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Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions

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Zoological Research 2024年第1期45卷 95-107页

作者： Hai-yang Wang Lan-Xiang Liu Xue-Yi Chen yang-Dong Zhang Wen-Xia Li Wen-Wen Li Lian Wang xiao-Long Mo Hong Wei ping Ji Peng Xie NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Stomatology and Affiliated Stomatological Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China Department of Neurology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Pathology Faculty of Basic MedicineChongqing Medical UniversityChongqing 400016China Department of Neurology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 401329China

The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many ***,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain *** study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any *** conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF *** results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of *** bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF *** constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular *** correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational *** correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular *** study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes.

关键词： Gut microbiota Hippocampal protein Post-translational modifications Succinylation Acetylation Phosphorylation

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印度“东向”中的东北部与次区域合作

亚太经济 2014年第4期 17-22页

作者：杨晓萍中国社会科学院亚太与全球战略研究院复旦大学

印度"东向"战略中存在较少的印度"东北部"地方因素考虑,这既是由于该地区参与"东向"的意愿、能力不足,更是由于该区域在印度地缘战略排名中靠后。然而,随着印度东北部地区安全局势的逐渐改善以及印度联邦政府政策的某些松动,印度东北部... 详细信息

印度"东向"战略中存在较少的印度"东北部"地方因素考虑,这既是由于该地区参与"东向"的意愿、能力不足,更是由于该区域在印度地缘战略排名中靠后。然而,随着印度东北部地区安全局势的逐渐改善以及印度联邦政府政策的某些松动,印度东北部地区深层次融入次区域合作的可能性增加。其中,孟中印缅地区合作机制最具增长潜力。在未来,次区域合作的务实推进仍需核心国家更高层次政治共识的达成。

关键词： “东向” 印度东北部次区域合作中印孟缅地区合作机制

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论马克思的类概念

西南大学学报（社会科学版） 2010年第4期36卷 82-87页

作者：杨晓平西南政法大学哲学系重庆市401120

马克思的类概念不同于费尔巴哈以及此前的一切哲学而具有全新的内涵。马克思把自觉自由的活动当作类的生活和本质的主要表征,进而揭示出自然界是类的对象即"无机的机体",而社会即自我与他者的统一关系,既是类的存在方式又是类借以占有... 详细信息

马克思的类概念不同于费尔巴哈以及此前的一切哲学而具有全新的内涵。马克思把自觉自由的活动当作类的生活和本质的主要表征,进而揭示出自然界是类的对象即"无机的机体",而社会即自我与他者的统一关系,既是类的存在方式又是类借以占有自己的自然存在的中介。马克思以人类社会和社会化的人类为立脚点,依据异化的扬弃与异化走着同一条道路,揭示出伴随异化的劳动的发展,必然扬弃私有制和分工,必然扬弃劳动的异化,并通过遭受普遍奴役因此要求废除人间一切奴役制的无产阶级的革命实践,必将实现人类解放,从而确立和实现类主体。

关键词：马克思类概念人与自然人与社会异化人类解放

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和谐辩证法新论

西南大学学报（社会科学版） 2011年第1期37卷 67-73,190页

作者：杨晓平西南政法大学哲学系重庆市401120

在黑格尔辩证法中,矛盾既是一种静态结构关系,又是一种动态历时过程:作为前者,矛盾是既对立又统一;作为后者,矛盾是由对立到统一。马克思通过赋予黑格尔抽象的和形式的辩证法以具体的和现实的内容而提出了实践辩证法,认为人类社会从无... 详细信息

在黑格尔辩证法中,矛盾既是一种静态结构关系,又是一种动态历时过程:作为前者,矛盾是既对立又统一;作为后者,矛盾是由对立到统一。马克思通过赋予黑格尔抽象的和形式的辩证法以具体的和现实的内容而提出了实践辩证法,认为人类社会从无阶级非对抗的原始社会进入到阶级社会,然后再在异化基础上扬弃异化,使联合起来的个人有计划地调节人与自然之间的物质变换,实现人与人、人与社会、人与自然的和谐统一。社会主义便是向这一理想社会过渡的社会,由于其本质所规定,其所有矛盾将在纳入人民内部矛盾的范围内加以解决。因此,辩证法在其价值诉求、理论旨归以及所展示的历史趋势的意义上,就是和谐辩证法,它不仅为人类历史的共产主义运动提供了指南,而且为构建社会主义和谐社会提供了理论根据。

关键词：黑格尔辩证法实践辩证法和谐辩证法社会主义和谐社会

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从四要素看书法与客观造化的融会内涵

西安交通大学学报（社会科学版） 2012年第4期32卷 103-109页

作者：杨晓萍西安交通大学人文社会科学学院陕西西安710049

客观造化是与书法相关的四要素之一;书法与客观造化的融会主要通过书法家的学习、创作,物化于书法作品之中,也可通过欣赏者对书法作品的欣赏来实现;书法与客观造化的融会肇自汉字与客观造化的融会,主要包括形象、体势、意味、道理四个层... 详细信息

客观造化是与书法相关的四要素之一;书法与客观造化的融会主要通过书法家的学习、创作,物化于书法作品之中,也可通过欣赏者对书法作品的欣赏来实现;书法与客观造化的融会肇自汉字与客观造化的融会,主要包括形象、体势、意味、道理四个层面,并以无形的融会为主,使之得到进一步的丰富与拓展。

关键词：书法艺术客观造化同构体势意味道理

Isocyanide-Based One-Pot Cascade Synthesis of 3-Acyl Isoindolinones

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Chinese Journal of Chemistry 2024年第3期42卷 259-263页

作者： Jia Liu Yi-Ming Zhu xiao-ping Xu Shun-Jun Ji Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu215123 China Suzhou Baolidi Functional Materials Research Institute SuzhouJiangsu215144 China

A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner via the reaction of o-bromobenzaldehydes,isocyanides,and carboxylic acids in the presence of palladium catalyst and base. The reaction employing easily available starting materials features simple operation and high efficiency. The mechanistic study showed that the reaction might undergo 1) Pd-catalyzed [3+2] cyclization of o-bromobenzaldehyde with isocyanide and the re-insertion of another molecule of isocyanide,2) addition of carboxylic acid to in situ formed ketenimine followed by a rearrangement relay to give 3,3-diacyl-substituted isoindolinone derivative. Further transformations of the obtained products through decarbonylation could also be realized.

关键词： One-pot reaction Isocyanide Pd catalysis Rearrangement reaction Isoindolinone

Thermally Conductive,Healable Glass Fiber Cloth Reinforced Polymer Composite based onβ-Hydroxyester Bonds Crosslinked Epoxy with Improved Heat Resistance

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Chinese Journal of Polymer Science 2024年第5期42卷 643-654,I0009页

作者： Fang Chen xiao-Yan Pang Ze-ping Zhang Min-Zhi Rong Ming-Qiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GD HPPC LabIGCMESchool of ChemistrySun Yat-sen UniversityGuangzhou510275China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang515200China

To simultaneously endow thermal conductivity,high glass transition temperature(Tg)and healing capability to glass fiber/epoxy(GFREP)composite,dynamic crosslinked epoxy resin bearing reversibleβ-hydroxyl ester bonds was reinforced with boron nitride nanosheets modified glass fiber cloth(GFC@BNNSs).The in-plane heat conduction paths were constructed by electrostatic self-assembly of polyacrylic acid treated GFC and polyethyleneimine decorated ***,the GFC@BNNSs were impregnated with the mixture of lower concentration(3-glycidyloxypropyl)trimethoxysilane grafted BN micron sheets,3,4-epoxycyclohexylmethyl 3,4-epoxycyclohexanecarboxylate and hexahydro-4-methylphthalic anhydride,which accounted for establishing the through-plane heat transport pathways and avoiding serious deterioration of mechanical *** resultant GFREP composite containing less boron nitride particles(17.6 wt%)exhibited superior in-plane(3.29 W·m^(-1)·K^(-1))and through-plane(1.16 W·m^(-1)·K^(-1))thermal conductivities,as well as high Tg of 204℃(Tg of the unfilled epoxy=177℃).The reversible transesterification reaction enabled closure of interlaminar cracks within the composite,achieving decent healing efficiencies estimated by means of tensile strength(71.2%),electrical breakdown strength(83.6%)and thermal conductivity(69.1%).The present work overcame the disadvantages of conventional thermally conductive composites,and provided an efficient approach to prolong the life span of thermally conductive GFREP laminate for high-temperature resistant integrated circuit application.

关键词： Thermally conductive composites Boron nitride High-temperature resistance β-Hydroxyl ester bond Healing

Inter-agency government information sharing under data-driven blockchain framework

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控制理论与应用 2024年第8期41卷 1369-1376页

作者： xiao Jiong-en HONG Ming DING Li-ping International Business School Guangdong University of Finance and EconomicsGuangzhou Guangdong 510320China Department of Electronic Business South China University of TechnologyGuangzhou Guangdong 510641China Institute of Software Chinese Academy of SciencesBeijing 100190China Guangzhou Institute of Software Application Technology Electronic Forensics LaboratoryGuangzhou Guangdong 511400China

The inter-agency government information sharing(IAGIS)plays an important role in improving service and efficiency of government ***,there is still no effective and secure way for data-driven IAGIS to fulfill dynamic demands of information sharing between government *** by blockchain and data mining,a data-driven framework is proposed for IAGIS in this ***,the blockchain is used as the core to design the whole framework for monitoring and preventing leakage and abuse of government information,in order to guarantee information ***,a four-layer architecture is designed for implementing the proposed ***,the classical data mining algorithms PageRank and Apriori are applied to dynamically design smart contracts for information sharing,for the purposed of flexibly adjusting the information sharing strategies according to the practical demands of government agencies for public management and public ***,a case study is presented to illustrate the operation of the proposed framework.

关键词： government data processing blockchain PageRank apriori

An Improved Modulation Strategy for Single-phase Three-level Neutral-point-clamped Converter in Critical Conduction Mode

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 981-990页

作者： Ning Li Yujie Cao xiaokang Liu Yan Zhang Ruotong Wang Lin Jiang xiao-ping Zhang School of Electrical Engineering Xi’an University of TechnologyXi’anChina the Department of Electronics Information and BioengineeringPolitecnico di MilanoMilanItaly Xi’an Jiaotong University Xi’anChina the Department of Electrical Engineering and Electronics University of LiverpoolLiverpoolU.K. the Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirminghamU.K.

Two-level totem-pole power factor correction(PFC)converters in critical conduction mode(CRM)suffer from the wide regulation range of switching ***,in highfrequency applications,the number of switching times increases,resulting in significant switching *** solve these issues,this paper proposes an improved modulation strategy for the single-phase three-level neutral-point-clamped(NPC)converter in CRM with *** optimizing the discharging strategy and switching state sequence,the switching frequency and its variation range have been efficiently *** detailed performance analysis is also presented regarding the switching frequency,the average switching times,and the effect of voltage gain.A 2 k W prototype is built to verify the effectiveness of the proposed modulation strategy and analysis *** with the totem-pole PFC converter,the switching frequency regulation range of the three-level PFC converter is reduced by 36.48%and the average switching times is reduced by 45.10%.The experimental result also shows a 1.2%higher efficiency for the three-level PFC converter in the full load range.

关键词： Critical conduction mode(CRM) on-board charger switching frequency range switching times power factor correction(PFC) three-level converter