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Nanoantidotes: A Detoxification System More Applicable to Clinical Practice

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Biomedical Engineering Frontiers 2023年第1期4卷 113-115页

作者： jiazhen yang Jianxun Ding Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022P.R.China School of Applied Chemistry and Engineering University of Science and Technology of China96 Jinzhai RoadHefei 230026P.R.China

Since 2010,there has been a much greater awareness of the problem of intoxication,which has become the most common form of accidental and intentional *** 2020,more than 90,000 people died of intoxication in the United States,which surpassed deaths due to motor vehicle accidents and firearms use to become the leading external cause of mortality.

关键词： death mortality Clinical

Immunologically effective poly(D-lactic acid) nanoparticle enhances anticancer immune response

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Science China Chemistry 2023年第4期66卷 1150-1160页

作者： Weiguo Xu Yuanzhen Su yang Ma Qi Wei jiazhen yang Xiuli Zhuang Jianxun Ding Xuesi Chen School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Thoracic Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033China

Chiral materials with the same atomic compositions exhibit different chemical,physical,and biological properties because of their distinct spatial ***,a chiral strategy was proposed to develop poly(lactic acid)(PLA)nanoparticle as an efficient nanoadjuvant to activate adaptive anticancer *** chiral nanovaccines were prepared by directly mixing amino-terminated PLA(PLLA-NH2 or PDLA-NH2)with the model protein antigen ovalbumin(OVA).After being injected into mice subcutaneously,both nanovaccines efficiently migrated to the lymph nodes to initiate the sequential anticancer immune *** with the PLLA nanovaccine(PLLA-OVA),the PDLA one(PDLA-OVA)contributed to more robust dendritic cell(DC)maturation,antigen presentation,and T lymphocyte *** addition to the activation of cellular immunity,PDLA-OVA also triggered a more vigorous activation of humoral immunity,which induced the production of more anti-OVA immunoglobulin G(IgG)than *** used as prophylactic or therapeutic nanovaccine toward murine melanoma models,PDLA-OVA triggered more potent adaptive anticancer immune responses that more effectively inhibited the cancer genesis and progression,indicating the significant potential of immunologically effective PDLA nanoadjuvant in cancer immunotherapy.

关键词： poly(D-lactic acid) chiral nanomaterial immune nanoadjuvant nanovaccine cancer immunotherapy

Density estimated physicochemical properties of alanine-based ionic liquid [C_7mim][Ala] and its application in selective transesterification of soybean oil

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Science China Chemistry 2012年第8期55卷 1677-1682页

作者： FANG DaWei LI Meng GE RiLe ZANG ShuLiang yang jiazhen GAO YanAn China Ionic Liquid Laboratory Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Rare and Scattered Elements Chemistry Liaoning UniversityShenyang 110036China School of Chemistry and Materials Science Liaoning Shihua UniversityFushun 113001China

Amino acid ionic liquid （AAIL） based on alanine, 1-n-heptyl-3-methylimidazolium alanine （[C7mim][Ala]）, has been prepared and characterized. Since the IL can form strong hydrogen bonds with water, trace amount of water is a problematic impurity in the IL. Using the standard addition method （SAM）, the densities were measured in the temperature range from 293.15 to 343.15±0.05 K. On the basis of the experimental data of density, the surface tension y, molar volume, and the molecular vol- ume Vm, molar enthalpy of vaporization AIgHm0, and the thermal expansion coefficients or, for [C7mim][Ala] were estimated using semi-empirical methods. Also the interstice model has been verified with good accordance. Then the [C7mim][Ala] was taken as catalyst in the transesterification reaction with fatty acid, where soybean oil was used as raw material and methanol as reactant. The amount of catalyst, alcohol consumption, reaction time, temperature and other factors of the reaction were inves- tigated. Using GC determination, the conversions were calculated by the internal standard method. The main ingredients of the products were identified by GC-MS as palm methyl ester and linoleic acid methyl ester only, which showed high selectivity in palmitic acid and linoleic acid.

关键词： alanine ionic liquid density transesterification

The ionic parachor and predicting properties of amino acid ionic liquid homologues of 1-alkyl-3-methylimidazolium glycine

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Science China Chemistry 2012年第7期55卷 1330-1337页

作者： TONG Jing HONG Mei WANG PanPan GUAN Wei FANG DaWei yang jiazhen Key Laboratory qf Green Synthesis and Preparative Chemistry of Advanced Materials Liaoning UniversityShenyang 110036China

The amino acid ionic liquids （AAILs） [C3mim][Gly] （1-propyl-3-methylimidazolium glycine） and [C4mim][Gly] （l-butyl-3- methylimidazolium glycine） have been prepared by the neutralization method and characterized by IH NMR spectroscopy and differential scanning calorimetry （DSC）. The values of their density, surface tension and refractive index were measured at （298.15 ± 0.05） K. Since the AAILs can form strong hydrogen bonds with water, small amounts of water are difficult to remove from the AAILs by common methods. In order to eliminate the effect of the impurity water, the standard addition method （SAM） was applied to these measurements. A new concept which is called the ionic parachor has been put forward. The [Cn mim]＋ cations were treated as a group of reference ions and the individual values of their ionic parachor were evaluated in terms of an extrathermodynamic assumption. Then, using the values of the ionic parachor of reference ions, the parachor, surface tension y and refractive index no of the ionic liquids investigated in this work were estimated. The estimated values correlate quite well with the corresponding experimental values.

关键词： ionic liquids ionic parachor glycine density surface tension extrathermodynamic assumption

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信息化环境下企业管理模式的研究

生产力研究 2003年第5期 243-245,257页

作者：杨家珍中国煤炭经济学院管理系山东烟台264005

信息技术迅猛发展及广泛应用 ,极大的改变了企业的生产经营环境 ,对企业管理产生了积极的、深远的、多层次、多角度的影响。本文对信息化环境下的企业管理进行了研究和探讨 ,结合当前一些新的管理思想和方法 ,提出了基于信息技术条件下... 详细信息

信息技术迅猛发展及广泛应用 ,极大的改变了企业的生产经营环境 ,对企业管理产生了积极的、深远的、多层次、多角度的影响。本文对信息化环境下的企业管理进行了研究和探讨 ,结合当前一些新的管理思想和方法 ,提出了基于信息技术条件下企业的管理模式。

关键词：信息化环境企业管理模式经营环境信息技术

1-乙基-3-甲基咪唑丙氨酸盐离子液体的低温热容研究

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中国科学：化学 2019年第7期49卷 1007-1013页

作者：周彩滨战德松杨家振中国医科大学附属口腔医院沈阳110002 辽宁大学化学院沈阳110036

本文合成了1-乙基-3-甲基咪唑丙氨酸盐离子液体,并通过核磁共振氢谱(~1H NMR)和差示扫描量热仪(DSC)对其进行了表征,确定合成了目标产物。热重分析(TGA)测试结果显示1-乙基-3-甲基咪唑丙氨酸盐离子液体的初始分解温度约为473.15 K,说明... 详细信息

本文合成了1-乙基-3-甲基咪唑丙氨酸盐离子液体,并通过核磁共振氢谱(~1H NMR)和差示扫描量热仪(DSC)对其进行了表征,确定合成了目标产物。热重分析(TGA)测试结果显示1-乙基-3-甲基咪唑丙氨酸盐离子液体的初始分解温度约为473.15 K,说明该离子液体具有较好的热稳定性。以低温绝热量热仪测试了该离子液体在80~400 K温区下的低温热容,将实验热容值拟合处理,得到了1-乙基-3-甲基咪唑丙氨酸盐离子液体固液相区的热容多项式方程,并通过热容多项式计算了该离子液体在298.15~400K的焓值、熵值以及吉布斯自由能。

关键词：热容热力学函数离子液体绝热量热丙氨酸

Dynamic Settings and Interactions between Basin Subsidence and Orogeny in Zhoukou Depression and Dabie Orogenic Belt

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Journal of Earth Science 2000年第3期19卷 175-177页

作者： Sun jiazhen yang Xianghua Faculty of Earth Resources, China University of Geosciences, Wuhan 430074, China Qiu Ronghua He Mingxi Exploration and Development Institute of Henan Oilfield, Nanyang 473132, China

This paper presents a study of the geo dynamic setting and the relation between orogenic uplift and basin subsidence in the inland Zhoukou depression and Dabie orogenic belt. Since the Mesozoic the evolution of Zhoukou depression can be divided into three stages: (1) foreland basin, (2) transitional stage, (3) fault depression. Formation and variations of basin were not only related to the orogenesis, but also consistent with the orogenic uplift.

关键词： foreland basin fault depression orogenic belt dynamic setting.

硼酸盐水溶液热力学研究——4.离子对[CaB(OH)_4]^+标准缔合常数的确定

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化学学报 1999年第9期57卷 992-996页

作者：孙柏杨家振宋彭生邓敏高岩岩中国科学院青海盐湖研究所西宁810008 辽宁大学化学系沈阳110036

在温度为278.15～318.15K范围内测定了含有不同Li_2B_4O_7和CaCl_2浓度测试液的无液接电池:Pt,H_2(101.325kPa)|Li_2B_4O_7(m_1),CaCl_2(m_2)AgCl-Ag的电动势E(V).在Pitzer电解质溶液理论基础上,用线性外推法确定离子对[CaB(OH)_4]~4的标准缔合常数K_d,并得到K_d随温度T变化的经验公式:pK_d=0.6857-359.72/T-4.632×10^(-3)T.同时计算得到了离子对缔合过程的热力学函数,指出形成该离子对的推动力是缔合熵.

关键词：水溶液热力学硼酸盐离子对缔合常数电动势

Prediction of the thermodynamic properties of 1-alkyl-3-methylimidazolium lactate ionic liquids [C_nmim][Lact](n=2,3,4,5,and 6) by parachor

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Science China Chemistry 2010年第12期53卷 2564-2570页

作者： FANG DaWei 1,3,TONG Jing 2,GUAN Wei 2,WANG Han 2 & yang jiazhen 1,3 1 Institute of Rare and Scattered Elements Chemistry,Liaoning University,Shenyang 110036,China 2 College of Chemistry,Liaoning University,Shenyang 110036,China 3 Key Laboratory of Rare and Scattered Elements,Liaoning Province,Shenyang 110036,China 1. Institute of Rare and Scattered Elements Chemistry Liaoning University Shenyang 110036 China3. Key Laboratory of Rare and Scattered Elements Liaoning Province Shenyang 110036 China2. College of Chemistry Liaoning University Shenyang 110036 China

An ionic liquid (IL) based on lactate,1-butyl-3-methylimidazolium lactate ([C4mim][Lact]),has been prepared and characterized by 1H nuclear magnetic resonance (NMR) spectroscopy and differential scanning calorimetry (DSC).Since the IL can form strong hydrogen bonds with water,trace water is a problematic impurity in the *** the standard addition method (SAM),the density,refractive index and surface tension of [C4mim][Lact] were measured in the temperature range (308.15 to 343.15 ± 0.05) *** the basis of the experimental data,the parachor and molar volume for [C4mim][Lact],and the molecular volume V m,surface tension γ,molar enthalpy of vaporization △lgHm 0,refractive index n D,and the thermal expansion coefficients,for the homologues [Cnmim][Lact] (n=2,3,4,5,and 6) were estimated using semi-empirical *** estimated values are in good agreement with the experimental data.

关键词： parachor lactate ionic liquid density surface tension refractive index