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Mutation-associated transcripts reconstruct the prognostic features of oral tongue squamous cell carcinoma

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International Journal of Oral Science 2023年第1期15卷 76-86页

作者： Libo Liang Yi Li Binwu Ying Xinyan huang Shenling Liao Jiajin yang Ga Liao General Practice Medical Center West China HospitalSichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Laboratory Medicine West China HospitalSichuan UniversityChengduChina West China School/Hospital of Stomatology Sichuan UniversityChengduChina Department of Information Management Department of Stomatology InformaticsWest China Hospital of StomatologySichuan UniversityChengduChina

Tongue squamous cell carcinoma is highly malignant and has a poor *** this study,we aimed to combine whole-genome sequencing,whole-genome methylation,and whole-transcriptome analyses to understand the molecular mechanisms of tongue squamous cell carcinoma *** tongue squamous cell carcinoma and adjacent normal tissues from five patients with tongue squamous cell carcinoma were included as five paired *** multi-omics sequencing,differentially methylated intervals,methylated loop sites,methylated promoters,and transcripts were screened for variation in all paired *** were analyzed to determine biological processes in tongue squamous cell *** found five mutated methylation promoters that were significantly associated with mRNA and lncRNA expression *** annotation of these transcripts revealed their involvement in triggering the mitogen-activated protein kinase cascade,which is associated with cancer progression and the development of drug resistance during *** prognostic signature models constructed based on WDR81 and HNRNPH1 and combined clinical phenotype-gene prognostic signature models showed high predictive efficacy and can be applied to predict patient prognostic risk in clinical *** identified biological processes in tongue squamous cell carcinoma that are initiated by mutations in the methylation promoter and are associated with the expression levels of specific mRNAs and ***,changes in transcript levels affect the prognosis of tongue squamous cell carcinoma patients.

关键词： squamous involvement signature

Correlation study between the square-coneenergy-absorbing structure and the frontal collisionbehaviour of leading vehicles

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Transportation Safety and Environment 2023年第3期5卷 60-77页

作者： Ping Xu Ying Gao Chong huang Chengxing yang Shuguang Yao Quanwei Che Key Laboratory of Traffic Safety on Track of Ministry of Education Centr al South UniversityChangsha 410075HunanChina CRRC Qingdao Sifang Co. LtdQingdao 266111ShandongChina

In order to study the influence of square-cone energy-absorbing structures on the mechanical behaviour of the ollision performance of the leading vehicle,a parameterization method for rapidly changing the performance of energy-absorbing structures was ***,a finite element simulation model of the collision of the leading vehicle with a square-cone energy-absorbing structure was ***,the platform force,the slope of the platform force and the initial peak force of the force-displacement curve derived from the energy-absorbing structure were studied for the collision performance of the leading ***,the correlation model of the square-cone energy-absorbing structure and the mechanical behaviour of the collision performance of the leading vehicle was established by the response surface *** results showed that the increase of the platform force of the energy-absorbing structure can effectively buffer the longitudinal impact of the train and reduce the nodding attitude of the *** increase of the platform force slope can not only effectively buffer the longitudinal impact and vertical nodding of the train,but also reduce the lateral swing of the *** increase in the initial peak force to a certain extent may lead to a change in the deformation mode,thereby reducing the energy-absorption *** correlation model can guide the design of the square-cone energy-absorbing structure and predict the deformation attitude of the leading vehicle.

关键词： square-cone energy-absorbing structure parametric method correlation model collision performance rail vehicle

贝伐珠单抗靶向治疗转移性结肠癌患者的临床研究

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中国生化药物杂志 2016年第7期36卷 155-157页

作者：曾茹陈莉林叶煌阳张映红吕晓君厦门大学附属第一医院肿瘤内科福建厦门361001

目的探讨贝伐珠单抗联合FOLFOX-6化疗方案治疗转移性结肠癌患者的临床效果。方法选取行化疗的转移性结肠癌患者84例进行本次临床研究,其中研究组（n=30）采用贝伐珠单抗注射液联合FOLFOX-6治疗,对照组（n=54）采用单纯FOLFOX-6化疗方案... 详细信息

目的探讨贝伐珠单抗联合FOLFOX-6化疗方案治疗转移性结肠癌患者的临床效果。方法选取行化疗的转移性结肠癌患者84例进行本次临床研究,其中研究组（n=30）采用贝伐珠单抗注射液联合FOLFOX-6治疗,对照组（n=54）采用单纯FOLFOX-6化疗方案治疗,隔14d治疗1次,连续治疗3-5次。对比2组患者的临床疗效及远期预后。结果研究组的缓解率46.67%、总有效率86.67%均显著高于对照组的14.81%、62.96%,差异均具有统计学意义（P〈0.05）;研究组的无进展生存期（progression-free survival,PFS）7.0个月、总生存期（overall survival,OS）21.0个月均显著长于对照组的4.0、15.0个月,差异均具有统计学意义（P〈0.05）;研究组24个月存活18例、失访2例,对照组24个月存活24例,失访3例,研究组的存活率与对照组比较差异无统计学意义（60.00%vs.44.44%,χ2=1.867）。结论贝伐珠单抗联合FOLFOX-6化疗方案治疗转移性结肠癌具有较好的临床效果及安全性。

关键词：贝伐珠单抗 FOLFOX-6 转移性结肠癌

Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology

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Chinese Chemical Letters 2012年第6期23卷 727-730页

作者： Xing Li Zhang yang yang Liu Jian He Wei Yun yang Zheng Zhang Jun Qing huang Huai Qiong Chen Yu Jun Liu College of Biological Science and Biotechnology Beijing Forestry University Beijing 100083 China Hainan Branch of Institute of Medicinal Plant Development （Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine） Chinese Academy of Medical Sciences Wanning 571533 China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 China School of Food ＆ Bioengineering Shandong Polytechnic University Jinan 250353 China

We used whole-tree agarwood-induction technology to produce agarwood from Aquilaria sinensis trees within 20 months, and evaluated the quality of this agarwood. The results showed its characteristics were similar to those of high-grade wild agarwood in terms of texture, chemical constituents, essential oil content, and ethanol-soluble extract content, with the lattermost quality far surpassing the requirement of traditional Chinese medicine agarwood, as indicated in Chinese Pharmacopoeia 2010. To the best of our knowledge, this is first study to show that high-quality agarwood can be produced in whole A. sinensis trees via a chemically induced technology.

关键词： Agarwood Aquilaria sinensis Chemically induced Quality Whole-tree agarwood-induction technology

Ammonium Impacts on Vibrations of Hydroxyl and Lattice of Phengite at High Temperature and High Pressure

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Journal of Earth Science 2021年第5期32卷 1278-1286页

作者： Weihua huang Yan yang Zeming Qi Wendi Liu Zhongping Wang Yan Liu Qunke Xia School of Earth Sciences Zhejiang UniversityHangzhou 310027China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Department of Physics University of Science and Technology of ChinaHefei 230026China

Dehydration in hydrous phases of the downgoing slab controls water release processes in subduction zones. Interplay between volatiles in hydrous minerals has complicated the previous knowledge of their dehydration. Phengite is an essential mineral carrying both hydrogen and nitrogen to the deep Earth. To further understand the link between nitrogen and dehydration process of phengite at an atomic level, we here carry out high temperature and high pressure vibrational spectroscopic investigations on hydroxyl and lattice of ammonium-bearing and ammonium-free phengites. The results show that heating to 800 oC hardly influences hydroxyl bonding strength, whereas pressure induces strengthening of hydrogen bonding until 10 GPa. Moreover, hydrogen transits between the sites with increasing temperature and pressure. The lattice modes soften with increasing temperature and stiffen under compression. Ammonium has no effect on hydroxyl bonding strength, but hinders hydrogen transition at high temperatures and high pressures. Ammonium does not influence the lattice at high pressures either, but delays softening of the lattice at high temperatures. These data unveil behavior of hydroxyl and lattice in phengite at high temperature and high pressure, and also evaluate ammonium impacts, shedding new lights on dehydration processes of phengite during subduction.

关键词： hydroxyl lattice ammonium phengite high temperature high pressure

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短波接收机前端中频、镜频高抑制比电路设计

武汉理工大学学报（信息与管理工程版） 2015年第1期37卷 8-11页

作者：陈永泰黄杨黎琴孙长景程龙臧滨唐静武汉理工大学信息工程学院湖北武汉430070 常州国光数据通信有限公司江苏常州213000

针对镜频和中频干扰对接收机性能影响的问题,分析了其原因并给出解决方案,设计了跟踪选频滤波器、逆切比雪夫陷波滤波器、5阶巴特沃斯低通滤波器,以及低噪声放大器的三级滤波方式所组成的短波接收机前端滤波放大电路,使短波接收机的中... 详细信息

针对镜频和中频干扰对接收机性能影响的问题,分析了其原因并给出解决方案,设计了跟踪选频滤波器、逆切比雪夫陷波滤波器、5阶巴特沃斯低通滤波器,以及低噪声放大器的三级滤波方式所组成的短波接收机前端滤波放大电路,使短波接收机的中频、镜频抑制比均大于90 d B,接收机的性能得到较大提高。

关键词：中频抑制比镜频抑制比逆切比雪夫陷波滤波巴特沃斯低通滤波

CRISPR/Cas9-mediated targeted mutation reveals a role for AN4 rather than DPL in regulating venation formation in the corolla tube of Petunia hybrida

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Horticulture Research 2021年第1期8卷 1798-1806页

作者： Bin Zhang Xiaojing Xu Renwei huang Sha yang Mingyang Li Yulong Guo Chongqing Engineering Research Center for Floriculture Key Laboratory of Horticulture Science for Southern Mountainous RegionsMinistry of EducationCollege of Horticulture and Landscape ArchitectureSouthwest University400716 ChongqingChina College of Agriculture Guizhou University550025 GuiyangGuizhouChina Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticultural Biological Resources College of Chemistry and Life SciencesChengdu Normal University611130 ChengduChina

Venation is a common anthocyanin pattern displayed in flowers that confers important ornamental traits to *** anthocyanin-related R2R3-MYB transcription factor,DPL,has been proposed to regulate corolla tube venation in petunia ***,however,we provide evidence redefining the role of DPL in petunia.A CRISPR/Cas9-mediated mutation of DPL resulted in the absence of the vein-associated anthocyanin pattern above the abaxial surface of the flower bud,but not corolla tube venation,thus indicating that DPL did not regulate the formation of corolla tube ***,quantitative real-time PCR analysis demonstrated that the spatiotemporal expression pattern of another R2R3-MYB gene,AN4,coincided with the formation of corolla tube venation in ***,overexpression of AN4 promoted anthocyanin accumulation by increasing the expression of anthocyanin biosynthesis ***/Cas9-mediated mutation of AN4 led to an absence of corolla tube venation,suggesting that this gene in fact determines this key plant *** together,the results presented here redefine the prime regulator of corolla tube venation,paving the way for further studies on the molecular mechanisms underlying the various venation patterns in petunia.

关键词： CRISPR/Cas9 pattern flowers

Microfluidic 3D printing polyhydroxyalkanoates-based bionic skin for wound healing

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Materials Futures 2022年第1期1卷 142-153页

作者： Wentai Guo Xiaocheng Wang Chaoyu yang Rongkang huang Hui Wang Yuanjin Zhao Department of Colorectal Surgery Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655People’s Republic of China Institute of Biomedical Innovation and Laboratory of Regenerative Medicine and Biomaterials Biomedical Material Conversion and Evaluation Engineering Technology Research Center of Guangdong ProvinceGuangzhou 510655People’s Republic of China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001People’s Republic of China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001People’s Republic of China

Biomimetic scaffolds with extracellular matrix(ECM)-mimicking structure have been widely investigated in wound healing applications,while insufficient mechanical strength and limited biological activity remain major ***,we present a microfluidic 3D printing biomimetic polyhydroxyalkanoates-based scaffold with excellent mechanical properties and hierarchical porous structures for enhanced wound *** scaffold is composed of poly(3-hydroxybutyrate-4-hydroxybutyrate)and polycaprolactone,endowing it with excellent tensile strength(2.99 MPa)and degradability(80%of weight loss within 7 d).The ECM-mimicking hierarchical porous structure allows bone marrow mesenchymal stem cells(BMSCs)and human umbilical vein endothelial cells(HUVECs)to proliferate and adhere on the ***,anisotropic composite scaffolds loaded with BMSCs and HUVECs can significantly promote re-epithelization,collagen deposition and capillary formation in rat wound defects,indicating their satisfactory in vivo tissue regenerative *** results indicate the feasibility of polyhydroxyalkanoates-based biomimetic scaffolds for skin repair and regeneration,which also provide a promising therapeutic strategy in diverse tissue engineering applications.

关键词： microfluidics 3D printing tissue engineering biomaterial P34HB wound healing

基于OBE理念塑料成型工艺及模具设计课程建设与改革

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科技创新与生产力 2018年第7期 107-109页

作者：盘茂森莫才颂刘好马李黄扬风李玲陶筱梅广东石油化工学院机电工程学院广东茂名525000

为了适应当前社会对应用型人才的需求,以建设高水平应用型理工大学为宗旨,基于OBE理念开展了"塑料成型工艺及模具设计"课程的教学改革和研究。本文主要对课程教学大纲、教学方法、教学实践以及教学评价考核等方面内容进行改革建设。通... 详细信息

为了适应当前社会对应用型人才的需求,以建设高水平应用型理工大学为宗旨,基于OBE理念开展了"塑料成型工艺及模具设计"课程的教学改革和研究。本文主要对课程教学大纲、教学方法、教学实践以及教学评价考核等方面内容进行改革建设。通过课堂教学和课外实践证明,学生的学习积极性和主动性大大增强,教学质量显著提高。

关键词： OBE理念塑料成型工艺及模具设计课程建设