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Bhlhe40 protects cochlear hair cell-like HEI-OC1 cells against H_(2)O_(2) ‑triggered oxidative injury

BIOCELL 2024年第6期48卷 991-999页

作者： LITING WEN XIAOXIA ZENG PEIXIONG CHEN DAPENG ZHAO yangyang LI XIANHAI ZENG Department of Otorhinolaryngology Longgang Otorhinolaryngology Hospital and Shenzhen Key Laboratory of OtorhinolaryngologyShenzhen Institute of OtorhinolaryngologyShenzhenChina

Background:Cochlear hair cell injury is a common pathological feature of hearing *** basic helix-loop-helix family,member e40(Bhlhe40),a gene belonging to the basic helix-loop-helix(bHLH)family,exhibits strong transcriptional repression ***:Oxidative damage,in House Ear Institute-Organ of Corti 1(HEI-OC1)cells,was caused using hydrogen peroxide(H2O2).The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 *** assays including cell counting kit-8(CCK-8),terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay(TUNEL),ﬂow cytometry,immunoﬂuorescence,and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability,apoptosis,oxidative stress levels,mitochondrial membrane potential and cellular ***,a dual-luciferase reporter assay was performed to conﬁrm the targeting of the histone deacetylases 2(Hdac2)by ***:The results revealed that Bhlhe40 was downregulated in H_(2)O_(2)-treated HEI-OC1 cells,but its overexpression improved cell viability and mitigated H_(2)O_(2)-induced oxidative injury in HEI-OC1 cells with increase of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)activities and decrease of reactive oxygen species(ROS)***,overexpression of Bhlhe40 suppressed H_(2)O_(2)-triggered cell senescence,as evidenced by the fact that the upregulation of P53,P21,and P16 in HEI-OC1 cells treated with H2O2 were all alleviated by Bhlhe40 *** we further veriﬁed that overexpression of Bhlhe40 could inhibit the expression of Hdac2,which may be related to the repression of Hdac2 ***:This study suggests that Bhlhe40 plays a protective role against senescence and oxidative damage in cochlear hair cells exposed to H2O2.

关键词： Bhlhe40 Oxidative injury Cochlear hair cell Histone deacetylases 2

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Do investors care about auditor assignments?Evidence from last-minute changes to signing auditors

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China Journal of Accounting Research 2024年第1期17卷 132-156页

作者： yangyang Wang Yiqun Xie Huanmin Yan Rui Zhang School of Accounting Jiangxi University of Finance and EconomicsNanchangChina School of Economics&Management Nanchang UniversityNanchangChina

Against the background of China’s strengthening of finance and accounting supervision,this study examines the practice among listed companies of changing signing auditors at the last minute and explores whether Chinese investors can capture this information in a timely *** find that China’s capital market responds significantly negatively to these last-minute changes,implying that investors perceive a potential negative impact of this *** analyses suggest that the characteristics of the change event,recent corporate events,and accounting firm capability significantly affect the stock price ***,in terms of the individual characteristics of signing auditors,external investors appear to comprehensively consider busyness level,industry experience,and the timing of the change to determine the causes and effects of the auditor change and make different market reactions *** addition,consistent with investor perceptions,we find that last-minute changes significantly impair the quality of financial statements,indicating that external investors’judgments based on information about changes in signing auditors are rational and effective.

关键词： Annual Financial Report Auditing Changing Signing Auditors at the Last Minute Market Response Financial Statement Quality

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Micro segment analysis of supercritical methane thermal-hydraulic performance and pseudo-boiling in a PCHE straight channel

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Petroleum Science 2024年第2期21卷 1275-1289页

作者： Qian Li Zi-Jie Lin Liu Yang yue Wang yue Li Wei-Hua Cai Laboratory of Thermo-Fluid Science and Nuclear Engineering Northeast Electric Power UniversityJilin132000JilinChina School of Energy and Power Engineering Northeast Electric Power UniversityJilin132000JilinChina

The printed circuit heat exchanger(PCHE) is receiving wide attention as a new kind of compact heat exchanger and is considered as a promising vaporizer in the LNG process. In this paper, a PCHE straight channel in the length of 500 mm is established, with a semicircular cross section in a diameter of 1.2 *** simulation is employed to investigate the flow and heat transfer performance of supercritical methane in the channel. The pseudo-boiling theory is adopted and the liquid-like, two-phase-like, and vapor-like regimes are divided for supercritical methane to analyze the heat transfer and flow *** results are presented in micro segment to show the local convective heat transfer coefficient and pressure drop. It shows that the convective heat transfer coefficient in segments along the channel has a significant peak feature near the pseudo-critical point and a heat transfer deterioration when the average fluid temperature in the segment is higher than the pseudo-critical point. The reason is explained with the generation of vapor-like film near the channel wall that the peak feature related to a nucleateboiling-like state and heat transfer deterioration related to a film-boiling-like state. The effects of parameters, including mass flow rate, pressure, and wall heat flux on flow and heat transfer were *** calculating of the averaged heat transfer coefficient of the whole channel, the traditional method shows significant deviation and the micro segment weighted average method is adopted. The pressure drop can mainly be affected by the mass flux and pressure and little affected by the wall heat flux. The peak of the convective heat transfer coefficient can only form at high mass flux, low wall heat flux, and near critical pressure, in which condition the nucleate-boiling-like state is easier to appear. Moreover,heat transfer deterioration will always appear, since the supercritical flow will finally develop into a filmboiling-like state. So hea

关键词： Printed circuit heat exchanger Vaporization Supercritical methane Pseudo-boiling Micro segment analysis

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The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis

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Neural Regeneration Research 2025年第5期20卷 1513-1520页

作者： Xueyun Shao Longfei He yangyang Liu Physical Education School Shenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Institute of Neuroscience ShenzhenGuangdong ProvinceChina

Brain-derived neurotrophic factor is a crucial neurotrophic factor that plays a significant role in brain health. Although the vast majority of meta-analyses have confirmed that exercise interventions can increase brain-derived neurotrophic factor levels in children and adolescents, the effects of specific types of exercise on brain-derived neurotrophic factor levels are still controversial. To address this issue, we used meta-analytic methods to quantitatively evaluate, analyze, and integrate relevant studies. Our goals were to formulate general conclusions regarding the use of exercise interventions, explore the physiological mechanisms by which exercise improves brain health and cognitive ability in children and adolescents, and provide a reliable foundation for follow-up research. We used the Pub Med, Web of Science, Science Direct, Springer, Wiley Online Library, Weipu, Wanfang, and China National Knowledge Infrastructure databases to search for randomized controlled trials examining the influences of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents. The extracted data were analyzed using Review Manager 5.3. According to the inclusion criteria, we assessed randomized controlled trials in which the samples were mainly children and adolescents, and the outcome indicators were measured before and after the intervention. We excluded animal experiments, studies that lacked a control group, and those that did not report quantitative results. The mean difference(MD;before versus after intervention) was used to evaluate the effect of exercise on brain-derived neurotrophic factor levels in children and adolescents. Overall, 531 participants(60 children and 471 adolescents, 10.9–16.1 years) were included from 13 randomized controlled trials. Heterogeneity was evaluated using the Q statistic and I^(2) test provided by Review Manager software. The meta-analysis showed that there was no heterogeneity among the studies(P = 0.67,

关键词： adolescents brain-derived neurotrophic factor children exercise meta-analysis randomized controlled trials

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Uplift of the central part of the Jinsha River， southeastern Tibetan Plateau: Evidence from apatite fission track dating and bedrock channel longitudinal profiles

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Journal of Earth Science 2024年

作者： yangyang Ren Youpu Dong Wenchang Li Faculty of Land Resource Engineering， Kunming University of Science and Technology

The initial timing of uplift at the southeastern margin of the Tibetan Plateau (SMTP) remain under debate， with estimates ranging from the Eocene， to the Oligocene. The Jinsha River was formed before the Miocene， therefore， it is likely to record the uplift information of the Tibetan Plateau， which is important for understanding the tectonic uplift of the SMTP. Here， we collected granite samples from the Yangla area in the middle part of the Jinsha River， and analyzed the uplift characteristics of the Cenozoic in the middle part of the Jinsha River by using the apatite fission tracks and the river longitudinal profiles. We show shat the uplift time of the first phase is about 25–20 Ma， and the uplift time of the second phase is about 5 Ma; From the channel profile， seven tributaries of the Jinsha Rivers also have developed two phase of knickpoints. The tributaries consist of three sections with distinct geomorphological parameters， each separated by knickpoints. We argue that large-scale uplift occurred in the Late Cenozoic on the SMTP， with different locations having different uplift times， and the interior may have undergone significant uplift in the Early Oligocene， but significant uplift of the SMTP occurred by the Late Oligocene to Early Miocene. The Jinsha River flowing from the interior of the plateau have developed multiple knick points during the uplift process， recording information of the uplift of the Tibetan Plateau.

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基于拟态防御的多接入边缘计算服务器异构性量化方法

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计算机应用与软件 2023年第6期40卷 276-281,349页

作者：岳阳阳付雄邓松南京邮电大学计算机学院江苏南京210023

基于拟态防御构造的多接入边缘计算服务器是一种新型的边缘计算安全系统,拟态防御具有异构和冗余等特性,通过这些特性可以阻断攻击者的攻击,提高系统的安全性与可靠性。在此基础上,提出一种衡量异构性的方法,将执行体集的异构性分解为... 详细信息

基于拟态防御构造的多接入边缘计算服务器是一种新型的边缘计算安全系统,拟态防御具有异构和冗余等特性,通过这些特性可以阻断攻击者的攻击,提高系统的安全性与可靠性。在此基础上,提出一种衡量异构性的方法,将执行体集的异构性分解为两部分计算,分别是复杂性和差异性,在理论上为拟态防御的异构性评估上提出一种新方法。实验表明,该方法优于Margalef指数、Shannon-Wiener指数和Simpson指数,更适用于多接入边缘计算中服务器的异构性量化。

关键词：拟态防御边缘计算服务器异构性量化

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Thermal transports in the MXenes family:Opportunities and challenges

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Nano Research 2024年第8期17卷 7700-7716页

作者： Yurui Liu yue Wu Xinwei Wang Department of Chemical and Biological Engineering Iowa State University618 Bissell AmesIA 50011USA Department of Mechanical Engineering 271 Applied Science Complex II1915 Scholl RoadIowa State UniversityAmesIA 50011USA

The carbides and nitrides of transition metals known as“MXenes”refer to a fast-growing family of two-dimensional materials discovered in *** to their unique nanolayer structure,superior electrical,mechanical,and thermal properties,MXenes have shown great potential in addressing the critical overheating issues that jeopardize the performance,stability,and lifetime of high-energy-density components in modern devices such as microprocessors,integrated circuits,and capacitors,*** outstanding intrinsic thermal conductivity of MXenes has been proved by experimental and theoretical *** MXenes-enabled high thermal conductivity composites incorporated with polymer matrix have also been reported and widely used as thermal management *** the booming heat dissipation demands,MXenes-enabled thermal management material is an extremely valuable and scalable option for modern electronics ***,the fundamental thermal transport mechanisms behind the MXenes family remain *** MXene thermal conductivity disparities between the theoretical prediction and experimental results are still *** better understand the thermal conduction in MXenes and provide more insights for engineering high-performance MXene thermal management materials,in this article,we summarize recent progress on thermal conductive *** essential factors that affect MXenes intrinsic thermal conductivities are tackled,selected MXenes-polymer composites are highlighted,and prospects and challenges are also discussed.

关键词： transition metal carbide(MXene) thermal transport two-dimensional materials thermally conductive composites

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Hierarchical Voronoi Structure Inspired by Cat Paw Pads Substantially Enhances Landing Impact Energy Dissipation

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Journal of Bionic Engineering 2024年第4期21卷 1847-1861页

作者： Da Lu Baoqing Pei yangyang Xu Mengyuan Hu Shijia Zhang Le Zhang Xin Huang Yangwei Wang Xueqing Wu Beijing Key Laboratory for Design and Evaluation Technology of Advanced Implantable&Interventional Medical Devices Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang University100083BeijingChina National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing Institute of Technology100081BeijingChina Shenzhen Institute of Beihang University 518000ShenzhenChina

When a human lands from a high drop,there is a high risk of serious injury to the lower *** the other hand,cats can withstand jumps and falls from heights without being fatally wounded,largely due to their impact-resistant paw *** aim of the present study was to investigate the biomechanism of impact resistance in cat paw pads,propose an optimal hierarchical Voronoi structure inspired by the paw pads,and apply the structure to bionic cushioning shoes to reduce the impact force of landing for *** microstructure of cat paw pads was observed via tissue section staining,and a simulation model was reconstructed based on CT to verify and optimize the structural cushioning *** distribution pattern,wall thickness of compartments,thickness ratio of epidermis and dermis,and number of compartments in the model were changed and simulated to achieve an optimal composed structure.A bionic sole was 3D-printed,and its performance was evaluated via compression test and a jumping-landing *** results show that cat paw pads are a spherical cap structure,divided from the outside to the inside into the epidermis,dermis,and compartments,each with different cushioning capacities.A finite element simulation of different cushioning structures was conducted in a cylinder with a diameter of 20 mm and a height of 10 mm,featuring a three-layer *** optimal configuration of the three layers should have a uniform distribution with 0.3–0.5 mm wall thickness,a 1:1–2 thickness ratio of epidermis and dermis,and 100–150 compartments.A bionic sole with an optimized structure can reduce the peak impact force and delay the peak arrival *** energy absorption rate is about 4 times that of standard *** jumping 80,100,and 120 cm,the normalized ground reaction force is also reduced by 8.7%,12.6%and 15.1%compared with standard *** study provides theoretical and technical support for effective protection against human lower limb landing injuries.

关键词： Cat paw pads Hierarchical Voronoi structure Landing impact Energy dissipation Bionic sole

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Nano-Ni-Induced Electronic Modulation of MoS2 Nanosheets Enables Energy-Saving H2 Production and Sulfide Degradation

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Energy & Environmental Materials 2024年第3期7卷 232-239页

作者： Fan Liu Xinghong Cai Yang Tang Wenqian Liu Qianwei Chen Peixin Dong Maowen Xu yangyang Tan Shujuan Bao Institute for Clean Energy & Advanced Materials School of Materials and EnergySouthwest University

Electrocatalytic hydrogen evolution and sulfion (S2-) recycling are promising strategies for boosting H2production and removing environmental ***,a nano-Ni-functionalized molybdenum disulfide （MoS2）nanosheet was assembled on steel mesh （Ni-MoS2/SM） for use in sulfide oxidation reaction-assisted,energy-saving *** and theoretical calculation results revealed that anchoring nano-Ni on highsurface-area slack MoS2 nanosheets not only optimized catalyst adsorption of polysulfides but also played an important role in promoting hydrogen evolution reaction kinetics by absorbing OHad,thereby greatly enhancing the catalytic performance toward sulfide oxidation reaction and hydrogen evolution ***,the Ni/MoS2-based hydrogen evolution reaction+sulfide oxidation reaction system achieved nearly 100%hydrogen production efficiency and only consumed 61%less power per kWh than the oxygen evolution reaction+hydrogen evolution reaction system,which suggested our proposed Ni-MoS2and novel hydrogen production system are promising for sustainable energy production.

关键词： hydrogen evolution reaction low energy consumption molybdenum disulfide sulfide oxidation reaction

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A Scholar of Dignity:Remembering Peter Luh

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1895-1897页

作者： Fei-yue Wang Macao University of Science and Technology Macao 999078China Beijing Engineering Research Center of Intelligent Systems and Technology Chinese Academy of SciencesBeijing 100190China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China

It was a shock and disbelief to learn of Peter's death last *** me,he was so fit in his figure,so healthy in his lifestyle,so mild and mindful in his social behavior,and so devout in his religious belief,......,I had ... 详细信息

关键词： religious Scholar belief

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