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World Journal of Integrated Traditional and Western Medicine 2020年第1期6卷 37-43页

作者： JIANG Hai-jun He Bin ZHANG Tong yang yu-fei Beijing University of Chinese Medicine Beijing100029China Xiyuan Hospital China Academy of Chinese Medical SciencesBeijing100091China

Colorectal cancer is one of the common malignant tumors in *** poses a serious threat to the national health of *** advanced colorectal cancer, the main goal of treatment is to prolong survival and improve quality of *** complements other advantages, showing good therapeutic ***, how to grasp the timing of integrated Chinese and Western Medicine for the treatment of advanced colorectal cancer and use the integrated Chinese and Western Medicine treatment methods flexibly contains profound therapeutic *** yu-fei is an authoritative expert in the field of integrated Chinese and Western medicine for colorectal *** is good at accurately grasping the timing of treatment of integrated Chinese and Western Medicine, and flexibly adjusts the treatment strategy according to the specific *** this paper, we shared Professor yang yu-fei's strategy for treating advanced colorectal cancer with emphasis on integrated Chinese and Western Medicine and attached a typical case, with a view to provide reference for the treatment of advanced colorectal cancer with integrated Chinese and Western Medicine.

关键词： Integrated Chinese and western medicine Advanced colorectal cancer Treatment timing art

基于图论分析对轻度创伤性颅脑损伤后睡眠障碍患者的脑结构网络改变的研究

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临床放射学杂志 2025年第1期44卷 47-52页

作者：俞越杨禹李洋蔡玉姣王扬李月峰苏辉江苏大学医学院镇江212013 江苏大学附属人民医院镇江212001 扬州大学第三临床医学院 225600

目的探究轻度创伤性颅脑损伤患者脑结构网络的改变与未来睡眠障碍的关联。方法前瞻性搜集轻度创伤性颅脑损伤患者198例(mTBI组)及与之匹配的健康对照者60名(HC组)。以出院3个月后的匹兹堡睡眠质量指数量表(PSQI)为评估手段,将轻度创伤... 详细信息

目的探究轻度创伤性颅脑损伤患者脑结构网络的改变与未来睡眠障碍的关联。方法前瞻性搜集轻度创伤性颅脑损伤患者198例(mTBI组)及与之匹配的健康对照者60名(HC组)。以出院3个月后的匹兹堡睡眠质量指数量表(PSQI)为评估手段,将轻度创伤性颅脑损伤患者分为睡眠障碍组(mTBI-SD组)和无睡眠障碍组(mTBI-ND组)。利用方差分析比较3组受试者脑结构网络属性。构建Logistic回归模型探究脑结构网络属性与未来睡眠障碍发病风险的关联。采用Pearson相关分析探究脑结构网络属性与PSQI评分的相关性。结果3组受试者脑结构网络属性存在显著的组间差异。与mTBI-ND组相比,mTBI-SD组表现出较高的特征路径长度,较低的左前扣带回和旁扣带回节点效率。Logistic回归模型显示特征路径长度(OR特征路径长度=0.74,95%CI:0.63~0.94,P<0.001)、左前扣带和旁扣带回的节点效率(OR ACG.L=0.70,95%CI:0.65~0.80,P<0.001)可以显著预测mTBI-SD的发生,受试者工作特征曲线下面积分别为0.75、0.74。相关分析结果显示mTBI-SD组的特征路径长度(r=-0.41,P<0.01)、左前扣带和旁扣带回的节点效率(r=-0.50,P<0.01)与发病后3个月的PSQI评分相关。结论mTBI显著改变患者的脑结构网络连接属性,存在特征路径长度、左前扣带回和旁扣带回的节点效率改变的患者更容易在未来发生睡眠障碍。

关键词：轻度创伤性颅脑损伤睡眠障碍结构网络图论分析

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang Bo Chen Hao Xu Deng Pan yu-yang Ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Wave Propagation in Fluid-Filled Single-Walled Carbon Nanotube Based on the Nonlocal Strain Gradient Theory

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Acta Mechanica Solida Sinica 2018年第4期31卷 484-492页

作者： yang yang Jinrui Wang yang yu Department of Engineering Mechanics Kunming University of Science and Technology Kunming 650051 China

A dynamic Timoshenko beam model is established based on the new nonlocal strain gradient theory and slip boundary theory to study the wave propagation behaviors of fluid-filled carbon nanotubes （CNTs） at nanoscale. The nanoscale effects caused by the CNTs and the inner fluid are simulated by the nonlocal strain gradient effect and the slip boundary effect, respectively. The governing equations of motion are derived and resolved to investigate the wave characteristics in detail. The numerical solution shows that the strain gradient effect leads to the stiffness enhancement of CNTs when the nonlocal stress effect causes the decrease in stiffness. The dynamic properties of CNTs are affected by the coupling of these two scale effects. The flow velocity of fluid inside the CNT is increased due to the slip boundary effect, resulting in the promotion of wave propagation in the dynamic system.

关键词： Nonlocal strain gradient theory Fluid-filled carbon nanotube Fluid boundarycondition Timoshenko beam Wave propagation

An Online Education Data Classification Model Based on TrMAdaBoost Algorithm

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Chinese Journal of Electronics 2019年第1期28卷 21-28页

作者： yu Lasheng WU Xu yang yu School of Information Science & Engineering Central South University

With the rapid development of network information technology and the wide application of smart phones, tablet PCs and other mobile terminals, online education plays an increasingly important role in social life. This article focuses on mining useful data from the massive online education data, by using transfer learning, relying on Hadoop, to construct Online education data classification framework(OEDCF), and design an algorithm TrAdaBoost. This algorithm overcomes the traditional classification algorithms in which the required data must be restricted to independent and identically distributed data, since online education using this new algorithm can achieve the correct classification even it has different data distribution. At the same time, with the help of Hadoop’s parallel processing architecture, OEDCF can greatly enhance the efficiency of data processing, create favorable conditions for learning analysis, and promote personalized learning and other activities of big data era.

关键词： Transfer learning Online education OEDCF AdaBoost algorithm Tr_MAdaBoost algorithm

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间充质干细胞分泌组发挥作用的分子机制

中国组织工程研究 2025年第7期29卷 1512-1522页

作者：李佳林张耀东娄艳茹于洋杨蕊北京大学第三医院妇产科生殖医学中心女性生育力促进全国重点实验室北京市100191 国家妇产疾病临床医学研究中心(北京大学第三医院) 北京市100191 辅助生殖教育部重点实验室(北京大学) 北京市100191 生殖内分泌与辅助生殖技术北京市重点实验室北京市100191 国家临床重点专科建设项目(2023)专项资金北京市100191

背景:大量研究证实间充质干细胞分泌组的治疗有效性与间充质干细胞相当,但对于其发挥作用的机制尚不清楚。目的:总结近年来关于间充质干细胞分泌组的研究进展,探究其发挥治疗作用的分子机制,分析目前面临的问题并展望未来发展方向。方法... 详细信息

背景:大量研究证实间充质干细胞分泌组的治疗有效性与间充质干细胞相当,但对于其发挥作用的机制尚不清楚。目的:总结近年来关于间充质干细胞分泌组的研究进展,探究其发挥治疗作用的分子机制,分析目前面临的问题并展望未来发展方向。方法:以“exosomes,mesenchymal stem cells secrete,extracellular vesicles,mesenchymal stem cells,mechanism”为英文检索词检索PubMed数据库相关文献,排除与文章研究目的无关及重复性文章,同时结合文献追踪的方法,最终纳入符合要求的109篇文献进行综述。结果与结论:(1)间充质干细胞分泌组通过递送遗传物质、免疫调节因子和生长因子等到靶细胞,通过激活靶细胞抗凋亡和促生存途径,调节血管生成,调节纤维化以及调节免疫微环境,促进组织修复和再生。(2)间充质干细胞分泌组在疾病治疗方面的潜力也得到证实,大量研究结果表明,间充质干细胞分泌组可以作为炎症疾病和退行性疾病的新型无细胞替代治疗方法。(3)近年来,经过工程化改造间充质干细胞分泌组发挥的治疗作用更加高效,但是由于间充质干细胞分泌组的异质性以及成分的复杂性,其发挥治疗作用的具体机制尚不清楚。(4)目前,仍需要进一步研究来明确间充质干细胞分泌组发挥治疗作用的关键靶点,并且未来应结合工程化和基因工程技术等,研发出具有创新性的特异型、增强型间充质干细胞分泌组。

关键词：间充质干细胞外泌体细胞外囊泡间充质干细胞分泌组免疫调节组织修复再生医学分子机制

Derivative-free reinforcement learning:a review

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Frontiers of Computer Science 2021年第6期15卷 75-93页

作者： Hong QIAN yang yu National Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China

Reinforcement learning is about learning agent models that make the best sequential decisions in unknown *** an unknown environment,the agent needs to explore the environment while exploiting the collected information,which usually forms a sophisticated problem to ***-free optimization,meanwhile,is capable of solving sophisticated *** commonly uses a sampling-andupdating framework to iteratively improve the solution,where exploration and exploitation are also needed to be well ***,derivative-free optimization deals with a similar core issue as reinforcement learning,and has been introduced in reinforcement learning approaches,under the names of learning classifier systems and neuroevolution/evolutionary reinforcement *** such methods have been developed for decades,recently,derivative-free reinforcement learning exhibits attracting increasing ***,recent survey on this topic is still *** this article,we summarize methods of derivative-free reinforcement learning to date,and organize the methods in aspects including parameter updating,model selection,exploration,and parallel/distributed ***,we discuss some current limitations and possible future directions,hoping that this article could bring more attentions to this topic and serve as a catalyst for developing novel and efficient approaches.

关键词： reinforcement learning derivative-free optimization neuroevolution reinforcement learning neural architecture search

A SVM Based Text Steganalysis Algorithm for Spacing Coding

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China Communications 2014年第A01期11卷 108-113页

作者： yang yu InformationSecurityCenter BeijingUniversityofPostsandTelecommunicationsBeijing100876China NationalEngineeringLaboratoryforDisasterBackupandRecovery Beijing100876China SchoolofMathematicsandInformationScience&Technology HebeiNormalUniversityofScience&Technology

Group distance coding is suitable for secret communication covered by printed documents. However there is no effective method against it. The study found that the hiding method will make group distances of text lines coverage on specified values, and make variances of group distances among N-Window text lines become small. Inspired by the discovery, the research brings out a Support Vector Machine （SVM） based steganalysis algorithm. To avoid the disturbance of large difference among words length from same line, the research only reserves samples whose occurrence-frequencies are ± 10dB of the maximum frequency. The results show that the correct rate of the SVM classifier is higher than 90%.

关键词： text steganalysis SVM steganalysis space-coding detecting

Energy globalization of China:Trade,investment,and embedded energy flows

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Journal of Geographical Sciences 2022年第3期32卷 377-400页

作者： yang yu Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institute of Strategy Research of Guangdong-Hong Kong-Macao Greater Bay Area Guangzhou 510070China

China is in a critical period of transforming from the oil and gas era to the renewable energy *** better understand the process of energy interaction between China and the rest of the world,this study aimed to investigate the basic theoretical cognition of global energy interaction and analyze the pattern and changes of energy interaction between China and the rest of the world with the method of complex networks,multi-region input-output analysis,and other technical *** main findings are as follows:(1)Chinas coal-based energy production structure and the huge demand for oil and gas indicate that ensuring overseas oil and gas supply is the most direct logic of energy interaction between China and the rest of the world,and the interaction scopes are mainly concentrated in oil-and gas-rich countries and regions.(2)With the development of renewable energy,the logic of energy interaction of China with the rest of the world has changed from countries and regions rich in oil and gas to countries with global renewable energy development and installation needs for its comparative advantages for manufacturing,which forms a renewable energy trade map that covers all major countries and regions in the world.(3)The overseas energy investment target of China has expanded from a limited number of host countries to Europe,Southeast Asia,and other countries and *** investment business is not only limited to the oil and gas field,but also expanded to solar energy,wind energy,hydro-power,and other renewable electricity generation projects.(4)As a global manufacturing and trading power,part of the energy consumed by China is embodied in the global production network and trade network for *** scope of energy interactions between China and the world will further expand to countries with general commodity trade relations with China,forming the global“energy hub”*** study can provide a theoretical perspective and decision-making for a deeper un

关键词： energy globalization energy interaction energy trade energy investment embodied energy energy transition

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BEND3 takes the rein

Science China(Life Sciences) 2023年第5期66卷 1210-1212页

作者： yang yu State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Transcription factors(TFs)interpret genome and guide gene expression through directly recognizing specific DNA sequences located in cis-elements and recruiting diverse transcription *** and DNA-binding motif interacti... 详细信息

关键词： diverse programs physiology