time of the emergence of most known CRF_BCs in *** are the implications for public health practice?The discovery of new CRFs will provide a basis for HIV-1 molecular tracing and intervention *** addition,HIV-1 recombination can alter viral biological *** study of HIV-1 gene variants needs to be intensified.

关键词： properties. China. intensified

Identification of the lower limit of high-quality source rocks and its relation to hydrocarbon accumulation——Taking the Beier Sag in the Hailaer Basin as an example

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Petroleum Science 2012年第1期9卷 10-17页

作者： Lu Shuangfang Chen Fangwen Li Jijun Wang Weiming Li Huiguang Cao Ruicheng ma yanling College of Geosciences Northeast Petroleum UniversityHeilongjiang 163318China Province Key Laboratory of Petroleum Accumulation Mechanism and Resource Prediction Heilongjiang 163318China The Halaer Exploratory Development Headquarters Daqing Oilfield Company Ltd.Heilongjiang 163000China

The theory of ＂source rock control＂ has evolved from source-rock-control hydrocarbon accumulation, to effective source-rock-control hydrocarbon accumulation, and to high-quality source- rock-control hydrocarbon accumulation. However, there are problems, such as whether high-quality source rocks exist or not？ What high-quality source rocks are, and how to identify them, are yet to be agreed upon. Aimed at this issue of concern to explorationists, and taking the Beier Sag in the Hailaer Basin as an example, this paper defines the high-quality source rocks and the lower limit for evaluation of high-quality source rocks, by using the inflection point on the relationship curve of hydrocarbon （oil） expulsion, which is calculated by the material balance principle, versus total organic carbon （TOC）. The results show that when TOC is low, all source rocks have limited hydrocarbon expulsion and slow growth rate, thus they cannot be high-quality source rocks. However, when TOC rises to some threshold, hydrocarbon expulsion increases significantly with TOC. This inflection point should be the lower limit of high-quality source rocks： those with TOC greater than the inflection-point value are high-quality source rocks. In addition, the lower limit of high-quality source rocks is also related to the type and maturity of organic matters in the source rocks, as well as the mineral components of the source rocks affecting the residual hydrocarbons. Theoretically, the lower limit of high-quality source rocks depends on geological conditions rather than being a constant value. However, for the sake of simplicity and practicability, in this paper TOC=2.0% is regarded as the lower limit of high-quality source rocks. The examination of such standard in the work area indicates that the high-quality source rocks in members K^n2 and K^n~ of the Nantun formation contribute 76% and 82% to oil generation, and 96% and 91% to oil expulsion, respectively. The distribution of high-quality source r

关键词： High-quality source rocks material balance oil generation oil expulsion hydrocarbongeneration potential Beier Sag

Implementing Routine HIV Screening in Hospitals:An Effective Practice to Expand HIV Testing—Xishuangbanna Prefecture,Yunnan Province,China,2019–2020

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China CDC weekly 2023年第13期5卷 283-286页

作者： Yidan Wang yanling ma Qiyu Zhu Wenyue Xu Haolan Sun Dongmin Li Cong Jin National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Yunnan Center for Disease Control and Prevention Kunming CityYunnan ProvinceChina Xishuangbanna Center for Disease Control and Prevention Xishuangbanna PrefectureYunnan ProvinceChina School of Chemistry and Molecular Biosciences University of QueenslandSt LuciaAustralia

Summary What is already known about this topic?Research evidence is insufficient to suggest whether routine human immunodeficiency virus(HIV)screening in healthcare settings is effective in promoting greater awareness of HIV-positive *** is added by this report?This study found that,following the implementation of routine HIV screening in hospitals in Xishuangbanna Prefecture,Yunnan Province,there was a significant increase in the number of HIV screenings,positive results,and the positive rate of HIV screening in primary-level *** are the implications for public health practice?Routine hospital-based HIV screening is effective in identifying HIV infections in areas with concentrated epidemics.

关键词： routine Prefecture identifying

Exploration of Cross-Cultural Pragmatic Failures in English Interpretation and Their Solutions

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Sino-US English Teaching 2023年第5期20卷 165-170页

作者： ma yanling Beijing International Studies University BeijingChina

From the perspective of international market development and international cultural exchange,English is the main applied language,especially in most western *** the deepening of global economic integration and international trade,cultural collisions are becoming increasingly frequent,and interpretation in different languages is inevitably ***,interpretation does not only mean transfer language,it also involves *** the practice of interpretation,some errors arise from the lack of cross-cultural awareness,which becomes pragmatic ***,this article will mainly discuss cross-cultural pragmatic failures in English interpretation with some examples and specific ***,it will introduce what pragmatic failures are and typical types of failures,clarify the relationship between English interpretation and pragmatic failures,and then elaborate on representative cross-cultural pragmatic failures in English ***,it will summarize the reasons and solutions that lead to cross-cultural pragmatic failures in English interpretation,putting forward corresponding suggestions for reducing cross-cultural pragmatic failures.

关键词： English interpretation cross cultural pragmatic failure solutions

A New Probe Into Translation Teaching From the Perspective of Context

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Sino-US English Teaching 2019年第11期16卷 445-451页

作者： ma yanling Beijing International Studies University BeijingChina

Translation,as a cross-linguistic and cross-cultural communication activity,is closely related to context,so context is an essential factor in translation *** traditional translation teaching,students’contextual awareness is weak,and there are few translation practice opportunities for *** a result,many students’translation level fails to meet the basic requirements of the *** paper attempts to introduce the concepts and theories of context into translation teaching,and then to explore the reforms and attempts that need to be made in translation teaching after the combination of context and translation *** also stresses that translation teachers are required to face new challenges and requirements coming from translation textbooks,teaching contents,and the creation of context,and to have a contextual perspective so as to achieve effective translation teaching.

关键词： context translation teaching translation talents

Intratumoural microbiota:a new frontier in cancer development and therapy

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Signal Transduction and Targeted Therapy 2024年第2期9卷 597-620页

作者： Yaqi Cao Hui Xia Xueyun Tan Chunwei Shi yanling ma Daquan Meng Mengmeng Zhou Zhilei Lv Sufei Wang Yang Jin Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesKey Laboratory of Respiratory Diseases of National Health CommissionState Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Engineering Research Center for Tumour-Targeted Biochemotherapy MOE Key Laboratory of Biological Targeted TherapyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Province Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Pathogen Biology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

Human microorganisms,including bacteria,fungi,and viruses,play key roles in several physiological and pathological *** studies discovered that tumour tissues once considered sterile actually host a variety of microorganisms,which have been confirmed to be closely related to *** concept of intratumoural microbiota was subsequently *** could colonise tumour tissues through mucosal destruction,adjacent tissue migration,and hematogenic invasion and affect the biological behaviour of tumours as an important part of the tumour *** studies have demonstrated that intratumoural microbiota potentially promote the initiation and progression of tumours by inducing genomic instability and mutations,affecting epigenetic modifications,promoting inflammation response,avoiding immune destruction,regulating metabolism,and activating invasion and *** more comprehensive and profound insights about intratumoral microbiota are continuously emerging,new methods for the early diagnosis and prognostic assessment of cancer patients have been under *** addition,interventions based on intratumoural microbiota show great potential to open a new chapter in antitumour therapy,especially immunotherapy,although there are some inevitable ***,we aim to provide an extensive review of the concept,development history,potential sources,heterogeneity,and carcinogenic mechanisms of intratumoural microorganisms,explore the potential role of microorganisms in tumour prognosis,and discuss current antitumour treatment regimens that target intratumoural microorganisms and the research prospects and limitations in this field.

关键词： tumour invasion metabolism

Simultaneous adsorption of lead and cadmium on MnO_2-loaded resin

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Journal of Environmental Sciences 2010年第2期22卷 225-229页

作者： Lijing Dong,Zhiliang Zhu,Hongmei ma,yanling Qiu,Jianfu ZhaoState Key Laboratory of Pollution Control and Resource Reuse,Tongji University,Shanghai 200092,China State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

MnO2-10aded D301 weak basic anion exchange resin has been used as adsorbent to simultaneously remove lead and cadmium ions from aqueous solution. The effects of adsorbent dosage, solution pH and the coexistent ions on the adsorption were investigated. Experimental results showed that with the adsorbent dosage more than 0.6 g/L, both Pb^2＋ and Cd^2＋ were simultaneously removed at pH range 5-6. Except for HPO4^2-, the high concentration coexistent ions such as Na^＋, K^＋, Cl^-, NO3^-, SO4^2- and HCO3^-, showed no significant effect on the removal efficiency of both Pb^2＋ and Cd^2＋ under the experimental conditions. The coexistence of Mg^2＋, Ca^2＋ caused the reduction of Cd^2＋ removal, but not for Pb^2＋. The adsorption equilibrium for Pb^2＋ and Cd^2＋ could be excellently described by the Langmuir isotherm model with R^2 〉 0.99. The maximum adsorption capacity was calculated as 80.64 mg/g for Pb^2＋ and 21.45 mg/g for Cd^2＋. The adsorption processes followed the pseudo first-order kinetics model. MnO2-loaded D301 resin has been shown to have a potential to be used as an effective adsorbent for simultaneous removal of lead and cadmium ions from aqueous solution.

关键词： MnO2-loaded resin adsorption cadmium lead simultaneous removal

SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria

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Virologica Sinica 2023年第4期38卷 520-530页

作者： Shan Zong Yan Wu Weiling Li Qiang You Qian Peng Chenghai Wang Pin Wan Tao Bai yanling ma Binlian Sun Jialu Qiao Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan430056China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Hubei University of MedicineShiyan442000China Division of Gastroenterology Tongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China Department of Respiratory and Critical Care Medicine Hubei Province Clinical Research Center for Major Respiratory DiseasesNHC Key Laboratory of Pulmonary DiseasesUnion HospitalTongji Medical CollegeHua Zhong University of Science and TechnologyWuhan430030China

Autophagy plays an important role in the interaction between viruses and host ***-CoV-2 infection can disrupt the autophagy process in target ***,the precise molecular mechanism is still *** this study,we discovered that the Nsp8 of SARS-CoV-2 could cause an increasing accumulation of autophagosomes by preventing the fusion of autophagosomes and *** further investigation,we found that Nsp8 was present on mitochondria and can damage mitochondria to initiate *** results of experiments with immunofluorescence revealed that Nsp8 induced incomplete ***,both domains of Nsp8 orchestrated their function during Nsp8-induced mitophagy,in which the N-terminal domain colocalized with mitochondria and the C-terminal domain induced auto/*** novel finding expands our understanding of the function of Nsp8 in promoting mitochondrial damage and inducing incomplete mitophagy,which helps us to understand the etiology of COVID-19 as well as open up new pathways for creating SARS-CoV-2 treatment methods.

关键词： SARS-CoV-2 Nsp8 Autophagy Mitophagy Mitochondrial damage

Cloning and prokaryotic expression of HGLP cDNA

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Chinese Science Bulletin 2001年第13期46卷 1089-1092页

作者： ZHOU Haijun HUANG Xiaowei ZHOU Yan LI Guangtao YIN Bin ma yanling PENG Xiaozhong YUAN Jiangang QIANG Boqin Institute of Basic Medical Sciences Chinese Academy of Medical Sciences&Peking Union Medical CollegeNational Center of Human Genome ResearchBeijing 100005China

A novel cDNA, HGLP, which encodes a G-protein coupled receptor (GPCR) like protein, has been isolated and cloned. The coding region of the human HGLP predicts a 7-transmembrane region protein with motifs of rhodopsin-like GPCR superfamily. Northern blot analysis reveals a 3-kb transcript in various human tissues examined. The N- and C-terminal coding regions of HGLP, which are deduced as non-transmembrane regions, have been amplified by PCR and cloned into pET30a+ vector. Then the re-combinant proteins are highly expressed in E. coli.

关键词： G-protein coupled receptor HGLP cDNA prokaryotic expression.