检索结果-南通市图书馆

Petroleum Science 2024年第1期21卷 674-682页

作者： jing He Kun Zhu Wei Jiang Dong-Ao Zhu Lin-Hua Zhu hai-Yan Huang Wen-Shuai Zhu Hua-Ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization

Text mining and data analysis identify potential drugs and pathways for polycystic ovary syndrome treatment

在线全文

学校读者我要写书评

暂无评论

Reproductive and Developmental Medicine 2024年第1期8卷 32-38页

作者： Xiao-jing Yuan Yan Wang hai-Yan yang Bin Zhao Medical Reproductive Center People's Hospital of Jiuquan CityJiuquan 735000China Department of Gynecological Oncology The Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou 545000China Xiamen Health and Medical Big Data Center Xiamen361001China

Objective:Polycystic ovarian syndrome(PCOS)is a common endocrine disorder affecting women of reproductive *** study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with ***:We extracted a common set of genes associated with PCOS using text mining and the microarray dataset ***,we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes,as well as protein–protein interaction(PPI)network ***,we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene–drug interaction analyses to identify potential drugs for further ***,we annotated pathways associated with the genes ***:Text mining and microarray analysis yielded 696 text mining genes(TMGs)and 2804 differentially expressed genes(DEGs).Among these,a set of 77 genes was found in both TMGs and ***,67 of these genes participated in constructing the PPI *** common hub genes were selected using the MCODE and CytoHubba ***,five out of seven genes were targeted by 15 existing ***:Four genes(FASLG,IL13,IL17A,andIL2RA),which are mainly related to the cytokine–cytokine receptor interaction pathway,could be prioritized as targets for PCOS.

关键词： Text mining Differentially expressed genes Polycystic ovary syndrome Drug discovery

“Steric Armor”Strategy of Blue Fluorescent Emitters against Photooxidation-Induced Degradation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第11期42卷 1223-1229页

作者： Sha-Sha Wang jing-Rui Zhang Kuan-De Wang Hao-Ran Li Peng-Hui Meng yang Zhou Xiang Yu Ying Wei Quan-You Feng Yu-He Kan Ling-hai Xie Centre for Molecular Systems and Organic Devices(CMSOD) State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced MaterialsJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjingJiangsu210023 China Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials School of Chemistry and Chemical EngineeringHuaiyin Normal UniversityHuai'anJiangsu223300 China

Stability against oxygen is an important factor affecting the performance of organic semiconductor *** photooxidation stability can prolong the service life of the device and maintain the mechanical and photoelectric properties of the ***,various encapsulation methods from molecular structure to macroscopic device level are used to improve photooxidation ***,we adopted a crystallization strategy to allow 14H-spiro[dibenzo[c,h]acridine-7,9′-fluorene](SFDBA)to pack tightly to resist fluorescence decay caused by *** this case,the inert group of SFDBA acts as a“steric armor”,protecting the photosensitive group from being attacked by ***,compared with the fluorescence quenching of SFDBA powder under 2 h of sunlight,SFDBA crystal can maintain its fluorescence emission for more than 8 h under the same ***,the photoluminescence quantum yields(PLQYs)of the crystalline film is 327%higher than that of the amorphous *** shows that the crystallization strategy is an effective method to resist oxidation.

关键词： Organic semiconductor Photooxidation Spirocyclic aromatic hydrocarbons Crystal engineering Fluorescence

LiNi_(1-x)Al_xO_2(x=0～0.6)的制备和结构演变

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高等学校化学学报 2005年第8期26卷 1484-1487页

作者：刘伟宫杰杨景海宗占国陈岗吉林大学材料科学与工程学院长春130023 吉林师范大学凝聚态物理研究所四平136000 长春大学应用物理研究所长春130022

通过研究LiNiO2和α-LiAlO2的制备条件,合成出LiNi1-xAlxO2(x=0～0.6)材料.XRD和XPS测试结果表明,各样品均具有α-NaFeO2型单相结构,并形成LiNi1-xAlxO2固溶体.随着Al固溶量x的增加,材料Ni(Al)—O结合能增加,晶胞的a轴缩短,c/a比增大,... 详细信息

通过研究LiNiO2和α-LiAlO2的制备条件,合成出LiNi1-xAlxO2(x=0～0.6)材料.XRD和XPS测试结果表明,各样品均具有α-NaFeO2型单相结构,并形成LiNi1-xAlxO2固溶体.随着Al固溶量x的增加,材料Ni(Al)—O结合能增加,晶胞的a轴缩短,c/a比增大,层状属性更加明显,结构稳定性增强.烧结实验结果表明,在低Al固溶量时,材料的合成需要在氧气气氛中进行,Al掺杂能够抑制结构中的Li缺位,降低材料形成温度及其在合成过程中对氧气的依赖程度.

关键词： LiNi1-xAlxO2 α-NaFeO2型结构固溶体结合能

Polymer-on-HOF:a new strategy for fabricating“armour-plated”HOFs to sequester radioactive anions

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第9期67卷 2958-2967页

作者： hai-Ruo Li Shitao Wu Xuezhuo jing Zhengyi Di Kun Liu Lu Wang Cheng-Peng Li Zhong Liu Miao Du College of Chemistry Tianjin Key Laboratory of Structure and Performance for Functional MoleculesTianjin Normal UniversityTianjin 300387China Shanghai Key Laboratory of High-Resolution Electron Microscopy School of Physical Science and TechnologyShanghaiTech UniversityShanghai 201210China Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Provincial Key Laboratory of Resources and Chemistry of Salt LakesQinghai Institute of Salt LakesChinese Academy of SciencesXining 810008China College of Material and Chemical Engineering Institute of New Energy Science and TechnologySchool of Future Hydrogen Energy TechnologyZhengzhou University of Light IndustryZhengzhou 450001China

The development of hydrogen-bonded organic frameworks(HOFs)faces significant constraints,primarily attributed to their fragile architectures and limited functionalization *** overcome these limitations,this work presents a new polymeron-HOF strategy by covalently tethering armor-like polymers onto the surface of *** application of this approach not only bolsters the stability of HOFs,but also facilitates the customization of their functional expansion in radionuclide *** optimized HOF-polymer materials display extraordinary ability in radionuclide sequestration,achieving uptake of I^(-)(0.699 g g^(-1)),IO_(3)^(-)(0.285 g g^(-1))and ReO_(4)^(-)(1.616 g g^(-1),setting a world record),fast adsorption kinetics(~100% removal within 45 s),and exceptional regeneration capability(>30 cycles)under continuous flow *** outstanding performances benefit from the internal porous channels and surface imidazolium polymer coatings of HOFs,as proved by density functional theory calculation and molecular dynamics *** work paves the way for the rational design of HOF-based hybrid materials tailored to versatile applications.

关键词： hydrogen-bonded organic frameworks(HOFs) post-synthetic modification radionuclide sequestration

Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第2期44卷 369-379页

作者： Ji LUO Jin ZHOU jing-zeng LUO hai-long WANG Xue-ling ZHAO Ru-dan ZHOU Department of Intensive Care Unit The First People's Hospital of ZiyangZiyang 641300China Department of Orthopedics Kunming Medical University Second Affiliated HospitalKunming 650033China Department of Orthopedics Kunming Medical University First Affiliated HospitalKunming 650032China Department of Orthopedics The Third People's Hospital of Yunnan ProvinceKunming 650200China

Objective:Matrix metalloproteinase 13(MMP13)is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens,modifying protein structures and regulating inflammatory responses,but its role in deep vein thrombosis(DVT)has not been *** purpose of this study was to investigate the potential effects of MMP13 and MMP13-related genes on the formation of ***:We altered the expression level of MMP13 in vivo and conducted a transcriptome study to examine the expression and relationship between MMP13 and MMP13-related genes in a mouse model of *** screening genes possibly related to MMP13 in DVT mice,the expression levels of candidate genes in human umbilical vein endothelial cells(HUVECs)and the venous wall were *** effect of MMP13 on platelet aggregation in HUVECs was investigated in ***:Among the differentially expressed genes,interleukin 1 beta,podoplanin(Pdpn),and factor VIII von Willebrand factor(F8VWF)were selected for analysis in *** MMP13 was inhibited,the expression level of PDPN decreased significantly in *** HUVECs,overexpression of MMP13 led to an increase in the expression level of PDPN and induced platelet aggregation,while transfection of PDPN-siRNA weakened the ability of MMP13 to increase platelet ***:Inhibiting the expression of MMP13 could reduce the burden of DVT in *** mechanism involves downregulating the expression of Pdpn through MMP13,which could provide a novel gene target for DVT diagnosis and treatment.

关键词： deep vein thrombosis matrix metalloproteinase 13 podoplanin

Pectolinarin inhibited LPS-stimulated inflammation in microglial BV_(2) cells via NF-κB signaling pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第6期9卷 12-18页

作者： Bin-Feng Cheng Xiao Feng Yu-Qian Dong Shao-Qin Jian Hao-Heng Yu jing-jing Li Ting Ma Jun Zhang Yao-Dong Zhang hai-Jie yang Lei Wang Xinxiang Key Laboratory of Stress Cell Biology School of Life Sciences and TechnologyXinxiang Medical UniversityXinxiang 453003China Henan Neural Development Engineering Research Center Henan Children’s HospitalZhengzhou 410000China

Background:Neuro-inflammation is regarded as one of the critical pathogenesis in neurodegenerative diseases,which is characterized by the activated microglial ***(Pec),a natural flavonoid that exists in many Chinese herbal medicines,has been reported to have various biological ***,the effects and mechanisms on neuro-inflammation are not ***:In this study,the inhibitory effects and mechanisms of Pec on neuro-inflammation were investigated in the LPS-stimulated microglial BV_(2) ***_(2) microglial cells were treated with Pec or vehicle,followed by ***-linked immunosorbent assay,real-time quantitative PCR,nitric oxide and reactive oxygen species assay,and western blot were performed to examine the effects of Pec on neuro-inflammatory ***:We showed that Pec significantly inhibited the expression of tumor necrosis factorαand interleukin 6 in mRNA and protein levels induced by ***,the production of nitric oxide,iNOS,reactive oxygen species,and COX-2 were suppressed by Pec in LPS-stimulated microglial BV_(2) *** addition,Pec inhibited LPS-induced inflammation via nuclear factor kappa B signaling pathway,as evidenced by the reduction of the phosphorylation of inhibitor of nuclear factor kappa-B kinase,the degradation of IκBα,and the nuclear translocation of ***:Taken together,Pec exhibited anti-inflammatory effects in LPS-stimulated microglial BV_(2) cells via nuclear factor kappa B signaling pathway,which might provide therapeutic potential for neuro-inflammation and neurodegenerative diseases.

关键词： neuroinflammation microglial cells pectolinarin NF-κB

Stability Switches of a Double-delayed Mussel-algae System

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年

作者： Zhi-chao JIANG jing-hua HE Bo-hai CHEN School of Liberal Arts and Sciences North China Institute of Aerospace Engineering

The stable switching phenomenon of a diffusion mussel-algae system with two delays and half saturation constant is studied. The stability of positive equilibrium and the existence of Hopf bifurcation on two-delay plane are investigated by calculating the stability switching curves. The normal form on the central manifold near Hopf bifurcation point is also derived. It can find that two different delays can induce the stable switches which cannot occur with the same delays. Through numerical simulations, the region of complete stability of system increases with the increase of half-saturation constant, indicating that the half-saturation constant contributes to the stability of system. In addition, double Hopf bifurcations may occur due to the intersection of bifurcation curves. These results show that two different delay and half-saturation constant have important effects on the system. The numerical simulation results validate the correctness of the theoretical analyses.

关键词：

Synergy of inside doped metals–Outside coated graphene to enhance hydrogen storage in magnesium-based alloys

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2024年第6期12卷 2462-2471页

作者： Kun Zhang Yu Chang jingjing Lei jing Chen Tingzhi Si Xiaoli Ding Ping Cui hai-Wen Li Qingan Zhang Yongtao Li School of Materials Science and Engineering&Low-Carbon New Materials Research Center Anhui University of TechnologyMaanshanAnhui 243002China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing100084 Hefei General Machinery Research Institute HefeiAnhui 230031China Key Laboratory of Green Fabrication and Surface Technology of Advanced Metal Materials of Ministry of Education Anhui University of TechnologyMaanshan 243002China

Grain growth of magnesium(Mg)and its hydride is one of the main reasons for kinetic and capacity degradation during the hydrogen absorption and desorption *** solve this problem,herein we propose a novel method involving synergistic effect of inside embedded metals and outside coated graphene to limit the growth of Mg and its hydride *** graphene coated Mg-Y-Al alloys were selected as a model system for demonstrating this positive effect where the Mg_(91)Y_(3)Al_(6)alloy was first prepared by rapidly solidified method and then high-pressure milled with 5 wt%graphene upon 5 MPa hydrogen gas for obtaining in-situ formed YAl_(2)and YH_(3)embedded in the MgH_(2)matrix with graphene shell(denoted as MgH_(2)-Y-Al@GR).In comparison to pure MgH_(2),the obtained MgH_(2)-Y-Al@GR composites deliver much better kinetics and more stable cyclic *** instance,the MgH_(2)-Y-Al@GR can release about 6.1 wt%H_(2)within 30 min at 300℃ but pure MgH_(2)only desorbs∼1.5 wt%H_(2).The activation energy for desorption of MgH_(2)-Y-Al@GR samples is calculated to be 75.3±9.1 kJ/mol that is much lower than approximately 160 kJ/mol for pure MgH_(2).Moreover,its capacity retention is promoted from∼57%of pure MgH_(2)to∼84%after 50th cycles without obvious particle agglomeration and grain *** synergistic effect of outside graphene coating with inside embedded metals which could provide a huge number of active sites for catalysis as well as inhibit the grain growth of Mg and its hydride is believed to be responsible for these.

关键词： Energy Hydrogen storage Mg alloys Synergy effect

Association of cardiometabolic multimorbidity with all-cause and cardiovascular disease mortality among Chinese hypertensive patients

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第2期21卷 211-218页

作者： Luo-Xi XIAO Zi-Yu WANG Jiang-Tao LI hai-Mei WANG Yi-Ming HAO Pan ZHOU Yu-Lin HUANG Qiu-Ju DENG Yong-Chen HAO Na yang Li-Zhen HAN Zhao yang Ping-Ping JIA Yue QI jing LIU Center for Clinical and Epidemiologic Research Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing Municipal Key Laboratory of Clinical EpidemiologyBeijingChina

BACKGROUND Hypertension usually clusters with multiple ***,the association between cardiometabolic multimorbidity(CMM)and mortality in hypertensive patients is *** study aimed to investigate the association between CMM and all-cause and cardiovascular disease(CVD)mortality in Chinese patients with *** The data used in this study were from the China National Survey for Determinants of Detection and Treatment Status of Hypertensive Patients with Multiple Risk Factors(CONSIDER),which comprised 5006 participants aged 19–91 *** was defined as the presence of one or more of the following morbidities:diabetes mellitus,dyslipidemia,chronic kidney disease,coronary heart disease,and *** proportional hazard models were used to calculate the hazard ratios(HR)with 95%CI to determine the association between the number of CMMs and both all-cause and CVD *** Among 5006 participants[mean age:58.6±10.4 years,50%women(2509 participants)],76.4%of participants had at least one *** mortality rate was 4.57,4.76,8.48,and 16.04 deaths per 1000 person-years in hypertensive patients without any comorbidity and with one,two,and three or more morbidities,*** the fully adjusted model,hypertensive participants with two cardiometabolic diseases(HR=1.52,95%CI:1.09–2.13)and those with three or more cardiometabolic diseases(HR=2.44,95%CI:1.71–3.48)had a significantly elevated risk of all-cause *** findings were similar for CVD mortality but with a greater increase in risk *** In this study,three-fourths of hypertensive patients had *** with two or more comorbidities was associated with a significant increase in the risk of all-cause and cardiovascular mortality among hypertensive patients,suggesting more intensive treatment and control in this high-risk patient group.

关键词： hypertensive patients morbidity