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Nano Research 2024年第3期17卷 1837-1855页

作者： Jialin Wang Kai Zhao changqing Ye Yanlin Song School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190China

The booming development of wearable devices has aroused increasing interests in flexible and stretchable *** mechanosensory functionality,these devices are highly desirable on account of their wide range of applications in electronic skin,personal healthcare,human–machine interfaces and ***,they are mostly limited by single electrical signal feedback,restricting their diverse applications in visualized mechanical *** by the mechanochromism of structural color materials,interactively stretchable electronics with optical and electrical dual-signal feedbacks are recently emerged as novel sensory platforms,by combining both of their sensing mechanisms and ***,recent studies on interactively stretchable electronics based on structural color materials are *** a brief introduction of their basic components(i.e.,stretchable electronics and mechanochromic structural color materials),two types of interactively stretchable electronics with respect to the nanostructures of mechanochromic materials are outlined,focusing primarily on their design considerations and fabrication ***,the main challenges and future perspectives of these emerging devices are discussed.

关键词： stretchable electronics structural color materials interactive sensing mechanochromism dual-signal feedbacks

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肝硬化与继发性骨质疏松症

中华肝脏病杂志 2021年第3期29卷 204-208页

作者：杨丽杨长青同济大学附属同济医院消化内科同济大学消化疾病研究所上海200065

骨质疏松症是一种由成骨细胞和破骨细胞活性失衡引发的骨量减少的疾病,是肝硬化、胆汁淤积性肝病、肝移植患者常见的并发症。过去几十年里关于免疫细胞激活、慢性炎症、肠道微生物等许多研究进展提高了对肝硬化继发性骨质疏松症的认识... 详细信息

骨质疏松症是一种由成骨细胞和破骨细胞活性失衡引发的骨量减少的疾病,是肝硬化、胆汁淤积性肝病、肝移植患者常见的并发症。过去几十年里关于免疫细胞激活、慢性炎症、肠道微生物等许多研究进展提高了对肝硬化继发性骨质疏松症的认识。现对肝硬化继发性骨质疏松症的流行病学、发病机制及诊治进展进行综述。

关键词：肝硬化继发性骨质疏松症骨密度慢性炎症肠道菌群

Recent advances in photoelectrochemistry-coupled dual-modal biosensors:From constructions to biosensing applications

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Nano Research 2024年第6期17卷 5512-5528页

作者： Yuxiang Dong Weisa Wang changqing Ye Yanlin Song School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190Chin

Precise and sensitive bioanalysis has been the major and urgent pursuit in pathologic diagnosis,food safety,environment monitoring,and drug ***(PEC)bioanalysis,as one of the most promising detection technologies,has rapidly expanded within the field of ***,most of reported PEC analysis approaches still suffer from weak external anti-interference ability,high background,and the risk of false positive or negative errors due to their inherent single-signal *** overcome these shortcomings,new PEC-coupled dual-modal analysis approaches have been developed,where a dual-response signal can be derived through two completely different mechanisms and independent signal transduction *** review introduces the basic principles of PEC biosensing and enumerates and classifies the substrate or probe selections,constructions,and applications of PEC-coupled dual-modal ***,the challenges and developmental prospects of PEC-coupled dual-mode sensing technologies are evaluated and *** hope that this review will provide valuable insights into the latest advancements and practical applications of dual-mode PEC bioanalysis,which will be of great interest to those seeking to stay informed in this field.

关键词： photoelectrochemistry biosensor electrochemistry colorimetry electrochemiluminescence fluorescence dual-mode detection

Acupotomy alleviates knee osteoarthritis in rabbit by regulating chondrocyte mitophagy via Pink1-Parkin pathway

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Journal of Traditional Chinese Medicine 2024年第3期44卷 468-477页

作者： ZHU Wenting GUO changqing DU Mei MA Yunxuan CUI Yongqi CHEN Xilin GUO changqing the Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100029China School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Department of Medical Technology Shijiazhuang Medical CollegeHebei 050599China

OBJECTIVE:To investigate the effect of acupotomy,on mitophagy and the Pink1-Parkin pathway in chondrocytes from rabbits with knee osteoarthritis(KOA).METHODS:A KOA model was established via the modified Videman *** were randomly divided into a control group(CON),KOA group and KOA+acupotomy group(Acu).Rabbits in the acupotomy group were subjected to acupotomy for 4 weeks after model *** behavior of the rabbits before and after intervention was *** degeneration was evaluated by optical microscopy and fluorescence *** level of mitophagy was evaluated by transmission electron microscopy,immunofluorescence and enzyme-linked immunosorbent assay(ELISA).The expression of phosphatase and tensin homolog(PTEN)-induced kinase 1(Pink1)-Parkin mitophagy pathway components was evaluated by immunofluorescence,Western blotting and real-time polymerase chain ***:In rabbits with KOA,joint pain,mobility disorders and cartilage degeneration were observed,the Mankin score was increased,collagen typeⅡ(Col-Ⅱ)expression was significantly decreased,mitophagy was inhibited,mitochondrial function was impaired,and factors associated with the Pink1-Parkin pathway were *** regulated the expression of Pink1-Parkin pathway-related proteins,the mitophagy-related protein microtubule-associated protein-1 light chain-3,the translocase of the outer membrane,and the inner mitochondrial membrane 23;increased the colocalization of mitochondria and autophagosomes;promoted the removal of damaged mitochondria;restored mitochondrial adenosine-triphosphate(ATP)production;and alleviated cartilage degeneration in rabbits with ***:Acupotomy played a role in alleviating KOA in rabbits by activating mitophagy in chondrocytes via the regulation of proteins that are related to the Pink1-Parkin pathway.

关键词： acupuncture therapy osteoarthritis knee mitophagy PTEN phosphohydrolase cartilage

Straw return influences the structure and functioning of arbuscular mycorrhizal fungal community in a rice-wheat rotation system

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Pedosphere 2024年第2期34卷 339-350页

作者： Silong ZHAI Junjie XIE Zongyi TONG Bing yang Weiping CHEN Roger TKOIDE Yali MENG Xiaomin HUANG Atta Mohi Ud DIN changqing CHEN Haishui yang College of Agriculture Nanjing Agricultural UniversityNanjing 210095China Department of Biology Brigham Young UniversityProvo UT 84602USA Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology Agricultural College of Yangzhou UniversityYangzhou 225009China National Research Center of Intercropping The Islamia University of BahawalpurBahawalpur 63100Pakistan Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural UniversityNanjing 210095China

Straw return is a sustainable soil fertility-building practice,which can affect soil microbial ***,how straw return affects arbuscular mycorrhizal fungi(AMF)is not well ***,we studied the impacts of different straw management treatments over eight years on the structure and functioning of AMF communities in a rice-wheat rotation *** straw management treatments included no tillage with no straw(NTNS),rotary tillage straw return(RTSR),and ditch-buried straw return(DBSR).The community structure of AMF was characterized using high-throughput sequencing,and the mycorrhizal functioning was quantified using an in situ mycorrhizal-suppression *** straw management treatments formed unique AMF community structure,which was closely related to changes in soil total organic carbon,available phosphorus,total nitrogen,ammonium,and *** compared with NTNS,RTSR significantly increased Shannon diversity in 0–10 cm soil layer,while DBSR increased it in 10–20 cm soil layer;DBSR significantly increased hyphal length density in the whole ploughing layer(0–20 cm),but RTSR only increased it in the subsurface soil layer(10–20 cm).The mycorrhizal responses of shoot biomass and nutrient(N and P)uptake were positive under both straw return treatments(RTSR and DBSR),but negative under *** community composition of AMF was significantly correlated to hyphal length density,and the latter was further a positive predictor for the mycorrhizal responses of plant growth and nutrient *** findings suggest that straw return can affect AMF community structure and functioning,and farmers should manage mycorrhizas to strengthen their beneficial effects on crop production.

关键词： community structure hyphal length density shoot biomass shoot N uptake shoot P uptake soil physicochemical properties straw management tillage

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融合K均值聚类和低秩约束的属性选择算法

中文信息学报 2018年第7期32卷 91-98页

作者：杨常清西安航空学院材料工程学院陕西西安710077

针对无监督属性选择算法无类别信息和未考虑属性低秩等问题,该文提出了一种融合K均值聚类和低秩约束的属性选择算法。算法在线性回归的模型框架中有效地嵌入自表达方法,同时利用K均值聚类产生伪类标签最大化类间距以更好地稀疏结构,并使... 详细信息

针对无监督属性选择算法无类别信息和未考虑属性低秩等问题,该文提出了一种融合K均值聚类和低秩约束的属性选择算法。算法在线性回归的模型框架中有效地嵌入自表达方法,同时利用K均值聚类产生伪类标签最大化类间距以更好地稀疏结构,并使用l2,p-范数代替传统的l2,1-范数,通过参数p来灵活调节结果的稀疏性,最后证明了该文算法具有执行线性判别分析的特点和收敛性。经实验验证,该文提出的属性算法与NFS算法、LDA算法、RFS算法、RSR算法相比分类准确率平均提高了17.04%、13.95%、3.6%和9.39%,分类准确率方差也是最小的,分类结果稳定。

关键词：属性选择自表达方法 K均值聚类低秩约束稀疏学习

中国海域沉积盆地咸水层二氧化碳地质封存潜力

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海洋地质与第四纪地质 2024年第3期44卷 98-114页

作者：陈建文王嘹亮王平康袁勇曹珂付玉通陆东宇杨长清李慧君王建强张银国龚建明孙晶赵化淋中国地质调查局青岛海洋地质研究所青岛266237 青岛海洋科技中心海洋矿产资源评价与探测技术功能实验室青岛266237 青岛市海洋地质碳封存工程研究中心青岛266237 青岛市海洋地质碳封存重点实验室青岛266237 中国地质调查局广州海洋地质调查局广州511458 中国地质调查局基础调查部北京100037

二氧化碳地质封存是二氧化碳捕集利用封存(CCUS)技术的关键环节,海域二氧化碳地质封存是将工业碳排放源或油气开发过程中捕集的二氧化碳,以超临界态注入到海底咸水层、废弃或开发中油气藏等地质体中,实现与大气长期隔离的过程。因远离... 详细信息

二氧化碳地质封存是二氧化碳捕集利用封存(CCUS)技术的关键环节,海域二氧化碳地质封存是将工业碳排放源或油气开发过程中捕集的二氧化碳,以超临界态注入到海底咸水层、废弃或开发中油气藏等地质体中,实现与大气长期隔离的过程。因远离人类居住地且有海水覆盖、具有“安全性高、环境风险小”特点,海域二氧化碳地质封存受到欧美等国家和地区的高度重视。本文在分析我国海域沉积盆地基本地质条件基础上,采用创新的模型体积法评价了我国海域沉积盆地咸水层二氧化碳地质封存潜力。研究表明,我国海域沉积盆地新生界厚度大,地壳稳定性较好,具有中低地温场特征,发育多套储碳-封盖组合,构造地层圈闭多,二氧化碳地质封存条件优越、咸水层封存潜力巨大。这将为我国海洋地质碳封存区带评价和目标区优选提供依据,对我国沿海省市碳达峰碳中和路径规划和离岸碳封存示范工程预研究具有重要意义。

关键词：二氧化碳地质封存中国海域沉积盆地模型体积法咸水层封存潜力

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脂质组学在肝纤维化中的意义

中华肝脏病杂志 2021年第5期29卷 484-487页

作者：陈帅杨长青同济大学附属同济医院消化科上海200065

多种病因引起的慢性肝脏疾病都可导致肝纤维化形成,并可进一步发展至肝硬化,严重威胁人类生命健康。脂质组学作为新兴研究领域在近年来蓬勃发展,已经在肝纤维化研究领域展现出巨大的潜力。现介绍脂质组学技术,以及探讨脂质在肝纤维化中... 详细信息

多种病因引起的慢性肝脏疾病都可导致肝纤维化形成,并可进一步发展至肝硬化,严重威胁人类生命健康。脂质组学作为新兴研究领域在近年来蓬勃发展,已经在肝纤维化研究领域展现出巨大的潜力。现介绍脂质组学技术,以及探讨脂质在肝纤维化中的致病机制、脂肪毒性生物学标志物和新兴治疗靶点的研究,并对未来肝纤维化领域的脂质组学发展提出展望。

关键词：脂质组学肝硬化诊断治疗

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高校教师队伍增长分析

太平洋学报 2005年第11期13卷 64-69页

作者：杨长青清华大学

高校教师队伍增长是由教师队伍外部交易收益和内部管理成本共同决定的。当教师队伍增长的内部管理成本超出外部交易收益的时候,增长难以为继,达到极限。高校教师队伍增长的路径一方面是“原版复制型”的做大模式。一方面则是“深入成长... 详细信息

高校教师队伍增长是由教师队伍外部交易收益和内部管理成本共同决定的。当教师队伍增长的内部管理成本超出外部交易收益的时候,增长难以为继,达到极限。高校教师队伍增长的路径一方面是“原版复制型”的做大模式。一方面则是“深入成长型”的做强模式。我国高校与政府的目标函数的高吻合性,导致教师队伍增长模式转变的困难。随着政府与高校关系的不断清晰化、大学治理结构的不断完善、自主运营能力的不断提高,才能有效实现高校教师队伍增长模式从原版复制型转变为深度成长型。

关键词：高校教师增长路径成本收益

Research Progress on MTHFR C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors

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Journal of Biosciences and Medicines 2023年第6期11卷 148-160页

作者： Yuwei Wang Lili Huo Zeyi Huang Xiaohui Shen Chenxue Jin changqing yang Department of Digestive Internal Medicine Heping Hospital Affiliated to Changzhi Medical College Changzhi China

Tumours of the digestive system include a number of malignant tumours such as oesophageal, gastric and colorectal cancers, which have the highest incidence and mortality rates in the world. Their occurrence is related to a variety of factors, such as diet, environment and genetics. As a key enzyme in the process of folate metabolism, MTHFR gene polymorphism plays an important role in the pathogenesis and development of gastrointestinal tumours. This paper provides a brief review of the relationship between MTHFR polymorphisms and digestive tumours, with a view to identifying the genetic effects of MTHFR, exploring the pathogenesis of digestive tract tumours and developing more effective prevention and treatment strategies.

关键词： MTHFR Polymorphism Esophageal Cancer Gastric Cancer Colorectal Cancer