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Predicting recurrence in osteosarcoma via a quantitative histological image classifier derived from tumour nuclear morphological features

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 836-848页

作者： Zhan Wang Haoda Lu Yan Wu Shihong Ren Diarra mohamed Diaty yanbiao fu Yi Zou Lingling Zhang Zenan Wang Fangqian Wang Shu Li Xinmi Huo Weimiao Yu Jun Xu Zhaoming Ye Department of Orthopedic Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Orthopedics Research Institute of Zhejiang University HangzhouChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouChina Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science&TechnologyNanjingChina Department of Pathology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Hematology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Bioinformatics Institute(BII) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore

Recurrence is the key factor affecting the prognosis of ***,there is a lack of clinically useful tools to predict osteosarcoma *** application of pathological images for artificial intelligence‐assisted accurate prediction of tumour out-comes is ***,the present study constructed a quantitative histological image classifier with tumour nuclear features to predict osteosarcoma outcomes using haema-toxylin and eosin(H&E)‐stained whole‐slide images(WSIs)from 150 osteosarcoma *** first segmented eight distinct tissues in osteosarcoma H&E‐stained WSIs,with an average accuracy of 90.63%on the testing *** tumour areas were auto-matically and accurately acquired,facilitating the tumour cell nuclear feature extraction *** on six selected tumour nuclear features,we developed an osteosarcoma histological image classifier(OSHIC)to predict the recurrence and survival of osteo-sarcoma following standard *** quantitative OSHIC derived from tumour nuclear features independently predicted the recurrence and survival of osteosarcoma patients,thereby contributing to precision ***,we developed a fully automated workflow to extract quantitative image features,evaluate the diagnostic values of feature sets and build classifiers to predict osteosarcoma ***,the present study provides a novel tool for predicting osteosarcoma outcomes,which has a broad application prospect in clinical practice.

关键词： diseases learning(artificial intelligence) surgery tumours

An　Emission　of　Complex　Particles　in　Coulomb　Instability　in　Reactions　30MeV／u^（40）Ar＋^（159）Tb　and　^（nat）Ag

维普期刊数据库评论

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IMP & HIRFL Annual Report 1996年第1期 6-8页

作者： Dai Guangxi, fu yanbiao He Zhigong Duan Limin Li Zuyu Zhang Baoguo and Liu Guoxing

ＡｎＥｍｉｓｓｉｏｎｏｆＣｏｍｐｌｅｘＰａｒｔｉｃｌｅｓｉｎＣｏｕｌｏｍｂＩｎｓｔａｂｉｌｉｔｙｉｎＲｅａｃｔｉｏｎｓ３０ＭｅＶ／ｕ^（４０）Ａｒ＋^（１５９）Ｔｂａｎｄ^（ｎａｔ）Ａｇ￥ＤａｉＧｕａｎｇｘｉ，；ＦｕＹ... 详细信息

ＡｎＥｍｉｓｓｉｏｎｏｆＣｏｍｐｌｅｘＰａｒｔｉｃｌｅｓｉｎＣｏｕｌｏｍｂＩｎｓｔａｂｉｌｉｔｙｉｎＲｅａｃｔｉｏｎｓ３０ＭｅＶ／ｕ^（４０）Ａｒ＋^（１５９）Ｔｂａｎｄ^（ｎａｔ）Ａｇ￥ＤａｉＧｕａｎｇｘｉ，；ＦｕＹａｎｂｉａｏ；ＨｅＺｈｉｇｏｎｇ；?..

关键词： 40Ar

Numerical simulation of nanosecond laser ablation and plasma characteristics considering a real gas equation of state

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Plasma Science and Technology 2021年第12期23卷 1-9页

作者：刘强敏琦苏茂根刘兴邦曹世权孙对兄董晨钟符彦飙 Key Laboratory of Atomic and Molecular Physics and functional Material of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070People's Republic of China Joint Laboratory of Atomic and Molecular Physics Northwest Normal University and Institute of Modern Physics of Chinese Academy of SciencesLanzhou 730070People's Republic of China

Based on the governing equations which include the heat conduction equation in the target and the fluid equations of the vapor plasma,a two-dimensional axisymmetric model for ns-laser ablation considering the Knudsen layer and plasma shielding effect is *** equations of state of the plasma are described by a real gas approximation,which divides the internal energy into the thermal energy of atoms,ions and electrons,ionization energy and the excitation energy of atoms and *** dynamic evolution of the silicon target and plasma during laser ablation is studied by using this model,and the distributions of the temperature,plasma density,Mach number related to the evaporation/condensation of the target surface,laser transmissivity as well as internal energy of the plasma are *** is found that the evolution of the target surface during laser ablation can be divided into three stages:(1)the target surface temperature increases continuously;(2)the sonic and subsonic evaporation;and(3)the subsonic *** result of the internal energy distribution indicates that the ionization and excitation energy plays an important role in the internal energy of the plasma during laser *** model is suitable for the case that the temperature of the target surface is lower than the critical temperature.

关键词： ns-laser ablation hydrodynamic model Knudsen layer equation of state

Fission　with　Companion　of　Particles　Emission　in　^（40）Ar＋^（159）Tb　and　^（nat）Ag　Reactions　at　30MeV／u

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IMP & HIRFL Annual Report 1996年第1期 5-6页

作者： Dai Guangxi, fu yanbiao, He Zhiyong Duan Limin Li Zuyu Zhang Baoguo and Liu Guoxing

ＦｉｓｓｉｏｎｗｉｔｈＣｏｍｐａｎｉｏｎｏｆＰａｒｔｉｃｌｅｓＥｍｉｓｓｉｏｎｉｎ^（４０）Ａｒ＋^（１５９）Ｔｂａｎｄ^（ｎａｔ）ＡｇＲｅａｃｔｉｏｎｓａｔ３０ＭｅＶ／ｕ￥ＤａｉＧｕａｎｇｘｉ，ＦｕＹａｎｂｉａｏ，Ｈ... 详细信息

ＦｉｓｓｉｏｎｗｉｔｈＣｏｍｐａｎｉｏｎｏｆＰａｒｔｉｃｌｅｓＥｍｉｓｓｉｏｎｉｎ^（４０）Ａｒ＋^（１５９）Ｔｂａｎｄ^（ｎａｔ）ＡｇＲｅａｃｔｉｏｎｓａｔ３０ＭｅＶ／ｕ￥ＤａｉＧｕａｎｇｘｉ，ＦｕＹａｎｂｉａｏ，ＨｅＺｈｉｙｏｎｇ；ＤｕａｎＬｉｍｉ?..

关键词： 40Ar

Comparison　between　Threefold　Fragmentation　and　Sequential　Fission　in^（40Ar）＋^（159）Tb　Reactions　at　30MeV／u

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IMP & HIRFL Annual Report 1996年第1期 9-10页

作者： Dai Guangxi fu yanbiao He Zhiyong Duan Limlin Li Zuyu Zhang Baoguo and Liu Guoxing

ＣｏｍｐａｒｉｓｏｎｂｅｔｗｅｅｎＴｈｒｅｅｆｏｌｄＦｒａｇｍｅｎｔａｔｉｏｎａｎｄＳｅｑｕｅｎｔｉａｌＦｉｓｓｉｏｎｉｎ^（４０Ａｒ）＋^（１５９）ＴｂＲｅａｃｔｉｏｎｓａｔ３０ＭｅＶ／ｕ￥ＤａｉＧｕａｎｇｘｉ；Ｆｕ... 详细信息

ＣｏｍｐａｒｉｓｏｎｂｅｔｗｅｅｎＴｈｒｅｅｆｏｌｄＦｒａｇｍｅｎｔａｔｉｏｎａｎｄＳｅｑｕｅｎｔｉａｌＦｉｓｓｉｏｎｉｎ^（４０Ａｒ）＋^（１５９）ＴｂＲｅａｃｔｉｏｎｓａｔ３０ＭｅＶ／ｕ￥ＤａｉＧｕａｎｇｘｉ；ＦｕＹａｎｂｉａｏ；ＨｅＺｈｉｙｏｎｇ...

关键词： Fragment

A　BGO　Detector　Array　Used　for　Intermediate　Mass　Fragment　Measurements　in　Intermediate　Energy　Heavy　Ion　Reactions

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IMP & HIRFL Annual Report 1996年第1期 159-160页

作者： Li Zuyu He Zhiyong Jin Genming Duan Limin Wang Hongwei Zhang Baoguo fu yanbiao and Dai Guangxi

ＡＢＧＯＤｅｔｅｃｔｏｒＡｒｒａｙＵｓｅｄｆｏｒＩｎｔｅｒｍｅｄｉａｔｅＭａｓｓＦｒａｇｍｅｎｔＭｅａｓｕｒｅｍｅｎｔｓｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒｇｙＨｅａｖｙＩｏｎＲｅａｃｔｉｏｎｓ￥ＬｉＺｕｙｕ；ＨｅＺ... 详细信息

ＡＢＧＯＤｅｔｅｃｔｏｒＡｒｒａｙＵｓｅｄｆｏｒＩｎｔｅｒｍｅｄｉａｔｅＭａｓｓＦｒａｇｍｅｎｔＭｅａｓｕｒｅｍｅｎｔｓｉｎＩｎｔｅｒｍｅｄｉａｔｅＥｎｅｒｇｙＨｅａｖｙＩｏｎＲｅａｃｔｉｏｎｓ￥ＬｉＺｕｙｕ；ＨｅＺｈｉｙｏｎｇ；ＪｉｎＧｅｎｍｉｎｇ...

关键词： Fragment

Investigation　of　Emission　Time　Scale　and　Emission　Mechanism　of　Intermediate　Mass　Fragments　for　^（40）Ar＋^（159）Tb　Reaction　at　30MeV／u

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IMP & HIRFL Annual Report 1996年第1期 34-35页

作者： Li Zuyu He Zhiyong Duan Limin Dai Guangxi Zhang Baoguo fu yanbiao Wang Hongwei and Jin Genming

ＩｎｖｅｓｔｉｇａｔｉｏｎｏｆＥｍｉｓｓｉｏｎＴｉｍｅＳｃａｌｅａｎｄＥｍｉｓｓｉｏｎＭｅｃｈａｎｉｓｍｏｆＩｎｔｅｒｍｅｄｉａｔｅＭａｓｓＦｒａｇｍｅｎｔｓｆｏｒ^（４０）Ａｒ＋^（１５９）ＴｂＲｅａｃｔｉｏｎａｔ３... 详细信息

ＩｎｖｅｓｔｉｇａｔｉｏｎｏｆＥｍｉｓｓｉｏｎＴｉｍｅＳｃａｌｅａｎｄＥｍｉｓｓｉｏｎＭｅｃｈａｎｉｓｍｏｆＩｎｔｅｒｍｅｄｉａｔｅＭａｓｓＦｒａｇｍｅｎｔｓｆｏｒ^（４０）Ａｒ＋^（１５９）ＴｂＲｅａｃｔｉｏｎａｔ３０ＭｅＶ／ｕ￥ＬｉＺｕｙｕ；ＨｅＺ...

关键词： 40Ar Fragment

类铷W^(37+)离子双电子复合速率系数的理论研究

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强激光与粒子束 2011年第4期23卷 1087-1090页

作者：张义钊符彦飙董晨钟苏茂根西北师范大学物理与电子工程学院兰州730070 西北师范大学与中国科学院近代物理研究所极端环境原子分子物理实验室兰州730070

利用全相对论组态相互作用理论方法,研究了类铷W37+离子从基组态3s23p63d104s24p64d经过双激发态(3s23p63d104s24p64d)-1nlnl′′(n,n′=4,5)的双电子复合过程,得到了该离子在温度为1~5×104eV范围内的总双电子复合速率系数。分析比较... 详细信息

利用全相对论组态相互作用理论方法,研究了类铷W37+离子从基组态3s23p63d104s24p64d经过双激发态(3s23p63d104s24p64d)-1nlnl′′(n,n′=4,5)的双电子复合过程,得到了该离子在温度为1~5×104eV范围内的总双电子复合速率系数。分析比较了不同电子激发的双电子复合速率系数,结果表明:4p电子激发的双电子复合速率系数在低温时给出了主要贡献,而3d的贡献在高温时突出。由于强组态相互作用,两电子一光子跃迁对双电子复合速率系数的贡献不可忽略,其中辐射跃迁4p54d5d5f-4p64f5d的贡献是双激发态4p54d5d5f总的双电子复合速率系数的5%。对双电子复合、辐射复合以及三体复合速率系数的比较表明,在所研究的温度范围内双电子复合速率系数最大。

关键词：双电子复合速率系数 W37+离子组态相互作用

高Q^2电子原子核单举准弹性散射截面的计算方法

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原子核物理评论 2017年第4期34卷 718-723页

作者：戴宏凯陈旭荣符彦飙西北师范大学电子与物理工程学院兰州730000 中国科学院近代物理研究所兰州730000

电子与原子核碰撞实验是通过中高能探针探测原子核结构的方法。本文提供了一个高Q^2单举准弹性电子原子核散射截面的计算方法,此方法是基于核子-核子短程关联的经验公式与弱束缚近似下的氘核散射截面模型。在弱束缚近似下,氘核可以看成... 详细信息

电子与原子核碰撞实验是通过中高能探针探测原子核结构的方法。本文提供了一个高Q^2单举准弹性电子原子核散射截面的计算方法,此方法是基于核子-核子短程关联的经验公式与弱束缚近似下的氘核散射截面模型。在弱束缚近似下,氘核可以看成是由近似自由质子与中子组成,质子与中子的短程关联可以忽略,氘核结构函数可以写成质子与中子结构函数线性组合,从而可以得到氘核的散射截面。根据氘核散射截面以及短程关联的经验公式,可以得到考虑短程关联的原子核A>2的散射截面。我们将计算得到的散射截面与已有的实验和及Bosted拟合方法的结果比较,发现本文的方法在大x和Q^2>2 GeV^2区域得到的结果与实验结果符合得较好并且对于一些重原子核,尤其是~4He核,明显优于Bosted方法的结果。

关键词：电子原子核准弹性散射核子-核子短程关联弱束缚近似