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C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang Xiaofei Niu Yingkai Wang yang Liu Cheng yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

1986～2010年松嫩平原土地利用程度空间格局变化研究

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哈尔滨师范大学自然科学学报 2016年第3期32卷 101-107页

作者：田旸那晓东臧淑英黑龙江省普通高等学校地理环境遥感监测重点实验室哈尔滨师范大学

在遥感与地理信息系统技术的支持下,分析松嫩平原1986～2010年土地利用变化的主要类型与转化方向.并采用5 km×5 km的网格对1986年、1995年、2000年、2010年4期土地利用图进行等间距系统采样,分别计算每一个网格的土地利用程度指数,分... 详细信息

在遥感与地理信息系统技术的支持下,分析松嫩平原1986～2010年土地利用变化的主要类型与转化方向.并采用5 km×5 km的网格对1986年、1995年、2000年、2010年4期土地利用图进行等间距系统采样,分别计算每一个网格的土地利用程度指数,分析松嫩平原近24年来土地利用程度的空间格局及其变化过程.结果表明：（1）1986～2010年,松嫩平原土地利用总体状况发生了显著的变化,总体呈现＂三增四减＂趋势,即耕地,城镇用地,林地的增长,而草地,未利用地,湿地和水域减少.（2）1986～2010年松嫩平原土地利用主导变化趋势为其他土地类型转变为耕地,1986～2000年土地利用主导变化趋势为草地转为耕地,1995～2010年主导变化趋势为耕地转为林地.（3）松嫩平原西部地区土地利用程度要低于其他区域,高值则集中分布在中部地区呈现出条带状.松嫩平原土地利用程度在过去的24年一直增加,松嫩平原中部地区土地利用程度稳定,北部的土地利用程度增加,西部土地利用程度降低.本研究可为松嫩平原景观格局的优化与生态系统服务功能的维护.

关键词：土地利用程度时空格局松嫩平原土地利用变化

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang Liu Huopo Chen Nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China

Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma yang Qu Jiaxin Ren Yingying Sun Zhen-Ni Guo Yi yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

德钦—中甸—大具断裂晚第四纪活动的地质与地貌表现

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地震研究 2014年第1期37卷 46-52页

作者：常祖峰张艳凤李鉴林臧阳云南省地震局云南昆明650224 云南大学云南昆明650091

根据野外地质、地貌调查结果,重点论述了德钦-中旬-大具断裂的几何展布、运动性质和最新活动时代.该断裂多处断错了晚更新世及全新世地层,具明显的右旋走滑兼正断性质,最新活动时代为晚更新世至全新世,水平滑动速率为1.7 ～2.0 mm/a,垂... 详细信息

根据野外地质、地貌调查结果,重点论述了德钦-中旬-大具断裂的几何展布、运动性质和最新活动时代.该断裂多处断错了晚更新世及全新世地层,具明显的右旋走滑兼正断性质,最新活动时代为晚更新世至全新世,水平滑动速率为1.7 ～2.0 mm/a,垂直滑动速率为0.6～0.7 mm/a.该断裂是川滇菱形块体西北边缘的一条重要的NW向走滑断裂,它与金沙江断裂带一起,共同构成了川滇菱形块体西北边界.

关键词：活动断裂晚第四纪滑动速率德钦—中甸—大具断裂

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HIV-GAG质粒DNA疫苗的纯化工艺

吉林大学学报（理学版） 2013年第4期51卷 720-723页

作者：刘新涛吴丛梅臧阳孙博殷玉和长春工业大学化学与生命科学学院长春130012 吉林大学生命科学学院长春130012

采用中空纤维超滤浓缩、离子交换介质和复合模式凝胶过滤介质纯化获得了HIV-GAG药用级质粒DNA疫苗,并对菌体培养、菌体裂解、粗提分离和柱层析等环节进行研究.实验结果表明,产品基本符合药用级的质粒DNA要求.

关键词： DNA疫苗菌体裂解离子交换介质复合模式凝胶过滤介质

Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson Yuan yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

2013年洱源M_S5.5地震烈度分布及震区活动构造背景研究

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中国地震 2014年第4期30卷 560-570页

作者：常祖峰张艳凤周青云虎雄林臧阳云南省地震局昆明市北市区北辰大道650041 云南大学昆明650091

2013年洱源MS5.5地震震区地质构造复杂,发育有NW向和NE向2组活动断裂。据野外调查和探槽揭示,震中附近的维西-乔后断裂为晚第四纪活动断裂,其新近活动时代主要在晚更新世晚期,全新世仍有较明显的活动迹象,运动性质以右旋走滑为主兼有正... 详细信息

2013年洱源MS5.5地震震区地质构造复杂,发育有NW向和NE向2组活动断裂。据野外调查和探槽揭示,震中附近的维西-乔后断裂为晚第四纪活动断裂,其新近活动时代主要在晚更新世晚期,全新世仍有较明显的活动迹象,运动性质以右旋走滑为主兼有正断。此次地震等烈度线呈NNW向的椭圆形展布,极震区达Ⅶ度,长15km,宽10km,面积约279km2。震源机制解显示:该震源断层为正断兼走滑破裂型,与维西-乔后断裂的运动学特征基本吻合;节面Ⅱ为NW向,与维西-乔后断裂走向基本一致。结合地震烈度分布、滑坡崩塌体分布和微震分布特征等分析推断,此次地震的发震构造应为维西-乔后断裂。震区地处滇西北横断山脉腹地,巨大的地形高差,强烈的表层岩石风化,是造成此次地震破坏较重的自然地理条件,而居民房屋多为抗震性能差的土木结构和砖木结构等简易建筑,是造成地震灾害加重的构筑物背景。

关键词： 2013年洱源5.5级地震等烈度线维西-乔后断裂地震烈度发震构造

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia Li Xiaojin Han Yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol