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Acanthopanax senticosus Protects Structure and Function of Mesencephalic Mitochondria in A Mouse Model of Parkinson's Disease

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Chinese Journal of Integrative Medicine 2018年第11期24卷 835-843页

作者： LIU Shu-min LI Xu-zhao ZHANG Shuai-nan yang zhi-ming WANG Ke-xin LU Fang WANG Chong-zhi YUAN Chun-su Drug Safety Evaluation Center Heilongjiang University of Chinese Medicine Department of Pharmacy Guiyang College of Traditional Chinese Medicine Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care University of Chicago

Objective： To investigate the neuro-protective effects of Acanthopanax senticosus Harms（EAS） on mesencephalic mitochondria and the mechanism of action, using a mouse model of Parkinson＇s disease（PD）. Methods： The chemical fingerprint analysis of the extract of Acanthopanax senticosus Harms（EAS） was performed using the ultra performance liquid chromatograph and time of flight mass spectrometry. Thirty mice were randomly divided into the control group, the MPTP model group, and the EAS treated group with MPTP（MPTP＋EAS group, 10 in each group）. The MPTP model group and the MPTP＋EAS group received MPTP-HCl（30 mg/kg i.p） once a day for 5 days. The control group received an equal volume of saline（20 m L/kg i.p） once a day for 5 days. Induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride daily（MPTP-HCl, 30 mg/kg） for 5 days, the PD mice were treated with EAS at 45.5 mg/kg daily for 20 days. The behavioral testing of mice was carried out using the pole-climbing test. The integrity and functions of neurons were examined in mesencephalic mitochondria in a PD mouse model, including nicotinamide adenine dinucleotide dehydrogenase ubiquinone flavoprotein 2（NDUFV2）, mitochondrially encoded nicotinamide adenine dinucleotide dehydrogenase 1（MT-ND1）, succinate dehydrogenase complex subunit A（SDHA）, and succinate dehydrogenase cytochrome b560 subunit（SDHC）. Results： After treatment with EAS, the behavioral changes induced by MPTP were attenuated significantly（P〈0.05）. EAS protected the mesencephalic mitochondria from swelling and attenuated the decreases in their membrane potential（both P〈0.05）, which was supported by an ultra-structural level analysis. The changes in reactive oxygen species（ROS）, malonic dialdehyde（MDA）, oxidative phosphorylation（OXPHOS） system 4 subunits levels and PD-related proteins expressions（parkin, Pink1, DJ-1, α-synuclein, and Lrrk2） reverted to near normal levels（all P〈0.05）, based on the results of immune-histological and Western blottin

关键词： Acanthopanax senticosus Harms Parkinson's disease mitochondrial dysfunction mitochondrial structural damage oxidative phosphorylation system

Flow structure around high-speed train in open air

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Journal of Central South University 2015年第2期22卷 747-752页

作者：田红旗黄莎杨明智 Key Laboratory of Traffic Safety on Track of Ministry of Education (Central South University) School of Traffic & Transportation Engineering Central South University

According to the analysis of the turbulent intensity level around the high-speed train, the maximum turbulent intensity ranges from 0.2 to 0.5 which belongs to high turbulent flow. The flow field distribution law was studied and eight types of flow regions were proposed. They are high pressure with air stagnant region, pressure decreasing with air accelerating region, low pressure with high air flow velocity region I, turbulent region, steady flow region, low pressure with high air flow velocity region II,pressure increasing with air decelerating region and wake region. The analysis of the vortex structure around the train shows that the vortex is mainly induced by structures with complex mutation and large curvature change. The head and rear of train, the underbody structure, the carriage connection section and the wake region are the main vortex generating sources while the train body with even cross-section has rare vortexes. The wake structure development law studied lays foundation for the train drag reduction.

关键词： flow around high-speed train turbulence intensity flow region vortex structure wake region

ZERO-TENSILE STRENGTH FOR RESULT COMPARISON IN CAVITATION INCEPTION TESTS

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Journal of Hydrodynamics 2001年第4期13卷 123-126页

作者： yang zhi-ming Department of Hydraulic Engineering, Wuhan University, Wuhan 430072, China Department of Hydraulic Engineering Wuhan University

The tensile strength of test liquid affects the cavitation inception numbers very seriously, and the zero-tensile strength as a criterion for detection of the cavitation inception numbers can be used, in order to reduce the influence of tensile strength. The scale effect on measuring zero-tensile strength of test liquid based on hydraulic methods must be considered. it is supposed that the zero-tensile strength can be defined by use of the comparative method, which unites the classical theory of cavitation inception with the modern one based on an identical criterion.

关键词： cavitation inception tensile strength scale effect

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初生空化比尺效应的讨论和验证

水动力学研究与进展（A辑） 2008年第5期23卷 580-584页

作者：杨志明武汉大学水利水电学院武汉430072

讨论了在常规循环水洞或在减压箱中进行模型空化试验时,关于初生空化比尺效应的不同观点。指出了在(?)压箱空化试验中使用的相似律存在的缺陷。为了有效研究初生空化比尺效应,规范液体的抗拉强度为零是必要的。用最新试验成果-喷嘴的初... 详细信息

讨论了在常规循环水洞或在减压箱中进行模型空化试验时,关于初生空化比尺效应的不同观点。指出了在(?)压箱空化试验中使用的相似律存在的缺陷。为了有效研究初生空化比尺效应,规范液体的抗拉强度为零是必要的。用最新试验成果-喷嘴的初生空化特性,再次验证了经验的初生空化比尺效应。

关键词：空化喷嘴比尺效应

THE RELATION BETWEEN INCIPIENT CAVITATION AND TENSILE STRENGTH OF A LIQUID

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Journal of Hydrodynamics 1990年第2期2卷 27-35页

作者： yang zhi-ming, Wuhan University of Hydraulic and Electric Engineering, Wuhan 430072, P.R.China

Since the first report on scale effect of cavitation inception with consideration of tensile strength of water was published in 1983 [1], a new technique for measuring tensile strength of liquid named by Dr. A. Keller, as 'Vortex-nozzle Cavitation Susceptibility Meter (CSM)' has been improved and developed through these years of usage. Some interesting concepts and techinque will be discussed in this paper. For example, how to calibrate the 'CSM', how to determine the 'Zero Tensile Strength of a Liquid' and how to determine the incipient cavitation number with consideration of the liquid's tensile strength.

关键词： body THE RELATION BETWEEN INCIPIENT CAVITATION AND TENSILE STRENGTH OF A LIQUID CSM test

THE TENSILE STRENGTH OF TEST WATER IN DIFFERENT CAVITATION TEST FACILITIES

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Journal of Hydrodynamics 1991年第4期3卷 55-60页

作者： yang zhi-ming Wuhan University of Hydraulic and Electric Engineering,Wuhan 430072,P.R.China

Since 1983 it has been reported many times that the tensile strength of a liquid has a noticeable influence on incipient cavitation test[1,2,3].In this paper some results indicate the characters of tensile strength of test wa- ter in different cavitation test facilities for example;characters in normal cavitation tunnel without free surface and in depression tank with free surface *** getting a comparable and stable test result of cavitation inception it is important to know the tensile strength of test water and to keep it stable.

关键词： test THE TENSILE STRENGTH OF TEST WATER IN DIFFERENT CAVITATION TEST FACILITIES der

Influence of enlarged section parameters on pressure transients of high-speed train passing through a tunnel

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Journal of Central South University 2018年第11期25卷 2831-2840页

作者： WANG Tian-tian LEE Chun-hian yang ming-zhi National Laboratory for Computational Fluid Dynamics School of Aeronautic Science and EngineeringBeihang University Key Laboratory of Traffic Safety on Track of Ministry of Education School of Traffic and Transportation Engineering Central South University

The influence of enlarged section parameters on pressure transients of high-speed train passing through a tunnel was investigated by numerical *** calculation results obtained by the structured and unstructured grid and the experimental results of smooth wall tunnel were *** simulation studies were conducted on three tunnel enlarged section parameters,the enlarged section distribution along circumferential direction,the enlarged section area and the enlarged section distribution along tunnel length *** calculation results show that the influence of the different enlarged section distributions along tunnel circumferential direction on pressure transients in the tunnel is basically *** is an optimal enlarged section area for the minimum value of the pressure variation amplitude and the average pressure variation in the *** law of the pressure variation amplitude and the average pressure variation of the enlarged section distribution along tunnel length direction are obtained.

关键词： high-speed train enlarged section parameters tunnel pressure transients

Current understanding of dystrophin-related muscular dystrophy and therapeutic challenges ahead

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Chinese Medical Journal 2006年第16期119卷 1381-1391页

作者： ZHOU Guang-qian XIE Hui-qi ZHANG Su-zhen yang zhi-ming Department of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China Centre for Cancer Research and Cell Biology Queen＇s University of Belfast Belfast BT12 6BJ UK

Objective To review the recent research progress in dystrophin-related muscular dystrophy includes X-linked hereditary Duchenne and Becker muscular dystrophies （DMD and BMD）. Data sources Information included in this article was identified by searches of PUBMED and other online resources using the key terms DMD, dystrophin, mutations, animal models, pathophysiology, gene expression, stem cells, gene therapy, cell therapy, and pharmacological. Study selection Mainly original milestone articles and timely reviews written by major pioneer investigators of the field were selected. Results The key issues related to the genetic basis and pathophysiological factors of the diseases were critically addressed. The availabilities and advantages of various animal models for the diseases were described. Major molecular and cellular therapeutic approaches were also discussed, many of which have indeed exhibited some success in pre-clinical studies but at the same time encountered a number of technical hurdles, including the efficient and systemic delivery of a functional gene and myogenic precursor/stem cells to repair genetic defects. Conclusions Further understanding of pathophysiological mechanisms at molecular levels and regenerative properites of myogenic precursor/stem cells will promote the development of multiple therapeutic strategies. The combined use of multiple strategies may represent the major challenge as well as the greatest hope for the therapy of these diseases in coming years.

关键词： dystrophin muscular dystrophy myogenic stem cells cell therapy gene therapy

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受电弓设备对列车气动特性影响的风洞试验

中南大学学报（自然科学版） 2011年第12期42卷 3894-3898页

作者：张雷杨明智中南大学交通运输工程学院轨道交通安全教育部重点实验室湖南长沙410075

为了充分了解和掌握在强侧风作用下受电弓设备(受电弓和导流罩)对高速列车气动性能的影响,通过风洞试验对强侧风下高速列车运行时的气动性能进行测量和分析。实验结果表明:当侧滑角小于15°时,列车模型阻力系数随着侧滑角的增大而增加,... 详细信息

为了充分了解和掌握在强侧风作用下受电弓设备(受电弓和导流罩)对高速列车气动性能的影响,通过风洞试验对强侧风下高速列车运行时的气动性能进行测量和分析。实验结果表明:当侧滑角小于15°时,列车模型阻力系数随着侧滑角的增大而增加,当侧滑角为15°时,阻力系数出现拐点,拐点后阻力系数开始下降,其侧向力系数的绝对值和升力系数随着侧滑角的增大而增加;受电弓设备对头车的影响较小,但可使中车侧向力系数的绝对值及阻力系数明显增加,使尾车的阻力系数明显减小,而侧向力系数明显增加;受电弓设备中"浴盆"式导流罩对高速列车阻力系数的影响强于"挡板"式导流罩的影响,但对升力系数及侧向力系数的影响弱于"挡板"式导流罩的影响。

关键词：受电弓导流罩高速列车气动性能风洞