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18F-FDG PET/CT makes a significant contribution to diagnosis of malignancy in patients with cervical lymphadenopathy： a study using optimal scale regression tests

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Chinese Medical Journal 2013年第4期126卷 659-667页

作者： OU yang lin shi Zhao-yin lin Zhi-gang Department of Imaging Medicine PLA 175 Hospital (Affiliated Southeast Hospital of Xiamen University) Zhangzhou Fujian 363000 China

Background The specificity and precision of lymphadenopathy assessment using US, CT and MRI are generally unsatisfactory, while fluorodeoxyglucose-positron emission tomography/computed tomography （18F-FDG PET/CT） can support this process by providing additional information about the lymph node features. However, which image features of 18F-FDG PET/CT play the key role in the diagnosis and cutoffs of malignant cervical lymphadenopathy still needs to be determined by further studies. Our study aimed to identify 18F-FDG PET/CT abnormalities that would assist in making a reliable diagnosis of malignant cervical lymphadenopathy in enlarged cervical lymph nodes of patients with unknown primary diseases. Methods One hundred and ninety-one consecutive patients of cervical lymphadenopathy with unknown primary causes were examined by 18F-FDG PET/CT from May 2007 to October 2011 and a definite diagnosis was established by pathologic biopsy. 18F-FDG PET/CT images were evaluated to identify the relevant abnormalities. All image features were analyzed by optimal scale regression tests to determine the important factors that were predictive for the diagnosis of malignant cervical lymphadenopathy and the cutoffs. Results The factors studied in 18F-FDG PET/CT images for predicting malignant cervical lymphadenopathy were sex, age, node location, size, shape, margins, maximum standard uptake value （SUV）, mean SUV, FDG uptake pattern and number of nodes. It was found that mean SUV, maximum SUV, FDG uptake pattern, location, size and margins were the important risk factors of cervical lymph nodes that could predict malignant cervical lymphadenopathy. Signs of mean SUV〉2.5 （or maximum SUV〉3.5）, nodular FDG uptake pattern, location of IIA, III, IV, VB, VI and VII regions, size〉1.5 cm and vague margins had their optimal diagnostic accuracy （Ac） and Youden index （YI）, further, combination of any three factors of these six important risk factors would led to the best diagnosticAc of 96% and

关键词： cervical lymphadenopathy FDG-PET/CT oncologic imaging

基于临床代谢组学与蛋白质组学研究粉葛治疗轻度血脂异常的作用机制

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中国中药杂志 2024年第10期49卷 2818-2827页

作者：易建云朱卫丰管咏梅周旭陈晓凡杨世林冯育林欧阳辉江西中医药大学中药固体制剂制造技术国家工程研究中心江西南昌330006 江西中医药大学现代中药制剂教育部重点实验室江西南昌330004 江西中医药大学循证医学研究中心江西南昌330004

研究粉葛临床上治疗轻度血脂异常潜在的代谢途径和作用靶点。采用UPLC-Q-TOF-MS和EASY-nLC-timsTOF-Pro2技术对轻度血脂异常患者在基线和服药12周后的血浆样品展开代谢组学和蛋白质组学研究。通过多元统计分析比较组间差异,并对轻度血... 详细信息

研究粉葛临床上治疗轻度血脂异常潜在的代谢途径和作用靶点。采用UPLC-Q-TOF-MS和EASY-nLC-timsTOF-Pro2技术对轻度血脂异常患者在基线和服药12周后的血浆样品展开代谢组学和蛋白质组学研究。通过多元统计分析比较组间差异,并对轻度血脂异常密切相关的代谢物和蛋白与临床血脂指标分别进行相关性分析,结合基因本体(Gene Ontology,GO)功能分析和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析结果,绘制粉葛治疗轻度血脂异常可能的作用途径和靶点。结果显示,粉葛治疗后患者血浆中共有56个差异代谢物和78个差异蛋白产生回调效应,包括脂质和糖代谢相关的蛋白或代谢物(ApoB-100、9,10-DHOME、GAPDH、PGK1、PGAM1、ENO1等)、炎症与氧化应激相关的蛋白或代谢物(氧化磷脂、PLA2G7、LTA4H等)。结果表明,粉葛治疗轻度血脂异常的作用机制可能与下调ApoB-100的过表达、激活PPARα/γ、促进脂肪和甘油的分解、缓解LTB4与氧化磷脂介导的氧化应激密切相关。

关键词：粉葛轻度血脂异常代谢组学蛋白质组学脂质代谢氧化应激

油茶枯饼总黄酮提取工艺优化、含量测定及其抗氧化活性研究

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饲料研究 2024年第11期47卷 89-95页

作者：董智丹王宝林黄氏玄庄许琼明杨世林陈晓春潘其明高红伟广西中医药大学药学院广西南宁530200 海防医药大学传统医学系海防180000 苏州大学江苏苏州215000 江西中医药大学江西南昌330000

研究旨在通过响应面法优化油茶枯饼中总黄酮的超声提取工艺,比较不同产地油茶枯饼总黄酮含量及其体外抗氧化活性。试验以广西壮族自治区南宁市的油茶枯饼为原料,基于单因素试验结果,以乙醇浓度、液料比、超声时间、超声功率为影响因素,... 详细信息

研究旨在通过响应面法优化油茶枯饼中总黄酮的超声提取工艺,比较不同产地油茶枯饼总黄酮含量及其体外抗氧化活性。试验以广西壮族自治区南宁市的油茶枯饼为原料,基于单因素试验结果,以乙醇浓度、液料比、超声时间、超声功率为影响因素,总黄酮得率为评价指标,运用Box-Behnken响应面法优化油茶枯饼中总黄酮的超声提取工艺。结果显示,乙醇浓度70%、液料比55 m L/g、超声时间45 min、功率500 W为油茶枯饼总黄酮超声提取的最佳工艺,在此条件下广西南宁市的油茶枯饼总黄酮提取率为3.44%。不同产地、批次的油茶枯饼总黄酮含量范围1.20%~3.54%,其中湖南省湘潭市的油茶枯饼总黄酮含量最高,广东省梅州市的油茶枯饼总黄酮含量最低。湖南省湘潭市油茶枯饼的1,1-二苯基-2-三硝基苯肼(DPPH)自由基清除能力最高,其IC_(50)值为0.59 g/L;广西壮族自治区玉林市油茶枯饼的2,2'-联氮-二(3-乙基-苯并噻唑-6-磺酸)二铵盐(ABTS+)自由基清除能力最高,其IC_(50)值为0.73 g/L。研究表明,试验可为挖掘油茶枯饼在畜禽饲养中的开发利用提供参考。

关键词：油茶枯饼总黄酮响应面法抗氧化活性

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Isolation and Characterization of Two New Compounds from Lysimachia Davurica

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Chemical Research in Chinese Universities 2005年第5期21卷 549-551页

作者： TIAN Jing-kui ZOU Zhong-mei XU Li-zhen yang shi-lin Department of Chinese Medicine Science and Engineering Zhefiang University Hangzhou 310027P. R. China Institute of Medicinal Plants Development Chinese Academy of Medical Scienees and Peking Union Medical College Beijing 100094 P. R. China

Two new saponins named davuricoside H and davuricoside K were isolated from the whole plant of Lysimachia davurica. The structures of davuricoside H and davuricoside K were determined by 1-D and 2-D NMR, MS techniques, and chemical methods to be 3β,16α ,28-trihydroxy-olean-12-en-30-oic acid-3-O-β-D-glucopyranosyl-（ 1→2 ）- [β-D-glucopyranosyl-（ 1 → 4 ） ] -α-L-arabinopyranoside and 3β,16or ,28-trihydroxy-olean-12-en-30-oic acid-3-O-{β-D- glucopyranosyl- （ 1 →2 ） - [β-D-glucopyranosyl- （ 1 →4 ） ] -α-L-arabinopyranosyl } -30-O-β-D-glucopyranosyl-ester.

关键词： Lysimachia davurica Triterpenoid saponin Davuficoside H Davuricoside K

A high-performance liquid chromatography with circular dichroism detector for determination of stereochemistry of 6, 9-oxygen bridge dibenzocyclooctadiene lignans from kadsura coccinea

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Chinese Journal of Natural Medicines 2015年第10期13卷 791-795页

作者： ZHU Hui XU Liang yang shi-lin LI He-Ran College of Pharmaceutical Sciences Soochow University

The stereochemistry of two 6, 9-oxygen bridge dibenzocyclooctadiene lignans from Kadsura coccinea, are difficult to separate and very unstable. The present study was designed to develop a high-performance liquid chromatography using circular dichroism detection for the analysis of the stereochemistry. A new 6, 9-oxygen bridge dibenzocyclooctadiene lignans named Kadsulignan Q was firstly found with an S-biphenyl configuration. The other compound was identified as Kadsulignan L with an R- biphenyl configuration. In order to obtain kinetic data on their reversible interconversion, the stability was measured at different deuterated solvents such as deuterated methanol, deuterated chloroform and deuterated dimethylsulfoxide. The lignans were more unstable and converted more easily in deuterated methanol than in deuterated chloroform and deuterated dimethylsulfoxide.

关键词： 6,9-Oxygen bridge dibenzocyclooctadiene lignans Kadsura coccinea High-performance liquid chromatography using circular dichroism detection(HPLC-CD) Kadsulignan Q Kadsulignan L

DECISION FUSION FOR WIRELESS SENSOR NETWORKS UNDER NAKAGAMI FADING CHANNELS

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Journal of Electronics(China) 2010年第2期27卷 177-182页

作者： Yuan Xiaoguang yang Wanhai shi lin School of Electronic Engineering Xidian University Xi＇an 710071 China

Decision fusion rules for Wireless Sensor Networks (WSNs) under Nakagami fading channels are investigated in this paper. Considering the application limitation of Likelihood Ratio Test fusion rule based on information of Channel Statistics using Series expansion (LRT-CSS),and the detection performance limitation of the Censoring based Mixed Fusion rule (CMF),a new LRT fusion rule based on information of channel statistics has been presented using Laplace approximation (LRT-CSL). Theoretical analysis and simulations show that the proposed fusion rule provides better detection performance than the Censoring based Mixed Fusion (CMF) and LRT-CSS fusion rules. Furthermore,compared with LRT-CSS fusion rule,the proposed fusion rule expands the application range of likelihood ratio test fusion rule.

关键词： Nakagami fading channels Wireless Sensor Network (WSN) Decision fusion

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基于面积加权GWT-GFT的水声目标识别

计算机技术与发展 2024年第7期34卷 108-115页

作者：陈鑫邵杰王星星杨鑫杨世逸林南京航空航天大学电子信息工程学院江苏南京211106

由于海洋环境的复杂性,水声目标的识别具有很大的挑战性。为解决这类复杂环境下特征提取的问题,提出了一种基于面积加权的图小波变换-图傅里叶变换(GWT-GFT)的分析方法。在完成数据预处理后,为了能够凸显顶点之间的关系,提出了一种新的... 详细信息

由于海洋环境的复杂性,水声目标的识别具有很大的挑战性。为解决这类复杂环境下特征提取的问题,提出了一种基于面积加权的图小波变换-图傅里叶变换(GWT-GFT)的分析方法。在完成数据预处理后,为了能够凸显顶点之间的关系,提出了一种新的基于顶点三角形面积的加权方法来构建图信号;构建好的图信号通过GWT分解为多尺度图分量;然后,利用GFT将这些分量从图域变换到特征值谱域进行分析;在此基础上,提取各分量特征值谱的特征;最后,利用基于高斯核函数的支持向量机(SVM)对获取的特征向量进行分类。基于水声信号shipsEar数据库,采用5折交叉验证方法进行验证。与现有的其它方法相比,所提的模型以36个特征在376656个样本上取得了97.22%的准确率,证明了该分析方法的有效性和鲁棒性。

关键词：水声目标识别 GWT-GFT 特征提取图信号处理顶点三角形面积加权

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基于改进的GAF算法的EEG情感识别

计算机技术与发展 2024年第5期34卷 109-116页

作者：王星星邵杰陈鑫杨世逸林杨鑫南京航空航天大学电子信息工程学院江苏南京210016

利用脑电图(EEG)信号对人类的情感进行识别一直是一个重要且具有挑战性的研究领域。传统的方法都是对一维EEG信号进行分析,然后提取特征进行识别;但这种方法需要提取许多时域或频域上的特征才能取得较好的识别效果。考虑到二维图像蕴含... 详细信息

利用脑电图(EEG)信号对人类的情感进行识别一直是一个重要且具有挑战性的研究领域。传统的方法都是对一维EEG信号进行分析,然后提取特征进行识别;但这种方法需要提取许多时域或频域上的特征才能取得较好的识别效果。考虑到二维图像蕴含的信息要远远比一维信号蕴含的信息丰富,因此将一维信号转换成二维图像可以提取更加有效的特征进行识别。为此,该文提出了一种基于改进的Gramian Angular Field(GAF)算法的EEG情感识别方法。首先,从EEG信号中提取alpha、beta、gama三个频段的子带信号;然后,提出了一种基于马氏距离加权的改进GAF算法将一维EEG信号转换成二维特征图像;接着,从二维图像中提取奇异值熵、图能量等特征;最后,利用卷积神经网络(CNN)对提取的EEG特征进行分类识别。基于广泛使用的DEAP数据集,针对四分类(HAHV、LAHV、LALV和HALV)情感识别任务,对该模型进行了验证。实验结果表明:所提算法的平均分类准确率达到92.63%,与现有的识别方法对比具有一定的优势。

关键词：脑电图情感识别格拉姆角场马氏距离卷积神经网络

Antioxidant and cardioprotective effects of Ilex cornuta on myocardial ischemia injury

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Chinese Journal of Natural Medicines 2017年第2期15卷 94-104页

作者： YUAN Yan PAN Shu yang shi-lin LIU Yan-Li XU Qiong-Ming Department of Pharmacology College of Pharmaceutical ScienceSoochow UniversitySuzhou 215123China Department of Pharmaceutical Chemistry Guizhou UniversityGuiyang 550025China Department of Pharmacognosy College of Pharmaceutical ScienceSoochow UniversitySuzhou 215123China

Previous studies have indicated that the Ilex genus exhibits antioxidant, neuroprotective, hepatoprotective, and antiinflammatory activities. However, the pharmacologic action and mechanisms of Ilex cornuta against cardiac diseases have not yet been explored. The present study was designed to investigate the antioxidant and cardioprotective effects of Ilex cornuta root with in vitro and in vivo models. The anti-oxidative effects of the extract of Ilex cornuta root(ICR) were measured by 2, 2-diphenyl-1- picrylhydrazyl(DPPH) free-radical scavenging and MTT assays as well as immunoassay. Furthermore, a rat model of myocardial ischemia was established to investigate the cardioprotective effect of ICR in vivo. Eight compounds were isolated and identified from ICR and exhibited DPPH free-radical scavenging activities. They also could increase cell viability and inhibit morphological changes induced by H_2O_2 or Na_2S_2O_4 in H9c2 cardiomyocytes, followed by increasing the SOD activities and decreasing the MDA and ROS levels. In addition, it could suppress the apoptosis of cardiomyocytes. In the rat model of myocardial ischemia, ICR decreased myocardial infarct size and suppressed the activities of LDH and CK. Furthermore, ICR attenuated histopathological alterations of heart tissues and the MDA levels, while increasing SOD activities in serum. In conclusion, these results suggest that ICR has cardioprotective activity and could be developed as a new food supplement for the prevention of ischemic heart disease.

关键词： Ilex cornuta Myocardial ischemia Antioxidant Apoptosis