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Hydrogen Sulfide Promotes Platelet Autophagy via􀀳􀀧􀀪􀀩􀀵􀀐􀄮􀀒􀀳􀀬􀀖􀀮􀀒􀀤􀁎􀁗􀀃􀀶􀁌􀁊􀁑􀁄􀁏􀁌􀁑􀁊􀀃􀁌􀁑􀀃􀀦􀁌􀁕􀁕􀁋􀁒􀁗􀁌􀁆􀀃􀀷􀁋􀁕􀁒􀁐􀁅􀁒􀁆􀁜􀁗􀁒􀁓􀁈􀁑􀁌􀁄

Journal of Clinical and Translational hepatology 2024年第7期12卷 625-633页

作者： Hua-Xiang yang yang-Jie Li yang-lan he Ke-Ke Jin Ling-Na Lyu Hui-Guo Ding Department of Gastroenterology and hepatology Beijing You’an Hospital Affiliated to Capital Medical UniversityBeijingChina

Background and Aims:The role of platelet autophagy in cirrhotic thrombocytopenia(CTP)remains *** study aimed to investigate the impact of platelet autophagy in CTP and elucidate the regulatory mechanism of hydrogen sulfide(H_(2)S)on platelet ***:Platelets from 56 cirrhotic patients and 56 healthy individuals were isolated for in vitro *** markers(ATG7,BECN1,LC3,and SQSTM1)were quantified using enzyme-linked immunosorbent assay,while autophagosomes were visualized through electron *** blotting was used to assess the autophagy-related proteins and the PDGFR/PI3K/Akt/mTOR pathway following treatment with NaHS(an H_(2)S donor),hydroxocobalamin(an H_(2)S scavenger),or AG 1295(a selective PDGFR-α/inhibitor).A carbon terachloride-induced cirrhotic BALB/c mouse model was *** mice with thrombocytopenia were randomly treated with normal saline,NaHS,or hydroxocobalamin for 15 *** in platelet count and aggregation rate were observed every three ***:Cirrhotic patients with thrombocytopenia exhibited significantly decreased platelet autophagy markers and endogenous H_(2)S levels,alongside increased platelet aggregation,compared to healthy *** vitro,NaHS treatment of platelets from severe CTP patients elevated LC3-II levels,reduced SQSTM1 levels,and decreased platelet aggregation in a dose-dependent manner.H_(2)S treatment inhibited PDGFR,PI3K,Akt,and mTOR *** vivo,NaHS significantly increased LC3-II and decreased SQSTM1 expressions in platelets of cirrhotic mice,reducing platelet aggregation without affecting the platelet ***:Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients.H_(2)S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling pathway.

关键词： Liver cirrhosis Thrombocytopenia Platelet Autophagy Hydrogen sulfide NaHS PDGFR-α PI3K/Akt/mTOR signaling

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High-entropy design boosts dielectric energy storage

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Rare Metals 2024年第8期43卷 4013-4015页

作者： Qiu-Ying Xia he Zhu Si lan yang Ren herbert Gleiter Institute of Nanoscience School of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Department of Physics City University of Hong KongHong Kong999077China

Dielectric capacitors are vital for advanced electronic and electrical power systems due to their impressive power density and ***,a persistent challenge has been enhancing their energy densities while maintaining high *** in Science,a novel high-entropy design for relaxor ferroelectric materials has been proposed,promising significant improvements in both energy density and efficiency for multilayer dielectric ceramic *** the crucial role of high-entropy design in energy storage materials and devices,this highlight focuses on interpreting the progress and significance of this innovative work.

关键词： ceramic dielectric energy

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Reaction Kinetic Equation for Char Combustion of Underground Coal Gasification

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Journal of China University of Mining and Technology 2006年第2期16卷 141-146页

作者： YU Hong-guan yang lan-he FENG Wei-min LIU Shu-qin SONG Zhen-qi School of Chemical and Environmental Engineering Shandong University of Science and Technology Qingdao Shandong 266510 China School of Mineral Resource and Geoscience China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Engineering Department Beizao Coal Mine Group Companies of Longkou Mining Industry Longkou Shangdong 265700 China School of Chemical and Environmental Engineering China University of Mining ＆ Technology Beijing 100083 China School of Mineral Resource and Environmental Engineering Shandong University of Science and Technology Qingdao Shandong 266510 China

Based on the quasi-steady-state approximation, the dynamic equation of char combustion in the oxidation zone of underground coal gasification (UCG) was derived. The parameters of the dynamic equation were determined at 900℃ using a thermo-gravimetric (TG) analyzer connected to a flue gas analyzer and this equation. The equation was simplified for specific coals, including high ash content, low ash content, and low ash fusibility ones. The results show that 1) the apparent reaction rate constant increases with an increase in volatile matter value as dry ash-free basis,2) the effective coefficient of diffusion decreases with an increase in ash as dry basis, and 3) the mass transfer coefficient is independent of coal quality on the whole. The apparent reaction rate constant, mass-transfer coefficient and effective coefficient of diffusion of six char samples range from 7.51×104 m/s to 8.98×104 m/s, 3.05×106 m/s to 3.23×106 m/s and 5.36×106 m2/s to 8.23×106 m2/s at 900℃, respectively.

关键词： underground coal gasification char combustion kinetic equation thermo-gravimetric

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The chlorine evolution reaction promoted by organocatalysts with amide functional groups

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Science China Chemistry 2024年第3期67卷 749-750页

作者： lan Zhao Liang-Nian he State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071China

Since the nineteenth century, the chlor-alkali process entails the electrochemical oxidation of sodium chloride solutions to Cl_(2) by the chlorine evolution reaction(CER) and the simultaneous production of sodium hyd... 详细信息

关键词： chlorine hydroxide promoted

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煤炭地下气化热爆炸技术模型实验研究

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中国矿业大学学报 2001年第3期30卷 244-247页

作者：杨兰和中国矿业大学资源与地球科学学院江苏徐州221008

鉴于我国在倾斜、缓倾斜或近水平煤层中进行地下气化所遇到的实际问题 ,提出了煤炭地下气化热爆炸 -温控爆破渗流燃烧技术 ,简述了热爆炸基本原理 ,介绍了模型试验台结构、爆破参数设计、测试系统及冷态试验 ,并对试验结果进行了分析 .... 详细信息

鉴于我国在倾斜、缓倾斜或近水平煤层中进行地下气化所遇到的实际问题 ,提出了煤炭地下气化热爆炸 -温控爆破渗流燃烧技术 ,简述了热爆炸基本原理 ,介绍了模型试验台结构、爆破参数设计、测试系统及冷态试验 ,并对试验结果进行了分析 .模型试验结果表明 ,温控爆破松动作用 ,提供了气固之间有效燃烧气化所需要的大反应表面 ,并形成渗流燃烧的气化条件 ,从而证明了将热爆炸 -温控爆破技术应用于煤炭地下气化过程的合理性和可靠性 .

关键词：煤炭地下气化热爆炸温控爆破渗流燃烧煤气热值爆破参数

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Generative Models for the Evolution of Transportation Systems

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Yixu he Hongyi Lin lan yang yang Liu School of Information Engineering， Chang'an University School of Vehicle and Mobility， Tsinghua University Department of Architecture and Civil Engineering， Chalmers University of Technology

As the development of big data and artificial intelligence accelerates， many studies have begun to incorporate methods of machine learning and deep learning to address multifaceted challenges within the field of transportation. Generative models， garnering increasing attention in recent years， are gradually bolstering the progression of intelligent transportation systems. This paper conducts an extensive investigation into the applications and potential of generative models in the evolution of transportation systems. It specifically delves into three primary areas: trajectory generation， traffic flow prediction， and autonomous driving. While generative models have already made significant contributions， their full capabilities remain underexplored. Consequently， this paper introduces promising avenues for future exploration， such as the potential integration of diffusion models in autonomous driving， harnessing generative models for infrastructure planning， and leveraging generative models to enhance traffic safety. It is anticipated that this paper will serve as a comprehensive and insightful reference for researchers and scholars engaged in generative models and their applications in the transportation domain.

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A Scalable Pillar Layered Metal-Organic Framework for Natural Gas Purification

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Chemical Research in Chinese Universities 2024年第4期40卷 675-681页

作者： LU Nan lan lan GAO Qiang LI Na BU Xian-he School of Materials Science and Engineering Nankai UniversityTianjin300350P.R.China State Key Laboratory of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin300071P.R.China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212003P.R.China

One-step harvest of high-purity methane(CH_(4))from ternary propane/ethane/methane(C_(3)H_(8)/C_(2)H_(6)/CH_(4))mixtures remains a desirable yet challenging goal for natural gas ***,adsorbents either suffer from high capacity and selectivity,or are caught in a dilemma of scalable ***,we demonstrate a scalable pillar layered metal-organic framework Ni-MOF for highly efficient one-step CH_(4)***-MOF exhibits high C_(2)H_(6)and C_(3)H_(8)uptakes of 83.3 and 86.1 cm^(3)/g at 298 K and 100 kPa and remarkable C_(2)H_(6)/CH_(4)(50/50,volume ratio,21.5)and C_(3)H_(8)/CH_(4)(50/50,volume ratio,212.0)***,high C_(2)H_(6)(42.2 cm^(3)/g at 10 kPa)and C_(3)H_(8)(64.7 cm^(3)/g at 5 kPa)capacities in the low-pressure region at 298 K were realized on Ni-MOF,suggesting the strong affinities of Ni-MOF towards C_(2)H_(6)and C_(3)H_(8).Furthermore,the dynamic breakthrough experiments revealed that purifying CH_(4)from natural gas in one-step can be achieved in Ni-MOF with high-purity(>99.8%)and productivity(346.0 cm^(3)/g).Most significantly,the production of Ni-MOF can be scalably synthesized at room temperature,rendering it promising potential for industrial *** combined advantages of exceptional separation performance,scalability,and cycle stability of Ni-MOF pave the way for one-step CH_(4)purification from natural gas.

关键词： Metal-organic framework Adsorption and separation Natural gas purification Scale-up synthesis

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Recent progress in photocatalytic NAD(P)H regeneration for photocatalytic-enzymatic-coupling system

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 1-24页

作者： Wei lan Maodi Wang Huicong Dai Qihua yang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Key Laboratory for Reactive Chemistry on Solid SurfacesInstitute of Physical ChemistryZhejiang Normal UniversityJinhua 321004China

The enzymatic redox reactions in natural photosynthesis rely much on the participation of cofactors,with reduced nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate(NADH/NADPH)or their oxidized form(NAD+/NADP+)as an important redox *** photocatalytic regeneration of expensive and unstable NADH/NADPH in vitro is an important process in enzymatic reduction and has attracted much research *** different types of photocatalysts have been developed for photocatalytic NADH/NADPH regeneration,the efficiency is still relatively *** elucidate the key factors affecting the performance of photocatalytic NADH/NADPH regeneration is helpful to rationally design the photocatalyst and improve the photocatalytic *** this paper,we overview the recent progress in photocatalytic NADH/NADPH regeneration with the focus on the strategies to improve the visible light adsorption,the charge separation and migration efficiency,as well as the surface reaction,which jointly determine the overall photocatalytic regeneration *** potential development of photocatalytic NADH/NADPH regeneration and photocatalyticenzymatic-coupling system is prospected finally.

关键词： photocatalytic-enzymatic coupling NAD(P)H regeneration photocatalysis efficiency

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Bioinspired supramolecular macrocycle hybrid membranes with enhanced proton conductivity

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Nano Research 2024年第2期17卷 797-805页

作者： Pengfei yang Linlin Xu Panagiotis Trogadas Marc-Olivier Coppens yang lan Centre for Nature Inspired Engineering Department of Chemical EngineeringUniversity College LondonLondon WC1E 7JEUK

Enhancing the proton conductivity of proton exchange membranes(PEMs)is essential to expand the applications of proton exchange membrane fuel cells(PEMFCs).Inspired by the proton conduction mechanism of bacteriorhodopsin,cucurbit[n]urils(CB[n],where n is the number of glycoluril units,n=6,7,or 8)are introduced into sulfonated poly(ether ether ketone)(SPEEK)matrix to fabricate hybrid PEMs,employing a nature-inspired chemical engineering(NICE)*** carbonyl groups of CB[n]act as proton-conducting sites,while the host–guest interaction between CB[n]and water molecules offers extra protonconducting ***,the molecular size of CB[n]aids in their dispersion within the SPEEK matrix,effectively bridging the unconnected proton-conducting sulfonic group domains within the SPEEK ***,all hybrid membranes exhibit significantly enhanced proton ***,the SPEEK membrane incorporating 1 wt.%CB[8](CB[8]/SPEEK-1%)demonstrates the highest proton conductivity of 198.0 mS·cm^(−1) at 60°C and 100%relative humidity(RH),which is 228%greater than that of the pure SPEEK membrane under the same ***,hybrid membranes exhibit superior fuel cell *** CB[8]/SPEEK-1%membrane achieves a maximum power density of 214 mW·cm^(−2),representing a 140%improvement over the pure SPEEK membrane(89 mW·cm^(−2))at 50°C and 100%*** findings serve as a foundation for constructing continuous proton-conducting pathways within membranes by utilizing supramolecular macrocycles as fuel cell electrolytes and in other applications.

关键词： supramolecular macrocycle proton conductivity cucurbit[n]uril proton exchange membrane fuel cell

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Global warming strengthens the association between ENSO and the Asian-Australian summer monsoon

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Science China Earth Sciences 2024年第1期67卷 309-312页

作者： Bao yang Minhui he School of Geography and Ocean Science Nanjing UniversityNanjing 210093China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Previous studies have widely reported the linkages between Asian-Australian monsoon and the ENSO(Wu,2008;Azad and Rajeevan,2016;Chen et al.,2020;Shekhar et al.,2022;Zhang J et al.,2022;Chen et al.,2023;Hau et al.,2023;heidemann et al.,2023).It is well accepted that the monsoon is weaker during the El Niño phase and stronger during the La Niña *** example,an anomalously strong western Pacific subtropical high in 2020,related to the La Niña event.

关键词： event monsoon Asian

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