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Advances in the study of gastric organoids as disease models

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1725-1736页

作者： yi-yang liu De-Kun Wu Ji-Bing Chen You-Ming Tang Feng Jiang Graduate School Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Teaching Experiment and Training Center Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Central Laboratory Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Digestive Disease Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina AIDS Research Center Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina

Gastric organoids are models created in the laboratory using stem cells and sophisticated three-dimensional cell culture *** models have shown great promise in providing valuable insights into gastric physiology and advanced disease *** review comprehensively summarizes and analyzes the research advances in culture methods and techniques for adult stem cells and induced pluripotent stem cell-derived organoids,and patient-derived *** potential value of gastric organoids in studying the pathogenesis of stomach-related diseases and facilitating drug screening is initially *** construction of gastric organoids involves several key steps,including cell extraction and culture,three-dimensional structure formation,and functional *** the structure and function of the human stomach by disease modeling with gastric organoids provides a platform to study the mechanism of gastric cancer induction by Helicobacter *** addition,in drug screening and development,gastric organoids can be used as a key tool to evaluate drug efficacy and toxicity in preclinical *** can also be used for precision medicine according to the specific conditions of patients with gastric cancer,to assess drug resistance,and to predict the possibility of adverse ***,despite the impressive progress in the field of gastric organoids,there are still many unknowns that need to be addressed,especially in the field of regenerative ***,the reproducibility and consistency of organoid cultures are major challenges that must be *** challenges have had a significant impact on the development of gastric ***,as technology continues to advance,we can foresee more comprehensive research in the construction of gastric *** research will provide better solutions for the treatment of stomach-related diseases and personalized medicine.

关键词： Organoids Stomach neoplasms Helicobacter pylori Drug evaluation Preclinical Precision

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新时代构建普职融通高中的现实逻辑与基本理路

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教育理论与实践 2024年第18期44卷 29-33页

作者：杨浏祎郑帅男康媛媛郑州大学河南音乐学院河南开放大学郑州大学马克思主义学院河南郑州450000

构建普职融通高中符合新时代中国教育创新改革的现实境况,是解决当前我国教育所面临复杂问题的重要突破口之一。普职融通高中是新时代促进“五育”融合的有效路径,而“五育”融合则是普职融通高中追求的育人目标。普职融通高中的构建既... 详细信息

构建普职融通高中符合新时代中国教育创新改革的现实境况,是解决当前我国教育所面临复杂问题的重要突破口之一。普职融通高中是新时代促进“五育”融合的有效路径,而“五育”融合则是普职融通高中追求的育人目标。普职融通高中的构建既是优化高质量教育体系的内在需求,也是助力国民经济快速发展的有力抓手,更是引导学生规划生涯发展的重要平台。推进普职融通高中建设,亟需加快转变“重普轻职”的思想观念,亟待明确普职融通高中构建的目标导向、基本原则、均等化理念和运行机制,并由此形成普通教育与职业教育之间平等双向融通的崭新局面。

关键词：普职融通高中目标导向基本原则均等化理念运行机制

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Synthesis of a Novel Diamine 4-[(4'-Butoxyphenoxy)carbonyl]phenyl-3",5"-diaminobenzoate and Corresponding Polyimides

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Chinese Chemical Letters 2006年第11期17卷 1511-1514页

作者： Li Gang REN Xiang yang liu yi GU State Key Laboratory of Polymeric Materials Engineering College of Polymer Science and Engineering Sichuan University Chengdu 610065

A novel diamine 4-[（4＇-butoxyphenoxy）carbonyl]phenyl-3＂,5＂-diaminobenzoate （BCDA） was synthesized from 4-butoxyphenol, 4-hydroxybenzoic acid and 3,5-dinitrobenzoic acid through four main intermediates, and a series of polyimides were also synthesized. All the intermediates and the final product were characterized by FTIR and 1H-NMR. The key step in synthesis route is selective hydrolyzation of two ester groups in 4-butoxyphenyl-4＇-acetoxybenzoate, by adjusting the reaction temperature and the concentration of ammonia, shorteding the reaction time. The properties of the novel polyimides, such as the aggregation structures, glass transition temperature, solubility and the pretilt angles, were carded out.

关键词： Synthesis polyimides side chain alignment film.

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A stable staggered-grid finite-difference scheme for acoustic modeling beyond conventional stability limit

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Petroleum Science 2024年第1期21卷 182-194页

作者： Jing-yi Xu yang liu National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China China University of Petroleum(Beijing) Karamay CampusKaramay 834000XinjiangChina

Staggered-grid finite-difference(SGFD)schemes have been widely used in acoustic wave modeling for geophysical *** improved methods are proposed to enhance the accuracy of numerical ***,these methods are inevitably limited by the maximum Courant-Friedrichs-Lewy(CFL)numbers,making them unstable when modeling with large time sampling intervals or small grid *** solve this problem,we extend a stable SGFD scheme by controlling SGFD dispersion relations and maximizing the maximum CFL ***,to improve modeling stability,we minimize the error between the FD dispersion relation and the exact relation in the given wave-number region,and make the FD dispersion approach a given function outside the given wave-number area,thus breaking the conventional limits of the maximum CFL ***,to obtain high modeling accuracy,we use the SGFD scheme based on the Remez algorithm to compute the FD *** addition,the hybrid absorbing boundary condition is adopted to suppress boundary reflections and we find a suitable weighting coefficient for the proposed *** derivation and numerical modeling demonstrate that the proposed scheme can maintain high accuracy in the modeling process and the value of the maximum CFL number of the proposed scheme can exceed that of the conventional SGFD scheme when adopting a small maximum effective wavenumber,indicating that the proposed scheme improves stability during the modeling.

关键词： Acoustic wave Staggered-grid finite-difference(SGFD) modeling Courant-friedrichs-lewy(CFL)number Stability

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Regulating silver nanowire size enables efficient photoelectric conversion

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Science China Chemistry 2020年第8期63卷 1046-1052页

作者： Jie Xu Kai Wang yi Li Tao-Tao Zhuang Huai-Ling Gao yang-yi liu Chuan-Xin He Shu-Hong Yu College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China Department Division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleCAS Center for Excellence in NanoscienceDepartment of ChemistryInstitute of Biomimetic Materials&ChemistryUniversity of Science and Technology of ChinaHefei 230026China

The increasing demand for the state-of-the-art transparent conductive electrodes has received great interest in synthesizing silver nanowires(AgNWs)with a uniform diameter that exhibit excellent conductance,transparency,flexibility and mechanical ***,we report the controllable synthesis of ultrathin AgNWs with high aspect ratio via a polyol-assisted *** diameter of AgNWs can be continuously modulated from 20 to 80 nm by simply adjusting the aging *** selfassembled films fabricated by using AgNWs with a diameter of 20 nm as building blocks enable an excellent performance and show a sheet resistance of^30Ω/sq and an optical transmittance of 94%.In addition,such nanowire-based conductive films can keep the excellent flexibility and resistance after bending 10,000 ***,the intelligent dimming films prepared by this AgNW films also have excellent flexibility and stability.

关键词： silver nanowires polyol-assisted process assembly transparent conductive film conductive electrode

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One-Pot Synthesis of Tetrafluoro- and Tetrachlorofluorescein Derivatives and Their Stabilization by ,6-Cyclodextrin

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Chinese Journal of Chemistry 2013年第5期31卷 612-616页

作者： LI-Li Tan ying-Wei yang yi-Pu liu Sean Xiao-An Zhang State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun Jilin 130012 China

A highly efficient one-pot procedure for the preparation of fluorescein-based dyes with relatively high yield was investigated. Significantly, introduction of these fluoro and chloro functional groups and forming host... 详细信息

关键词： fluorescein cyclodextrin photostability cucurbituril one-pot synthesis supramolecular chemistry

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Cu-alanine complex-derived CuO electrocatalysts with hierarchical nanostructures for efficient oxygen evolution

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Chinese Chemical Letters 2021年第7期32卷 2239-2242页

作者： Xinran Li Changli Wang yang-yi liu Huaiguo Xue Huan Pang Qiang Xu School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009China AIST-Kyoto University Chemical Energy Materials Open Innovation Laboratory(ChEM-OlL) National Institute of Advanced Industrial Science and Technology(A1ST)Kyoto 606-8501Japan

Nowadays,Cu-based materials have attracted extensive attention as electrocatalysts,while the inherent reason of the filling of high anti-bonding state of Cu d band(3 d^(10)4 s^(1))makes it difficult to hybridize with O2 p band of oxygen intermediates during the adsorption process of oxygen evolution reaction(OER).To increase the efficiency of Cu-based electrocatalysts,efforts have been made to optimize the electronic structures and to create surface defects and hierarchical nanostructures with more exposed accessible active ***,we report a facile method for preparing CuO electrocatalysts with hierarchical nanostructures using the Cu-alanine complex as a precursor through room-temperature chemical precipitation and subsequent calcination in *** of products obtained at different calcination temperatures reveal the relationship between OER activities and the material characteristics such as specific surface areas,crystal growth orientations,and element *** product obtained at 500℃exhibits the smallest overpotential of 290 mV in 1.0 mol/L KOH for electrocatalyzing *** with various characterizations of CuO electrocatalysts after OER activities,the possible catalytic mechanism and the influence factors of their OER performance are also discussed.

关键词： Copper complex precursor Copper oxide Hierarchical nanostructure Electrocatalysis Oxygen evolution reaction

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Anisotropic nanowire growth via a self-confined amorphous template process： A reconsideration on the role of amorphous calcium carbonate

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Nano Research 2016年第5期9卷 1334-1345页

作者： Li-Bo Mao Lei Xue Denis Gebauer Lei liu Xiao-Fang Yu yang-yi liu Helmut Colfen Shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the Microscale Collaborative Innovation Center of Suzhou Nano Science and Technology CAS Center for Excellence in Nanoscience Department of Chemistry University of Science and Technology of China Hefei 230026 China Department of Chemistry University of Konstanz Universitatsstrasse 10 Box 714 D-78457 Konstanz Germany

Calcium carbonate crystals with various morphologies have been found in a variety of biospecimens and artificially synthesized structures. Usually, the diversity in morphology can be attributed to different types of interactions between the specific crystal faces and the environment or the templates used for the growth of CaCO3 crystals. On the other hand, isotropic amorphous calcium carbonate （ACC） has been recognized as the precursor of other crystalline calcium carbonate forms for both in vivo and in vitro systems. However, here we propose a self-confined amorphous template process leading to the anisotropic growth of single-crystalline calcite nanowires. Initiated by the assembly of precipitated nanoparticles, the calcite nanowires grew via the continuous precipitation of partly crystallized ACC nanodroplets onto their tips. Then, the crystalline domains in the tip, which were generated from the partly crystallized nanodroplets, coalesced in the interior of the nanowire to form a single-crystalline core. The ACC domains were left outside and spontaneously formed a protective shell to retard the precipitation of CaCO3 onto the side surface of the nanowire and thus guided the highly anisotropic growth of nanowires as a template.

关键词： amorphous calcium carbonate calcite nanowire anisotropic growth self-confined amorphous template

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Spatio-temporal analysis of urbanization and land and water resources efficiency of oasis cities in Tarim River Basin

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Journal of Geographical Sciences 2014年第3期24卷 509-525页

作者： yang Yu liu yi Institute of Geographic Sciences and Nature Resources Research CAS Beijing 100101 China

This paper examines the spatial pattern of land and water resources as well as urbanization and their interactions in the Tarim River Basin, Xinjiang, China. In order to do so, we extract the data associated with efficiency of land and water resources and urbanization for the years of 1995, 2000, 2005 and 2008. Specifically the paper investigates the extent to which agglomeration of population and economic activities varies geographically and inter- plays with spatial pattern of resources efficiency through computation of Global Moran＇s I index, Getis-Ord Gi＊ index and a coordinated development model. The method used provides clear evidence that urbanization, land and water resources efficiency have shown uneven spatial pattern due to oasis distribution, climate, and initial phase of urban development. Some conclusions can be drawn as follows. （1） Agglomeration and dispersion of urbanization are not consistent with those of land and water resources efficiency. （2） Evolution of the hot and cold spots of urbanization, and land and water resources efficiency, in different trajecto- ries, indicate that there are no significant interactions between them. （3） The evidence that numbers of hot and cold spots of the three factors present varying structures reveals the dominance of unequal urban development in the study area. （4） Significant differences are also found between sub-river basins in terms of the three factors, which is a reflection of the complex physical geography of the area. （5） The degree of coordinated development of cities in the Tarim River Basin is generally low in part as a reflection of difference in spatial patterns of the three factors. It is also shown that the pattern of the degree of coordinated development is relatively stable compared with evolution of hot and cold spots of the three factors.

关键词： ESDA Tarim River Basin oasis cities land and water resources efficiency spatio-temporal variation

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Trace Cobalt Doping and Defect Engineering of High Surface Area α-Ni(OH)_(2) for Electrocatalytic Urea Oxidation

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Energy & Environmental Materials 2024年第2期7卷 111-118页

作者： yi liu Zhihui yang Yuqin Zou Shuangyin Wang Junying He School of Metallurgy and Environment Central South UniversityChangsha 410083China State Key Laboratory of Chem/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Owing to the intrinsically sluggish kinetics of urea oxidation reaction(UOR)involving a six-electron transfer process,developing efficient UOR electrocatalyst is a great challenge remained to be ***,by taking advantage of 2-Methylimidazole,of which is a kind of alkali in water and owns strong coordination ability to Co^(2+)in methanol,trace Co(1.0 mol%)addition was found to induce defect engineering onα-Ni(OH)_(2)in a dual-solvent system of water and *** characterization results revealed that the synthesized electrocatalyst(WM-Ni_(0.99)Co_(0.01)(OH)_(2))was a kind of defective nanosheet with thickness around 5-6 nm,attributing to the synergistic effect of Co doping and defect engineering,its electron structure was finely altered,and its specific surface a rea was tremendously enlarged from 68 to 172.3 m^(2)g^(-1).With all these merits,its overpotential to drive 10 mA cm^(-2)was reduced by 110 ***,the interfacial behavior of UOR was also well deciphered by operando electrochemical impedance spectroscopy.

关键词： defect engineering electrocatalysis small molecule oxidation

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