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World Journal of Integrated Traditional and Western Medicine 2020年第1期6卷 37-43页

作者： JIANG Hai-jun He Bin ZHANG Tong yang Yu-fei Beijing University of Chinese Medicine Beijing100029China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China

Colorectal cancer is one of the common malignant tumors in *** poses a serious threat to the national health of *** advanced colorectal cancer, the main goal of treatment is to prolong survival and improve quality of *** complements other advantages, showing good therapeutic ***, how to grasp the timing of integrated Chinese and Western Medicine for the treatment of advanced colorectal cancer and use the integrated Chinese and Western Medicine treatment methods flexibly contains profound therapeutic *** Yu-fei is an authoritative expert in the field of integrated Chinese and Western medicine for colorectal *** is good at accurately grasping the timing of treatment of integrated Chinese and Western Medicine, and flexibly adjusts the treatment strategy according to the specific *** this paper, we shared Professor yang Yu-fei's strategy for treating advanced colorectal cancer with emphasis on integrated Chinese and Western Medicine and attached a typical case, with a view to provide reference for the treatment of advanced colorectal cancer with integrated Chinese and Western Medicine.

关键词： Integrated Chinese and western medicine Advanced colorectal cancer Treatment timing art

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi Liang fei yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia

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Nano Research 2025年第1期18卷 195-207页

作者： Chun Zhu Yifei yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun fei yang Key Laboratory of Agro-Forestry Environmental Processes and Ecological Regulation of Hainan Province School of Environmental Science and EngineeringHainan UniversityHaikou 570228China

Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low concentration and sluggish *** work reports a three-dimensional porous electrode with binary Co_(2)Cu_(1)hydroxy phosphate embedded into the surface of Ni_(3)Co_(1)oxy/hydroxides(CoCu-PH@NiCo/Ni,“PH”means phosphate-hydroxide),which delivers a yield of 4.13 mg·h^(-1)·cm^(-2)with a high Faraday efficiency of 92.6%under a low nitrate concentration of 40 mM and provide an impressive *** embedded structure of the as-prepared catalyst exhibits unique metal coordination ligands and valence states different from the unitary *** electrochemical in situ infrared spectra and theoretical calculations revealed that the Co sites with the ability to dissociate water molecular to form adsorbed OH*can effectively provide the required protons for the deoxygenation and hydrogenation steps during NO3-conversion,thereby,effectively reducing the energy barrier of the key transition states in the NO3RR process to improve the intrinsic *** demonstrate that the rational design of binary components with the appropriate ability to activate water molecules as well as the threedimensional porous skeletal structure are expected to promote effectively the low-concentration nitrates conversion to ammonia.

关键词： nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed

On the Dynamics of a Family of Entire Functions

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2047-2072页

作者： fei yang Department of Mathematics Nanjing University

We prove that for any bounded type irrational number 0 〈 0 〈 1, the boundary of theSiegel disk of fα（z） = e^2πiθsin（z）＋ αsin^3（z）, a E C, which centered at the origin, is a quasicircle passing through 2,... 详细信息

关键词： Siegel disk quasicircle quasiconformal surgery

PREPARATION OF ENTANGLEMENT STATES IN A TWO-SPIN SYSTEM BY LYAPUNOV-BASED METHOD

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Journal of Systems Science & Complexity 2012年第3期25卷 451-462页

作者： fei yang Shuang CONG Department of Automation University of Science and Technology of China Key Laboratory of Quantum Information University of Science and Technology of ChinaChinese Academy of Sciences

A stable Lyapunov-based control law is proposed for entanglement states preparation in this paper. Tbe mathematical model of a two-spin system is constructed in interaction picture. An average value of observable operator is selected as the Lyapunov fllnction. This paper designs the observable operator to make sure that the target state is stable in Lyapunov sense. Then the authors analyze the convergence of the control system, and demonstrate that the Bell states are asymptotically stable under the control law designed. Compared with other methods, the control method proposed in this paper has the advantages of easy design and convergence to the target states. Numerical simulation experiments for the preparation of Bell states are implemented.

关键词： Entanglement Lyapunov-based method interaction picture observable operator.

The Hot Spots Conjecture on a Class of Domains in R^n with n≥3

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 639-646页

作者： Peng-fei yang School of Science Beijing Institute of Technology Beijing 100081 China

In this paper, we define a class of domains in R^n. Using the synchronous coupling of reflecting Brownian motion, we obtain the monotonicity property of the solution of the heat equation with the Neumann boundary cond... 详细信息

关键词： synchronous coupling reflecting Brownian motion hot spots conjecture Neumann eigenfunctions

Numerical study on hydrodynamic characteristics of spherical bubble contaminated by surfactants under higher Reynolds numbers

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Chinese Journal of Chemical Engineering 2022年第5期35卷 268-283页

作者： Tao Sun Mingjun Pang yang fei School of Mechanical Engineering and Rail Transit Changzhou UniversityChangzhou 213164China

It is of significance to investigate deeply the hydrodynamic featu res of the bubble co ntaminated by impurities in view of the fact that the industrial liquid is difficult to keep absolutely *** the basis of the finite volume method,the bubble interface contaminated by the surfactant(1-pentanol)is achieved through solving the concentration transport equations in liquid and along the bubble interface,and solving the absorption and desorption equation at the bubble *** the three-dimensional momentum equation is solved at the same *** is investigated in detail on the influence of interfacial contamination degrees(described with the cap angleθ)on hydrodynamic characteristics of the spherical bubble when the bubble Reynolds number(Re)is larger than ***θis realized by changing the surfactant concentration(C_(0)) in *** present results show that the hydrodynamic characteristics,such as interfacial concentration,interfacial shear stress,interfacial velocity and wake flow,are related to both Re and C_(0) for the contaminated *** C_(0) is relatively low in liquid(i.e.,the contamination degree of the bubble interface is relatively slight),the hydrodynamic characteristics of the bubble can still keep the 2 D features even if Re>*** decrease ofθor the increase of Re can promote the appearance of the unsteady wake *** the present investigation,when Re>200 andθ≤60°,the hydrodynamic characteristics of the bubble show the 3D phenomena,which indicates that axisymmetric model is no longer valid.

关键词： Bubble Higher Reynolds number Interfacial parameters Wake flow Adsorption Desorption

General relative error criterion and M-estimation

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Frontiers of Mathematics in China 2013年第3期8卷 695-715页

作者： Ying yang fei YE Department of Mathematical Sciences Tsinghua University Beijing 100084 China

Relative error rather than the error itself is of the main interest in many practical applications. Criteria based on minimizing the sum of absolute relative errors （MRE） and the sum of squared relative errors （RLS） were proposed in the different areas. Motivated by K. Chen et al.＇s recent work [J. Amer. Statist. Assoc., 2010, 105： 1104-1112] on the least absolute relative error （LARE） estimation for the accelerated failure time （AFT） model, in this paper, we establish the connection between relative error estimators and the M-estimation in the linear model. This connection allows us to deduce the asymptotic properties of many relative error estimators （e.g., LARE） by the well-developed M-estimation theories. On the other hand, the asymptotic properties of some important estimators （e.g., MRE and RLS） cannot be established directly. In this paper, we propose a general relative error criterion （GREC） for estimating the unknown parameter in the AFT model. Then we develop the approaches to deal with the asymptotic normalities for M-estimators with differentiable loss functions on R or R／{0} in the linear model. The simulation studies are conducted to evaluate the performance of the proposed estimates for the different scenarios. Illustration with a real data example is also provided.

关键词： Relative error accelerated failure time model M-estimation asymptotic normality general loss function

Improved thermal design methodology for wind power converters

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Journal of Modern Power Systems and Clean Energy 2013年第3期1卷 285-291页

作者： fei yang Liang GUO NARI Technology Development Co. Ltd.Nanjing 210061China

This paper presents an improved thermal design methodology for wind power *** combines analysis and experimental thermal design tools,including heat transfer correlations,flow network modeling(FNM),computational fluid dynamics(CFD),and experimental measurement ***,a systemic product development process is introduced and an effective combination between the product development process and the thermal design methodology is *** draft CFD modeling at the initial design stage is ***,it uses the detailed CFD modeling and experimental measurement techniques to provide a higher degree of accuracy at latter design *** key advantage of the improved methodology is its emphasis on the use of varied design tools,each of which is actively applied at its optimal point in the proposed product development ***,during the earlier stages of the product development process,the thermal risk is systematically reduced,and longterm reliability of products is maintained in a higher degree.

关键词： Flow network modeling(FNM) Computational fluid dynamics(CFD) Prototype Simulation Experimental measurement

Adding Sub-chain Method for Structural Synthesis of Planar Closed Kinematic Chains

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Chinese Journal of Mechanical Engineering 2012年第2期25卷 206-213页

作者： DENG Zongquan yang fei TAO Jianguo State Key Laboratory of Robotics and System Harbin Institute of TechnologyHarbin 150080China

For at least the past five decades,structural synthesis has been used as a main means of finding better mechanisms with some predefined *** structural synthesis,isomorphism identification is still a problem unsolved well,and to solve this problem is very significant to the design of new *** to the given degree of freedom（DOF） and link connection property of planar closed chain mechanisms,vertex assortment is *** solving the isomorphism problem,a method of the adding sub-chains is proposed with the detailed steps and algorithms in the synthesizing *** this method,the identification code and formation code of every topological structure are achieved,therefore many isomorphic structures could be eliminated in time during structural synthesis by comparing those codes among different topological graphs,resulting in the improvement of synthesizing efficiency and accuracy,and the approach for eliminating rigid sub-chains in and after the synthesizing process is also *** examples are given,including how to add sub-chains,how to detect simple rigid sub-chains and how to obtain identification codes and formulation codes et *** the adding sub-chain method,the relative information of some common topological graphs is given in the form of *** comparison result is coincident with many literatures,so the correctness of the adding sub-chain method is *** method will greatly improve the synthesizing efficiency and accuracy,and has a good potential for application.

关键词： structural synthesis adding sub-chain method identification code formation code rigid sub-chains