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Occurrence and infection risk of waterborne pathogens in Wanzhou watershed of the Three Gorges Reservoir, China

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Journal of Environmental Sciences 2013年第9期25卷 1913-1924页

作者： Guosheng Xiao Zhaodan Wang ji'an Chen Zhiqun Qiu yanjie Li Junsheng Qi Wenyi Liu Weiqun Shu Department of Environmental Hygiene School of Military Preventive Medicine Third Military Medical University College of Life Science and Engineering Chongqing Three Gorges University

The Three Gorges Reservoir （TGR）, formed by China＇s Yangtze Three Gorges Project, is the largest lake in the world, but there is too little information available about fecal contamination and waterborne pathogen impacts on this aquatic ecosystem. During two successive 1-year study periods （July 2009 to July 2011）, the water quality in Wanzhou watershed of the TGR was tested with regard to the presence of fecal indicators and pathogens. According to Chinese and World Health Organization water quality standards, water quality in the mainstream was good but poor in backwater areas. Salmonella, Enterohemorrhagic Escherichia coli （EHEC）, Giardia and Cryptosporidium were detected in the watershed. Prevalence and concentrations of the pathogens in the mainstream were lower than those in backwater areas. The estimated risk of infection with Salmonella, EHEC, Cryptosporidium, and Giardia per exposure event ranged from 2.9 × 10 -7 to 1.68 × 10-5 , 7.04 × 10-10 to 2.36 × 10-7 , 5.39 × 10-6 to 1.25 × 10-4 and 0 to 1.2 × 10-3 , respectively, for occupational divers and recreational swimmers exposed to the waters. The estimated risk of infection at exposure to the 95% upper confidence limit concentrations of Salmonella, Cryptosporidium and Giardia may be up to 2.62 × 10-5 , 2.55 × 10-4 and 2.86 × 10-3 , respectively. This study provides useful information for the residents, health care workers and managers to improve the safety of surface water and reduce the risk of fecal contamination in the TGR.

关键词： the Three Gorges Reservoir microbial risk assessment fecal contamination waterborne pathogen fecal indicator

剖宫产术后再次妊娠孕妇分娩方式选择的影响因素及临床护理分析

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中国医药科学 2021年第1期11卷 144-147页

作者：钟春媚柏智纪艳洁乔洁王明喜罗合英广东省东莞市东南部中心医院产科广东东莞523000

目的探讨剖宫产术后再次妊娠孕妇分娩方式选择的影响因素及临床护理。方法选择广东省东莞市东南部中心医院产科2018年6月至2020年4月收治的100例剖宫产术后再次妊娠孕妇作为研究对象,根据其所选择的分娩方式进行分组,将选择阴道分娩的... 详细信息

目的探讨剖宫产术后再次妊娠孕妇分娩方式选择的影响因素及临床护理。方法选择广东省东莞市东南部中心医院产科2018年6月至2020年4月收治的100例剖宫产术后再次妊娠孕妇作为研究对象,根据其所选择的分娩方式进行分组,将选择阴道分娩的孕妇纳入参照组(55例),将选择剖宫产术辅助分娩的孕妇纳入研究组(45例)。比较两组的妊娠信息,分析其剖宫产术后再次妊娠分娩方式选择的影响因素,并提出合理的临床护理对策。结果两组剖宫产与再次妊娠间隔时间、月收入、产前体重比较,差异无统计学意义(P>0.05),研究组阴道分娩史、宫口扩张<5 cm、恐惧疼痛、文化程度低发生率高于参照组,差异有统计学意义(P<0.05);多因素Logistic回归分析结果表明,剖宫产术后再次妊娠孕妇分娩方式选择的危险因素是阴道分娩史、宫口扩张<5 cm、恐惧疼痛及文化程度低。结论宫口扩张<5 cm、恐惧疼痛是剖宫产术后再次妊娠孕妇分娩方式选择的独立影响因素,根据其因素给予针对性的护理干预,以降低孕妇剖宫产术的选择率。

关键词：剖宫产术再次妊娠孕妇宫缩疼痛高危妊娠

生物有机肥替代化肥对葡萄生长与土壤肥力的影响

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中国农业科技导报 2024年第4期26卷 195-205页

作者：韩秀丽李嘉伟张杰郭艳杰张丽娟吉艳芝河北农业大学资源与环境科学学院河北省农田生态环境重点实验室河北产业协同创新中心河北保定071001 河北农业大学华北作物改良与调控国家重点实验室河北保定071001

为了明确生物有机肥替代化肥对‘赤霞珠’葡萄产量、品质与土壤肥力的影响,于2019—2020年设置传统水肥(CK)、优化水肥(Opt)及优化水肥中化肥氮的20%(B1)和40%(B2)分别由生物有机肥替代,比较不同处理下的土壤养分含量及葡萄的产量和品... 详细信息

为了明确生物有机肥替代化肥对‘赤霞珠’葡萄产量、品质与土壤肥力的影响,于2019—2020年设置传统水肥(CK)、优化水肥(Opt)及优化水肥中化肥氮的20%(B1)和40%(B2)分别由生物有机肥替代,比较不同处理下的土壤养分含量及葡萄的产量和品质。结果表明,优化水肥及施用生物有机肥替代部分化肥能较好地改善土壤理化性质,提升土壤肥力,促进葡萄生长。其中,B1处理可显著增加葡萄园经济效益,2年平均收益较CK提高33.59%;B2处理提升土壤肥力效果较好,与CK相比,成熟期0—40 cm土层的pH与硝态氮含量均有降低,有机质显著增加,与Opt处理相比,成熟期0—40 cm土层土壤的有效磷、速效钾含量分别显著提升109.90%、32.20%。由此表明,生物有机肥替代部分化肥是实现果园高效、安全、持续生产的有效途径。

关键词：生物有机肥替代产量品质土壤肥力赤霞珠

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Protective effects of gastrodine on dendritic spines in kainic acid-injured neurons

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Neural Regeneration Research 2011年第36期6卷 2810-2814页

作者： Yangfei ji Boai Zhang yanjie jia Guifang Sun Yu Liu Tao Peng Yanru Liu Xingrong Ma Department of Neurology First Affifiated Hospital Zhengzhou University Zhengzhou 450052 Henan Province China

EphB2 affects neuronal cells by altering the dendritic spines. The present study analyzed the neu-roprotective effects of gastrodine by measuring EphB2 expression in rat neural cells cultured in vitro and injured by kainic acid. Gastrodine （12.5, 25, and 50 mg/L） improved morphology in kainic acid-injured neurons, reduced lactate dehydrogenase leakage, decreased neuronal apoptosis, and increased EphB2 expression in neuronal cells. A moderate dose of 25 mg/L gastrodine resulted in the most significant effects. These results suggested that gastrodine suppressed the neurotoxic effects of excitatory amino acids and provided neuroprotection by remodeling neuronal dendritic spines.

关键词： gastrodine kainic acid cell culture EphB2 neuron neuroprotection

兴安落叶松天然林3个主要树种单木断面积生长模型

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中南林业科技大学学报 2024年第9期44卷 1-10页

作者：王建军陈科屹何友均吕延杰许单云何亚婷谢和生卢佶中国林业科学研究院林业科技信息研究所北京100091 国家林业和草原局华东调查规划院浙江杭州310019

【目的】构建兴安落叶松Larix gmelinii天然林3个主要树种组的断面积生长混合效应模型,提高断面积生长模型的预估精度,为兴安落叶松天然林的林分生长动态研究提供理论参考。【方法】以大兴安岭林区兴安落叶松天然林的主要树种组(兴安落... 详细信息

【目的】构建兴安落叶松Larix gmelinii天然林3个主要树种组的断面积生长混合效应模型,提高断面积生长模型的预估精度,为兴安落叶松天然林的林分生长动态研究提供理论参考。【方法】以大兴安岭林区兴安落叶松天然林的主要树种组(兴安落叶松、白桦、栎类)为研究对象,采用4期森林资源连续清查的626块复测样地数据,首先使用多元逐步回归方法建立单木断面积生长模型,其次在最优基础模型的基础上,引入样地随机效应,建立单木断面积生长混合效应模型,最后对模型进行检验。【结果】期初胸径(D)的倒数(1/D)、每公顷株数(N)、大于对象木的胸高断面积和(B_(L))、对象木胸径与林分算数平均胸径之比(B_(L)/D)、海拔(E)以及坡度和坡向的组合(T_(c))对兴安落叶松天然林单木断面积的生长有显著影响(P<0.05)。考虑样地随机效应的混合效应模型的赤池信息准则(AIC)、贝叶斯信息准则(BIC)明显降低,对数似然值(LogLik)明显增大。引入异方差函数和自相关结构后,提高了混合效应模型预估的精度;混合效应模型的平均绝对误差(Bias)和均方根误差(RMSE)均比基础模型的低,兴安落叶松、白桦、栎类最优混合效应模型的R^(2)分别由0.435提高到0.658、由0.354提高到0.489、由0.307提高到0.379。【结论】与基础模型相比,考虑层次结构的混合效应模型能显著地改善模型的拟合效果,为内蒙古大兴安岭地区兴安落叶松天然林的林分生长动态预测提供了具有生物学意义和统计学可靠性的断面积生长模型。

关键词：断面积异方差自相关结构混合效应模型兴安落叶松天然林

米拉贝隆对帕金森病合并膀胱过度活动症患者逼尿肌功能的影响

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国际泌尿系统杂志 2024年第2期44卷 252-255页

作者：张许平康延杰李小辉姬亚杰李艳段智慧郑州大学附属洛阳中心医院神经内科洛阳471000 郑州大学附属洛阳中心医院泌尿外科洛阳471000

目的探讨米拉贝隆对帕金森病合并膀胱过度活动症患者逼尿肌功能的影响。方法选取2019年5月至2021年11月在本院就诊的40例合并膀胱过度活动症的帕金森病患者作为研究对象,患者均口服米拉贝隆12周,观察并比较治疗前后的尿动力学检查结果... 详细信息

目的探讨米拉贝隆对帕金森病合并膀胱过度活动症患者逼尿肌功能的影响。方法选取2019年5月至2021年11月在本院就诊的40例合并膀胱过度活动症的帕金森病患者作为研究对象,患者均口服米拉贝隆12周,观察并比较治疗前后的尿动力学检查结果、膀胱过度活动症症状评分(OABSS)和尿失禁生活质量评分(I-QOL)。结果所有患者治疗后的残余尿量(PVR)均0.05)。治疗后的日尿次数、夜尿次数、尿急次数、尿失禁次数及OABSS较治疗前降低,差异均有统计学意义(均P<0.05)。治疗12周后患者的I-QOL较治疗前提高,差异有统计学意义(P<0.05)。1例患者出现高血压,其余患者无不良反应发生。结论米拉贝隆可明显减少帕金森合并膀胱过度活动症患者的逼尿肌无抑制收缩次数,提高BC,增加膀胱容量,改善膀胱过度活动症症状,提高生活质量,且并不会降低逼尿肌压力及增加尿潴留风险。

关键词：帕金森病膀胱过度活动症米拉贝隆逼尿肌

A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared

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Light(Science & Applications) 2022年第5期11卷 842-854页

作者： Nan Ding yanjie Wu Wen Xu jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai ji Zhou Hongwei Song State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Dalian Minzu UniversityDalian 116600China State Kay Lab of New Ceramics and Fine Processing Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic ***,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction ***,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,*** narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of ***,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+***,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+*** contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 *** work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices.

关键词： optoelectronic heterojunction ultraviolet

A non-invasive smart scaffold for bone repair and monitoring

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Bioactive Materials 2023年第1期19卷 499-510页

作者： Yazhuo Huang Lingyu Zhang Yongrong ji Hongpei Deng Mingce Long Shengfang Ge yanjie Su Siew Yin Chan Xian Jun Loh Ai Zhuang jing Ruan Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai200011China Key Laboratory of Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano ElectronicsSchool of ElectronicsInformation and Electrical EngineeringShanghai Jiaotong UniversityShanghai200240China Key Laboratory of Thin Film and Microfabrication Technology(Ministry of Education) School of Environmental Science and EngineeringShanghai Jiaotong UniversityShanghai200240China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03Singapore138634Singapore

Existing strategies for bone defect repair are difficult to *** scaffold materials that can quantify the efficiency of new bone formation are important for bone regeneration and *** nanotubes(CNT)have promising bioactivity and electrical *** this study,a noninvasive and intelligent monitoring scaffold was prepared for bone regeneration and monitoring by integrating carboxylated CNT into chemically cross-linked carboxymethyl chitosan *** scaffold(0.5%w/v)demonstrated improved mechanical properties with good biocompatibility and electrochemical *** voltammetry and electrochemical impedance spectroscopy of CNT scaffold responded sensitively to seed cell differentiation degree in both cellular and animal ***,the CNT scaffold could make up the easy deactivation shortfall of bone morphogenetic protein 2 by sustainably enhancing stem cell osteogenic differentiation and new bone tissue formation through CNT *** research provides new ideas for the development of noninvasive and electrochemically responsive bioactive scaffolds,marking an important step in the development of intelligent tissue engineering.

关键词： Carbon nanotube Osteogenesis Electrochemical response Noninvasive monitoring Tissue engineering

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李东垣内伤病辨治思路探析及思辨

中国中医基础医学杂志 2024年第2期30卷 185-189页

作者：赵妍婕刘世威宋素花山东中医药大学济南250355

《内外伤辨惑论》为金元四大家李东垣著作之一,其卷中部分主要论述了内伤病的病机证治等内容。李东垣所论内伤病是由脾胃受损所导致的一种不足之病,生理基础主要与脾胃的生成和布散精微功能有关,核心病机为脾胃受损所导致的精气不足及... 详细信息

《内外伤辨惑论》为金元四大家李东垣著作之一,其卷中部分主要论述了内伤病的病机证治等内容。李东垣所论内伤病是由脾胃受损所导致的一种不足之病,生理基础主要与脾胃的生成和布散精微功能有关,核心病机为脾胃受损所导致的精气不足及阴火上冲,时令主气也会改变内伤病的主要矛盾。针对不断变化的病机,李东垣立甘温除热、补气升阳等法,又有补中益气汤、参术调中汤等方随于后,形成了完整的内伤病辨治体系。李东垣理法十分精妙,多脱胎于先贤经典,笔者在文献梳理的基础上,选甘温除热、按而收之、风药升阳三点,思辨推敲其本义,以便灵活运用于临床。

关键词：李东垣《内外伤辨惑论》脾胃时令气机升降甘温生发