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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng hua yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan huaNG Yin yang hua WANG Xintian SHI Jianping LIU Lixia FU Yacheng QUAN Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang Xiu-Liang Xu Jiang-hua yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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可控核聚变技术的生成:能源约束、能源伦理与能源革命

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中国矿业大学学报（社会科学版） 2025年第1期27卷 112-127页

作者：杨华同济大学人文学院、科研管理部

由于传统能源使用的困境和气候变化的威胁,人类社会加大了寻求有效解决能源危机的努力。但是,光伏、风电等新能源和新一代核裂变能源由于各自的技术及资源风险,有着极大的不确定性,难以成为能源转型的核心角色。可控核聚变技术经过了几... 详细信息

由于传统能源使用的困境和气候变化的威胁,人类社会加大了寻求有效解决能源危机的努力。但是,光伏、风电等新能源和新一代核裂变能源由于各自的技术及资源风险,有着极大的不确定性,难以成为能源转型的核心角色。可控核聚变技术经过了几十年的发展,虽然目前仍面临诸多困难,但业已取得若干阶段性成功,已经看到实现技术突破的曙光。可控核聚变技术能量密度高,资源广泛易得,拥有安全性、永续性和环境友好性等诸多潜在益处,是破解人类发展能源瓶颈的颠覆性技术。不过,科学技术是一把双刃剑,可控核聚变技术在力图解决能源供给问题的同时,也可能带来一系列新问题,比如引发新一轮能源技术竞赛、产生新的能源霸权等。由于能源在人类生存与发展中的基础性地位,从能源伦理的角度对可控核聚变技术产生的影响与风险进行前瞻性研判和哲学反思是至关重要的。可控核聚变的成功将动摇“能源的稀缺性原则”,挑战现有能源现实主义,部分消解能源生态末日论的核心观点,将对传统能源哲学产生革命性影响。

关键词：可控核聚变聚变能源能源哲学能源伦理技术创新

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基于英语学习活动观的初中英语多模态阅读教学实践——以Unit 13 Section B 2b Rethink,Reuse,Recycle!为例

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英语教师 2025年第1期 121-125页

作者：杨桦广东省东莞市可园中学广东东莞523000

阐述指向英语学习活动观的英语多模态阅读教学的内涵和特点。以人教版新目标初中《英语》九年级Unit 13 Section B 2b Rethink,Reuse,Recycle!为例,探索在英语学习活动观的基础上,如何以梳理阅读主题线索、实现多项技能整合、构建关联... 详细信息

阐述指向英语学习活动观的英语多模态阅读教学的内涵和特点。以人教版新目标初中《英语》九年级Unit 13 Section B 2b Rethink,Reuse,Recycle!为例,探索在英语学习活动观的基础上,如何以梳理阅读主题线索、实现多项技能整合、构建关联意识、进行情境模拟迁移和收集数据评估为手段,开展一系列综合性、关联性、实用性的多模态阅读教学,以提升学生的英语学科核心素养,真正达到学科育人的教学目标。

关键词：英语学习活动观初中英语多模态阅读教学

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A 2-Stage Strategy for Non-Stationary Signal Prediction and Recovery Using Iterative Filtering and Neural Network

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Journal of Computer Science & Technology 2019年第2期34卷 318-338页

作者： Feng Zhou Hao-Min Zhou Zhi-hua yang Li-hua yang School of Information Science Guangdong University of Finance and Economics Guangzhou 510320 China School of Mathematics Georgia Institute of Technology Atlanta GA 30332 U.S.A. Guangdong Province Key Laboratory of Computational Science Guangzhou 510275 China School of Mathematics Sun Yat-sen University Guangzhou 510275 China

Predicting the future information and recovering the missing data for time series are two vital tasks faced in various application *** are often subjected to big challenges,especially when the signal is nonlinear and nonstationary which is common in *** this paper,we propose a hybrid 2-stage approach,named IF2FNN,to predict(including short-term and long-term predictions)and recover the general types of time *** the first stage,we decompose the original non-stationary series into several“quasi stationary”intrinsic mode functions(IMFs)by the iterative filtering(IF)*** the second stage,all of the IMFs are fed as the inputs to the factorization machine based neural network model to perform the prediction and *** test the strategy on five datasets including an artificial constructed signal(ACS),and four real-world signals:the length of day(LOD),the northern hemisphere land-ocean temperature index(NHLTI),the troposphere monthly mean temperature(TMMT),and the national association of securities dealers automated quotations index(NASDAQ).The results are compared with those obtained from the other prevailing *** experiments indicate that under the same conditions,the proposed method outperforms the others for prediction and recovery according to various metrics such as mean absolute error(MAE),root mean square error(RMSE),and mean absolute percentage error(MAPE).

关键词： iterative filtering factorization machine neural network time series data recovery

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Perturbation of Yamabe Equation on Iwasawa N Groups in Presence of Symmetry

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1575-1590页

作者： Qiao hua yang School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

Let G be a simple Lie group of real rank one and N be in the Iwasawa decomposition of G. Under the assumption of some symmetries, we obtain an existent result for the nonlinear equation △NU ＋（1 ＋ ∈K（x, z））u2＊-1 = 0 on N, which generalizes the result of Malchiodi and Uguzzoni to the Kohn＇s subelliptic context on N in presence of symmetry.

关键词： Heisenberg type groups Yamabe equations simple Lie group of real rank one

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Alterations of RNA Editing for the Mitochondrial ATP9 Gene in a New orf220-type Cytoplasmic Male-sterile Line of Stem Mustard （Brassica juncea var. tumida）

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Journal of Integrative Plant Biology 2007年第5期49卷 672-677页

作者： Jing-hua yang Laboratory of Genetic Resources & Functional Improvement for Horticultural Plants Department of Horticulture Zhejiang University Hangzhou 310029 China Laboratory of Horticultural Plant Growth Development & Biotechnology Ministry of Agriculture Zhejiang University Hangzhou 310029 China

RNA editing for the mitochondrlal ATP9 gene of encoding regions has been observed in both cytoplasmic malesterile and maintainer lines of stem mustard, where its editing capacity varied spatially and temporally in the cytoplasmic male sterility （CMS） line. There were four RNA editing sites for the mitochondrial ATP9 gene according to Its normal editing sites in mustard, of which three sites occurred as C-to-U changes and one as a U-to-C change. As a result, the hydrophobicity of deduced ATP9 protein was reduced due to the conversions at its 17th, 45th and 64th positions. Meanwhile, the conservation of deduced ATP9 protein was enhanced by changes at the 56th position. Loss of a specific editing site for ATP9 was observed in juvenile roots, senile roots, senile leaves and floret buds of the CMS line. Comparatively, complete RNA editing for ATP9 gene was retained in juvenile roots, juvenile leaves and floret buds of its maintainer line; however, the loss of a specific editing site for ATP9 gene occurred at senile roots and senile leaves in its maintainer line. These observations allow us to produce a hypothesis that the dysfunction of a specific mitochondrial gene arising from RNA editing could probably be a factor triggering CMS and organ senescence through unknown cross-talk pathways during development.

关键词： ATP9 Brassica juncea cytoplasmic male sterility RNA editing.

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Symplectic Structures of Two Kinds of Nonsymmetric Differential Operators

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 543-556页

作者： Wei-hua yang School of Mathematics and Physics Beijing University of Technology

Non-self-adjoint quasi-differential expression M and its formal adjoint M＋may generate nonsymmetric ordinary differential operators. Although minimal operators T0, T＋0 generated by M, M＋are not symmetric, they form an adjoint pair. In this paper, author studies regularly solvable operators with respect to the adjoint pair T0, T＋0 in two kinds of conditions and give their geometry description in the corresponding ways.

关键词： regularly solvable operators symplectic space self-adjoint operator pair

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Vibrational Resonance in Fractional-Order Anharmonic Oscillators

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Chinese Physics Letters 2012年第10期29卷 97-100页

作者： yang Jian-hua School of Mechanical and Electrical Engineering China University of Mining and TechnologyXuzhou 221116

The phenomenon of vibrational resonance in fractional-order anharmonic oscillators is *** on the method of separating slow and fast motions,the approximate solution of the response amplitude is *** analytical and numerical results show that not only the high-frequency signal but also the fractional-order damping can induce vibrational *** present results provide a new way to control periodical signals in coupled systems.

关键词： harmonic vibrational fractional

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