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应激与生命意义感的曲线关系:基于意义建构视角

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中国临床心理学杂志 2024年第3期32卷 645-649,638页

作者：阳光耀陈一笛北京林业大学人文社会科学学院心理学系北京100083

目的:考察应激与生命意义感的曲线关系,并从意义建构视角解释其内在机制。方法:选取青少年生活事件量表(T1)、意义建构量表(T1)和生命意义感量表(T2),对236名大学生(男性99人,女性137人)进行间隔1个月的半纵向调查。结果:(1)应激量平方... 详细信息

目的:考察应激与生命意义感的曲线关系,并从意义建构视角解释其内在机制。方法:选取青少年生活事件量表(T1)、意义建构量表(T1)和生命意义感量表(T2),对236名大学生(男性99人,女性137人)进行间隔1个月的半纵向调查。结果:(1)应激量平方项与意义建构、寻求意义感及拥有意义感均显著负相关,意义建构与寻求意义感及拥有意义感均显著正相关。(2)中介效应分析显示,控制应激量一次项时,意义建构在应激量平方项与寻求意义感及拥有意义感之间均起显著中介作用。结论:应激与意义建构、寻求意义感、拥有意义感呈倒“U”形关系,意义建构在应激平方项与寻求意义感和拥有意义感之间发挥中介作用。相对于经历过高或过低累积应激的个体,经历了中等程度应激的个体通过高意义建构策略提升生命意义感。

关键词：应激生命意义感意义建构曲线关系

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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

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Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie yang Wanrong Jiang Xinyuan Zhang Zhaohui yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui Chen Xingyue Xiao Xiayin yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

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异枝竹属的名实问题

植物分类学报 2001年第1期39卷 65-67页

作者：杨光耀赵奇僧江西农业大学林学院南昌330045 南京林业大学南京210037

将异枝竹属MetasasaW .T .Lin作为酸竹属AcidosasaC .D .ChuetC .S .ChaoexKengf.的异名处理。异枝竹MetasasacarinataW .T .Lin和白环异枝竹Metasasaalbo farinosaW .T .Lin作为新组合名Aci dosasananunica (McCl.)C .S .ChaoetG .Y .Y... 详细信息

关键词：异枝竹属酸竹属异名禾本科

Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone

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Cell Research 2004年第4期14卷 315-323页

作者： Li yang, Jin Bo yang, Jia CHEN, guang yao YU, Pei ZHOU, Lei LEI, Zhen Zhen WANG, Catherine CY CHANG, XinYing yang, Ta Yuan CHANG, Bo Liang LI State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 320 Yueyang Road Shanghai 200031, China. Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03756 USA. State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 Chi

In macrophages, the accumulation of cholesteryl esters synthesized by the activated acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) results in the foam cell formation, a hallmark of early atherosclerotic lesions. In this study, with the treatment of a glucocorticoid hormone dexamethasone (Dex), lipid staining results clearly showed the large accumulation of lipid droplets containing cholesteryl esters in THP-1-derived macrophages exposed to lower concentration of the oxidized low-density lipoprotein (ox-LDL). More notably, when treated together with specific anti-ACAT inhibitors, the abundant cholesteryl ester accumulation was markedly diminished in THP-1-derived macrophages, confirming that ACAT is the key enzyme responsible for intracellular cholesteryl ester synthesis. RT-PCR and Western blot results indicated that Dex caused up-regulation of human ACAT1 expression at both the mRNA and protein levels in THP-1 and THP-1-derived macrophages. The luciferase activity assay demonstrated that Dex coul

关键词： ACAT dexamethasone macrophage cholesteryl ester gene promoter.

Bilevel Optimal Scheduling of Island Integrated Energy System Considering Multifactor Pricing

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Energy Engineering 2025年第1期122卷 349-378页

作者： Xin Zhang Mingming yao Daiwen He Jihong Zhang Peihong yang Xiaoming Zhang School of Automation and Electrical Engineering Inner Mongolia University of Science and TechnologyBaotou014010China

In this paper,a bilevel optimization model of an integrated energy operator(IEO)–load aggregator(LA)is constructed to address the coordinate optimization challenge of multiple stakeholder island integrated energy system(IIES).The upper level represents the integrated energy operator,and the lower level is the electricity-heatgas load *** to the benefit conflict between the upper and lower levels of the IIES,a dynamic pricing mechanism for coordinating the interests of the upper and lower levels is proposed,combined with factors such as the carbon emissions of the IIES,as well as the lower load interruption *** price of selling energy can be dynamically adjusted to the lower LA in the mechanism,according to the information on carbon emissions and load interruption *** benefits and win-win situations are achieved between the upper and lower ***,CPLEX is used to iteratively solve the bilevel optimization *** optimal solution is selected according to the joint optimal discrimination *** results indicate that the sourceload coordinate operation can reduce the upper and lower operation *** the proposed pricingmechanism,the carbon emissions and load interruption power of IEO-LA are reduced by 9.78%and 70.19%,respectively,and the capture power of the carbon capture equipment is improved by 36.24%.The validity of the proposed model and method is verified.

关键词： Bilevel optimal scheduling load aggregator integrated energy operator carbon emission dynamic pricing mechanism

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毛竹光合动态研究

林业科学研究 2005年第5期18卷 551-555页

作者：施建敏郭起荣杨光耀江西农业大学江西省竹子种质资源与利用重点实验室江西南昌330045

采用L i-6400测定毛竹光合作用在不同时间尺度上的动态变化,同时对毛竹叶绿素含量的年动态进行了研究。结果表明:毛竹夏、秋季的光合日变化为双峰曲线,冬、春季的光合日变化为单峰曲线,气孔部分关闭是引起毛竹夏、秋季光合“午睡”现象... 详细信息

采用L i-6400测定毛竹光合作用在不同时间尺度上的动态变化,同时对毛竹叶绿素含量的年动态进行了研究。结果表明:毛竹夏、秋季的光合日变化为双峰曲线,冬、春季的光合日变化为单峰曲线,气孔部分关闭是引起毛竹夏、秋季光合“午睡”现象的主要原因;毛竹光合年动态变化为三峰曲线,峰值分别在3月、6月和8月出现,年均值为6.03μmol.m-2.s-1;毛竹叶绿素含量年动态变化为双峰曲线,峰值分别在2月和10月出现,年均值为2.18mg.g-1。通过综合比较本文和其他毛竹光合作用的测定结果,认为气候条件和研究方法的不一致很可能是导致众多研究结果存在差异的主要原因。

关键词：毛竹生理生态光合作用叶绿素含量动态变化

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毛竹蒸腾动态研究

林业科学研究 2007年第1期20卷 101-104页

作者：施建敏郭起荣杨光耀江西农业大学江西省竹子种质资源与利用重点实验室江西南昌330045

采用L i-6400测定毛竹蒸腾作用在不同时间尺度上的动态变化,结果表明:毛竹夏、秋季的蒸腾日变化为双峰曲线,冬、春季的蒸腾日变化为单峰曲线;毛竹蒸腾年动态变化为单峰曲线,1月份最低,仅为0.29 mmol.m-2.s-1;8月份最高,达3.90 mmol.m-2.... 详细信息

采用L i-6400测定毛竹蒸腾作用在不同时间尺度上的动态变化,结果表明:毛竹夏、秋季的蒸腾日变化为双峰曲线,冬、春季的蒸腾日变化为单峰曲线;毛竹蒸腾年动态变化为单峰曲线,1月份最低,仅为0.29 mmol.m-2.s-1;8月份最高,达3.90 mmol.m-2.s-1;年均值为1.46 mmol.m-2.s-1。与毛竹光合动态相比,不同季节毛竹的蒸腾作用与光合作用日变化一致,年变化则略有不同,光合年动态变化为三峰曲线,而蒸腾作用年动态变化为单峰曲线。

关键词：毛竹生理生态蒸腾作用动态变化

Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu Ning Zhang Dongyu Wei Guoqing yang Lilingxuan yao Xinyue Xu yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness