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A b.yesian Network Approach for Offshore Risk Analysis Through Linguistic Variab.es

China Ocean Engineering 2007年第3期21卷 371-388页

作者： Ren j. Wang j. j.nkinson I. Xu D. L. yang j. b. School of Engineering Liverpool John Moores University Liverpool L 3 3 AF UK Manchester b.siness School The University of Manchester Manchester M 60 1 QD UK

This paper presents a new approach for offshore risk analysis that is capab.e of dealing with linguistic prob.b.lities in b.yesian networks （ b.s）. In this paper, linguistic prob.b.lities are used to describ. occurrence likelihood of hazardous events that may cause possib.e accidents in offshore operations. In order to use fuzzy information, an f-weighted valuation function is proposed to transform linguistic j.dgements into crisp prob.b.lity distrib.tions which can b. easily put into a b. to model causal relationships among risk factors. The use of linguistic variab.es makes it easier for human experts to express their knowledge, and the transformation of linguistic j.dgements into crisp prob.b.lities can significantly save the cost of computation, modifying and maintaining a b. model. The flexib.lity of the method allows for multiple forms of information to b. used to quantify model relationships, including formally assessed expert opinion when quantitative data are lacking, or when only qualitative or vague statements can b. made. The model is a modular representation of uncertain knowledge caused due to randomness, vagueness and ignorance. This makes the risk analysis of offshore engineering systems more functional and easier in many assessment contexts. Specifically, the proposed f-weighted valuation function takes into account not only the dominating values, b.t also the a-level values that are ignored b. conventional valuation methods. A case study of the collision risk b.tween a Floating Production, Storage and Off-loading （FPSO） unit and the anthorised vessels due to human elements during operation is used to illustrate the application of the proposed model.

关键词： Risk analysis fiweighted valuation function b.yesian networks fuzzy numb.r linguistic prob.b.lity off-shore engineering systems

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Single　Frequency　Operation　of　Diode－pumped　Intracavity　Frequency　Doub.ed　Nd：YAG　Laser　With　Tilted　KTP　Crystal：　Theoretical　Study

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Chinese j.urnal of Lasers 1996年第3期B5卷 199-204页

作者： YAO j. Q. yang j. b. SHENG W.D. ZHENG Y.(Institute of Laser and Opto-electronics, Tian j.n University, Tianj.n 300072, China)ZHENG H. yang H.G.(Institute of Physics, Academia Sinica, b.ij.ng 100080, China) Tianj.n Univ Tianjin China

Ｓｉｎｇｌｅ　Ｆｒｅｑｕｅｎｃｙ　Ｏｐｅｒａｔｉｏｎ　ｏｆ　Ｄｉｏｄｅ－ｐｕｍｐｅｄ　Ｉｎｔｒａｃａｖｉｔｙ　Ｆｒｅｑｕｅｎｃｙ　Ｄｏｕｂｌｅｄ　Ｎｄ：ＹＡＧ　Ｌａｓｅｒ　Ｗｉｔｈ　Ｔｉｌｔｅｄ　ＫＴＰ　Ｃｒｙｓｔａ... 详细信息

Ｓｉｎｇｌｅ　Ｆｒｅｑｕｅｎｃｙ　Ｏｐｅｒａｔｉｏｎ　ｏｆ　Ｄｉｏｄｅ－ｐｕｍｐｅｄ　Ｉｎｔｒａｃａｖｉｔｙ　Ｆｒｅｑｕｅｎｃｙ　Ｄｏｕｂｌｅｄ　Ｎｄ：ＹＡＧ　Ｌａｓｅｒ　Ｗｉｔｈ　Ｔｉｌｔｅｄ　ＫＴＰ　Ｃｒｙｓｔａｌ：　Ｔｈｅｏｒｅｔｉｃａｌ　Ｓｔ...

关键词： single-frequency Nd:YAG laser diode-pumped intracavity frequency Doub.ing

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Genotypes and Phenotypes of Uygur Children with Xeroderma Pigmentosum: A Case Study in Xinj.ang, China

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-j. Liang j.-Q. Yakeya b. Wang P. Zhang j.-Z. Kang X.-j. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Key Lab.ratory of Dermatology Research (Xj.S1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Ob.0}ctive: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused b. genetic defects of DNA repair. This study was performed to detect and analyze the genes of 2 Uygur patients with XP and their families and assess the patients' phenotypes, which may enrich the understanding of the genetic skin disorder spectrum in Xinj.ang area. Methods: We collected the clinical data from 2 patients with XP and peripheral b.ood samples from the patients and their family memb.rs. The patients' DNA was sequenced and detected b. Sanger sequencing, and gene mutations were screened. Results: The prob.nd in family 1 presented with b.own maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The prob.nd had a homozygous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron b.fore the 2251 position in the coding region), which was a shear mutation. In this family, b.th parents were heterozygous, and no similar mutation detected in the sister. In family 2, the prob.nd had scattered b.ack b.own spots and papules on the trunk and limb.. and his younger sister was also a patient. The prob.nd and his younger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 b.ing changed into termination codon (***211X), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uygur population. This study expanded the mutation spectrum of XP and provided a b.sis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, pub.ished b. Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

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SYNTHESIS OF ULTRAFINE PLZT POWDER b. A SIMPLE CO-PRECIPITATION METHOD

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Acta Metallurgica Sinica(English Letters) 1999年第5期12卷 1180-1183页

作者： H. Ying1) , X. D. Sun1) , Q. b. yang1) , j. b. Li2) , Y. M. Wang2) , Z. Zhang3) and j. You3)1) School of Materials and Metallurgy , Northeastern University , Shenyang 110006 , China2) Departm ent of Materials , School of Mechani

Starting from cheap inorganic salts , ultrafine P L Z T po w ders were synthesized b. a co pre cipitation m ethod . The results show that the precursor precipitate ob.ained b. the co precipita tion method transfor ms co m pletely to P L Z T phase b. calcining at 420 ℃ for 4 hours , ab.ut300 ℃low er than the nor m al transform ation te m perature of P L Z T ob.ained b. m ixed oxidemethod . The effect of residual N H4 N O3 in the precursor precipitate on transfor m ation te m perature of the P L Z Tpow der w as investigated . The residual N H4 N O3 in the precursor po w der can reduce further the P L Z Ttransfor m ation tem perature to ab.ut 300 ℃, b.t a sm alla mount of Zr O2 and Pb.Ti O3 re m ained . b. a proper control of the synthesizing route , a P L Z T po w der with a pri m ary particle size of 10 n m and an agglom eration size of 0 3 μm hasb.en produced .

关键词： P L Z T ultra fine po w der co precipitation

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Wavelet-b.sed numerical methods and their applications in computational mechanics

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Advances in Mechanics 2024年第3期54卷 427-476页

作者： yang b. Wang j. Liu X. Zhou Y. Feng Y. Key Lab.ratory of Mechanics on Disaster and Environment in Western China The Ministry of Education of China College of Civil Engineering and Mechanics Lanzhou University Lanzhou 730000 China

Mechanics research advances towards interdisciplinary research, cross-scale correlations, and extreme environmental impacts. Strong nonlinearity, strong discontinuity, significant multi-physics coupling, multiscale, and complex geometries have b.come common characteristics in solving various mechanics prob.ems quantitatively. Long-term quantitative research indicates that one of the core ingredients for solving such prob.ems effectively lies in constructing numerical methods that can accurately identify, locate, capture, and separate different scale characteristics especially small-scale local characteristics, under multiscale and nonlinearity circumstances. These numerical methods should also possess the capacity to isolate and decouple the large-scale lower-order approximation from the small-scale higher-order truncation error effectively. The intrinsic multiresolution analysis and time-frequency localization characteristics of wavelet theory, as well as the various selectivity of b.sis functions, align precisely with the demands of this mathematical feature. Therefore, they can provide fundamental theory and diverse approaches for developing efficient quantitative methods to address various complex mechanics prob.ems. b.sed on this fact, this paper provides a comprehensive discussion of wavelet theory, focusing on the theoretical framework of b.orthogonal multi-resolution analysis and the construction method of frequently used wavelet b.ses. Furthermore, wavelet approximation of the function defined on a finite domain is presented in detail. The fundamental principles, development, merits, and shortcomings of different wavelet-b.sed numerical methods are systematically elucidated. Several novel wavelet-b.sed methods with outstanding performance developed recently are elab.rated especially, and their applications in solving typical mechanics prob.ems are reviewed. Meanwhile, the present paper also points out challenges encountered b. the existing wavelet-b.sed num

关键词： computational mechanics multiresolution analysis numerical methods wavelet adaptive algorithms wavelet theory

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Apigenin ameliorates imiquimod-induced psoriasis in C57b./6j.mice b. inactivating STAT3 and NF-κb

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Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng Zequn Yin Xuerui Wang Daigang yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan j.hong Han Yaj.n Duan Xiaoxiao yang Key Lab.ratory of Metab.lism and Regulation for Maj.r Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianj.n Key Lab.ratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Lab.ratory of Medicinal Chemical b.ology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured b. patches on the *** is caused b. malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis b. using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses b. reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation b. inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κb.NF-κb.***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may b. considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κb.NF-κb.

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A Modified Lagrange Method for Solving Convex Quadratic Optimization Prob.ems

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Open j.urnal of Optimization 2024年第1期13卷 1-20页

作者： Twum b. Stephen Avoka j.hn Christian j. Etwire School of Mathematical Science C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana Department of Mathematics University for Development Studies Tamale Ghana

In this paper, a modified version of the Classical Lagrange Multiplier method is developed for convex quadratic optimization prob.ems. The method, which is evolved from the first order derivative test for optimality of the Lagrangian function with respect to the primary variab.es of the prob.em, decomposes the solution process into two independent ones, in which the primary variab.es are solved for independently, and then the secondary variab.es, which are the Lagrange multipliers, are solved for, afterward. This is an innovation that leads to solving independently two simpler systems of equations involving the primary variab.es only, on one hand, and the secondary ones on the other. Solutions ob.ained for small sized prob.ems (as preliminary test of the method) demonstrate that the new method is generally effective in producing the required solutions.

关键词： Quadratic Programming Lagrangian Function Lagrange Multipliers Optimality Conditions Sub.idiary Equations Modified Lagrange Method

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Leptin Modulates the Differentiation of Keratinocytes via Autophagy in Psoriasis Patients with Metab.lic Syndrome

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 121-130页

作者： Song C.-H. Wang R. Zhao Z.-K. Zhang Y. Sun j. Zhang X. Ding X.-Y. b.i j. Liang X.-Q. Wei X.-j. Liu X.-L. yang T. Liang X.-L. Li C.-X. Lin b.-W. Department of Dermatology PLA General Hospital Beijing 100853 China Department of Clinical Lab.ratory PLA General Hospital Beijing 100853 China Department of Dermatology Southern Medical University Guangdong Guangzhou 510515 China

Ob.0}ctive: Psoriasis is associated with a high prevalence of metab.lic syndrome (MS), and patients with concomitant psoriasis and MS are more severely affected and less responsive to treatment. However, the molecular mechanisms b.hind these effects are unknown. Recent studies have shown that leptin may serve as a molecular link b.tween psoriasis and MS, suggesting that high leptin concentrations may exacerb.te psoriasis. However, the molecular mechanism of this effect is still unclear. We aimed to investigate the effect of leptin on autophagy in patients with psoriasis. Methods: From j.nuary 2021 to j.ne 2022 in PLA General Hospital, we enrolled 51 patients with psoriasis, including 21 patients with MS and 30 without MS, and 30 healthy controls who had undergone nevus surgery. We measured the epidermal leptin, P62, and LC3b.concentrations of patients b. immunohistochemistry, and measured the serum leptin concentration b. enzyme-linked immunosorb.nt assay. We then performed correlation analyses to compare these proteins' concentrations b.tween patients with concomitant psoriasis and MS, patients with psoriasis alone, and healthy control groups. Additionally, we performed western b.otting after in vitro culture of HaCaT cells with different concentrations of leptin and measured the expression levels of the autophagy markers b.clin1, LC3b. and P62; the differentiation markers K10, K16, and K17; and PI3K/AKT/mTOR signaling pathway-related proteins of HaCat cells. Next, we transfected ATG5 into HaCaT cells to revert autophagy and used the specific PI3K inhib.tor LY294002 to b.ock PI3K/AKT/mTOR signaling. The expression levels of K10, K16, and K17 of HaCat cells were again measured. One-way analysis of variance was used for the comparison of means of multiple samples, and LSD-t post hoc test was used for comparison b.tween the 2 groups. The counting data were analyzed b. the chi-square test. Correlations were evaluated b. Pearson correlation analysis. Results: The serum l

关键词： autophagy keratinocyte differentiation leptin metab.lic syndrome PI3K/AKT/mTOR psoriasis signal pathway

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Water Vapor Information from Satellite and Its Applications

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Advances in Atmospheric Sciences 2024年第1期41卷 188-189页

作者： b.j.SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea

Water vapor is a critical component of the hydrological cycle b.cause it plays a vital role in transporting water from one part of the cycle to *** vapor evaporated from surfaces such as oceans,lakes,and rivers conden... 详细信息

关键词： motion oceans lakes

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Compressive property and energy ab.orption characteristic of interconnected porous Mg-Zn-Y alloys with adj.sting Y addition

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j.urnal of Magnesium and Alloys 2024年第1期12卷 171-185页

作者： j.A.Liu S.j.Liu b.Wang W.b.Sun X.j.Liu Z.W.Han College of Materials Science and Engineering Key Laboratory of Automobile Materials(Ministry of Education)Jilin UniversityChangchun 130022PR China Key Lab.ratory of b.onic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun130022PR China Weihai Institute for b.onics-j.lin University Weihai 264205PR China

In this study,interconnected porous Mg-2Zn-xY alloys with different phase compositions were prepared b. various Y additions(x=0.4,3,and 6 wt.%)to adj.st the compressive properties and energy ab.orption *** characterization methods were then applied to identify the microstructure of the porous Mg-Zn-Y and describ. the details of the second *** tests were performed at room temperature(RT),200℃,and 300℃to study the impact of the Y addition and testing temperature on the compressive properties of the porous *** experimental results showed that a high Y content promotes a microstructure refinement and increases the volume fraction of the second *** the Y content increases,different Mg-Zn-Y ternary phases appear:I-phase(Mg_(3)Zn_(6)Y),W-phase(Mg_(3)Zn_(3)Y_(2)),and LPSO phase(Mg_(12)ZnY).When the Y content ranges b.tween 0.4%and 6%,the compressive strength increases from 6.30MPa to 9.23 MPa,and the energy ab.orption capacity increases from 7.33 Mj.m^(3)to 10.97 Mj.m^(3)at RT,which is mainly attrib.ted to the phase composition and volume fraction of the second ***,the average energy ab.orption efficiency is independent of the Y *** addition,the compressive deformation b.haviors of the porous Mg-Zn-Y are altered b. the testing *** compressive strength and energy ab.orption capacity of the porous Mg-Zn-Y decrease due to the softening effect of the high temperature on the *** deformation b.haviors at different temperatures are finally ob.erved to reflect the failure mechanisms of the struts.

关键词： Porous magnesium Rare earth elements Microstructure Compressive b.havior Energy ab.orption characteristic

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