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Parameter determination to calculate water environmental capacity in Zhangweinan Canal Sub-basin in China

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Journal of Environmental Sciences 2010年第6期22卷 904-907页

作者： Yingxia Li ,Ruzhi Qiu,Zhifeng yang,chunhui Li,Jingshan Yu State Key Laboratory of Water Environment Simulation,School of Environment,Beijing Normal University,Beijing,100875,China. State Key Laboratory of Water Environment Simulation School of Environment Beijing Normal University Beijing 100875 China

Zhangweinan canal sub-basin （ZWN） has the most serious water resource shortage and water pollution problems in north of China. To calculate the water environmental capacity in ZWN, determination methods for design flow rates and degradation coefficients were discussed in this study. Results showed that 90% and 50% hydrological guarantee flow rates were suitable to be the design flow rates for rainy and dry seasons, respectively. Degradation coefficients of CODMn and NH3-N were 0.25 day^-1 and 0.15 day^-1 for branch streams and 0.5 day^-1 and 0.25 day^-1 for mainstreams, respectively in ZWN. With one-dimensional water quality simulation model, water environmental capacities were calculated to be 82,139 tons/yr for CODMn and 2394 tons/yr for NH3-N in ZWN.

关键词： degradation coefficient design flow rate water environmental capacity Zhangweinan

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白洋淀鱼类产卵场初步调查

河北渔业 2024年第2期 24-28页

作者：杨春晖许玉甫王慎知张超张德昭张海鹏河北省海洋与水产科学研究院(河北省海洋渔业生态环境监测站) 河北秦皇岛066000 雄县农业农村局河北雄县071899 河北农业大学海洋学院河北秦皇岛066000

为了解白洋淀鱼类产卵场,更好地保护渔业资源,于2021年4—6月首次进行了白洋淀鱼类产卵场调查,掌握了3种黏草性卵鱼类:鲫(Carassius auratus)、小黄黝鱼(Micropercops swinhonis)、鲤(Cyprinus carpio)的产卵及产卵场分布情况,其中后塘... 详细信息

为了解白洋淀鱼类产卵场,更好地保护渔业资源,于2021年4—6月首次进行了白洋淀鱼类产卵场调查,掌握了3种黏草性卵鱼类:鲫(Carassius auratus)、小黄黝鱼(Micropercops swinhonis)、鲤(Cyprinus carpio)的产卵及产卵场分布情况,其中后塘淀产卵场分布最为密集。

关键词：白洋淀鱼类产卵场

Biomimetic“Gemini nanoimmunoregulators”orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1345-1361页

作者： Honglin Huang Ningxi Li Xiaodan Wei Qingzhi Li Junhan Guo Geng yang Hong yang Lulu Cai Yiyao Liu chunhui Wu Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s Hospitaland School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China

A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer ***,a new type of spatiotemporal biomimetic“Gemini nanoimmunoregulators”was engineered to activate robust systemic photoimmunotherapy by integrating the triple-punch of amplified immunogenic cell death(ICD),tumor-associated macrophages(TAMs)phenotype reprogramming and programmed cell death ligand 1(PD-L1)***“Gemini nanoimmunoregulators”PM@RM-T7 and PR@RM-M2 were constructed by taking the biocompatible mesoporous polydopamine(mPDA)as nanovectors to deliver metformin(Met)and toll-like receptor 7/8 agonist resiquimod(R848)to cancer cells and TAMs by specific biorecognition via wrapping of red blood cell membrane(RM)inlaid with T7or M2 ***/Met@RM-T7(abbreviated as PM@RM-T7)was constructed to elicit an amplified in situ ICD effect through the targeted PTT and effectively stimulated the anticancer ***,PD-L1 on the remaining cancer cells was degraded by the burst metformin to prevent immune ***,mPDA/R848@RM-M2(abbreviated as PR@RM-M2)specifically recognized TAMs and reset the phenotype from M2 to M1 state,thus disrupting the immunosuppressive microenvironment and further boosting the function of cytotoxic T *** pair of sister nanoimmunoregulators cooperatively orchestrated the comprehensive anticancer activity,which remarkably inhibited the growth of primary and distant 4T1 tumors and prevented malignant *** study highlights the spatiotemporal cooperative modalities using multiple nanomedicines and provides a new paradigm for efficient cancer immunotherapy against metastatic-prone tumors.

关键词： Biomimetic immunoregulator Spatiotemporal delivery Targeted photothermal therapy Amplified immunogenic cell death Immunosuppressive tumor microenvironment PD-L1 degradation TAMs phenotype reversion Metastasis inhibition

Targeting the extracellular matrix for NF1-associated neurofibroma treatment

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Chinese Journal of Plastic and Reconstructive Surgery 2024年第2期6卷 87-93页

作者： chunhui Jiang NHC Key Laboratory of Cell Transplantation First Affiliated Hospital of Harbin Medical University23 Youzheng StreetHarbin 150001HeilongjiangChina

Neurofibromatosis type 1(NF1)is one of the most common genetic disorders that predisposes patients to benign and malignant tumors of the peripheral nervous *** and cutaneous neurofibromas are NF1-associated benign *** their benign nature,they can cause tremendous morbidity in patients with *** drug options are limited to the MEK inhibitor,selumetinib,which is the only approved drug for pediatric patients with plexiform *** strategies have substantial therapeutic potential for NF1-associated *** review discusses the fibrotic features of plexiform and cutaneous neurofi-bromas focusing on the pathological composition of the extracellular *** also highlights the core pathways implicated in the biochemical and biophysical regulation of the extracellular matrix remodeling in tumor imitation and ***,this review provides a brief outlook on how exploring novel vulnerabilities residing in the aberrant extracellular matrix and their underlying pathways can benefit the treatment of NF1-associated neurofibromas.

关键词： Neurofibromatosis type 1 Cutaneous neurofibroma Plexiform neurofibroma Fibrosis Extracellular matrix Basement membrane

An MPXV mRNA-LNP vaccine candidate elicits protective immune responses against monkeypox virus

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Chinese Chemical Letters 2024年第8期35卷 466-470页

作者： Yuxin Tian Mengjun Li yang yang chunhui Li Yun Peng Haiyin yang Mengyuan Zhao Pengfei Wu Shaobo Ruan Yuanyu Huang Chenguang Shen Minghui yang Advanced Research Institute of Multidisciplinary Science School of Life ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China BSL-3 Laboratory(Guangdong) Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthDepartment of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510280China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China

The monkeypox virus(MPXV)outbreak,declared a Public Health Emergency of International Concern(PHEIC)by the World Health Organization(WHO)in 2022,continues to pose a significant threat due to the absence of vaccines or drugs for MPXV *** this study,we developed an mRNA vaccine that expressing the A29L antigen,a specific protein of the intracellular mature *** vaccine utilizes a thermostable ionizable lipid nanoparticle(iLNP)platform and has been administered to *** find-ings demonstrate that the MPXV A29L mRNA vaccine candidate induces robust cross-neutralizing immune responses against both vaccinia virus(VACV)and MPXV live ***,immunization with the vaccine candidate provided protection against the VACV challenge in *** findings underscore the potential of mRNA-LNP vaccines as safe and effective candidates against monkeypox *** the current absence of specific interventions for MPXV infection,our study represents a significant step forward in developing a viable solution to combat this ongoing public health threat.

关键词： Monkeypox virus mRNA vaccine Lipid-nano particle A29L VACV

Direct Chemical Synthesis of L10-FePtAu nanoparticles with high coercivity

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Direct Chemical Synthesis of L10-FePtAu nanoparticles with h...

Dynamic impact properties of deep sandstone under thermal-hydraulicmechanical coupling loads

第十七届全国晶体生长与材料学术会议(CCCG-17)

作者： Yongsheng Yu chunhui yang School of Chemical Engineering and Technology Harbin Institute of Technology

Recently,solution synthesis allowsthe preparation of monodispersed FePt nanoparticles(NPs) with a narrow size distribution,composition control and well defined shapes.1-3 However,the assynthesized FePt NPs typically adopt a face-centered cubic(fcc) structure,which is unsuitable for data storage and permanent magnetic applications,becauseof the superparamagnetic property of fcc-FePt phase at room *** ordering phasetransformation requires high temperature(>550℃)***,high temperature annealing leads to complete decomposition of the surfactant on the surface of each NP and consequently produces an undesirable aggregation and sintering.4,5Here,we report a new method to directly prepare L10-FePtAu NPs from solution *** unique feature of this synthesis is that oleylamine(OAm)in the synthesis serves as surfactant,solvent and reducing agent at the same time and no other strong reducing agent was used in the *** simply heating the solution of Fe(acac)3,Pt(acac)2(acac=acetylacetonate) and gold acetate with OAm to 350 ℃,L10-FePtAu NPs could be directly obtained without further *** the current reaction condition,NP sizes were controlled to be 5.5 to 11.0 nm by changing the amount of Au *** composition of NPs could be simply controlled by the amounts of the precusors used in the *** highest coervicity of 12.15 kOe at room temperature could be achieved for the NPs with 32%Au doping,which is much higher than the coercivities reported by the previous studies on solution-synthesized FePt *** reported one-pot synthesis of L10-FePtAu NPs may help to build superstrong magnets for magnetic ordata storage applications.

关键词： nanoparticles FePt chemical synthesis coercivity

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Journal of Mountain Science 2024年第6期21卷 2113-2129页

作者： CAO chunhui DING Haonan ZOU Baoping School of Civil Engineering and Architecture Zhejiang University of Science and TechnologyHangzhou 310023China Zhejiang-Singapore Joint Laboratory for Urban Renewal and Future City Hangzhou 310023China

The deep rock mass within coal mines situated in a challenging environment are characterized by high ground stress,high geotemperature,high osmotic water pressure,and dynamic disturbances from mechanical *** investigate the impact of this complex mechanical environment on the dynamic characteristics of roof sandstone in self-formed roadways without coal pillars,standard specimens of deep sandstone from the 2611 upper tunnel working face of the Yongmei Company within the Henan Coal Chemical Industry Group in Henan,China were prepared,and an orthogonal test was *** a self-developed geotechnical dynamic impact mechanics test system,triaxial dynamic impact tests under thermal-hydraulicmechanical coupling conditions were conducted on deep *** results indicate that under high confining pressure,deep sandstone exhibits pronounced brittle failure at low temperatures,with peak strength gradually decreasing as temperature and osmotic water pressure ***,under low confining pressure and low temperature,the brittleness of deep sandstone weakens gradually,while ductility ***,sandstone demonstrates higher peak strength at low temperatures under high axial pressure conditions,lower peak strength at high temperatures,and greater strain under low axial pressure and high osmotic water *** in impact air pressure and osmotic water pressure have proportionally greater effects on peak stress and peak *** 50%of the input strain energy is utilized as effective energy driving the sandstone fracture *** analysis identifies the optimal combination of factors affecting the peak stress and peak strain of *** the coupling effect,intergranular and transgranular fractures occur within the *** images illustrate that the damage forms range from minor damage with multiple fissures to extensive fractures and severe *** study elucidates the varied dynamic impact me

关键词： Deep sandstone Thermal-hydraulicmechanical coupling Dynamic impact Stress-strain Failure Modes Polar analysis

Improvement on the Luminescence Property of Y, Sb Co-doped PbWO_4 Single Crystal

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High Technology Letters 2001年第2期7卷 87-88页

作者：杨春晖 Shi Pengfei Chen Gang Department of Applied Chemistry Harbin Institute of Tecnology Beijing Glass Research Institute

The effect of Y and Sb co-doping on the luminescence property of PbWO 4 crystals has been investigated. Compared with undoped PbWO4, the transmittance and emission peak intensity of Y∶Sb∶PbWO 4 crystals were obviously improved. In addition, its transmittance cutoff wavelength and emission peak shifted to the shorter one. The mechanism of effect of Y and Sb on the transmittance spectra was briefly discussed. The light yield of Y∶Sb∶PbWO 4 crystals was 25p.e./MeV, which was two times of that of undoped PbWO 4. Our experiments showed that Y and Sb co-doping was a selectable method to improve the luminescence property of PbWO 4.

关键词： Y∶Sb∶PbWO4 crystal Transmittance Exicted-emission spectra Light yield

山东省招远市1985-2023年肝癌死亡流行特征及趋势分析

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社区医学杂志 2024年第16期22卷 546-550页

作者：翟玉庭郝建辉宁巍巍王璐赵梓旭李桂刚杨春晖招远市疾病预防控制中心慢性非传染性疾病防治科招远市玲珑中心卫生院公共卫生科招远市人民医院普外科

目的分析招远市1985-2023年肝癌死亡率变化情况，为肝癌防控提供依据。方法基于招远市全死因监测数据，提取1985-2023年肝癌死亡资料。采用Excel 2010和SAS9.3软件计算粗死亡率、标化率、累积率、截缩率；采用Joinpoint5.0软件对1985-... 详细信息

目的分析招远市1985-2023年肝癌死亡率变化情况，为肝癌防控提供依据。方法基于招远市全死因监测数据，提取1985-2023年肝癌死亡资料。采用Excel 2010和SAS9.3软件计算粗死亡率、标化率、累积率、截缩率；采用Joinpoint5.0软件对1985-2023年肝癌的中标率进行回归分析，计算年度变化百分率(APC)。采用死亡率的差别分解计算人口因素和非人口因素的贡献。结果招远市1985-2023年共计死亡9 080例，粗死亡率为42.31/10万，仅次于胃癌、肺癌，为恶性肿瘤死亡顺位第3位。中标率为21.30/10万，世标率为28.03/10万；随着年龄的增加，肝癌的死亡率呈现上升趋势。肝癌标化死亡率AAPC=-0.95,P>0.05;标化率1985-1998年呈上升趋势，APC=4.00,1998-2023年呈下降趋势，APC=-3.43,P<0.05。人口因素一直是肝癌死亡率升高的因素，人口因素的作用越来越明显，非人口因素作用在1995-1999年达到最大化，其后开始减弱，是2010-2023年死亡率下降的主要因素。结论招远市肝癌死亡率虽然已呈下降趋势，但仍处于较高水平，是严重危害招远市居民健康的重要癌症。建议在招远市开展肝癌的早诊早治，降低肝癌死亡率。

关键词：肝癌死亡率变化趋势招远市