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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu liu Michael Chopp Michael Millman yanfeng li Pasquale Cepparulo Amy Kemper Chao li li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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A Scheme for Dense Coding in the Non-Symmetric Quantum Channel

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Chinese Physics Letters 2004年第7期21卷 1195-1197页

作者： yanfeng-li WANGMei-Yu CollegeofPhysics HebeiNormalUniversityShijiazhuang050016

We investigate the dense coding in the case of non-symmetric Hilbert spaces of the sender and receiver's particles sharing the quantum maximally entangled state. The efficiency of gaining classical information is also considered. We conclude that when a more level particle is with the sender, she can obtain a non-symmetric quantum channel from a symmetric one by entanglement transfer. Thus the efficiency of information transmission is improved.

关键词： Quantum entanglement

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Bayesian estimation of a power law process with incomplete data

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Journal of Systems Engineering and Electronics 2021年第1期32卷 243-251页

作者： HU Junming HUANG Hongzhong li yanfeng School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Transportation and Automotive Engineering Xihua UniversityChengdu 610039China Center for System Reliability and Safety University of Electronic Science and Technology of ChinaChengdu 611731China

Due to the simplicity and flexibility of the power law process,it is widely used to model the failures of repairable *** statistical inference on the parameters of the power law process has been well developed,numerous studies largely depend on complete failure data.A few methods on incomplete data are reported to process such data,but they are limited to their specific cases,especially to that where missing data occur at the early stage of the *** framework to handle generic scenarios is *** overcome this problem,from the point of view of order statistics,the statistical inference of the power law process with incomplete data is established in this *** theoretical derivation is carried out and the case studies demonstrate and verify the proposed *** statistics offer an alternative to the statistical inference of the power law process with incomplete data as they can reformulate current studies on the left censored failure data and interval censored data in a unified *** results show that the proposed method has more flexibility and more applicability.

关键词： incomplete data power law process Bayesian inference order statistics repairable system

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Probabilistic Teleportation of One-Particle State of S-level

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Communications in Theoretical Physics 2003年第3X期40卷 273-278页

作者： yanfeng-li BAIYan-Kui CCAST(WorldLaboratory) P.O.Box8730Beijing100080China DepartmentofPhysics HebeiNormalUniversityShijiazhuang050016China

A scheme for probabilistically teleporting an unknown one-particle state of S-level by a group of pairs of partially entangled 2-level particle state is proposed. In this scheme unitary transformation and local measurement take the place of Bell state measurement, then proper unitary transformation and the measurement on an auxiliary qubit with the aid of classical communication are performed. In this way the unknown one-particle state of S-level can be transferred onto a group of remote 2-level particles with certain probability. Furthermore, the receiver can recover the initial signal state on an S-level particle at his hand.

关键词：直接傅里叶变换概率输运二阶粒子态量子输运量子态量子论局部测量

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Probabilistic Cloning and Quantum Computation

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Chinese Physics Letters 2004年第6期21卷 995-998页

作者： GAOTing yanfeng-li WANGZhi-Xi CollegeofMathematicsandInformationScience HebeiNormalUniversityShijiazhuang050016 CCAST(WorldLabora tory)POBox8730Beijing100080 DepartmentofMathematics CapitalNormalUniversityBeijing100037

We discuss the usefulness of quantum cloning and present examples of quantum computation tasks for which the cloning offers an advantage which cannot be matched by any approach that does not resort to quantum cloning. In these quantum computations, we need to distribute quantum information contained in the states about which we have some partial information. To perform quantum computations, we use a state-dependent probabilistic quantum cloning procedure to distribute quantum information in the middle of a quantum computation.

关键词： Quantum computers

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A Critical study on Fire-induced Aerodynamics of Balcony Spill Plumes

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Journal of Thermal Science 2008年第3期17卷 281-287页

作者： Junmei li yanfeng li Yun liu Suduo Xue The college of Architecture and Civil Engineering Beijing University of Technology Beijing 100124 China

Balcony spill plume is one of the main plume forms in an atrium fire, its thermal behavior which is important to the designers for the smoke control system design is still not well understood now. The fire-induced aerodynamics of balcony spill plume would be studied by the numerical method in this paper. Some uncertainties relating to the available calculation methods for the smoke production rate would be reexamined. Numerical results indicated that using an entrainment coefficient 0.11 would be better than 0.16 in describing the entrainment behavior, end effect should not be ignored for the plume being not two-dimensional （2-D）. Suitable empirical spill plume equations would be recommended for the smoke management system design.

关键词： balcony spill plume atrium fire numerical method smoke management

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Quantum Logic Network for Probabilistic Cloning Quantum States

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Communications in Theoretical Physics 2005年第1期43卷 73-78页

作者： GAOTing yanfeng-li WANGZhi-Xi DepartmentofMathematics CapitalNormalUniversityBeijing100037China／／CollegeofMathematicsandInformationScienceHebeiNormalUniversityShijiazhuang050016China／／CCAST（WorldLaboratory）P.O.Box8730Beijing100080China DepartmentofPhysics HebeiNormalUniversityShijiazhuang050016China／／CCAST（WorldLaboratory）P.O.Box8730Beijing100080China DepartmentofMathematics CapitalNormalUniversityBeijing100037China

We construct efficient quantum logic network for probabilistic cloning the quantum states used in imple mented tasks for which cloning provides some enhancement in performance.

关键词： quantum logic network probabilistic cloning quantum state

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Ultrasound Computed Tomography of Knee Joint

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Chinese Journal of Electronics 2020年第4期29卷 705-716页

作者： li Ruijing CHEN Houjin PENG Yahui li Jupeng li yanfeng School of Electronic and Information Engineering Beijing Jiaotong University

Ultrasound computed tomography(UCT)is considered to have great potential for the early diagnosis of knee joint *** prior knowledge and sound speeds of tissues, UCT can diagnose a variety of symptoms and the extent of tissue ***, no existing studies can reconstruct the sound speed distributions of knee joints in ***,in this study, sound speed distributions of knee joints are reconstructed to provide an imaging basis for the formulation of a treatment *** addition, Full waveform inversion(FWI) methods are utilized to estimate highresolution ***, for media with large variations in sound speeds, traditional FWI methods may lead to a cycle-skipping phenomenon and incorrect convergence ***, this study proposes a multi-centerfrequency source based FWI method to overcome the above limitations.A penalized least-squares optimization problem is constructed to obtain a numerical solution of the sound speed *** simulations are conducted to prove the effectiveness and robustness of the proposed ***, the reasons for selecting the center frequencies of sources are *** numerical knee joint phantoms are used to evaluate the *** results suggest that the biases of the reconstructed images are less than 1% under a 5% noise condition.

关键词： Sound speed Knee joint Image reconstruction Ultrasound computed tomography Full waveform inversion

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Sitting or Standing Data Acquisition Based Breast Ultrasound Computed Tomography

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Chinese Journal of Electronics 2021年第5期30卷 909-917页

作者： li Ruijing CHEN Houjin PENG Yahui li Jupeng li yanfeng School of Electronic and Information Engineering Beijing Jiaotong University

Ultrasound computed tomography(UCT)is a promising approach for early breast cancer ***, current studies which use prone posture to collect breast ultrasonic data cause four problems, a long non-data-acquisition time, inconvenient, possible chances for cross infection, and a large area occupied by *** purpose of this study is to estimate a complete breast UCT image by using sitting or standing data acquisition, which can obtains a more rapid, convenient and sanitary examination process, and a less space occupied by equipment. Therefore, this study proposes a sitting or standing data acquisition based breast UCT method, which is a more practical data acquisition method for breast UCT. This study places a uniform soft sleeve on the outside of the breast so that it would not be deformed significantly due to the change of body posture. Because the soft sleeve is an influencing factor from outside for breast imaging, this study discusses the considerations for selecting that. Computer simulations are conducted to prove the effectiveness of the proposed method. Results suggest that, by using a soft sleeve whose sound speed is between 1450 m/s and 1550 m/s, the proposed method is effective; the biases of the reconstructed images are less than 1% under the 5% noise condition.

关键词： practical data acquisition method biological organs nondata-acquisition time breast imaging breast ultrasonic data data acquisition computerised tomography cancer breast ultrasound computed tomography biomedical ultrasonics acoustic tomography sanitary examination process soft sleeve image reconstruction data acquisition based breast UCT method medical image processing breast cancer screening computer simulations

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Numerical Studies on Fire-induced Thermal Plumes

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Journal of Thermal Science 2005年第4期14卷 374-381页

作者： Junmei li yanfeng li Wan Ki CHOW Huairong HUANG The College of Architecture and Civil Engineering Beijing University of Technology Beijing 100022China Department of Building Services Engineering The Hong Kong Polytechnic University Hong Kong China

Most of the expressions describing fire plumes reported in the literature are known to be based on experiments. Due to different experimental methods, the geometry of the fire sources, fuel types and surrounding conditions, it is difficult to derive a comprehensive picture of a plume with its temperature and velocity fields on the basis of existing theoretical work. Computational Fluid Dynamics （CFD）, which is regarded as a practical engineering tool in fire engineering by the experts, is sure to be able to give more details of the plume behavior under various situations. Aerodynamics for thermally-induced plumes will be studied numerically with CFD. Four typical axisymmetric plume equations will be assessed in this paper, and investigations will be useful for fire engineers in designing smoke management systems in an affordable fashion. This is a critical point in implementing engineering performance-based fire code.

关键词： thermal plume fire CFD smoke management.

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