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Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment

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Emergency and Critical Care Medicine 2022年第4期2卷 225-232页

作者： Jing yang Shuting Chang Jing Liu Guanzhao Zhang Yue Wang Baixue Zhang Zifan nie Yuanbao Dong bo Li Binzhou Medical University YantaiShandongChina Department of Cardiology Shandong University Zibo Central HospitalZiboShandongChina Zibo Key Laboratory of Atherosclerosis and Vascular Calcification ZiboShandongChina Weifang Medical University WeifangShandongChina Department of Intravenous Drug Dispensing Shandong University Zibo Central HospitalZiboShandongChina Shandong First Medical University JinanShandongChina Weifang Fangzi District People’s Hospital WeifangShandongChina.

Background:Drug-coated balloons(DCBs)are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease,but their efficacy in treating acute myocardial infarction needs to be further ***:A meta-analysis of 7 studies was conducted to make a comparison with the results of DCB and drug-eluting stent implantation after a median follow-up of 15 ***:A total of 922 patients were included in this analysis in total,including 375 patients in the DCB group and 547 patients in the stent group.A total of 962 vascular diseases were manifested in the 2 *** 6 to 24 months of follow-up,there was no statistically significant difference with respect to major adverse cardiovascular events(odds ratio[OR]:0.82;95%confidence interval[CI]:0.52–1.29;Z=0.85;P=0.39),cardiac death(OR:0.92;95%CI:0.39–2.12;Z=0.21;P=0.84),target lesion revascularization(OR:1.09;95%CI:0.53–2.25;Z=0.24;P=0.81),late lumen loss(MD:−0.05;95%CI:−0.15 to 0.06;Z=0.85;P=0.40),or dual antiplatelet therapy(DAPT)(OR:1.04;95%CI:0.53–2.05;Z=0.11;P=0.91)between the 2 *** the DCB group,persistent residual stenosis or C-F dissection occurrence necessitated that a total of 30 patients receive extra bailout *** rate of bailout stenting was 11.8%(95%CI:7.1–16).Moreover,the DCB group had a shorter DAPT duration compared with the stent ***:Drug-coated balloons with shorter DAPT durations may be as effective and safe as stent therapy in treating acute myocardial infarction.

关键词： Acute myocardial infarction Drug-coated balloon Dual antiplatelet therapy Paclitaxel-coated balloon

Effect of Extrusion Temperature on the Microstructure and Mechanical Properties of Mg–5Al–2Ca Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第8期28卷 1015-1023页

作者： Kun Su Kun-kun Deng Fang-jun Xu Kai-bo nie Li Zhang Xiao Zhang Wei-jian Li College of Materials Science and Engineering Shanxi Key Laboratory of Advanced Magnesium-Based MaterialsTaiyuan University of Technology

In this work, the Mg–5Al–2Ca alloy was extruded at 573, 623 and 673 K, with a ratio of 16：1 and a constant speed of 3 mm/s. Results demonstrate that the Al2Ca particle is formed in Mg–5Al–2Ca alloy. The size, amount and distribution of Al2Ca particles are influenced evidently by extrusion temperature. Unlike previous reports, the intensity of basal texture increases with increasing extrusion temperature, and the reasons are analyzed and given. Even though the average grain size increases as the extrusion temperature increased from 573 to 623 K, the YS, UTS and elongation of asextruded Mg–5Al–2Ca alloy are almost kept the same at 573 and 623 K. The reason is speculated as the balance of grain size, Al2Ca phase and texture at the two temperatures. The work hardening rate depends on extrusion temperature, and the largest θ value of Mg–5Al–2Ca alloy is obtained when the extrusion was performed at 623 K.

关键词： Mg–Al–Ca alloy Extrusion Microstructure Mechanical properties Work hardening

CircDOCK7 facilitates the proliferation and adipogenic differentiation of chicken abdominal preadipocytes through the gga‑miR‑301b‑3p/ACSL1 axis

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Journal of Animal Science and Biotechnology 2023年第6期14卷 2290-2315页

作者： Weihua Tian Ye Liu Wenhui Zhang Ruixue nie Yao Ling bo Zhang Hao Zhang Changxin Wu National Engineering Laboratory for Animal Breeding Beijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Background Abdominal fat deposition depends on both the proliferation of preadipocytes and their maturation into adipocytes,which is a well-orchestrated multistep process involving many regulatory *** RNAs(circRNAs)have emergingly been implicated in mammalian ***,circRNA-mediated regulation in chicken adipogenesis remains *** previous circRNA sequencing data identified a differentially expressed novel circRNA,8:27,886,180|27,889,657,during the adipogenic differentiation of chicken abdominal *** study aimed to investigate the regulatory role of circDOCK7 in the proliferation and adipogenic differentiation of chicken abdominal preadipocytes,and explore its molecular mechanisms of competing endogenous RNA underlying chicken *** Our results showed that 8:27,886,180|27,889,657 is an exonic circRNA derived from the head-to-tail splicing of exons 19–22 of the dedicator of cytokinesis 7(DOCK7)gene,abbreviated as ***7 is mainly distributed in the cytoplasm of chicken abdominal preadipocytes and is stable because of its RNase R resistance and longer ***7 is significantly upregulated in the abdominal fat tissues of fat chickens compared to lean chickens,and its expression gradually increases during the proliferation and adipogenic differentiation of chicken abdominal ***,the gain-and loss-of-function experiments showed that circDOCK7 promoted proliferation,G0/G1-to S-phase progression,and glucose uptake capacity of chicken abdominal preadipocytes,in parallel with adipogenic differentiation characterized by remarkably increased intracellular lipid droplet accumulation and triglyceride and acetyl coenzyme A content in differentiated chicken abdominal ***,a pull-down assay and a dual-luciferase reporter assay confirmed that circDOCK7 interacted with gga-miR-301b-3p,which was identified as an inhibitor of chicken abdominal adipogene

关键词： Abdominal fat deposition Adipogenesis Chickens CircDOCK7 Competing endogenous RNA MiRNA sponge

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分子对接在筛选抗宫颈癌药物中的研究进展

中国临床药理学与治疗学 2024年第8期29卷 955-960页

作者：王丹张文艳罗仁洁陈元静韩雪曲波冯石芳聂夏子刘会玲甘肃中医药大学第一临床医学院甘肃兰州730000 甘肃省人民医院妇科甘肃兰州730000

宫颈癌是最常见的妇科恶性肿瘤之一,在淋巴结转移和远处转移的情况下,五年生存率显著下降,因此研发新型抗宫颈癌药物对于治疗宫颈癌有重大的意义。分子对接技术是计算机辅助药物设计技术中最常用的研究方法之一,在筛选药物有效成分、发... 详细信息

宫颈癌是最常见的妇科恶性肿瘤之一,在淋巴结转移和远处转移的情况下,五年生存率显著下降,因此研发新型抗宫颈癌药物对于治疗宫颈癌有重大的意义。分子对接技术是计算机辅助药物设计技术中最常用的研究方法之一,在筛选药物有效成分、发现药物作用于肿瘤的靶点以及探索抗肿瘤药物的作用机制中被广泛应用。本文将分子对接技术在抗宫颈癌药物筛选、抗肿瘤靶标确定方面以及抗宫颈癌作用机制等方面作一综述,为筛选抗宫颈癌药物及新药研发提供更充分的理论依据。

关键词：宫颈癌分子对接虚拟筛选靶标蛋白作用机制

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Microstructure and mechanical behavior of Mg-5Zn matrix influenced by particle deformation zone

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Journal of Materials Science & Technology 2021年第1期60卷 8-20页

作者： Quan-xin Shi Cui-ju Wang Kun-kun Deng Kai-bo nie Yucheng Wu Wei-min Gan Wei Liang Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China GMS at MLZ Helmholtz-Zentrum GeesthachtGarchingGermany

The effect of particle deformation zone(PDZ) on the microstructure and mechanical properties of SiC_(p)/Mg-5Zn composites was ***,the work hardening and so ftening behavior of SiC_(p)/Mg-5Zn composites influenced by PDZ size were analyzed and discussed using neutron diffraction under in-situ tensile *** evolution of FWHM(full width at half maximum) extracted from the diffraction pattern of SiC_(p)/Mg-5Zn composites was used to interpret the modification of dislocation density during in-situ tension,which discovered the effect of dislocation on the work hardening behavior of SiC_(p)/Mg-5Zn *** addition,the tensile stress reduction(△P_i) values during in-situ tension test were calculated to analyze the effect of PDZ size on the softening behavior of SiC_(p)/Mg-5Zn *** results show that the work hardening rate of SiC_(p)/Mg-5Zn composites increased with the enlargement of PDZ size,which was attributed to the grain size of SiC_(p)/Mg-5Zn composites increased with the enlargement of PDZ ***,the stress reduction(△P_i) values increased continuously during in-situ tensile for SiC_(p)/Mg-5Zn composites due to the increased stored energy produced during plastic deformation,which provided a driving force for the softening ***,the effect of grain size on the softening behavior is greater than that of the stored energy,which led to the tensile stress reduction(△P_i) values of P30(d_(PDZ)=30 μm)-SiC_(p)/Mg-5Zn composite were higher than that of P60(d_(PDZ)=60 μm)-SiC_(p)/Mg-5Zn composite when the ε_(ri) were 0.25,0.5,0.75 and 1,respectively.

关键词： PDZ size SiC_(p)/Mg-5Zn composites Work hardening behavior Softening In-situ tensile Neutron diffraction

Microstructure and mechanical properties of Mg-4Zn-xGd(x=0,0.5,1,2)alloys

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Journal of Magnesium and Alloys 2020年第2期8卷 441-451页

作者： Cui-ju Wang Jin-wen Kang Kun-kun Deng Kai-bo nie Wei Liang Wei-guo Li Shanxi Key laboratory of advanced magnesium-based materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024PR China Engineering training center Taiyuan University of TechnologyTaiyuan 030024PR China

The present work inainly focuses on tlie effect of minor cofiteut of Gd cicmcnt on the micrGstmcturc and mechanical properties of Mg Zn *** Mg-4Zn-xGd(x=0,0.5,1,2)alloys were fabricated and subjected to extrusion at 280℃ with the ratio of 25:*** revealed that the addition of Gd could inhibit the dynamic recrystallization(DRX)of Mg-4Zn alloy,and both the size and volume fraction of DRXed grains demonstrated a decreasing tendency as the Gd content increased from 0.5 to 2 wt.%.It is the weakening effect on DRX behavior that lead to the smaller amount of fine precipitate and the stronger texture *** compared with the Mg-4Zn alloy,the yield strength and ultimate tensile strength of Mg-4Zn-xGd alloys were improved obviously by the addition of minor content of Gd,however,at the expense of *** tensile properties with the yield strength of〜369.8 MPa and ultimate tensile strength of〜400.3 MPa were obtained when the Gd content was 2 wt.%.

关键词： Magnesium alloy Dynamic recrystallization Dynamic precipitation Microstructure Mechanical properties

Variable angle spectroscopic ellipsometry and its applications in determining optical constants of chalcogenide glasses in infrared

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Chinese Physics B 2018年第6期27卷 454-460页

作者： Ning-Ning Wei Zhen yang Hong-bo Pan Fan Zhang Yong-Xing Liu Rong-Ping Wang Xiang Shen Shi-Xun Dai Qiu-Hua nie Laboratory of Infrared Material and Devices Advanced Technology Research InstituteNingbo UniversityNingbo 315211China Key Laboratory of Photoelectric Materials and Devices of Zhejiang Province Ningbo 315211China

The principle of variable angle spectroscopic ellipsometry（VASE） and the data analysis models, as well as the applications of VASE in the characterization of chalcogenide bulk glasses and thin films are reviewed. By going through the literature and summarizing the application scopes of various analysis models, it is found that a combination of various models, rather than any single data analysis model, is ideal to characterize the optical constants of the chalcogenide bulk glasses and thin films over a wider wavelength range. While the reliable optical data in the mid-and far-infrared region are limited, the VASE is flexible and reliable to solve the issues, making it promising to characterize the optical properties of chalcogenide glasses.

关键词： chalcogenide glasses/thin films VASE optical constants infrared

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耐腐蚀性能和拉伸性能提升的α型钛合金设计

稀有金属材料与工程 2024年第4期53卷 947-953页

作者：马喜龙松木一弘尚志丰苏宏基贾博文聂国权石家庄铁道大学材料科学与工程学院河北石家庄050043 广岛大学工学部日本广岛739-8527 石家庄铁道大学机械工程学院河北石家庄050043

通过2个电子参数(结合次数bo_(t)和d轨道能级Mdt)提出了新设计的α型钛(α-Ti)合金。新设计合金Ti-5Al-4Zr-3.6Sn、改性合金Ti-5Al-3Sn-1.9Zr和参考合金Ti-5Al-2.5Sn具有相同的bo_(t)值(3.847)以及不同的Mdt值(2.430,2.426,2.422)。测试了3种α-Ti合金的极限抗拉伸强度(σ_(UTS))、断裂应变(ɛ_(f))和热盐腐蚀性能。3种α-Ti合金均采用冷坩埚悬浮熔炼技术进行制备。结果表明,3种合金样品均具有均匀的微观结构。在3种α-Ti合金中测量到的α单相晶粒尺寸约为600μm。Ti-5Al-4Zr-3.6Sn合金的σ_(UTS)和ɛ_(f)值为801 MPa和16%,Ti-5Al-3Sn-1.9Zr合金的σ_(UTS)和ɛ_(f)值为708 MPa和15%,Ti-5Al-2.5Sn合金的σ_(UTS)和ɛ_(f)值为603 MPa和15%。热盐腐蚀测试进行28.8ks后显示Ti-5Al-4Zr-3.6Sn、Ti-5Al-3Sn-1.9Zr和Ti-5Al-2.5Sn合金的失重率为2.61%、2.83%和3.10%。σ_(UTS)、ɛ_(f)和耐热盐腐蚀结果表明,新设计合金Ti-5Al-4Zr-3.6Sn是一种有实际应用潜力的钛合金材料。

关键词：合金设计 α型钛合金冷坩埚悬浮熔炼拉伸性能热盐腐蚀测试

Long-Term Effect of Fertilizer and Rice Straw on Mineral Composition and Potassium Adsorption in a Reddish Paddy Soil

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Journal of Integrative Agriculture 2013年第4期12卷 694-710页

作者： LIAO Yu-lin ZHENG Sheng-xian nie Jun XIE Jian LU Yan-hong QIN Xiao-bo Soil and Fertilizer Institute of Hunan Province Hunan Academy of Agricultural Sciences/Scientific Observing and Experimental Station of Arable Land Conservation (Hunan) Ministry of Agriculture Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences/The Key Laboratory for Agro-Environment Ministry of Agriculture

Increasing K＋ adsorption can be an effective alternative in building an available K pool in soils to optimize crop recovery and minimize losses into the environment. We hypothesized that long-term fertilization might change K＋ adsorption because of changes in the chemical and mineralogical properties of a rice （Oryza sativa L.）. The aims of this study were （i） to determine clay minerals in paddy soil clay size fractions using X-ray diffraction methods and a numerical diagramdecomposition method; （ii） to measure K＋ adsorption isotherms before and after H202 oxidation of organic matter, and （iii） to investigate whether K＋ adsorption is correlated with changes in soil chemical and mineral properties. The 30-yr longterm fertilization treatments caused little change in soil organic C （SOC） but a large variation in soil mineral composition. The whole-clay fraction （〈5 Jam） corresponded more to the fertilization treatment than the fine-clay fraction （〈1 gin） in terms of percentage of illite peak area. The total percentage of vermiculite-chlorite peak area was significantly negatively correlated with the total percentage ofillite peak area in the 〈5 lam soil particles （R=-0.946, P〈0.0006）. Different fertilization treatments gave significantly different results in K＋ adsorption. The SOC oxidation test showed positive effects of SOC on K＋ adsorption at lower K＋ concentration （≤120 mg L-0 and negative effects at higher K＋ concentration （240 mg L-l）. The K＋ adsorption by soil clay minerals after SOC oxidization accounted for 60-158% of that by unoxidized soils, suggesting a more important role of soil minerals than SOC on K＋ adsorption. The K＋ adsorption potential was significantly correlated to the amount of poorly crystallized illite present （R--0.879, P=0.012）. The availability of adsorbed K＋ for plant growth needs further study.

关键词： long-term experiment mineral composition potassium adsorption reddish paddy soil