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Potential efficacy and mechanism of eight mild-natured and bitterflavored TCMs based on gut microbiota:A review

Chinese Herbal Medicines 2024年第1期16卷 42-55页

作者： Wenquan Su Yanan yang Xiaohui Zhao Jiale Cheng Yuan Li Shengxian Wu Chongming Wu Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine Tianjin 301617China

The mild-natured and bitter-flavored traditional Chinese medicines(MB-TCMs)are an important class of TCMs that have been widely used in clinical practice and recognized as safe long-term treatments for chronic ***,as an important class of TCMs,the panorama of pharmacological effects and the mechanisms of MB-TCMs have not been systemically *** studies have shown that gut microbiota can mediate the therapeutic activity of TCMs and help to elucidate the core principles of TCM medicinal *** this systematic review,we found that MB-TCMs commonly participated in the modulation of metabolic syndrome,intestinal inflammation,nervous system disease and cardiovascular system disease in association with promoting the growth of beneficial bacteria Bacteroides,Akkermansia,Lactobacillus,Bifidobacterium,Roseburia as well as inhibiting the proliferation of harmful bacteria Helicobacter,Enterococcus,Desulfovibrio and *** alterations,correspondingly,enhance the generation of protective metabolites,mainly including short-chain fatty acids(SCFAs),bile acid(BAs),5-hydroxytryptamine(5-HT),indole and gamma-aminobutyric acid(GABA),and inhibit the generation of harmful metabolites,such as proinflammatory factors trimethylamine oxide(TAMO)and lipopolysaccharide(LPS),to further exert multiplicative effects for the maintenance of human health through several different signaling ***,this present review has attempted to comprehensively summarize the relationship between MB-TCMs and gut microbiota by establishing the TCMs-gut microbiota-metabolite-signaling pathway-diseases axis,which may provide new insight into the study of TCM medicinal theories and their clinical applications.

关键词： bile acid gamma-aminobutyric acid 5-hydroxytryptamine mild-natured and bitter-flavored traditional Chinese medicines property theory short-chain fatty acids traditional Chinese medicine trimethylamine oxide

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Targeting LTA4H facilitates the reshaping of the immune microenvironment mediated by CCL5 and sensitizes ovarian cancer to Cisplatin

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Science China(Life Sciences) 2024年第6期67卷 1226-1241页

作者： Zhengyang Guo Jiaqi Huang Xiao Huo Chen Huang Xiaotong Yu Yan Sun Yanfang Li Tianhui He Hongyan Guo Jianling yang Lixiang Xue Cancer Center of Peking University Third Hospital Beijing 100191China Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Peking University Third Hospital Cancer Center Department of Radiation OncologyPeking University Third HospitalBeijing 100191China Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Ovarian cancer is the most lethal and aggressive gynecological cancer with a high recurrence rate and is often diagnosed *** ovarian cancer,multiple metabolic enzymes of lipid metabolism are abnormally expressed,resulting in metabolism *** a characteristic pathway in polyunsaturated fatty acid(PUFA)metabolism,arachidonic acid(AA)metabolism is disturbed in ovarian ***,we established a 10-gene signature model to evaluate the prognostic risk of PUFA-related *** 10-gene signature has strong robustness and can play a stable predictive role in datasets of various platforms(TCGA,ICGC,and GSE17260).The high association between the risk subgroups and clinical characteristics indicated a good performance of the *** data further indicated that the high expression of LTA4H was positively correlated with poor prognosis in ovarian *** of LTA4H enhanced sensitivity to Cisplatin and modified the characteristics of immune cell infiltration in ovarian ***,our results indicate that CCL5 was involved in the aberrant metabolism of the AA/LTA4H axis,which contributes to the reduction of tumor-infiltrating CD8+T cells and immune escape in ovarian *** findings provide new insights into the prognosis and potential target of LTA4H/CCL5 in treating ovarian cancer.

关键词： ovarian cancer polyunsaturated fatty acids prognostic risk model LTA4H tumor immunity CCL5

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弱电网下基于电网电压前馈的并网逆变器阻抗重塑控制策略

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电工技术学报 2024年第8期39卷 2553-2566页

作者：杨明杨倬李玉龙朱军河南理工大学电气工程与自动化学院河南省煤矿装备智能检测与控制重点实验室焦作454003

弱电网下,锁相环在基波以上频段引入的负阻特性,会降低系统输出阻抗的相位,严重影响系统稳定性。鉴于此,该文通过系统控制框图等效变换,推导得到可以消除锁相环负阻特性的电网电压前馈函数,进而提出一种基于电网电压前馈控制的并网逆变... 详细信息

弱电网下,锁相环在基波以上频段引入的负阻特性,会降低系统输出阻抗的相位,严重影响系统稳定性。鉴于此,该文通过系统控制框图等效变换,推导得到可以消除锁相环负阻特性的电网电压前馈函数,进而提出一种基于电网电压前馈控制的并网逆变器阻抗重塑控制策略。同时,为了提高该策略的普适性,该文利用函数近似和多目标约束为电网电压前馈函数的优化提供两种设计方法,并从系统基波电流跟踪性能、并网功率因数等方面进行误差分析,从而证明其函数优化设计方法的可行性。理论分析表明,优化后的电网电压前馈控制策略,可以有效地对系统输出阻抗相位特性进行重塑,很大程度上拓宽了系统对电网阻抗的适应范围。最后,通过仿真与实验验证所提控制策略的有效性。

关键词：弱电网并网逆变器阻抗重塑锁相环稳定性

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Interface optimization of graphene paper-Cu composite prepared by electrodeposition

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Journal of Iron and Steel Research International 2024年第1期31卷 64-73页

作者： Jing Guo Hai-jing Wang Shuang-juan Liu Peng Zhang Jing-yu Tang Wei-yang Zhang Han-jie Guo Peng-cheng Wang Cai Meng School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China Advanced Technology and Materials Co. Ltd.Beijing100083China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei230027AnhuiChina

A room-temperature electrodeposition method with an organic electrolyte was developed to fabricate a HNO3-pretreated graphene paper Cu(GP'-Cu)*** improve the interfacial bonding of GP'-Cu composite,magnetron sputtering technology was used to create a"sandwich"structural gradient GP'-Cu *** selection of the intermediate transition layer metal was based on two-dimensional *** electron microscopy,X-ray photoelectron spectroscopy,and other analytical methods confirmed that the addition of an intermediate transition metal(Cr,Ni)layer reduced the gap distance and enhanced the interfacial bonding of the GP'and Cu deposited *** GP'-Ni-Cu composite exhibited the largest increase in tensile strength and *** addition,it had the highest thermal diffusivity and elongation at break among the GP'-Cu,GP'-Cr-Cu and GP'-Ni-Cu composites.

关键词： Graphene paper Two-dimensional disregistry Magnetron sputtering Metal composite

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考虑需求响应的交直流混合配电网分布式光伏承载能力鲁棒评估方法

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高电压技术 2024年第1期50卷 83-92,I0003-I0005页

作者：杨志淳杨帆闵怀东胡伟雷杨刘瑜国网湖北省电力有限公司电力科学研究院武汉430077 湖北方源东力电力科学研究有限公司武汉430077

鲁棒优化通常采用多面体模型来描述分布式光伏出力的不确定性,却忽略了分布式光伏出力的时空相关性,为此,该文建立了分布式光伏的时空相关性多面体模型,提出了考虑需求侧响应的交直流混合配电网分布式光伏承载能力鲁棒评估方法。首先,... 详细信息

鲁棒优化通常采用多面体模型来描述分布式光伏出力的不确定性,却忽略了分布式光伏出力的时空相关性,为此,该文建立了分布式光伏的时空相关性多面体模型,提出了考虑需求侧响应的交直流混合配电网分布式光伏承载能力鲁棒评估方法。首先,建立分布式光伏出力不确定性的时空相关性多面体模型和电价激励型需求侧响应模型,以最大化分布式光伏并网容量为目标,考虑交直流混合配电网中多种运行约束和调节策略,建立交直流混合配电网分布式光伏承载能力两阶段鲁棒评估模型,并采用列与约束生成算法进行迭代求解。在70节点系统上验证了算法的有效性,仿真结果表明:不同的管理策略有助于提升交直流混合配电网的分布式光伏承载能力。

关键词：承载能力交直流混合配电网需求侧响应混合整数二阶锥规划两阶段鲁棒优化

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Study on myocardial infarction based on nationwide inpatient sample database:a bibliometric analysis from 2000 to 2022

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Emergency and Critical Care Medicine 2024年第1期4卷 22-27页

作者： Tianyi Zhang Xue yang Qian Zhuang Yuhua Liu Huajuan Bai Jianchao Liu Zhouheng Ye Institution of Hospital Management Department of Medical Innovation and ResearchChinese PLA General HospitalBeijingChina Outpatient Department The Second Medical Center and National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijingChina Department of Special Operations Medicine The Sixth Medical CenterChinese PLA General HospitalBeijingChina.

Background:Studies on myocardial infarction(MI)based on large medical databases have become popular in recent *** influence of the National Inpatient Sample(NIS),the largest collection of administrative healthcare data across the United States,on the field of MI has not been well *** study aimed to quantify the contribution of NIS to MI research using bibliometric ***:We searched the Web of Science Core Collection database to identify publications on MI using NIS from 2000 to *** indicators,such as the number of publications,citations,and Hirsch index(H-index),were summarized by years,authors,organizations,and *** and CiteSpace software were used to analyze the keywords and trends of the hot ***:A total of 342 articles on MI based on NIS were included.A significant growth in outputs related to MI using the NIS from 2000 to 2020 was *** publications were mainly from the United *** Mayo Clinic was the most prolific institution and had the most citations and the highest *** American Journal of Cardiology ranked first among journals with the highest number of publications,citations,and *** and healthcare management are the main focuses of this *** risks and care are receiving increased ***:This study suggests that NIS significantly contributes to high-quality output in MI *** efforts are needed to improve the impact of knowledge gained from the NIS on MI.

关键词： Administrative healthcare database Bibliometrics Big data Myocardial infarction National Inpatient Sample

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复合式高速无人直升机飞行力学建模及操纵策略研究

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系统工程与电子技术 2024年第7期46卷 2481-2489页

作者：杨洋黄维宁杨永文徐亮李华松沈阳飞机设计研究所扬州协同创新研究院江苏扬州225000 沈阳飞机设计研究所辽宁沈阳110000

双螺旋桨复合式高速无人直升机同时具备了直升机和固定翼飞机的优势,是目前高速飞行器的研究热门之一。针对双螺旋桨复合式高速无人直升机进行了飞行力学相关分析和操纵策略研究。首先,以干扰因子的方式构建旋翼对机翼的气动干扰模型,... 详细信息

双螺旋桨复合式高速无人直升机同时具备了直升机和固定翼飞机的优势,是目前高速飞行器的研究热门之一。针对双螺旋桨复合式高速无人直升机进行了飞行力学相关分析和操纵策略研究。首先,以干扰因子的方式构建旋翼对机翼的气动干扰模型,机身模型采用风洞实验数据,然后,建立该直升机的非线性飞行动力学模型。针对操纵冗余问题,提出一种操纵策略,以权重系数来分配操纵通道,通过添加平均螺距杆纵向通道,由螺旋桨平均螺距控制前飞速度。在此基础上进行配平,实现了各个杆操纵量在3个模式间的光滑过渡,从而验证了操纵策略的合理性。

关键词：双螺旋桨复合式高速无人直升机操纵冗余飞行动力学模型操纵策略

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High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance

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Journal of Integrative Agriculture 2024年第1期23卷 155-165页

作者： Jia Fu Jie Fan Chenxi Zhang Yongyao Fu Baohang Xian Qiyuan Yu Xin Huang Wen yang Shanchun Chen Yongrui He Qiang Li Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China School of Advanced Agriculture and Bioengineering Yangtze Normal UniversityChongqing 408100China National Citrus Engineering Research Center Chongqing 400712China

One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri ***(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory *** detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were *** the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this *** TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis *** mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional *** CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via *** high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance *** addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties.

关键词： citrus bacterial canker(CBC) high-throughput screening system transcription factor(TF) yeast-one hybrid(Y1H) CsPrx25

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Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients:insight from the ANGEL-ACT registry

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Stroke & Vascular Neurology 2024年第3期9卷 289-294,I0248-I0250页

作者： Dapeng Sun Xinguang yang Xiaochuan Huo Raynald- Baixue Jia Xu Tong Anxin Wang Ning Ma Feng Gao Dapeng Mo Zhongrong Miao Interventional Neuroradiology Department of NeurologyBeijing Tiantan HospitalCaptial Medical UniversityBeijingChina Department of Neurology Sun Yat-Sen Memorial HospitalGuangzhouGuangdongChina Cerebrovascular Disease Department Neurological Disease CenterBeijing Anzhen HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy(EVT)for acute vertebrobasilar artery occlusion(VBAO).Methods Participants of the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischaemic Stroke(ANGEL-ACT)registry were selected for the *** recanalisation was defined as patients did not achieve a 90-day good outcome(modified Rankin Scale≤3)despite successful recanalisation(modified Treatment in Cerebral Ischaemia Scale≥2b)after the *** logistic regression analysis was conducted to find independent predictors of futile recanalisation in VBAO patients undergoing *** Three hundred and fifteen patients with VBAO who achieved successful recanalisation after EVT were included in current analysis,of whom,155(49.2%)suffered futile recanalisation,and 160 achieved effective *** the multivariable analysis,we found admission National Institutes of Health Stroke Scale(NIHSS)≥19(OR 4.81,95%CI 2.76 to 8.39,p<0.001),platelet-lymphocyte ratio(PLR)≥162.2(OR 1.93,95%CI 1.14 to 3.27,p=0.001),onset-to-puncture time(OTP)≥334min(OR 2.15,95%CI 1.25 to 3.68,p=0.005)and use of general anesthesia(GA)(OR 1.87,95%CI 1.09 to 3.22,p=0.024)were associated with futile *** Futile recanalisation after EVT occurred 49.2%of VBAO patients in the ANGEL-ACT ***≥19,PLR≥162.2,OTP≥334min and use of GA were independent predictors of futile recanalisation.

关键词： patients anesthesia occlusion

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双碳结构增强硅橡胶智能复合材料的力电响应

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复合材料学报 2024年第4期41卷 1852-1861页

作者：万帮伟杨洋赵艳芳昆明理工大学、建筑工程学院昆明650500 云南省土木工程防灾重点实验室昆明650500

可拉伸应变传感器在减隔震领域具有广阔的应用前景,然而,研发低成本和高稳定性可拉伸应变传感器仍然是一个巨大挑战。本文采用开炼法制备出多壁碳纳米管(MWCNT)-导电炭黑(CB)/甲基乙烯基硅橡胶(VMQ)导电纳米复合材料。研究MWCNT与CB之... 详细信息

可拉伸应变传感器在减隔震领域具有广阔的应用前景,然而,研发低成本和高稳定性可拉伸应变传感器仍然是一个巨大挑战。本文采用开炼法制备出多壁碳纳米管(MWCNT)-导电炭黑(CB)/甲基乙烯基硅橡胶(VMQ)导电纳米复合材料。研究MWCNT与CB之间的协同效应对复合材料分散性能、导电性能、力学性能及电阻-应变响应性能影响。结果表明:添加CB后复合材料力学性能提升,具有较低的渗流阈值(1.24wt%),5000次循环加载-卸载过程中表现出优异的电阻-应变响应稳定性。此外,MWCNT-CB/VMQ复合材料相比于MWCNT/VMQ、CB/VMQ复合材料在电阻-应变响应性能中没有出现肩峰现象,同时解释了肩峰现象机制。通过SEM发现复合材料中MWCNT和CB均匀分布及形成的协同效应是低阈值和稳定电阻-应变响应性能的重要原因。通过隧道效应理论模型解释了电阻-应变响应机制。该复合材料对减隔震结构应变监测具有巨大潜力。

关键词：多壁碳纳米管炭黑硅橡胶电阻-应变响应结构健康监测智能传感材料

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