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International Journal of Mining Science and Technology 2024年第7期34卷 925-941页

作者： Bin Yu Mingxian Peng yang tai Shuai Guo State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Mines China University of Mining and TechnologyXuzhou 221116China

In order to solve the problem that current theory models cannot accurately describe thick-hard roof(THR)elastic energy and assess the mine tremor disasters,a theoretical method,a Timoshenko beam theory on Winkler foundation was adopted to establish the THR’s periodic breaking *** superposition principle was used for this complex model to derive the calculation formulas of the elastic energy and impact load on hydraulic ***,the influence of roof thickness h,cantilever length L_(1),and load q on THR’s elastic energy and impact load was ***,the effect of mine tremor disasters was ***,it is revealed that:(1)The THR’s elastic energy U exhibits power-law variations,with the fitted relationships U=0.0096L_(1)^(3.5866^),U=5943.9h^(-1.935),and U=21.049q^(2).(2)The impact load on hydraulic supports F_(ZJ) increases linearly with an increase in the cantilever length,thickness,and applied *** fitted relationships are F_(ZJ)=1067.3L_(1)+6361.1,F_(ZJ)=125.89h+15100,and F_(ZJ)=10420q+3912.6.(3)Ground hydraulic fracturing and liquid explosive deep-hole blasting techniques effectively reduce the THR’s cantilever length at periodic breakages,thus eliminating mine tremor disasters.

关键词： Dynamic disaster Energy Hard and thick roof Timoshenko beam

Colon signet-ring cell carcinoma with chylous ascites caused by immunosuppressants following liver transplantation:A case report

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2343-2350页

作者： Ying Li yang tai Hao Wu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chylous ascites is caused by disruption of the lymphatic system,which is characterized by the accumulation of a turbid fluid containing high levels of triglycerides within the abdominal *** two most common causes are cirrhosis and tuberculosis,and colon signer ring cell carcinoma(SRCC)due to the use of immunosuppressants is extremely rare in cirrhotic patients after liver transplantation,making it prone to misdiagnosis and missed *** SUMMARY A 52-year-old man who underwent liver transplantation and was administered with immunosuppressants for 8 months was admitted with a 3-month history of progressive abdominal ***,based on lymphoscintigraphy and lymphangiography,lymphatic obstruction was considered,and cystellar chyli decompression with band lysis and external membrane stripping of the lymphatic duct was ***,his abdominal distention was persistent without *** paracentesis revealed allogenic cells in the ascites,and immunohistochemistry analysis revealed adenocarcinoma cells with phenotypic features suggestive of a gastrointestinal *** endoscopy was performed,and biopsy showed atypical signet ring cells in the ileocecal *** patient eventually died after a three-month follow-up due to progression of the *** Colon SRCC,caused by immunosuppressants,is an unusual but un-neglected cause of chylous ascites.

关键词： Colonic signer ring cell carcinoma Immunosuppressant Chylous ascites Cirrhosis Liver transplantation Case report

Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis

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World Journal of Hepatology 2024年第8期16卷 1156-1166页

作者： Ying Li Xin Quan yang tai Yu-Tong Wu Bo Wei Hao Wu Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical Medicine Chongqing Medical UniversityChongqing 400016China

BACKGROUND Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing ***,it remains unclear whether a concrete causal association exists between immunocyte phenotypes and liver *** To explore the concrete causal relationships between immunocyte phenotypes and liver cirrhosis through a mendelian randomization(MR)*** Data on 731 immunocyte phenotypes were obtained from genome-wide assoc-iation *** cirrhosis data were derived from the Finn Gen dataset,which included 214403 individuals of European *** used inverse variable weighting as the primary analysis method to assess the causal *** analyses were conducted to evaluate heterogeneity and horizontal *** The MR analysis demonstrated that 11 immune cell phenotypes have a positive association with liver cirrhosis[P1]and that 9 immu-nocyte phenotypes were negatively correlated with liver cirrhosis(P1)and negatively linked to 10 immune cell phenotypes(P0.05).CONCLUSION This bidirectional two-sample MR study demonstrated a concrete causal association between immunocyte phenotypes and liver *** findings offer new directions for the treatment of liver cirrhosis.

关键词： Liver cirrhosis Immune cell Immunocyte phenotype Mendelian analysis Causal association

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通过语义三元组和网络药理学发现抑郁症药物

科学技术与工程 2024年第23期24卷 9793-9803页

作者：邰杨芳苏鑫华国旻吴娟山西医科大学基础医学院太原030001 山西医科大学管理学院太原030001

基于抑郁症相关医学文献信息挖掘潜在抗抑郁药并揭示其抗抑郁相关机制和通路,为抑郁症药物的研发提供方向。通过SemRep提取与抑郁症相关的语义三元组,限定语义关系和语义类型确定潜在药物。从PubChem、GeneCards等数据库获取潜在药物和... 详细信息

基于抑郁症相关医学文献信息挖掘潜在抗抑郁药并揭示其抗抑郁相关机制和通路,为抑郁症药物的研发提供方向。通过SemRep提取与抑郁症相关的语义三元组,限定语义关系和语义类型确定潜在药物。从PubChem、GeneCards等数据库获取潜在药物和抑郁症的靶点并取二者的交集后,构建交集靶点的蛋白相互作用(protein-protein interaction,PPI)网络。通过Cytoscape分析PPI网络,确定核心靶点。通过R软件对核心靶点进行GO(gene ontology)和KEGG(kyoto encyclopedia of genes and genomes)分析。最后,通过AutodockTool软件对核心靶点与潜在药物进行分子对接分析。结果表明Hydrocortisone、Benzodiazepine、Curcumin、Metformin、Nicotine、Risperidone等6种药物为潜在抗抑郁药,这些药物通过炎症、神经递质的调节等生物过程以及MAPK(mitogen activated protein kinase)、TNF(tumor necrosis factor)等信号通路发挥抗抑郁作用,并且与抑郁症核心靶点间结合性能良好。此外,Benzodiazepine和Nicotine在临床实践中存在成瘾和滥用的风险,在抑郁症治疗中的作用可能有限。可见基于语义三元组和网络药理学发现抑郁症药物新知识,可以节约时间和经济成本,也能为临床药物使用提供新的方向。

关键词：语义三元组抑郁症语义关系药物分析分子对接

生地大黄汤对脑出血大鼠的保护作用及对肠道菌群和短链脂肪酸的影响

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时珍国医国药 2024年第1期35卷 101-104页

作者：杨文泰刘成海俞晓飞上海中医药大学附属曙光医院上海200120 上海中医药大学附属龙华医院上海200032

目的观察生地大黄汤对脑出血大鼠的保护作用及对肠道菌群和短链脂肪酸的影响。方法 30只大鼠随机分为假手术组、模型组、生地大黄汤组。于造模后6h生地大黄汤组灌胃生地大黄汤(18.51g·kg^(-1)·d^(-1)),假手术组和模型组灌胃等量生理... 详细信息

目的观察生地大黄汤对脑出血大鼠的保护作用及对肠道菌群和短链脂肪酸的影响。方法 30只大鼠随机分为假手术组、模型组、生地大黄汤组。于造模后6h生地大黄汤组灌胃生地大黄汤(18.51g·kg^(-1)·d^(-1)),假手术组和模型组灌胃等量生理盐水,每天1次,连续干预3d。分别于造模后3 h、1 d、3 d进行神经功能评分;造模后3d采集粪便标本,通过细菌16S rRNA高通量测序法比较各组肠道菌群的物种组成,气相色谱法检测大鼠粪便中短链脂肪酸(SCFAs)含量;造模后3d取脑组织测量脑含水量及TUNEL阳性细胞检测。结果造模后3 d,与假手术组比较,模型组大鼠肠道菌群结构紊乱,短链脂肪酸(SCFAs)含量降低,神经功能缺损评分、脑含水量、脑组织细胞凋亡数升高;生地大黄汤可改善模型组大鼠的各项指标。结论生地大黄汤对脑出血大鼠具有保护作用,该作用可能与恢复肠道微生物菌群正常构成和升高短链脂肪酸的浓度有关。

关键词：生地大黄汤脑出血肠道菌群短链脂肪酸大鼠

The Anhydride-Amic Acid-Imide Forms of Maleinized Soybean Oil

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Chinese Journal of Polymer Science 2023年第12期41卷 1829-1835,I0005页

作者： Yun Zhou Yan-Bin Huang Wan-tai yang Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Vegetable oil is one of the most promising renewable feedstocks as an alternative to fossil resources,but there are few studies aiming to transform it into hydrophilic *** proposed a facile method to prepare water-soluble derivatives from soybean oil,which could become water resistant again after simple heat *** model vegetable oil,soybean oil(SO),was first reacted with maleic anhydride(MA)by the Alder ene reaction to obtain maleinized soybean oil(SOMA),and SOMA was further reacted with gaseous ammonia to obtain the maleamic acid form(SOMA-Amic acid),which was very soluble in water(solubility>100 mg/mL).The obtained water-soluble product was converted to the water-resistant maleimide form(SOMA-Imide)by a simple heat *** potential application of these vegetable oil derived materials was demonstrated in paper sizing as an ***-Amic acid was demonstrated to be a novel green material,which can be used in an aqueous process and then heat-treated to become water-resistant in the final product.

关键词： Soybean oil Anhydride-amic acid-imide forms Maleinization

Photo-grafting Poly(acrylic acid) onto Poly(lactic acid) Chains in Solution

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Chinese Journal of Polymer Science 2020年第2期38卷 137-142,I0005页

作者： Jia-Xing Wang Yan-Bin Huang Wan-tai yang Department of Chemical Engineering Tsinghua University

Poly(lactic acid)(PLA)is one of the most important bio-plastics,and chemical modification of the already-polymerized poly(lactic acid)chains may enable optimization of its material properties and expand its application *** this study,we demonstrated that poly(lactic acid)can be readily dissolved in acrylic acid at room temperature,and acrylic acid can be graft-polymerized onto poly(lactic acid)chains in solution with the help of photoinitiator benzophenone under 254 nm ultraviolet(UV)*** photo-grafting polymerization of acrylic acid(PAA)has only been studied before in the surface modification of polymer *** graft ratio could be controlled by various reaction parameters,including irradiation time,benzophenone content,and monomer/polymer *** photo-grafting reaction resulted in high graft ratio(graft ratio PAA/PLA up to 180%)without formation of homopolymers of acrylic *** the PAA/PLA graft ratio was higher than 100%,the resulting PLA-g-PAA polymer was found dispersible in *** pros and cons of the photo-grafting reaction were also discussed.

关键词： Photo-grafting Polymer modification Poly(acrylic acid) Poly(lactic acid)

微肿瘤PTC药敏检测优化骨肉瘤二线化疗方案选择的作用研究

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安徽医专学报 2024年第1期23卷 46-48页

作者：肖太阳黄杰邹勇信丰县人民医院江西信丰341600

目的:探讨微肿瘤(PTC)药敏检测优化骨肉瘤二线化疗方案选择的作用研究。方法:收集医院内行二线化疗方案治疗的50例骨肉瘤患者,根据治疗方案不同分组,其中12例患者采用伊立替康+长春新碱(A组),15例患者采用白蛋白结合型紫杉醇(B组);13例... 详细信息

目的:探讨微肿瘤(PTC)药敏检测优化骨肉瘤二线化疗方案选择的作用研究。方法:收集医院内行二线化疗方案治疗的50例骨肉瘤患者,根据治疗方案不同分组,其中12例患者采用伊立替康+长春新碱(A组),15例患者采用白蛋白结合型紫杉醇(B组);13例患者采用吉西他滨+多西他赛治疗(C组),10例患者给予长春瑞滨(D组)。比较各组微肿瘤PTC药敏检测结果、临床疗效及不良反应。结果:B组患者微肿瘤PTC药敏有效率高于A组、B组、D组(P0.05);B组患者临床治疗总有效率高于A组、B组、D组(P0.05)。各组患者间不良反应的差异无统计学意义(P>0.05)。结论:微肿瘤PTC药敏检测与临床疗效结果相近,提示微肿瘤PTC药敏检测对骨肉瘤二线化疗方案选择具有指导价值。

关键词：骨肉瘤微肿瘤药敏二线化疗

枯草芽孢杆菌的生理功能及其在畜禽生产中的应用

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中国畜牧兽医 2024年第4期51卷 1511-1519页

作者：张关锋杨泰宋先凡徐伟伟阳治康陈清华湖南农业大学动物科学技术学院长沙410128 长沙市生物饲料工程技术研究中心长沙410209 湖南百宜科技集团有限公司长沙410128 湖南德邦牧业有限公司长沙410000

枯草芽孢杆菌是一类可形成芽孢的具有多种生理功能且对动物机体无毒副作用的理想益生菌。在饲料中添加枯草芽孢杆菌具有调节畜禽肠道功能、平衡微生物区系,提高免疫力和促生长等作用。枯草芽孢杆菌还可以作为饲料发酵菌种,经发酵后的饲... 详细信息

枯草芽孢杆菌是一类可形成芽孢的具有多种生理功能且对动物机体无毒副作用的理想益生菌。在饲料中添加枯草芽孢杆菌具有调节畜禽肠道功能、平衡微生物区系,提高免疫力和促生长等作用。枯草芽孢杆菌还可以作为饲料发酵菌种,经发酵后的饲料会降低抗营养因子的含量,提高营养物质的含量,从而促进畜禽对饲料养分的消化和吸收。枯草芽孢杆菌内生芽孢的特性,可以保证其在饲料生产和畜禽内环境条件下的功能稳定性以及作为疫苗表达载体的独特优势。因此,枯草芽孢杆菌在畜禽生产中具有十分广阔的应用前景。作者综述了枯草芽孢杆菌的生物学特性、生理功能及其在畜禽生产中的应用,以期为枯草芽孢杆菌在畜禽生产中的应用提供一定的参考。

关键词：枯草芽孢杆菌肠道菌群发酵菌种疫苗表达载体

社会科学本土化的前提与建构——基于社会事实“四因说”的分析

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三峡大学学报（人文社会科学版） 2024年第1期46卷 11-18,115页

作者：李钧鹏杨太文华中师范大学社会学院湖北武汉430079 湖北省社会发展与社会政策研究中心湖北武汉430079

对社会科学本土化的既有探讨往往存在价值预设。虽然不乏客观公正的论述和分析,但普遍的问题是分析框架不完整或太偏重结论的梳理。如果将社会科学本土化视为一种文化传播与融合的过程,一方面可以借助“四因说”建构分析本土化的框架,... 详细信息

对社会科学本土化的既有探讨往往存在价值预设。虽然不乏客观公正的论述和分析,但普遍的问题是分析框架不完整或太偏重结论的梳理。如果将社会科学本土化视为一种文化传播与融合的过程,一方面可以借助“四因说”建构分析本土化的框架,另一方面可从既往的结论分析转向前提分析。首先,把“要不要本土化”的价值命题搁置,而仅探讨“本土化成为可能的前提”这一事实命题;其次,通过引入“四因说”为坐标系,从异质性质料的对接、形式结合的方式、理论主张的目的和本土化过程的动力与阻力四个方面梳理本土化主张。

关键词：本土化四因说社会科学社会事实