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Neurofibromatosis type 1 with multiple gastrointestinal stromal tumors:A case report

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World Journal of Clinical Cases 2023年第10期11卷 2336-2342页

作者： Min-Quan Yao Yu-Peng Jiang Bing-Hong Yi Yong yang Da-Zhuang Sun jin-Xing Fan Department of Gastrointestinal Surgery Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina Endoscopy Center Tongxiang First People’s HospitalJiaxing 314500Zhejiang ProvinceChina

BACKGROUND Neurofibromatosis type 1(NF1)is characterized by café-au-lait patches on the skin and the presence of *** stromal tumor(GIST)is the most common non-neurological tumor in NF1 *** NF1-associated GIST,KIT and PDGFRA mutations are frequently absent and imatinib is *** resection is first-line *** SUMMARY A 56-year-old woman with NF1 was hospitalized because of an incidental pelvic *** examination was notable for multiple café-au-lait patches and numerous subcutaneous soft nodular masses of the skin of the head,face,trunk,and *** abdomen was soft and *** masses were *** rectal examination was *** computed tomography was suspicious for GIST or solitary fibrous *** was performed,which identified eight well-demarcated masses in the *** were resected and pathologically diagnosed as *** patient was discharged on day 7 after surgery without *** tumor recurrence was evident at the 6-mo *** Laparoscopy is effective for both diagnosis and treatment of NF1-associated GIST.

关键词： Neurofibromatosis type 1 Gastrointestinal stromal tumors KIT PDGFRA Laparoscopy Case report

Accelerating materials discovery using machine learning

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Journal of Materials Science & Technology 2021年第20期79卷 178-190页

作者： Yongfei Juan Yongbing Dai yang yang Jiao Zhang Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai200240China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai200240China

The discovery of new materials is one of the driving forces to promote the development of modern society and technology innovation,the traditional materials research mainly depended on the trial-and-error method,which is time-consuming and ***,machine learning(ML)methods have made great progress in the researches of materials science with the arrival of the big-data era,which gives a deep revolution in human society and advance science ***,there exist few systematic generalization and summaries about the applications of ML methods in materials *** this review,we first provide a brief account of the progress of researches on materials science with ML employed,the main ideas and basic procedures of this method are emphatically *** the algorithms of ML which were frequently used in the researches of materials science are classified and ***,the recent meaningful applications of ML in metal materials,battery materials,photovoltaic materials and metallic glass are reviewed.

关键词： Materials discovery Materials design Materials properties prediction Machine learning Data-driven

Influence of mineral species on oil-soil interfacial interaction in petroleum-contaminated soils

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Chinese Journal of Chemical Engineering 2023年第9期61卷 147-156页

作者： yang yang Dandan Liu Xing Liang Xiaobing Li National Center for Coal Preparation and Purification Engineering Research China University of Mining and TechnologyXuzhou 221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China

The mineral species in soils vary in a wide variety of places,thus resulting in the petroleumcontaminated soil(PCS)with complex ***,the research on the effect of mineral species on oil-soil interactions in PCS takes on a critical *** this study,the desorption and adsorption behaviors of aromatic hydrocarbons(Ar)on two minerals surfaces were ***,the interfacial forces between minerals and Ar were studied and the sources of these forces were ***,molecular dynamics(MD)simulations were conducted to gain insight into the interfacial interaction *** revealed by the results of this study,in comparison with Qs-Ar(quartz sand,Qs),Mnt-Ar(montmorillonite,Mnt)contaminants required higher temperature and activation energies for thermal desorption(201.95 kJ·mol^(-1)vs.127.82 kJ·mol^(-1))The above difference was generated since the adhesive forces between Ar and Mnt surfaces were greater than those between Ar and *** indicated by the analysis of the adhesion force sources,the van der Waals forces were responsible for facilitating oil adhesion to mineral surfaces,even though the electrostatic force prevented oil-mineral ***,the hydrophobic forces facilitated adhesion in 3 *** MD results demonstrated that compared with the Qs system,there existed larger binding energies between Ar and Mnt,a lower diffusion coefficient for Ar on the Mnt surface,as well as more significant adsorption of Ar on *** general,the different mineral species affect the strength of the interaction at the oil-soil interface,which is a guideline for proposing targeted oil-soil separation measures.

关键词： Oil-soil interface Thermal desorption Isothermal adsorption Extended-DLVO(EDLVO) Molecular dynamics

Mechanical Properties of Railway High-strength Manufactured Sand Concrete:Typical Lithology,Stone Powder Content and Strength Grade

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期 194-203页

作者：王振李化建 HUANG Fali yang Zhiqiang WEN Jiaxin SHI Henan Railway Engineering Research Institute China Academy of Railway Science Corporation Limited State Key Laboratory for Track Technology of High-Speed Railway

In order to achieve the large-scale application of manufactured sand in railway high-strength concrete structure,a series of high-strength manufactured sand concrete (HMC) are prepared by taking the manufactured sand lithology (tuff,limestone,basalt,granite),stone powder content (0,5%,10%,15%) and concrete strength grade (C60,C80,C100) as *** evolution of mechanical properties of HMC and the correlation between cubic compressive strength and other mechanical properties are *** to river sand,manufactured sand enhances the cubic compressive strength,axial compressive strength and elastic modulus of concrete,while its potential microcracks weaken the flexural strength and splitting tensile strength of *** powder content displays both positive and negative effects on mechanical properties of HMC,and the stone powder content is suggested to be less than 10%.The empirical formulas between cubic compressive strength and other mechanical properties are proposed.

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Isomeric fluorescence sensors for wide range detection of ionizing radiations

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Defence Technology（防务技术） 2024年第4期34卷 247-257页

作者： Jimin Han Tianyu yang Li yang Yuanjian Li State Key Laboratory of Explosion Science and Technology of China Beijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China

In order to achieve a wider range of ionizing radiations detection,novel fluorescence sensing materials have been developed that utilize the fluorescence enhancement phenomenon caused by the intramolecular photoinduced electron transfer(PET)*** perylene diimide isomers PDI-P and PDI-B were designed and synthesized,and their molecular structures were characterized by high-resolution Fourier transform mass spectrometry(HRMS),nuclear magnetic resonance hydrogen and carbon spectroscopy(~1H and~(13)C NMR).The interaction between ionizing radiation and fluorescent molecules was simulated by HCl *** results show that combining PDIs and HCl can improve fluorescence through the retro-PET *** the similarities in chemical structures,the fluorescent enhancement multiple of PDI-B with aromatic amine as electron donor is much higher than that of PDI-P with alkyl *** the direct irradiation experiments of ionizing radiation,the emission enhancement multiples of PDI-P and PDI-B are 2.01 and 45.4,***,density functional theory(DFT)and time-dependent density functional theory(TDDFT)calculations indicate that the HOMO and HOMO-1 energy ranges of PDI-P and PDI-B are 0.54 e V and 1.13 e V,respectively.A wider energy range has a stronger driving force on electrons,which is conducive to fluorescence *** femtosecond transient absorption spectroscopy(fs-TAS)and transient fluorescence spectroscopy(TFS)tests show that PDI-B has shorter charge separation lifetime and higher electron transfer rate *** both isomers can significantly reduce LOD during PET process,PDI-B with aromatic amine has a wider detection range of 0.118—240 Gy due to its larger emission enhancement,which is a leap of three orders of *** breaks through the detection range of gamma radiation reported in existing studies,and provides theoretical support for the further study of sensitive and effective new materials for ionizing radiation dete

关键词： Perylene imide Intramolecular PET Ionizing radiation detection Fluorescence sensor Isomers

Ultra-low noise L-band cryogenic astronomical receiver for the FAST telescope

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Research in Astronomy and Astrophysics 2021年第7期21卷 269-280页

作者： Hong-Fei Liu Chuan He jin Wang Peng Jiang Sheng-Wang Wang yang Wu Hang Zhang jin-You Song Xiang-Wei Shi Ming-Lei Guo National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China The 16th Research Institute of China Electronics Technology Group Corporation Hefei 230043China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

This paper presents an ultra-low noise L-band radio astronomical cryogenic receiver for the Fivehundred-meter Aperture Spherical radio Telescope(FAST) telescope. The development of key low noise microwave parts of coupling low noise amplifier(Coupling-LNA) and conical quad-ridge orthogonal mode transducers(OMT) and reasonable system integration achieve outstanding performance of receiver. It covers the frequency range of 1.2 GHz to 1.8 GHz. Novel cryogenic Coupling-LNAs with low noise, large return loss, high dynamic range and the function of coupling calibration signals are developed for the proposed receiver. Amplification and coupling function circuits are integrated as a single Coupling-LNA with full noise temperature of 4 K at the physical temperature of 15 K. Its return loss is more than 18 d B, and output1 d B compression power is +5 d Bm. A cryogenic dewar is fabricated to provide 55 K and 15 K cryogenic environment for OMT and Coupling-LNAs, respectively. The receiver's system noise temperature is below9 K referred to feed aperture plane. Benefiting from optimal design and precise mechanical treatment, good scattering performance of OMT and equalized radiation patterns of horn are achieved with an antenna efficiency above 75%.

关键词： telescopes analytical observational

A Shear-wave Splitting Study of the Yingjiang M_S6.1 Earthquake Sequence Occurring on May 30,2014

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Earthquake Research in China 2016年第2期30卷 177-185页

作者： Li jin Gao Yuan Xu Fukun Xiang yang Xiang Yuan Liu Geng Earthquake Administration of Xinjiang Uygur Autonomous Region Urumqi 830011China Institute of Earthquake Science CEABeijing 100036China Earthquake Administration of Yunnan Province Kunming 650041China

Earthquakes of M_S5. 6 and M_S6.1 occurred in Yingjiang,Yunnan on May 24 and May 30,2014 respectively. In this paper,we use the waveform data recorded by mobile seismic stations( KAC) which were set up in the source area after the Yingjiang MS5. 6earthquake on May 24,2014 to study the shear-wave splitting characteristics of Yingjiang M_S6.1 earthquake sequence with the SAM method. The result shows that predominant polarization of fast shear-waves before the M_S6.1 earthquake is consistent with the direction of regional principal compressive stress,and predominant polarization of fast shear-waves before the M_S6.1 earthquake show better consistency and smaller dispersion compared to after the M_S6.1 earthquake,and there may be a deflection for the fast shearwaves predominant polarization between the M_S6.1 earthquake sequence and foreshock sequence. We found that the time-delays generally exhibited a lower level before the M_S6.1earthquake and a relatively higher value after the M_S6.1 earthquake.

关键词： Yingjiang earthquake sequence Foreshock Shear-wave splittingPolarization of fast shear-waves Time-delays

Design,Synthesis and Molecular Docking of a Novel Small-molecule Inhibitor of Caspase-3

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Chemical Research in Chinese Universities 2010年第2期26卷 256-258页

作者： ZHANG jin-liang GUO yang-hong GAO Chao-hui WANG En-si REN Zhong-yuan FANG Xue-xun WANG Ji-dong College of Life Science School of Pharmaceutical Sciences College of Chemistry Jilin University Changchun 130021 P. R. China

4,5-Dihydro-3-methylbenzo[1,2-b]furan-4,5-dione（4） was identified as a novel and potent inhibitor of caspase-3 through structural modification of an existing drug, sodium tanshinone IIA sulfonate（STS）. Compound 4 showed high potency against caspase-3 in vitro（ICso=0. 13μmol/L）. Molecular docking study further provided an insight into the interaction of compound 4 with activated caspase-3. Hence, this small-molecule caspase-3 inhibitor could be a oromising theraoeutic candidate against diseases caused by abnormally up-regulated apptosis.

关键词： Caspase-3 Inhibitor Docking simulation

Detection of hybridization of protein microarrays using an oblique-incidence reflectivity difference method

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Science China(Physics,Mechanics & Astronomy) 2010年第7期53卷 1230-1233页

作者： LU Heng WEN Juan WANG Xu YUAN Kun LU HuiBin ZHOU YueLiang jin Kui-Juan yang GuoZhen LI Wei RUAN KangCheng Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Proteomics Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Mouse-Immunoglobulin G(mouse-IgG) with different concentrations in a range from 1000 to 0.0128 μg/mL and a specific hybridization with goat anti-mouse IgG were detected successfully by using an oblique-incidence reflectivity difference(OI-RD) *** detection signals,consisting of an imaginary part(Im{Δp-Δs}) and a real part(Re{Δp-Δs}) of OI-RD,were obtained *** detection results of hybridization by OI-RD were in accord with that of traditional fluorescent *** particular,we label-freely detected the washed mouse-IgG microarray with a series of concentrations and acquired a linear correlation between OI-RD intensities and the protein concentrations in logarithmic *** detection sensitivity of OI-RD can reach 14 *** experimental results suggest that the OI-RD method has potential applications in proteomics and clinical diagnosis.

关键词： protein microarrays oblique-incidence reflectivity difference(OI-RD) label-free detection