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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du Ming gao yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Senescence in chronic wounds and potential targeted therapies

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Burns & Trauma 2022年第1期10卷 742-756页

作者： Xuerong Wei Minxiong Li Zijun Zheng Jun Ma yanbin gao Lianglong Chen Yujie Peng Shengxiang Yu Lei Yang Department of Burns Nanfang HospitalSouthern Medical UniversityJingxi StreetBaiyun DistrictGuangzhou510515China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of Medicine639 Zhizaoju Road200011ShanghaiChina

Chronic wounds(*** wounds,pressure wounds,vascular ulcers,etc.)do not usually heal in a timely and orderly manner but rather last for years and may lead to irreversible adverse events,resulting in a substantial financial burden for patients and ***,a large amount of evidence has proven that cellular senescence has a crucial influence on chronic nonhealing *** a defensive mechanism,cell senescence is a manner of cell-cycle arrest with increased secretory phenotype to resist death,preventing cells from stress-induced damage in cancer and noncancer diseases.A growing amount of research has advanced the perception of cell senescence in various chronic wounds and focuses on pathological and physiological processes and therapies targeting senescent ***,previous reviews have failed to sum up novel understandings of senescence in chronic wounds and emerging strategies targeting ***,we discuss the characteristics and mechanisms of cellular senescence and the link between senescence and chronic wounds as well as some novel antisenescence strategies targeting other diseases that may be applied for chronic wounds.

关键词： Chronic wounds Senescence Senolytics Targeted therapies Diabetic wound Pressure wound Vascular ulcer

Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair:A one-step strategy

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Bioactive Materials 2021年第8期6卷 2613-2628页

作者： Zijun Zheng Minxiong Li Pengwei Shi yanbin gao Jun Ma Yuchen Li Lei Huang Zhangfeifan Yang Lei Yang Department of Burns Nanfang HospitalSouthern Medical UniversityJingxi StreetBaiyun DistrictGuangzhou510515PR China Department of Emergency Nanfang HospitalSouthern Medical UniversityJingxi StreetBaiyun DistrictGuangzhou510515PR China Department of Statistics University of British Columbia2329 West MallVancouverV6T 1Z4BCCanada

Although employed to release growth factors(GFs)for regenerative medicine,platelet-rich plasma(PRP)has been hindered by issues like burst *** on collagen sponge scaffolds(CSSs)modified with polydopamine(pDA),a novel dermal regeneration template(DRT)was ***,whether it could efficiently deliver PRP and even foster wound healing remained *** this work,after PRP was prepared and pDA-modified CSSs(pDA-CSSs)were fabricated,microscopic observation,GFs release assay and in-vitro biological evaluations of pDA-CSSs with PRP(pDA-CSS@PRP)were performed,followed by BALA-C/nu mice full-thickness skin defects implanted with pDA-CSS@PRP covered by grafted skins(termed as a One-step strategy).As a result,scanning electron microscope demonstrated more immobilized platelets on pDA-CSS′surface with GFs’controlled release via enzyme-linked immunosorbent assay,compared with *** line with enhanced in-vitro proliferation,adhesion and migration of keratinocytes&endothelial cells,pDA-CSS@PRP were histologically revealed to accelerate wound healing with less scar via rapid angiogenesis,arrangement of more mature collagen,guiding cells to spread,*** conclusion,pDA-CSSs have potential to serve as a novel DRT capable of delivering PRP,which may foster full-thickness skin defect healing by means of a One-step strategy.

关键词： Polydopamine Sustained release Platelet-rich plasma Dermal regeneration template Full-thickness skin defect

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两种K_0固结土样的强度比及其各向异性

同济大学学报（自然科学版） 2019年第5期47卷 634-639页

作者：高彦斌同济大学土木工程学院上海200092

K_0固结(侧向约束的固结)可导致土的各向异性.通过对比上海软黏土的原状土样和重塑土样的三轴ACUC(K_0固结压缩剪切)、ACUE(K_0固结拉伸剪切)试验以及直剪试验得到的强度比,研究这两种土样所具有的不同结构对K_0正常固结软黏土强度比及... 详细信息

K_0固结(侧向约束的固结)可导致土的各向异性.通过对比上海软黏土的原状土样和重塑土样的三轴ACUC(K_0固结压缩剪切)、ACUE(K_0固结拉伸剪切)试验以及直剪试验得到的强度比,研究这两种土样所具有的不同结构对K_0正常固结软黏土强度比及其各向异性的影响.三轴ACUC、ACUE试验中,在3.7倍于结构屈服应力的正常固结范围内,原状土样在不同固结压力下表现出与重塑土样不同的有效应力路径、极限状态线、有效内摩擦角和强度比.当固结压力较小时,原状土样表现出比重塑土样明显偏大的ACUE强度,因而呈现出较小的强度各向异性;随着固结压力的增大及结构进一步破损,原状土样的强度各向异性逐渐增大而接近重塑土.因此,在对K_0正常固结软黏土的三轴强度比及其各向异性的研究中,这种与固结压力相关的结构效应值得关注.直剪快剪试验结果表明,正常固结范围内两种K_0固结土样的强度比几乎相同,因而可以忽略结构效应对直剪快剪强度的影响.

关键词：软黏土结构效应强度比三轴试验强度各向异性

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原位十字板试验测得的软粘土灵敏度

同济大学学报（自然科学版） 2016年第9期44卷 1356-1362页

作者：高彦斌同济大学地下建筑与工程系上海200092 同济大学岩土及地下工程教育部工程重点试验室上海200092

收集了国内两个地区(上海和杭州湾)以及美国和日本一些地区软粘土的勘察数据,对原位十字板试验(FVT)和无侧限抗压强度试验(UCT)这两种试验所测得的灵敏度和强度进行了详细的对比与分析,并对重塑方式的影响进行了研究.发现这些地区普遍存... 详细信息

收集了国内两个地区(上海和杭州湾)以及美国和日本一些地区软粘土的勘察数据,对原位十字板试验(FVT)和无侧限抗压强度试验(UCT)这两种试验所测得的灵敏度和强度进行了详细的对比与分析,并对重塑方式的影响进行了研究.发现这些地区普遍存在FVT试验得到的灵敏度要明显小于UCT试验结果,会严重低估软粘土的灵敏度;而原状土强度和重塑土强度均要大于UCT试验结果,重塑土强度尤其明显.其中重塑方式是一个重要影响因素.研究还发现FVT试验得到的重塑土强度、灵敏度与土的液性指数的相关性随着液性指数的增大而明显变差,与一些广泛使用的经验关系也差别较大.这些结果应该引起工程界的重视.

关键词：软粘土灵敏度强度液性指数原位十字板试验(FVT) 无侧限抗压强度试验

Functional and binding studies of gallic acid showing platelet aggregation inhibitory effect as a thrombin inhibitor

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Chinese Herbal Medicines 2022年第2期14卷 303-309页

作者： Yuxin Zhang Xing Wang Binan Lu yanbin gao Yanling Zhang Yatong Li Hongjuan Niu Lu Fan Zongran Pang Yanjiang Qiao Key Laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing 100081China Beijing Key Lab of Traditional Chinese Medicine Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China Key Laboratory of TCM-Information Engineer of State Administration of TCM School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing 100029China

Objective:This study was devoted to identifying natural thrombin inhibitors from traditional Chinese medicine(TCM)and evaluating its biological activity in vitro and binding ***:A combination strategy containing molecular docking,thrombin inhibition assay,surface plasmon resonance(SPR)and molecular dynamics simulation were applied to verify the study ***:Gallic acid was confirmed as a direct thrombin inhibitor with IC;of 9.07μmol/L and showed a significant inhibitory effect on thrombin induced platelet ***-based binding studies demonstrated that gallic acid interacted with thrombin with a KDvalue of 8.29μmol/*** dynamics and binding free energy analysis revealed that thrombin-gallic acid system attained equilibrium rapidly with very low fluctuations,the calculated binding free energies was-14.61 kcal/***230,Glu232,Ser235,Gly258 and Gly260 were the main amino acid residues responsible for thrombin inhibition by gallic acid,providing a mechanistic basis for further ***:This study proved that gallic acid is a direct thrombin inhibitor with platelet aggregation inhibitory effect,which could provide a basis for the follow-up research and development for novel thrombin inhibitors.

关键词： gallic acid molecular dynamics natural thrombin inhibitor platelet aggregation surface plasmon resonance

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上海软黏土强度固有各向异性

同济大学学报（自然科学版） 2013年第11期41卷 1658-1663页

作者：高彦斌楼康明同济大学土木工程学院上海200092 同济大学岩土及地下工程教育部重点实验室上海200092 广州市城市规划勘测设计研究院广东广州510060

采用室内异形十字板试验对上海淤泥质黏土原生结构导致的不排水抗剪强度的固有各向异性特征进行研究.从基坑中取得筒状土样,然后采用两个具有不同长宽比的矩形板头和三个不同角度(30°,45°和60°)的菱形板头进行室内异形十字板剪切试验... 详细信息

采用室内异形十字板试验对上海淤泥质黏土原生结构导致的不排水抗剪强度的固有各向异性特征进行研究.从基坑中取得筒状土样,然后采用两个具有不同长宽比的矩形板头和三个不同角度(30°,45°和60°)的菱形板头进行室内异形十字板剪切试验,得到了原状土在不同方向破坏面上的不排水抗剪强度.结果表明:由于上海软黏土原生结构的影响,在总应力为零的情况下,其不排水抗剪强度随着破坏面与水平面夹角的增大而增大,即破坏面为水平向时强度最小,竖直向时强度最大.十字板试验结果与直剪试验、无侧限抗压强度试验的结果有很好的一致性.推荐采用Casagrande和Carrillo提出的公式来计算上海软黏土各向异性不排水强度.

关键词：软黏土原生结构各向异性强度十字板剪切试验

圆锥(台)形人造山体地基竖向附加应力及沉降

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同济大学学报（自然科学版） 2020年第7期48卷 945-952页

作者：高彦斌姚天骄同济大学土木工程学院上海200092

采用布辛涅斯克解,给出了圆锥形和圆台形荷载作用下地基中心竖向附加应力计算公式,发现竖向附加应力随深度衰减要远大于其他类型荷载下的结果;采用弹性有限元法,给出了圆锥形荷载作用下地基中任意位置的竖向附加应力系数图,解决了圆锥... 详细信息

采用布辛涅斯克解,给出了圆锥形和圆台形荷载作用下地基中心竖向附加应力计算公式,发现竖向附加应力随深度衰减要远大于其他类型荷载下的结果;采用弹性有限元法,给出了圆锥形荷载作用下地基中任意位置的竖向附加应力系数图,解决了圆锥和圆台荷载下任意位置竖向附加应力以及地表沉降的计算问题。工程案例验证了采用该方法给出轴对称附加应力解的必要性;并通过一个算例分析了两个圆锥形山体作用下地基的竖向附加应力和地表沉降的相互影响规律。

关键词：圆锥(台)形荷载布辛涅斯克解竖向附加应力沉降

上海软黏土的非水相有机液体固结渗透仪渗透试验

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同济大学学报（自然科学版） 2024年第10期52卷 1543-1550页

作者：高彦斌居奕含同济大学土木工程学院上海200092

在饱和黏性土的非水相有机液体(NAPL)渗透试验中,NAPL-土的相互作用易导致土样收缩而产生侧壁渗漏,影响试验结果的可靠性。采用固结渗透仪开展了上海淤泥质黏土的煤油渗透试验,研究竖向固结压力pv的大小和土样结构性对侧壁渗漏以及试验... 详细信息

在饱和黏性土的非水相有机液体(NAPL)渗透试验中,NAPL-土的相互作用易导致土样收缩而产生侧壁渗漏,影响试验结果的可靠性。采用固结渗透仪开展了上海淤泥质黏土的煤油渗透试验,研究竖向固结压力pv的大小和土样结构性对侧壁渗漏以及试验结果的影响。研究结果表明,絮凝结构的原状土样在pv为50 kPa、200 kPa下均存在侧壁渗漏,测得的渗透系数偏大,在pv=400 kPa下可得到可靠的试验结果。对于分散结构的重塑土,在pv=400 kPa下仍然存在侧壁渗漏。根据原状土样的孔径分布以及在pv=400 kPa下的渗透试验结果,讨论了上海淤泥质黏土中NAPL渗透的基本特性,对了解沿海软黏土中NAPL类污染物的迁移特征有指导价值。

关键词：非水相有机液体渗透试验饱和黏性土侧壁渗漏固结渗透仪