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Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression

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Bioactive Materials 2022年第4期7卷 443-459页

作者： Junjun yang Xin Wang Yahan Fan Xiongbo Song Jiangyi Wu Zhenlan Fu Tao Li yang huang ZheXiong Tang Shuo Meng Na Liu Jiajia Chen Pingju Liu Liu yang Xiaoyuan Gong Cheng Chen Center for Joint Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China College of Medical Informatics Chongqing Medical UniversityChongqing400016China Blood Transfusion Department Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing400038China Department of Sports Medicine Peking University Shenzhen HospitalPeking UniversityShenzhen518036China Key Laboratory of Freshwater Fish Reproduction and Development Ministry of EducationLaboratory of Molecular Developmental BiologySchool of Life SciencesSouthwest UniversityChongqing400038China Biomedical Analysis Center Army Medical University(Third Military Medical University)Chongqing400038China Department of Orthopedics Zunyi Traditional Chinese Medicine HospitalZunyi563099China

Intra-articular injection of mesenchymal stem cells(MSCs)is a promising strategy for osteoarthritis(OA)***,more and more studies reveal that the injected MSCs have poor adhesion,migration,and survival in the joint cavity.A recent study shows that tropoelastin(TE)regulates adhesion,proliferation and phenotypic maintenance of MSCs as a soluble additive,indicating that TE could promote MSCs-homing in regenerative *** this study,we used TE as injection medium,and compared it with classic media in MSCs intra-articular injection such as normal saline(NS),hyaluronic acid(HA),and platelet-rich plasma(PRP).We found that TE could effectively improve adhesion,migration,chondrogenic differentiation of infrapatellar fat pad MSCs(IPFP-MSCs)and enhance matrix synthesis of osteoarthritic chondrocytes(OACs)in indirect-coculture ***,TE could significantly enhance IPFP-MSCs adhesion via activation of integrin β1,ERK1/2 and vinculin(VCL)in *** addition,intra-articular injection of TE-IPFP MSCs suspension resulted in a short-term increase in survival rate of IPFP-MSCs and better histology scores of rat joint *** of integrin β1 or ERK1/2 attenuated the protective effect of TE-IPFP MSCs suspension in *** conclusion,TE promotes performance of IPFP-MSCs and protects knee cartilage from damage in OA through enhancement of cell adhesion and activation of integrin β1/ERK/VCL *** findings may provide new insights in MSCs intra-articular injection for OA treatment.

关键词： Tropoelastin Osteoarthritis Infrapatellar fat pad MSCs

Machine learning methods to predict cadmium(Cd)concentration in rice grain and support soil management at a regional scale

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Fundamental Research 2024年第5期4卷 1196-1205页

作者： Bo-yang huang Qi-Xin Lü Zhi-Xian Tang Zhong Tang Hong-Ping Chen Xin-Ping yang Fang-Jie Zhao Peng Wang Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource Utilization College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China Centre for Agriculture and Health Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China

Rice is a major dietary source of the toxic metal cadmium(Cd).Concentration of Cd in rice grain varies widely at the regional scale,and it is challenging to predict grain Cd concentration using soil *** lack of reliable predictive models hampers management of contaminated ***,we conducted a three-year survey of 601 pairs of soil and rice samples at a regional *** 78.3%of the soil samples exceeded the soil screening values for Cd in China,and 53.9%of rice grain samples exceeded the Chinese maximum permissible limit for *** models were developed using multiple linear regression and machine learning *** correlations between rice grain Cd and soil total Cd concentrations were poor(R^(2)<0.17).Both linear regression and machine learning methods identified four key factors that significantly affect grain Cd concentrations,including Fe-Mn oxide bound Cd,soil pH,field soil moisture content,and the concentration of soil reducible *** machine learning-based support vector machine model showed the best performance(R2=0.87)in predicting grain Cd concentrations at a regional scale,followed by machine learning-based random forest model(R^(2)=0.67),and back propagation neural network model(R^(2)=0.64).Scenario simulations revealed that liming soil to a target pH of 6.5 could be one of the most cost-effective approaches to reduce the exceedance of Cd in rice *** together,these results show that machine learning methods can be used to predict Cd concentration in rice grain reliably at a regional scale and to support soil management and safe rice production.

关键词： Cadmium Food safety Heave metals Machine learning Soil contamination Predictive model

Erianin inhibits oral cancer cell growth,migration,and invasion via the Nrf2/HO-1/GPX4 pathway

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 437-445页

作者： Xiu-Yun Tian Rui Han Qing-yang huang Mei-Yun Zhou Bin Luo Xin-Ru Chen Jin-Cheng Xu Department of Stomatology the First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000AnhuiChina Bengbu Medical College Anhui Engineering Technology Research Center of Biochemical PharmaceuticalsBengbu 233030AnhuiChina

Objective:To evaluate the effect of erianin on the viability,migration,and invasion of KB cells and elucidate its underlying ***:Cell Counting Kit-8,colony formation,wound healing,and Transwell assays were used to determine the proliferation,migration,and invasion of oral cancer KB ***,malondialdehyde(MDA)and glutathione(GSH)levels were *** probes were used to detect changes in intracellular reactive oxygen species and iron ***,the expressions of ferroptosis-related proteins,NF-E2-related factor 2(Nrf2),ferritin heavy chain 1(FTH1),heme oxygenase 1(HO-1),and glutathione peroxidase 4(GPX4)were analyzed by Western blotting ***:Erianin induced ferroptosis and inhibited the proliferation,migration,and invasion of KB ***,erianin decreased GSH level,increased MDA level,elevated intracellular ROS and Fe2+contents,and downregulated the expression of the ferroptosis-related proteins Nrf2,HO-1,GPX4,and FTH1 in KB *** effects of erianin were effectively reversed by a ferroptosis inhibitor,***:Erianin inhibits the proliferation,migration,and invasion of oral cancer cells and induces ferroptosis via the Nrf2/HO-1/GPX4 signaling ***,erianin may be a potential candidate for the treatment of oral cancer.

关键词： Erianin Ferroptosis Oral cancer Reactive oxygen species Therapy Nrf2/HO-1/GPX4

A Sensitive Material for Specifically Treating Tetracycline in Water Environment

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Chinese Journal of Structural Chemistry 2021年第5期40卷 646-652,530页

作者： OU Min-Rui ZHANG Zi-Hui WEN Yu-Kai XU Xiao-Ping yang huang-Hao College of Chemical Engineering Fuzhou UniversityFuzhou 350116China College of Chemistry Fuzhou UniversityFuzhou 350116China

There are currently many materials for treating residual antibiotics in the environment, but none of them can specifically remove antibiotics. In addition, these materials are not sensitive enough to low concentrations of antibiotics. Here we show that a sensitive and specific material was developed by the preparation of magnetic Fe_(3)O_(4)-PAMAM-antibody complexes for treating tetracycline. The prepared antibody complexes can specifically treat tetracycline from aqueous solutions and the tetracycline removal ability by adsorption was also investigated. Controlled experiments were carried out with the effects of solution pH, temperature, and initial concentration of the tetracycline. The tetracycline was completely removed within 35 min at room temperature 30 ℃ with the maximum removal rate of almost 100%. Therefore, this material for specifically combining antigen and antibody to treat tetracycline indicated good application prospects for the waste water treatment.

关键词： complex material antibody specificity tetracycline water treatment

Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases

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Bioactive Materials 2024年第6期36卷 272-286页

作者： Kaiwang Xu huang yang Jinghua Fang Kaijie Qiu Haotian Shen Guanrui huang Qiangqiang Zheng Canlong Wang Tengjing Xu Xinning Yu Jiajie Wang Yunting Lin Jiacheng Dai Yuting Zhong Hongyun Song Sunan Zhu Siheng Wang Zhuxing Zhou Guang yang Zhengwei Mao Zongyou Pan Xuesong Dai Department of Orthopedic Surgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China Orthopedics Research Institute Zhejiang UniversityHangzhou310009China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou310009China Clinical Research Center of Motor System Disease of Zhejiang Province Hangzhou310009China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Hepatobiliary and Pancreatic Surgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China Zhejiang University Hangzhou310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhou310000China

Nanoliposomes have a broad range of applications in the treatment of autoimmune inflammatory diseases because of their ability to considerably enhance drug *** their clinical application,nanoliposomes must be able to realize on-demand release of drugs at disease sites to maximize drug-delivery efficacy and minimize side ***,responsive drug-release strategies for inflammation treatment have been explored;however,no specific design has been realized for a responsive drug-delivery system based on pyroptosis-related ***,we report a pioneering strategy for self-adaptive pyroptosis-responsive liposomes(R8-cardiolipin-containing nanoliposomes encapsulating dimethyl fumarate,RC-NL@DMF)that pre-cisely release encapsulated anti-pyroptotic drugs into pyroptotic *** activated key pyroptotic protein,the N-terminal domain of gasdermin E,selectively integrates with the cardiolipin of liposomes,thus forming pores for controlled drug release,pyroptosis,and inflammation ***,RC-NL@DMF exhibited effective therapeutic efficacies to alleviate autoimmune inflammatory damages in zymosan-induced arthritis mice and dextran sulfate sodium-induced inflammatory bowel disease *** novel approach holds great promise for self-adaptive pyroptosis-responsive on-demand drug delivery,suppressing pyroptosis and treating autoimmune inflammatory diseases.

关键词： Nanoliposome Pyroptosis Autoimmune inflammatory diseases Responsive drug delivery Anti-inflammation

Development of Physical Library for Short Channel CMOS / SOI Integrated Circuits

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Journal of Systems Engineering and Electronics 1992年第4期3卷 16-18,2-6页

作者： Zhang Xing, Lu Quan, Shi Yongguan, yang Yinghua, huang Chang

An 'Integrated Device and Circuit simulator' for thin film (0.05-0.2μm) submicron (0.5μm) and deep submicron (0.15, 0.25,0.35μm) CMOS/ SOI integrated circuit has been developed. This simulator has been used for design and fabrication and physical library development of thin film submicron and deep submicron CMOS/ SOI integrated circuit.

关键词： Development of Physical Library for Short Channel CMOS In SOI Integrated Circuits

Design and Test of Multibus Adapter System on a Chip for Fault Tolerant Computer Systems

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Journal of Systems Engineering and Electronics 1992年第4期3卷 5-6,2页

作者： yang Yinghua, huang Chang, Meng Biao, Zhang Xing, Yu Shan

In order to improve the system reliability and performance and to reduce the system cost, volume and weight, we have designed, fabricated and tested the multibus adapter system of a trimodular redundant fault tolerant computer system on a single chip of 5000 gate CMOS gate array. The design, fabrication and test of this single chip system will be discussed..

关键词： bus Design and Test of Multibus Adapter System on a Chip for Fault Tolerant Computer Systems Chip Test

铬铁矿矿物包裹体的聚焦离子束-透射电镜研究

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地球科学 2020年第12期45卷 4604-4616页

作者：黄阳邓浩中国地质大学地球科学学院全球大地构造中心湖北武汉430074 中国地质大学资源学院湖北武汉430074

铬铁矿矿物包裹体可以记录其成岩成矿时物理化学条件(温度、压力等)、化学成分演化、熔/流体富集活动规律等关键信息.然而传统的二维分析方法无法全面获取形态微小、成分复杂的包裹体信息.通过聚焦离子束-透射电镜(FIB-TEM)联用对华北... 详细信息

铬铁矿矿物包裹体可以记录其成岩成矿时物理化学条件(温度、压力等)、化学成分演化、熔/流体富集活动规律等关键信息.然而传统的二维分析方法无法全面获取形态微小、成分复杂的包裹体信息.通过聚焦离子束-透射电镜(FIB-TEM)联用对华北克拉通遵化豆荚状铬铁矿中矿物包裹体进行观察测试,在三维空间上发现包裹体的矿物种类丰富(硅酸盐、铂族、碳酸盐等),矿物形态复杂多变,且包裹体矿物中发育位错、部分开放晶界/相界、熔流体痕迹等显微-超显微结构.因此综合矿物种类、形态、显微结构等信息推断遵化铬铁矿具有复杂的形成条件和演化过程.

关键词：聚焦离子束透射电子显微镜矿物包裹体显微-超显微结构 3D信息

Influence of copper minerals on cyanide leaching of gold

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Journal of Central South University of Technology 2001年第1期8卷 24-28页

作者： JIANG Tao,ZHANG Yu zu,yang Yong bin,huang Zhu cheng (Department of Mineral Engineering, Central South University, Changsha 410083, China) 1. Department of Mineral Engineering Central South University 410083 Changsha China

The paper thermodynamically examined the behavior of various copper minerals in cyanide solu tions and investigated the influence of copper minerals on cyanide leaching of gold. In elucidating the influence of copper minerals on cyanide leaching of gold, copper minerals were classified into two types according to their solubility in cyanide solutions by proposing two concepts, cyaniding easily soluble copper (E Cu ) and cyaniding insoluble copper. The former involves copper occurrence in metal, oxides and secondary sulfides, and the latter refers mainly to primary sulfides. Experimental results show that not all the total copper in an ore affected cyanide leaching of gold, while cyaniding easily soluble copper turns out to be the decisive factor that interferes with gold cyanidation by causing decrease in gold cyanidation recovery and increase in cyanide consumption. When cyaniding easily soluble copper content ( w E(Cu) ) lies in the range of 0 0.25%, it linearly affects gold cyanidation recovery ( R ) as well as cyanide consumption ( m c). The regression equations have been worked out to be R (%)=94.177 5-142.735 7 w E(Cu) with a correlation coefficient of -0.902 and m c=5.590 7+33.572 9 w E(Cu) with a correlation coefficient of 0.945, respectively.

关键词： copper mineral gold cyanidation leaching