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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-xin yang Bao-Xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

WTO《促进发展的投资便利化协定》透明度条款及我国实施方案

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国际商务研究 2025年第1期46卷 59-72页

作者：杨欣中国石油大学(华东) 山东青岛266580

《促进发展的投资便利化协定》旨在提高国家投资政策透明度,简化外国投资审核程序,创造规范性、便利化和高透明度的投资环境。透明度措施是该协定最重要的措施之一,通过投资信息公布、单一窗口平台建设、投诉评论机制构建等措施着力提... 详细信息

《促进发展的投资便利化协定》旨在提高国家投资政策透明度,简化外国投资审核程序,创造规范性、便利化和高透明度的投资环境。透明度措施是该协定最重要的措施之一,通过投资信息公布、单一窗口平台建设、投诉评论机制构建等措施着力提高国际投资透明度。我国不仅是该协定谈判的坚定引领者,也是该协定履行的积极行动者,加入该协定以来,采取一系列措施优化便利投资环境,提高透明度水平。然而,当前我国在国际投资透明度立法体例、国际投资透明度具体要求以及国际投资单一窗口平台建设方面均与该协定透明度要求存在差距,应当从修改立法体例、完善具体要求以及完善国际投资单一窗口等3个方面探究我国投资透明度措施与该协定条款的良好衔接方案,构建高度透明、高效便利的国际投资环境。

关键词：《促进发展的投资便利化协定》投资便利化透明度

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The effects of Shen Song yang xin Jiao Nang on heart rate turbulence and heart rate variation in patients with chronic heart failure

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The effects of Shen Song Yang Xin Jiao Nang on heart rate tu...

Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

中华医学会心电生理和起搏分会第十次全国学术年会

作者： Zhen yang,Shaobin Jia,Xuezhong Wang,Yong Sha,Zhijun Liu,Weina Guo Heart Center,the General Hospital of Ningxia Medical University 750000

Objective To study the antiarrhythmic effects of Shen Song yang xin Jiao Nang,atraditional Chinese medicine,as detected by heart rate variation(HRV) and heart rate turbulence(HRT),in patients with chronic heart failure(CHF). Methods Sixty-six CHF patients,with the inclusion criterion of aged>18 years old and let ventricular ejection fraction(LVEF)yang xin Jiao Nang daily in three divided doses in addition to standard medicine therapy,or the control group(n=34),which were treated only with standard medicine therapy without Shen Song yang xin Jiao *** mean time of follow-up was 3 *** and after three months of treatment,continuous ECG monitoring,echocardiography,HRT and HRV were calculated,and clinical end points including all cause mortality,ventricular tachyc-ardia ventricular fibrillation,were recorded. Results After treatment,HR and TO significantly decreased in both groups(P0.05). Aftertreatment,there were statistically significant difference in the changes of HR,TO,TS,sNN50 total, pNN50,SDNN,SDNNI,SDANN,LF,HF between two groups(P0.05).The occurrence rates of ventricular tachycardia and proxysmal atrial fibrillation in study group were significantly lower than those in control group(Pyang xin Jiao Nang can improve the impaired HRT in patients with CHF, which might be one of its anti-arrhythmic mechanisms.

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN LU KANG WANG YUANHONG PENG MENG CHEN LIN ZHONG LUJI HUANG FU CHENG xinDAN SHENG xin yang MANZHAO OUyang GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Super-resolution processing of passive millimeter-wave images based on adaptive projected Landweber algorithm

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Journal of Systems Engineering and Electronics 2008年第4期19卷 709-716页

作者： Zheng xin yang Jianyu School of Electronic and Engineering Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

Passive millimeter wave （PMMW） images inherently have the problem of poor resolution owing to limited aperture dimension. Thus, efficient post-processing is necessary to achieve resolution improvement. An adaptive projected Landweber （APL） super-resolution algorithm using a spectral correction procedure, which attempts to combine the strong points of all of the projected Landweber （PL） iteration and the adaptive relaxation parameter adjustment and the spectral correction method, is proposed. In the algorithm, the PL iterations are implemented as the main image restoration scheme and a spectral correction method is included in which the calculated spectrum within the passband is replaced by the known low frequency component. Then, the algorithm updates the relaxation parameter adaptively at each iteration. A qualitative evaluation of this algorithm is performed with simulated data as well as actual radiometer image captured by 91.5 GHz mechanically scanned radiometer. From experiments, it is found that the super-resolution algorithm obtains better results and enhances the resolution and has lower mean square error （MSE）. These constraints and adaptive character and spectral correction procedures speed up the convergence of the Landweber algorithm and reduce the ringing effects that are caused by regularizing the image restoration problem.

关键词： passive millimeter wave imaging super-resolution Landweber algorithm inverse problems spectral extrapolation.

P-Laplace Equation for the Grushin Type Operator

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Acta Mathematica Sinica,English Series 2023年第5期39卷 923-938页

作者： Ji Zheng HUANG xin xin yang School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China

Let Gλ,λ>0,be a Grushin type operator on Rn×*** this paper,we will first establish existence and uniqueness for the p-Laplace equation for Gλ,then we prove the regularity of *** order to prove our results,we will ... 详细信息

关键词： solutions. inequality uniqueness

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Different patterns of molecular,carbon and hydrogen isotope compositions of n-alkanes between heterotrophic plant and its hosts

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Frontiers of Earth Science 2020年第4期14卷 783-788页

作者： xin yang Xianyu Huang State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan430078China Hubei Key Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan430078China

This study investigates the molecular,carbon,and hydrogen isotope compositions of n-alkanes in eight pairs of a holoparasitic plant(Cuscuta chinensis)and its *** is unexpected that *** has a higher concentration of n-alkanes than its hosts in seven of the eight pairs,and it is preferentially dominated by n-C_(29) alkane(representing>75%of the total n-alkanes).In addition,theδ^(13)C values of C_(29) alkane in *** are less negative(avg.1.8‰)than those in the hosts,while theδ^(2)H values of C_(29) alkane are more negative in ***(the difference averages 48‰).We propose that the ^(2)H-depletion of n-alkanes in the stem parasite *** may result from the utilization of stem water with less influence from evapotranspiration or the use of newly synthesized carbohydrates which is ^(2)H-depleted relative to stored *** results highlight the importance of plant nutrient status on the molecular and isotopic compositions of leaf waxes,which shed light on the(paleo)ecological potential of leaf waxδ^(2)H values.

关键词： heterotrophic plant Cuscuta n-alkane carbon isotope hydrogen isotope

Impact of essential oils and organic acids on the growth performance,digestive functions and immunity of broiler chickens

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Animal Nutrition 2018年第4期4卷 388-393页

作者： xin yang Hongliang xin Chengbo yang Xiaojun yang College of Animal Science and Technology Northwest A&F UniversityYangling712100China Jefo Nutrition Inc. Saint-HyacintheQuebecJ2S 7B6Canada

The aim of the experiment was to study the effects of feeding blends of sorbic acid, fumaric acid, and thymol(EOA) on growth performance, digestive functions, and immunity of broiler chickens. A total of 640 one-day-old male Cobb 500 chicks with similar BW(41.8 ± 0.6 g) were randomly divided into 4dietary treatment groups consisting of 10 replicates with 16 birds per replicate and fed a basal diet until d 42(CON) or diets with 0.15 g/kg enramycin during the grower period(AG), 0.30 g/kg EOA during the grower period(EG), or 0.30 g/kg EOA during the finisher period(EF). At d 42, the feed conversion ratio was reduced(P < 0.05) for birds in EG group compared with other groups. Birds in EG group showed a higher villus height of the duodenum and jejunum and muscular layers of the duodenum and ileum than birds in CON group(P < 0.05). Compared with other groups, crypt depth of the jejunum and ileum was markedly increased(P < 0.05) by EOA supplementation during the finisher period at d 42. The EOA supplementation during grower period increased significantly lipase, trypsin and chymotrypsin activities of the duodenum at d 21 and 42, as well as lipase and trypsin at d 21, and trypsin and chymotrypsin at d 42 in the jejunum, and trypsin and chymotrypsin activities of the ileum at d 21 compared to the control diet(P < 0.05). Birds of EG and EF groups showed a higher(P < 0.05) spleen index than birds of CON group. The level of secretory immunoglobulin A in duodenal and ileal mucosa was increased(P < 0.05) in EF group at d 42 compared with other groups. In conclusion, the results indicate that EOA can be effectively applied in broiler diets, especially during the grower phase by improving intestinal morphology and increasing digestive enzyme activity.

关键词： Broiler chicken Digestive functions Essential oils Growth performance Immunity Organic acids