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Recent Advances in Mechanistic Understanding of Metal-Free Carbon Thermocatalysis and Electrocatalysis with Model Molecules

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Nano-Micro Letters 2024年第7期16卷 74-97页

作者： Wei Guo Linhui Yu Ling tang Yan Wan yangming Lin CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Institute of Urban Environment Chinese Academy of SciencesXiamen 361021People’s Republic of China

Metal-free carbon,as the most representative heterogeneous metal-free catalysts,have received considerable interests in electro-and thermo-catalytic reac-tions due to their impressive performance and *** the past decade,well-designed carbon catalysts with tunable structures and heteroatom groups coupled with various characterization techniques have proposed numerous reaction ***,active sites,key intermediate species,precise structure-activity relationships and dynamic evolution processes of carbon catalysts are still rife with controversies due to the monotony and limitation of used experimental *** this Review,we sum-marize the extensive efforts on model catalysts since the 2000s,particularly in the past decade,to overcome the influences of material and structure limitations in metal-free carbon *** both nanomolecule model and bulk model,the real contribution of each alien species,defect and edge configuration to a series of fundamentally important reactions,such as thermocatalytic reactions,electrocatalytic reactions,were systematically *** with in situ techniques,isotope labeling and size control,the detailed reaction mechanisms,the precise 2D structure-activity relationships and the rate-determining steps were revealed at a molecular ***,the outlook of model carbon catalysis has also been proposed in this work.

关键词： Metal-free carbon catalysts Model catalyst Electrocatalysis Active site Reaction mechanisms

A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

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Science China(Life Sciences) 2023年第10期66卷 2201-2213页

作者： Lili Wu Anqi Zheng yangming tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen Wu Shaogui Zeng Hang Yang Qihui Wang George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China Hybio Pharmaceutical Co. Ltd.Shenzhen 518109China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhen 518112China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Hubei Jiangxia Laboratory Wuhan 430299China Chinese Center for Disease Control and Prevention(China CDC) Beijing 102206China

Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple *** variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory *** previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral ***,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal *** results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.

关键词： SARS-CoV-2 peptide fusion inhibitor pan-coronavirus viral infection intranasal delivery

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TAFRO综合征的诊治进展

内科 2022年第5期17卷 546-550页

作者：汤杨明(综述) 蓝梅(审校) 广西壮族自治区人民医院血液内科南宁市530021

TAFRO综合征是特发性多中心型Castleman病的一个罕见亚型,以血小板计数减少(T)、全身性水肿(A)、发热(F)、骨髓网状纤维化/肾功能不全(R)和器官肿大(O)为临床特征,其发病与白细胞介素(IL)-6和血管内皮生长因子等有关。目前TAFRO综合征... 详细信息

TAFRO综合征是特发性多中心型Castleman病的一个罕见亚型,以血小板计数减少(T)、全身性水肿(A)、发热(F)、骨髓网状纤维化/肾功能不全(R)和器官肿大(O)为临床特征,其发病与白细胞介素(IL)-6和血管内皮生长因子等有关。目前TAFRO综合征尚缺乏标准治疗方案,推荐治疗方案包括糖皮质激素、利妥昔单抗、免疫调节剂和IL-6受体拮抗剂等。由于TAFRO综合征发病率低,临床上较罕见,临床医师缺乏对该病的认识。本文就TAFRO综合征近年来的诊断和治疗进展进行综述。

关键词： Castleman病特发性多中心 TAFRO综合征白细胞介素-6 病因发病机制诊断治疗综述

来那度胺二线治疗老年多中心型Castleman病长期缓解二例报道并文献复习

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中国全科医学 2022年第3期25卷 368-372页

作者：汤杨明石仁州蓝梅李学军温宗华陆晓晨广西壮族自治区人民医院血液科广西壮族自治区南宁市530021 广西壮族自治区人民医院病理科广西壮族自治区南宁市530021

一线治疗失败或复发的老年多中心型Castleman病(MCD)患者尚无标准的治疗方案,国外文献报道来那度胺对于复发/难治的MCD有一定疗效,但中文文献报道较少。本文报道2例来那度胺二线治疗老年复发/难治的MCD患者后取得长期缓解,并对相关文献... 详细信息

一线治疗失败或复发的老年多中心型Castleman病(MCD)患者尚无标准的治疗方案,国外文献报道来那度胺对于复发/难治的MCD有一定疗效,但中文文献报道较少。本文报道2例来那度胺二线治疗老年复发/难治的MCD患者后取得长期缓解,并对相关文献进行复习,提示来那度胺治疗MCD有效,可以作为治疗复发/难治MCD的一种选择。老年MCD患者本身可能一般状况差,存在各种合并症,从而可能从以来那度胺为基础的治疗方案中获益。

关键词：多中心型Castleman病老年人来那度胺复发难治病

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盐酸二甲双胍缓释片的人体生物等效性研究

药物评价研究 2022年第1期45卷 78-83页

作者：胡朝英郜丹宋岩李想李林唐洋明李庆洋张兰首都医科大学宣武医院药学部 Ⅰ期临床研究中心国家老年疾病临床医学研究中心北京100053 深圳瀚宇药业有限公司广东深圳518057

目的评价中国健康受试者空腹和餐后状态下单次口服盐酸二甲双胍缓释片的生物等效性。方法采用单剂量、随机、开放、两制剂、两周期、交叉对照的试验设计,健康受试者每周期在空腹或餐后状态下口服盐酸二甲双胍缓释片受试制剂和参比制剂50... 详细信息

目的评价中国健康受试者空腹和餐后状态下单次口服盐酸二甲双胍缓释片的生物等效性。方法采用单剂量、随机、开放、两制剂、两周期、交叉对照的试验设计,健康受试者每周期在空腹或餐后状态下口服盐酸二甲双胍缓释片受试制剂和参比制剂500 mg。采用经验证的液相色谱-串联质谱(LC-MS/MS)法测定二甲双胍的血浆浓度,使用Phoenix WinNonlin 8.0计算药动学参数并用SAS 9.4软件进行生物等效性评价。结果空腹状态下,受试制剂和参比制剂中二甲双胍C_(max)分别为(733.00±178.25)、(665.80±146.58)ng·mL^(−1),AUC_(0~t)分别为(4848.60±1204.80)、(4743.00±1104.34)h·ng·mL^(−1),AUC_(0~∞)分别为(4940.70±1219.48)、(4832.58±1093.55)h·ng·mL^(−1)。餐后状态下,受试制剂和参比制剂中二甲双胍C_(max)分别为(519.10±92.55)、(475.50±65.88)ng·mL^(−1),AUC_(0~t)分别为(5989.20±1112.01)、(5946.50±1094.81)h·ng·mL^(−1),AUC_(0~∞)分别为(6052.20±1118.35)、(6049.80±1062.28)h·ng·mL^(−1)。受试制剂和参比制剂二甲双胍C_(max)、AUC_(0~t)和AUC_(0~∞)几何均值比的90%置信区间均在80.00%~125.00%的生物等效性范围内。结论盐酸二甲双胍缓释片受试制剂和参比制剂在空腹和餐后状态下均具有生物等效性。

关键词：盐酸二甲双胍缓释片生物等效性药动学 LC-MS/MS

自体外周血干细胞移植治疗系统性硬化病四例远期疗效观察

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中华风湿病学杂志 2019年第10期23卷 673-678页

作者：霍晓聪蓝梅汤杨明黄新翔黄玉葵雷静李永敢朱霞李学军林金盈广西壮族自治区人民医院风湿免疫科南宁530021

目的探讨自体外周血干细胞移植(AHSCT)治疗SSc的远期疗效。方法2007年5月至2009年6月对4例SSc患者进行AHSCT治疗。干细胞动员方案为环磷酰胺+粒细胞集落刺激因子(G-CSF),预处理方案为环磷酰胺50 mg·kg-1·d-1,4 d。移植后观察患者改良R... 详细信息

目的探讨自体外周血干细胞移植(AHSCT)治疗SSc的远期疗效。方法2007年5月至2009年6月对4例SSc患者进行AHSCT治疗。干细胞动员方案为环磷酰胺+粒细胞集落刺激因子(G-CSF),预处理方案为环磷酰胺50 mg·kg-1·d-1,4 d。移植后观察患者改良Rodnan皮肤评分(mRSS)、高分辨CT率(HRCT)评分、肺功能等指标的变化。结果移植后6个月内,4例患者mRSS改善,HRCT评分、肺功能好转或稳定。移植6个月至1年内,1例持续好转,2例病情出现反复,经免疫抑制治疗后再次稳定。随访8.7(4.1~9.8)年,3例稳定,1例死亡。移植相关并发症有感染、肝功能损害,无移植相关死亡。结论以环磷酰胺为预处理方案的AHSCT治疗SSc安全有效。对病程短、进展快、水肿期的患者移植后疗效显著。但长期疗效差,容易反复,需要巩固维持治疗。

关键词：硬皮病,系统性外周血干细胞移植

A sulfotransferase gene BnSOT-like1 has a minor genetic effect on seed glucosinolate content in Brassica napus

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The Crop Journal 2020年第5期8卷 855-865页

作者： yangming Wang Shubei Wan Hao Fan Mao Yang Weiyan Li Rongzhan Guan State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural UniversityNanjing 210095JiangsuChina Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural UniversityNanjing 210095JiangsuChina

The theory and associated selection methods of classical quantitative genetics are based on the multifactorial or polygene *** genes or quantitative trait loci(QTL)in modern quantitative genetics based on a“major gene plus polygenes”genetic system have been paid much attention in genetic ***,it remains unclear how the numerous minor genes act,although the polygene theory has sustained genetic improvement in plants and animals for more than a hundred *** the present study,we identified a novel minor gene,BnSOT-like1(BnaA09g53490D),which is a sulfotransferase(SOT)gene catalyzing the formation of the core glucosinolate(GSL)structure in Brassica *** gene has been occasionally found during investigations of plant height-related genes,but has not been identified by QTL mapping because of its small phenotypic effects on GSL *** overexpression of BnSOT-like1 up-regulated the expression of aliphatic GSL-associated genes,leading to a high seed aliphatic GSL content,and the overexpression of the allelic gene Bnsot-like1 did not increase seed GSL *** findings suggest that the SOT gene has a marked effect on a quantitative trait from a reverse genetics standpoint,but a minor effect on the quantitative trait in its natural biological *** of the redundancy of GSL biosynthetic genes in the allotetraploid species ***,mutations of a single functional gene in the pathway will not result in significant phenotypic changes,and that the genes in biosynthetic pathways such as BnSOT-like1 in our study have minor effects and may be called polygenes in contrast to the reported three regulatory genes(BnHAG1s)which strongly affect GSL content in *** present study has shed light on a minor gene for a quantitative trait.

关键词： Brassica napus Glucosinolate content Minor gene Sulfotransferase ICIM

江西省A村一起清洗畜禽运输车辆导致的人间布鲁氏菌病聚集性疫情调查

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首都公共卫生 2024年第2期18卷 104-108页

作者：赵志坚宗俊李鹏熊桃平罗通邹方冰陈阳明唐兴东黄贵义江西省抚州市疾病预防控制中心 344100 江西省疾病预防控制中心抚州市南丰县疾病预防控制中心

目的调查江西省抚州市南丰县A村布鲁氏菌病(以下简称布病)聚集性疫情原因、传播方式和危险因素,为防控类似事件提供建议。方法开展病例个案流行病学调查,通过现场堪查及走访开展现场卫生学调查,制定统一调查表开展风险暴露回顾性队列... 详细信息

目的调查江西省抚州市南丰县A村布鲁氏菌病(以下简称布病)聚集性疫情原因、传播方式和危险因素,为防控类似事件提供建议。方法开展病例个案流行病学调查,通过现场堪查及走访开展现场卫生学调查,制定统一调查表开展风险暴露回顾性队列调查,组织调查对象开展布鲁氏菌感染初筛及确证实验。对结果进行描述与分析。结果 2020年1月—2023年6月,该村先后共发生3次人间布病聚集发病,涉及该村3户家庭成员,共发生8例布病确诊病例,1例隐性感染者。经回顾性调查发现,暴露畜禽运输车辆(清洗车辆或清洗产生的粪便与水雾)人群患病率为13.43%(9/67),未暴露患病率为0(0/38),两者比较,差异有统计学意义(P<0.05),进一步分析发现接触车辆上留置的粪便(RR=10.48,95%CI:1.39~79.18)、冲洗车辆表面污物(RR=4.73,95%CI:1.46~15.33)、暴露冲洗产生的水雾为危险因素(P<0.05)。培养分离出2株布鲁氏菌,一株为羊1型,另一株为羊2型。结论本次事件为一起因违规清洗畜禽运输车辆导致的人间布病聚集性疫情。运输畜禽车辆监管不到位、村民违规从事畜禽车辆清洗、操作不规范是导致本次布病聚集性发病的主要原因。建议农业、交通部门加强对畜禽运输车辆备案与监管,统筹推进畜禽运输车辆洗消场所建设,加强从业人员培训与健康监测,提高公共卫生部门对畜禽运输车辆清洗环节人畜共患疾病防控的关注。

关键词：布鲁氏菌病畜禽车辆清洗聚集性疫情疫情调查

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王阳明家训思想及其价值意蕴

晋城职业技术学院学报 2024年第2期17卷 74-80页

作者：唐齐广西师范大学马克思主义学院广西桂林541006

传统家训文化是中华优秀传统文化的重要组成部分,反映了农耕文明时期人民对立身、治家、处事、平天下等的美好追求与价值判断。王阳明的家训思想是其心学思想的组成部分,其中蕴含了丰富的修身之道、立德之道、经世济民之道等。新时代,... 详细信息

传统家训文化是中华优秀传统文化的重要组成部分,反映了农耕文明时期人民对立身、治家、处事、平天下等的美好追求与价值判断。王阳明的家训思想是其心学思想的组成部分,其中蕴含了丰富的修身之道、立德之道、经世济民之道等。新时代,在传统文化与现代社会的深度融合中,充分挖掘、阐发和弘扬王阳明家训思想中的有益成分,对新时代中国特色社会主义精神文明建设具有重要意义。

关键词：王阳明家训思想精神文明建设