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Safflower Yellow Inhibits Progression of Hepatocellular Carcinoma by Modulating Immunological Tolerance via FAK Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 339-347页

作者： JI Hua-feng yang zi-qiang HAN Jun-jun LI He-fang JIN Zhao-qing CHEN Wei-qing CHEN Fei-hua GONG Mou-chun Department of General Surgery First People's Hospital of Hangzhou Lin'an DistrictHangzhou(311300)China

Objective To explore the anti-tumor effect of safflower yellow(SY)against hepatocellular carcinoma(HCC)and the underlying potential *** An in vitro model was established by mixing Luc-Hepa1-6 cells and CD3^(+)CD8^(+)T cells,followed by adding programmed cell death protein 1(PD-1)antibody(Anti-mPD-1)with or without *** apoptosis was detected by flow cytometry and the level of inflammatory cytokines was determined by enzyme-linked immunosorbent *** protein levels of programmed cell death 1 ligand 1(PD-L1),chemokine ligand(CCL5),C-X-C motif chemokine ligand 10(CXCL10)were measured by Western *** in situ animal model was established in mice followed by treatment with anti-mPD-1 with or without *** imaging was monitored with an AniView 100 imaging *** establish the FAK-overexpressed Luc-Hepa1-6 cells,cells were transfected with adenovirus containing pcDNA3.1-FAK for 48 *** The fluorescence intensity,apoptotic rate,release of inflammatory cytokines,and CCL5/CXCL10 secretion were dramatically facilitated by anti-mPD-1(P<0.01),accompanied by an inactivation of PD-1/PD-L1 axis,which were extremely further enhanced by SY(P<0.05 or P<0.01).Increased fluorescence intensity,elevated percentage of CD3+CD8+T cells,facilitated release of inflammatory cytokines,inactivated PD-1/PD-L1 axis,and increased CCL5/CXCL10 secretion were observed in Anti-mPD-1 treated mice(P<0.01),which were markedly enhanced by SY(P<0.05 or P<0.01).Furthermore,the enhanced effects of SY on inhibiting tumor cell growth,facilitating apoptosis and inflammatory cytokine releasing,suppressing the PD-1/PD-L1 axis,and inducing the CCL5/CXCL10 secretion in Anti-mPD-1 treated mixture of Luc-Hepa1-6 cells and CD3+CD8+T cells were abolished by FAK overexpression(P<0.01).Conclusion SY inhibited the progression of HCC by mediating immunological tolerance through inhibiting FAK.

关键词： hepatocellular carcinoma safflower yellow Chinese medicine tumor microenvironment programmed cell death protein 1 focal adhesion kinase

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黑水虻成虫的触角感器超微结构及其对气味物质的嗅觉反应

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昆虫学报 2024年第6期67卷 806-815页

作者：王鑫桐周琼田苏周凯灵杨自强湖南师范大学生命科学学院长沙410081 宁乡丰裕生物科技有限公司长沙410600

【目的】明确黑水虻Hermetia illucens成虫触角感器的超微结构,探究其雌雄成虫对气味物质的嗅觉反应。【方法】利用透射电子显微镜观察黑水虻成虫触角感器的超微结构,再分别采用触角电位测量系统和Y型嗅觉仪测试雌雄成虫对异戊酸、乳酸... 详细信息

【目的】明确黑水虻Hermetia illucens成虫触角感器的超微结构,探究其雌雄成虫对气味物质的嗅觉反应。【方法】利用透射电子显微镜观察黑水虻成虫触角感器的超微结构,再分别采用触角电位测量系统和Y型嗅觉仪测试雌雄成虫对异戊酸、乳酸、乙酸乙酯和壬醛4种气味物质的触角电位(electroantennogram, EAG)反应和行为响应。【结果】黑水虻成虫触角上的毛形感器表皮壁厚,壁上无孔,内部感器淋巴液中有神经树突;腔锥形感器腔内有多分支的锥形突起,锥形突起的表皮壁薄,壁上有微孔,内部感器淋巴液中有神经树突。EAG测试结果表明,所测试的4种气味物质在各浓度下都能引起雌雄黑水虻成虫明显的EAG反应,不同气味物质引起的反应随浓度变化呈现不同趋势。其中,雌雄成虫对异戊酸的EAG反应均最大,二者的EAG反应相对值均随浓度升高而升高;雌成虫对乳酸的EAG反应随浓度升高先升高后降低,雄成虫对乳酸的EAG反应趋势则相反;对于乙酸乙酯和壬醛两种气味物质的EAG反应,随着测试浓度的升高,黑水虻雌成虫的EAG反应呈现出先降低后升高的趋势,而雄成虫的EAG反应则各不相同且无规律。行为选择测试结果表明,0.001-0.1μg/μL乳酸对黑水虻雌成虫有显著的吸引作用,0.1μg/μL异戊酸对雄成虫有显著的吸引作用。【结论】黑水虻成虫触角鞭节上的毛形感器可能为温湿度感器,腔锥形感器可能为嗅觉感器。黑水虻雌雄成虫的触角均对高浓度的异戊酸比较敏感;低浓度的乳酸、异戊酸对黑水虻成虫具有一定的引诱作用,有作为引诱剂成分的潜力。

关键词：黑水虻透射电子显微镜嗅觉感器触角电位行为选择嗅觉反应

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Simulations of a two-stream backward-wave oscillator with a slot-hole structure

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Chinese Physics B 2012年第1期21卷 518-523页

作者： Shi Zong-Jun Tang Xiao-Pin yang zi-qiang Lan Feng Liang Zheng Terahertz Research Centre School of Physical ElectronicsUniversity of Electronic Science and Technology of ChinaChengdu 610054China

We study a two-stream backward-wave oscillator with a slot-hole structure at short millimeter waves with the help of a three-dimensional particle-in-cell simulation. In order to increase the interaction region of the electron beam, the efficiency and the output power, a slot-hole loaded rectangular waveguide structure used as the high-frequency system is proposed. Based on the mechanism of the backward-wave oscillator, a slow-wave oscillator with a frequency of 0.14 THz is designed. The simulations show that the output power and the efficiency of the oscillator can be enhanced due to the coupling between the two beams through the slot holes. The interaction efficiency is 5.18%, and the starting current density is below 5 A. cm^-2 for the two beams. These attractive results indicate that, based on the two-stream backward-wave oscillator, we can get short millimeter wave sources with high power and low current density.

关键词： slot-hole structure short millimeter wave two-stream backward-wave oscillator

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Facile synthesis of hierarchical NiO/NiFe_(2)O_(4) microsphere composite as efficient visible photocatalyst for 2,4-DCP degradation

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Rare Metals 2024年第4期43卷 1580-1588页

作者： Shabana Shaheen Shuai Xu Ji Bian Amir Zada zi-Qing Zhang yang Qu Li-qiang Jing Key Laboratory of Functional Inorganic Materials Chemistry(Ministry of Education) International Joint Research Center and Lab for Catalytic TechnologySchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Department of Chemistry Abdul Wali Khan UniversityMardan23200Pakistan

It is highly desired to develop efficient photocatalysts with recycling property for practical application to degrade toxic ***,nanosheet-assembled NiFe_(2)O_(4)microspheres with commendable activity are successfully synthesized by a facile solvothermal reaction with NH4F as the modifier,and their photoactivities are further improved by coupling with NiO through an in situ growth *** optimized nickel oxide(NiO)/nickel ferrite(NiFe_(2)O_(4))microsphere composite(5NiO/NFO-4)exhibits a satisfactory photocatalytic activity for 2,4-dichlorophenol(2,4-DCP)degradation under visible-light irradiation,which is attributed to its wide visible-light response,well-designed hierarchical structure and enhanced charge transfer and separation by coupling NiO as a high-level energy platform to accept ***,it is found that the NiO/NiFe_(2)O_(4)microsphere photocatalysts can be easily collected and recycled owing to the distinctive magnetic *** work provides a feasible route to rational design visible-light-driven photocatalysts with high-activity for environmental remediation and purification with good recyclability.

关键词： NiFe_(2)O_(4) microspheres NiO/Fe_(2)O_(4) composite Charge separation Visible-light photocatalysis 2 4-Dichlorophenol degradation

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Solidification crack characteristics and sensitivity of peritectic steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1668-1679页

作者： Ya-qiang Li Jian-hua Liu zi-ming Wang Ying-ying Li yang He Xiao-wei Li Department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Hebei Special Vehicle Modification Technology Innovation Center Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou 213164JiangsuChina

The characteristics and sensitivity of solidification cracks in peritectic steels were investigated using directional solidifi-cation *** cracks were observed in both hypoperitectic steels(12CrlMoV,15CrMo)and hyper-peritectic steel(20CrMo)during solidification at growth velocities of 15,50,and 80 pm/*** the dendritic boundaries,sulphide precipitates were found,promoting crack *** on the statistical analysis of interdendritic cracks in peritectic steels,the area ratio(RA)of interdendritic cracks in a directional solidification structure was proposed to evaluate the crack sensitivity of peritectic ***,the crack sensitivities of peritectic steels(12CrlMoV,15CrMo,and 20CrMo)were tested,evaluated,and compared with the surface crack rates of three types of steels produced from a steel *** results demonstrated that RA was in good agreement with that of the steel plant,and the crack sensitivity of 12CrlMoV steel was the strongest,followed by that of 15CrMo and 20CrMo ***,RA can be used to evaluate the crack sensitivity of peritectic steel.

关键词： Peritectic steel-Directional solidification Growth velocity Dendritic structure Solidification crack Crack sensitivity

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Multistage Microstructured Ionic Skin for Real-Time Vital Signs Monitoring and Human-Machine Interaction

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Energy & Environmental Materials 2024年第6期7卷 218-229页

作者： Xueke Wang Jinyu zi Yi Chen qiang Wu Zhimin Xiang Yongqiang Tu Peng yang Yanfen Wan National Center for International Research on Photoelectric and Energy Materials Yunnan Key Laboratory for Micro/Nano Materials&TechnologyYunnan Key Laboratory of Electromagnetic Materials and DevicesSchool of Materials and EnergyYunnan UniversityKunming 650091China

Skin-like electronics research aiming to mimic even surpass human-like specific tactile cognition by operating perception-to-cognition-to-feedback of stimulus to build intelligent cognition systems for certain imperceptible or inappreciable signals was so ***,we constructed an all-in-one tri-modal pressure sensing wearable device to address the issue of power supply by integrating multistage microstructured ionic skin(MM i-skin)and thermoelectric self-power staffs,which exhibits high sensitivity *** MM i-skin with multi-stage“interlocked”configurations achieved precise recognition of subtle signals,where the sensitivity reached up to 3.95 kPa^(−1),as well as response time of 46 ms,cyclic stability(over 1500 cycles),a wide detection range of 0–200 ***,we developed the thermoelectricity nanogenerator,piezoelectricity nanogenerator,and piezocapacitive sensing as an integrated tri-modal pressure sensing,denoted as P-iskin,T-iskin,and C-iskin,*** multifunctional ionic skin enables real-time monitoring of weak body signals,rehab guidance,and robotic motion recognition,demonstrating potential for Internet of things(IoT)applications involving the artificial intelligence-motivated sapiential healthcare Internet(SHI)and widely distributed human-machine interaction(HMI).

关键词： bio-template method integrated device ionic skin skin-like microstructure tri-modal pressure sensing

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Properties of the Environmental-Friendly Si/Al Composite for Electronic Packages Fabricated by Squeeze Casting Technology

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上海交通大学学报 2007年第S2期41卷 144-149页

作者：武高辉修子扬张强 School of Materials Science and Eng. Harbin Institute of Technology

High reinforcement-content aluminum matrix composite,with a high thermal conductivity,the adjustable coefficient of thermal expansion(CTE),low density and costs,have been extensively applied in electronic *** Sip/Al composites were fabricated by squeeze casting *** microstructure observation showed that the composites were dense and macroscopically homogeneous,with no micro-holes and obvious *** linear CTEs of Sip/Al composites lay between(7.6～8.1)×10^-6 ℃^-1,and the thermal conductivity was larger than 100 W/(m·℃).The composites also had lower density(2.4 g/cm^3),higher special strength and special *** electroless nickel method was used to deposit a continuous and uniform layer on the composites surface,which can meet the reliability testing demands of the diodes with Sip/Al composite baseplate.

关键词： Si particles aluminum matrix composite thermal expansion thermal conductivity

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Research on thermal insulation materials properties under HTHP conditions for deep oil and gas reservoir rock ITP-Coring

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Petroleum Science 2024年第4期21卷 2625-2637页

作者： Zhi-qiang He He-Ping Xie Ling Chen Jian-Ping yang Bo Yu zi-Jie Wei Ming-Zhong Gao State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering College of Water Resource and Hydropower Sichuan University Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green Energy College of Civil and Transportation Engineering Shenzhen University School of Mechanical Engineering Sichuan University College of Polymer Science and Engineering Sichuan University

Deep oil and gas reservoirs are under high-temperature conditions, but traditional coring methods do not consider temperature-preserved measures and ignore the influence of temperature on rock porosity and permeability, resulting in distorted resource assessments. The development of in situ temperaturepreserved coring(ITP-Coring) technology for deep reservoir rock is urgent, and thermal insulation materials are key. Therefore, hollow glass microsphere/epoxy resin thermal insulation materials(HGM/EP materials) were proposed as thermal insulation materials. The materials properties under coupled hightemperature and high-pressure(HTHP) conditions were tested. The results indicated that high pressures led to HGM destruction and that the materials water absorption significantly increased; additionally,increasing temperature accelerated the process. High temperatures directly caused the thermal conductivity of the materials to increase; additionally, the thermal conduction and convection of water caused by high pressures led to an exponential increase in the thermal conductivity. High temperatures weakened the matrix, and high pressures destroyed the HGM, which resulted in a decrease in the tensile mechanical properties of the materials. The materials entered the high elastic state at 150.C, and the mechanical properties were weakened more obviously, while the pressure led to a significant effect when the water absorption was above 10%. Meanwhile, the tensile strength/strain were 13.62 MPa/1.3%and 6.09 MPa/0.86% at 100.C and 100 MPa, respectively, which meet the application requirements of the self-designed coring device. Finally, K46-f40 and K46-f50 HGM/EP materials were proven to be suitable for ITP-Coring under coupled conditions below 100.C and 100 MPa. To further improve the materials properties, the interface layer and EP matrix should be optimized. The results can provide references for the optimization and engineering application of materials and thus technical su

关键词： Deep oil and gas reservoir rock In situ temperature-preserved coring (ITP-Coring) Hollow glass microsphere/epoxy resin thermal insulation materials (HGM/EP materials) High-temperature and high-pressure (HTHP) Physical and mechanical properties

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基于知识图谱的鼓风机轴承温度智能预测

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计算机系统应用 2024年第2期33卷 105-114页

作者：韩春荣杨自强郭俊温王鹏飞伍小龙孙晨暄北京城市排水集团有限责任公司北京100044 北京工业大学信息学部北京100124

轴承温度是衡量鼓风机是否正常运行的重要指标之一.然而,轴承通常安装在狭小密闭的空间中,导致其温度难以实时准确检测.为了解决这个问题,设计了基于知识图谱的鼓风机轴承温度智能预测方法.利用统计方法分析鼓风机运行系统,获取与轴承... 详细信息

轴承温度是衡量鼓风机是否正常运行的重要指标之一.然而,轴承通常安装在狭小密闭的空间中,导致其温度难以实时准确检测.为了解决这个问题,设计了基于知识图谱的鼓风机轴承温度智能预测方法.利用统计方法分析鼓风机运行系统,获取与轴承温度相关的影响因素.结合运行机理和领域知识构建知识图谱,提取影响轴承温度的直接和间接特征变量.采用双模块模糊神经网络对知识图谱进行推理,实现对鼓风机轴温的实时准确预测.结果表明,基于知识图谱的鼓风机轴承温度智能预测方法可以准确地建模鼓风机系统,具有良好的温度预测能力.该项研究可以为轴承温度的实时监测和变化趋势预测提供支持.

关键词：轴承温度目标预测知识图谱模糊神经网络检测方法

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你也需要蒙特卡罗方法——一个得心应手的工具

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数理统计与管理 2007年第1期26卷 178-188页

作者：杨自强中国科学院数学与系统科学研究院计算数学与科学工程计算研究所北京100080

本文通过几个例子和通俗的语言简要介绍蒙特卡罗(MC)方法的应用.文中例子显示,即使是一些尚无其它办法计算的复杂问题,应用MC方法也可以获得可用的结果,并且使用中档的个人电脑也可以在极短的时间内完成.文中还提供了一个品质优良的随... 详细信息

本文通过几个例子和通俗的语言简要介绍蒙特卡罗(MC)方法的应用.文中例子显示,即使是一些尚无其它办法计算的复杂问题,应用MC方法也可以获得可用的结果,并且使用中档的个人电脑也可以在极短的时间内完成.文中还提供了一个品质优良的随机数发生器,据此读者不难把MC方法立刻用于自己的研究工作中。

关键词：统计模拟拟蒙特卡罗随机数统计量分布非最小二乘拟合优化问题高维积分计算

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