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Oxidative Stress:Role in Acetamiprid-Induced Impairment of the Male Mice Reproductive System

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Agricultural Sciences in China 2011年第5期10卷 786-796页

作者： ZHANG Jiao-jiao WANG Yi XIANG Hai-yang li Meng-xue li Wen-hao MA Kai-ge WANG Xian-zhong ZHANG Jia-hua College of Animal Science and Technology Southwest University Chongqing 400716 P.R.China

Acetamiprid has a wide range of influence on physiological functions in *** objective of this study was to examine the effect of acetamiprid on the reproductive function of male mice,and to study the role of oxidative stress in acetamiprid-induced damage to the *** adult Kunmin male mice （25-30 g） were divided into five groups （n=10 per group）,i.e.,control,blank,acetamiprid alone,acetamiprid and vitamin E,and vitamin E *** groups were treated for 35 *** results showed that acetamiprid significantly decreased the body weight and the weight of testosterone-responsive organs,such as the testis,epididymis,seminal vesicle,and ***,acetamiprid also significantly reduced the serum testosterone concentration,and decreased sperm count,viability,motility,and the intactness of the acrosome （P〈0.05 for each parameter）.The mice treated with acetamiprid had damaged seminiferous tubules and Leydig cells based on the histological structure of testes;there was degeneration of the mitochondria and endoplasmic reticulum of Leydig *** deleterious effects of acetamiprid may be mediated by increasing oxidative stress,as acetamiprid increased malondialdehyde and nitric oxide in the testes,reduced the activity of catalase,glutathione peroxidase,superoxide dismutase,and activated *** concentration of acetamiprid in the testes was lower than that in liver,so did the concentrations of liver function tests,including aspartate transaminase （AST）,alanine transaminase （ALT） and alkaline phosphatase （ALP）,which suggest that male reproductive function may be affected through the indirect action of its *** E significantly ameliorated the effects of *** conclude that acetamiprid damages male reproductive function through inducing oxidative stress in the testes.

关键词： acetamiprid oxidative stress reproductive function testis

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng xue-yang li Xiao-Yu yang Huan Wang ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways

Effect of water extracts of larch on growth of Manchurian walnut seedlings

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Journal of Forestry Research 2005年第4期16卷 285-288页

作者： yang li-xue College of Forestry Northeast Forestry University Harbin 150040 PR. China

A study was conducted to detect the effect of water extracts from different parts such as root, bark, branch and leaf, of adult larch, Larix gmelini, trees on growth of Manchurian walnut, Juglans mandshudca, seedlings and the allelopathy between the two tree species. Four concentrations （100 g. kg i, 50 g. kg^-1, 25 g. kg^-1 and 12.5 g. kg^-1） were prepared for each kind of extracts. Result showed that the water extracts with low and moderate concentrations accelerated the growth of collar diameter and increased biomass and root/shoot ratio of walnut seedlings. The water extracts from branches and barks with low and moderate concentrations accelerated the height growth of the seedlings, while those from leaves and roots slightly decreased the height growth of seedlings. The fact that application of water extracts of larch improved the growth of Manchurian walnut attributes possibly to the allelopathy between the two tree species.

关键词： Juglans mandshurica Larix gmelini Water extract Collar diameter Tree height Root/shoot ratio Allelopathy

Simple bone cysts in children treated with intracystic fibrin sealant injection

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Chinese Medical Journal 2006年第6期119卷 523-525页

作者： TANG xue-yang liU li-jun PENG Ming-xing XIANG Bo Department of Pediatric Surgery Huaxi Hospital of Sichuan University Chengdu 610041 China

Simple bone cyst （SBC）, also known as a unicameral or solitary cyst, is a benign fluid-filled cavity found primarily at the proximal ends of long bones in children. Treatment is warranted if the pain or a pathologic fracture occurs or if a child is at risk of pathologic fractures. The spectrum of treatments proposed for SBC management ranges from simple Kirschner wire drill-hole, resection or curettage with or without bone grafting to using a cannulated screw for continuous decompression, steroid injection and the latest experience of the use of percutaneous autologous marrow grafting. However, clinical practice of these treatments is limited because of their unsatisfactory effect and possible complications.

关键词： bone cyst fibnn sealant percutaneous puncture

Incidence of congenital heart disease in Beijing, China

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Chinese Medical Journal 2009年第10期122卷 1128-1132页

作者： yang xue-yong li Xiao-feng LV Xiao-dong liU Ying-long Pediatric Cardiac Center Department of Surgery Cardiovascular Institute and Fu Wai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background The incidence of congenital heart disease has been studied in developed countries for many years, but rarely in the mainland of China. Fetal echocardiographic screening for congenital heart disease was first performed in Beijing in the early 2000s, but the impact was not clear. The current study was undertaken to determine the incidence of congenital heart disease in Beijing, China and to estimate the impact of fetal echocardiography on the incidence of liveborn congenital heart disease.Methods The study involved all infants with congenital heart disease among the 84 062 total births in Beijing during the period of January 1 and December 31, 2007. An echocardiographic examination was performed on every baby suspected to have congenital heart disease, prenatally or/and postnatally.Results A total of 686 infants were shown to have congenital heart disease among 84 062 total births. The overall incidence was 8.2/1000 total births. Mothers of 128 of 151 babies diagnosed prenatally were chosen to terminate the pregnancy. Two of the 151 infants died in utero. A specific lesion was identified for each infant and the frequencies of lesions were determined for each class of infants （total births, stillbirths and live births）. The incidence of congenital heart disease in stillbirths and live births was 168.8/1000 and 6.7/1000, respectively. The difference between the incidence of total birth and the incidence of live birth was statistically significant （P 〈0.001）. Conclusions The incidence of liveborn congenital heart disease in Beijing is within the range reported in developed countries. Fetal echocardiography reduce significantly the incidence of liveborn congenital heart disease.

关键词： incidence congenital heart disease prenatal diagnosis fetal echocardiography pregnancy termination

俄罗斯大果沙棘(Hippophae rhamnoides L.)种子萌发特性

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生态学报 2007年第6期27卷 2215-2222页

作者：杨立学东北林业大学林学院哈尔滨150040

俄罗斯丘依斯克大果沙棘(Hippophae rhamnoides L.)为优良的沙棘引进种。经测定,俄罗斯大果沙棘丘依斯克种子的千粒重为17.75g,与其它沙棘属的种子相比,其千粒重较大,为其2倍左右。四唑(TTC,1.0%)染色测种子的生活力的结果表明:有生活... 详细信息

俄罗斯丘依斯克大果沙棘(Hippophae rhamnoides L.)为优良的沙棘引进种。经测定,俄罗斯大果沙棘丘依斯克种子的千粒重为17.75g,与其它沙棘属的种子相比,其千粒重较大,为其2倍左右。四唑(TTC,1.0%)染色测种子的生活力的结果表明:有生活力的种子占97.75%,说明俄罗斯大果沙棘种子饱满度好;染色结果与对比发芽实验的结果很接近,说明用四唑染色来测定俄罗斯大果沙棘种子的发芽能力是较准确的方法。在水、气适宜的条件下,分别研究了温度分别为15、20、25、30℃,光照强度分别为25%、50%、75%、100%的不同处理对丘依斯克种子萌发的影响,并采用胚根生长量和全株生物量对沙棘种子发芽效果进行了评价,提出了沙棘种子发芽的最适温度和光强。结果表明,在25℃条件下,种子萌发最早,发芽势高达33.0%±4.76%,发芽率高达95.5%±1.5%,且主根生长量和生物量最大,分别为(4.5±0.09)cm和(0.137±0.002)g;75%光强最适合沙棘种子萌发,种子萌发最早,发芽势高达61.5%±1.7%,发芽率高达86.0%±1.1%,且主根生长量和生物量最大,分别为(3.7±0.2)cm和(0.108±0.004)g。因此,在直播营造大果沙棘林时,应首选25℃的温度条件,同时,建议进行适度遮荫处理。

关键词：大果沙棘温度光照强度种子萌发幼苗生长

采煤沉陷区不同造林树种恢复土壤酚酸物质对土壤微生物的影响

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应用生态学报 2017年第12期28卷 4017-4024页

作者：及利杨立学东北林业大学林学院哈尔滨150040 吉林省林业科学研究院长春130033

酚酸物质是影响微生物群落和结构的最重要因子之一,研究酚酸物质在不同造林树种土壤中的变化规律及其与微生物群落结构的关系,有助于更好地了解和揭示采煤沉陷区恢复造林条件下微生物群落变化的机制.本研究在双鸭山宝山采煤沉陷区的撂... 详细信息

酚酸物质是影响微生物群落和结构的最重要因子之一,研究酚酸物质在不同造林树种土壤中的变化规律及其与微生物群落结构的关系,有助于更好地了解和揭示采煤沉陷区恢复造林条件下微生物群落变化的机制.本研究在双鸭山宝山采煤沉陷区的撂荒地基础上营造三针一阔(红松、落叶松、樟子松和杨树)人工林,测定这4种造林地土壤酚类物质、11种酚酸物质和微生物群落结构.结果表明:复合态酚含量总体表现为人工林显著高于撂荒地,其中,落叶松人工林和杨树人工林的复合态酚含量较高,落叶松人工林和红松人工林的总酚含量显著高于撂荒地,红松人工林的水溶性酚含量显著高于撂荒地;在11种酚酸物质中,阿魏酸、松香酸、β-谷甾醇、齐墩果酸、莽草酸、亚油酸和硬脂酸的含量在人工林土壤中较高.土壤酚类物质与土壤微生物生物量不存在显著的相关关系,个别的酚酸物质与土壤微生物的相关关系显著,其中,阿魏酸、松香酸和β-谷甾醇对土壤微生物生物量有明显的促进作用,与真菌和真菌/细菌存在显著的正相关关系.杨树人工林的酚酸物质含量较高,说明营造杨树人工林对采煤沉陷区的土壤恢复有益.

关键词：采煤沉陷区土壤微生物酚酸物质造林

Rational Thoughts on Reconstructing Rural Resident's living Style

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Journal of Northeast Agricultural University(English Edition) 2009年第4期16卷 87-92页

作者： SUN Yujuan XU Jingbo yang xue SUN Zhanfeng li Qingzhang College of liberal and Social Science Northeast Agricultural University Harbin 150030 China

The construction of rural residents＇ living style is the fundamental significance of building the new socialist countryside. With the deep development of the urban and rural, rural residents＇ living style has changed profoundly on the labour, consumption, entertainment, marriage and family, etc., and the differences of living style between the urban and rural are becoming smaller and smaller. Therefore, this paper suggested to promote the rural residents to build the scientific, cultural and healthy modern life style, and put forward the rational development thoughts.

关键词： rural resident living style construction

Association between Fruit and Vegetable Intake and Arterial Stiffness: The China-PAR Project

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Biomedical and Environmental Sciences 2023年第12期36卷 1113-1122页

作者： liU Shuai liU Fang Chao li Jian Xin HUANG Ke Yong yang xue li CHEN Ji Chun CAO Jie CHEN Shu Feng HUANG Jian Feng SHEN Chong LU Xiang Feng GU Dong Feng Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100730China School of Medicine Southern University of Science and TechnologyShenzhen 518055GuangdongChina

Objective This study aimed to investigate the association between fruit and vegetable intake and arterial *** We conducted a cohort-based study comprising 6,628 participants with arterial stiffness information in the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project. A semi-quantitative food-frequency questionnaire was used to assess baseline(2007–2008) and recent(2018–2021) fruit and vegetable intake. We assessed changes in fruit and vegetable intake from2007–2008 to 2018–2021 in 6,481 participants. Arterial stiffness was measured using the arterial velocity–pulse index(AVI) and arterial pressure-volume index(API). Elevated AVI and API values were defined according to diverse age reference *** Multivariable-adjusted linear regression models revealed that every 100 g/d increment in fruit and vegetable intake was associated with a 0.11 decrease in AVI(B =-0.11;95% confidence interval [CI]:-0.20,-0.02) on average, rather than API(B = 0.02;95% CI:-0.09, 0.13). The risk of elevated AVI(odds ratio [OR] = 0.82;95% CI: 0.70, 0.97) is 18% lower in individuals with high intake(≥ 500 g/d) than in those with low intake(line and follow-up(OR = 0.64;95% CI: 0.49, 0.83).Conclusion Fruit and vegetable intake was negatively associated with arterial stiffness, emphasizing recommendations for adherence to fruit and vegetable intake for the prevention of arterial stiffness.

关键词： Fruit Vegetable Arterial stiffness Cardiovascular disease