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Characteristics Variation of Atmospheric CO_(2)and CH_(4)in Yongxing Island,South China Sea

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Journal of Ocean University of China 2024年第2期23卷 438-446页

作者： lv Honggang JIANG Yifei WANG Haiyan Key Laboratory of Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural Resources(MNR)Beijing 100081China National Marine Environmental Forecasting Center Beijing 100081China

Using the observation data in Yongxing Island,South China Sea(SCS)from December 2013 to November 2018,the multiple time scales variation of atmospheric CO_(2)and CH_(4)were analyzed to understand their temporal variation characteristics and controlling *** regional-averaged background mole fractions of CO_(2)and CH_(4)both show a single-period sinusoidal variation with a lower value at noon and a higher value in the wee *** the seasonal scale,they exhibited a significant seasonal difference with higher values in winter and lower values in *** the annual scale,CO_(2)and CH_(4)both show an increasing trend,with an annual growth rate of approximately 3.2 ppm and 12 ppb,*** annual growth rate at this site was higher than the global *** change in atmospheric CO_(2)and CH_(4)in Yongxing Island was probably caused by the higher emission of the surrounding areas and the airflows driven by ***,the long-term and high-resolution greenhouse gases(GHGs)dataset will aid relevent researchers and decision-makers in performing more in-depth studies for GHG sources in order to derive effective strategies.

关键词： carbon dioxide methane observation backward trajectory atmospheric transport

Clinical characteristics of patients with early gastric prematurity cancer and analysis of complications by endoscopic resection

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3898-3904页

作者： Hong Zhao Xiang-Yu Shi Li-Li lv yan-Zong Lai Xiao-Xiao Bao Jian-Wen Hu Department of Gastroenterology Dongyang People’s HospitalDongyang 322100Zhejiang ProvinceChina Department of Gastroenterology Yiwu Tianxiang Medical East HospitalYiwu 322100Zhejiang ProvinceChina Department of Pathology Dongyang People’s HospitalDongyang 322100Zhejiang ProvinceChina

BACKGROUND Gastric cancer,a prevalent malignancy,poses a severe threat to the health of residents in *** intervention in early stages can extend patients’*** To analyze clinical characteristics of patients with early gastric cancer and efficacy and risk of complications associated with endoscopic *** This study included 175 patients with early gastric cancer treated at our hospital,with no restrictions on sex or *** data,pathological information,and endoscopic biopsy results were *** clinical characteristics of early gastric cancer were analyzed,and endoscopic resection was *** efficacy and incidence of complications were *** analysis was performed using SPSS 26.0 and GraphPad Prism 8.0 *** A total of 175 patients with early gastric cancer were included,with 75.43%(n=132)males and 24.57%(n=43)females.38.29%(n=67)and 35.43%(n=62)of patients had a history of smoking and alcohol consumption,*** included diabetes(8.57%,n=15),coronary heart disease(10.29%,n=18),and hypertension(43.43%,n=76),which was highly prevalent.A history of abdominal surgery and family history of digestive system cancer accounted for 21.14%and 17.14%,*** most common lesion location was the antral part of the stomach(52.00%,n=91),followed by the gastric angle,body,and *** pathological types were predominantly high-grade intraepithelial neoplasia(28.00%,n=49)and well-differentiated adenocarcinoma(26.86%,n=47),followed by moderately differentiated adenocarcinoma,high-moderately differentiated adenocarcinoma,and moderate-lowly differentiated adenocarcinoma.89.14%of the patients had intestinal metaplasia and 85.14%had *** endoscopic resection,re-examination revealed that 13 patients had cancer cells at the tissue margin,with a positive margin rate of 7.43%.Postoperative complications included no cases of gastrointestinal obstruction,but incisional infec

关键词： Early gastric cancer Clinical characteristics Endoscopic resection Complications

Drought decreases the positive impact of warming on an alpine grassland community

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Science China Earth Sciences 2024年第10期67卷 3226-3238页

作者： Wang A Wangwang lv yang ZHOU Bowen LI Jianping SUN Jingya lv Lanying CHEN Dorji TSECHEO Shiping WANG Key Laboratory of Tibetan Plateau Earth Resources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China School of Ecology and Environment Tibet UniversityLhasa 850000China University of the Chinese Academy of Sciences Beijing 100049China

Temperature and precipitation are the main factors determining plant community succession and aboveground net primary productivity(ANPP)in natural ***,most climate manipulative experiments have mainly focused on their impacts in isolation,especially in alpine *** we explored the relative effects and interaction of warming and precipitation alteration on succession and ANPP using a 7-year experiment involving warming with precipitation alteration(increase(IP)or decrease(DP))in precipitation relative to ambient precipitation(AP)on the Tibetan *** results showed that warming and warm-wet conditions increased species richness,diversity index,height and cover of overall ***,decreasing precipitation reduced them,but increased *** and the rate of change in community ***,warming mitigated the impacts of decreased precipitation on plant community composition,and the interactive effects of warming and altered precipitation on cover,height and plant ANPP varied with year and plant ***,warming increased community ANPP through increases in forb ANPP or non-dominant species ANPP and biodiversity regardless of change in ***,decreased precipitation reduced community ANPP via decreases in the ANPP of sedges and forbs and *** alteration affected the relationship between biodiversity and community ANPP regardless of warming(IP

关键词： Alpine grassland Climate warming Precipitation alteration Community composition Biodiversity Above-ground net primary productivity

Pollution characteristics and quantitative source apportionment of heavy metals within a zinc smelting site by GIS-based PMF and APCS-MLR models

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Journal of Environmental Sciences 2024年第10期144卷 100-112页

作者： Huagang lv Zhihuang Lu Guangxuan Fu Sifang lv Jun Jiang Yi Xie Xinghua Luo Jiaqing Zeng Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Zhuzhou Qingshuitang Technology Co. Ltd.Zhuzhou 412000China New World Environment Protection Group of Hunan Changsha 410083China

The abandoned smelters present a substantial pollution threat to the nearby soil and *** this study,63 surface soil samples were collected from a zinc smelter to quantitatively describe the pollution characteristics,ecological risks,and source apportionment of heavy metal(loid)s(HMs).The results revealed that the average contents of Zn,Cd,Pb,As,and Hg were 0.4,12.2,3.3,5.3,and 12.7 times higher than the risk screening values of the construction sites,***,the smelter was accumulated heavily with Cd and Hg,and the contribution of Cd(0.38)and Hg(0.53)to ecological risk was 91.58%.ZZ3 and ZZ7 were the most polluted workshops,accounting for 25.7%and 35.0%of the pollution load and ecological risk,*** influence of soil parent materials on pollution was minor compared to various workshops within the *** with PMF,APCS-MLR and GIS analysis,four sources of HMs were identified:P1(25.5%)and A3(18.4%)were atmospheric deposition from the electric defogging workshop and surface runoff from the smelter;P2(32.7%)and A2(20.9%)were surface runoff of As-Pb foul acid;P3(14.5%)and A4(49.8%)were atmospheric deposition from the leach slag drying workshop;P4(27.3%)and A1(10.8%)were the smelting process of zinc *** paper described the distribution characteristics and specific sources of HMs in different process workshops,providing a new perspective for the precise remediation of the smelter by determining the priority control factors.

关键词： Smelter site Heavy metal(loid)s Source apportionment Positive matrix factorization Absolute principal component score-multiple linear regression

PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity

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Science China(Life Sciences) 2024年第9期67卷 2033-2035页

作者： Meihan Gong Ye Yuan Zhongye Dai Xuejiao lv Jiacheng Su Dawei Huo lin Niu Xu Chen Xudong Wu State Key Laboratory of Experimental Hematology The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical EpigeneticsKey Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Bone Marrow Transplantation Center the First Affiliated HospitalZhejiang University School of MedicineLiangzhu LaboratoryInstitute of HematologyZhejiang UniversityHangzhou 311113China

Dear Editor,Polycomb group proteins,conserved epigenetic transcriptional repressors,are crucial for orchestrating diverse developmental gene expression programs(Schuettengruber et al.,2017).The polycomb repressive complex 2(PRC2)catalyzes H3 lysine-27 trimethylation(H3K27me3)to establish a delicate balance with H3K4me3,forming a bivalent chromatin state at target gene promoters and thereby poising them for subsequent transcription activation(Bernstein et al.,2006).

关键词： valent thereby subsequent

Finite Groups with Some Bounded Codegrees

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1778-1784页

作者： Dong Fang yanG Yu ZENG Heng lv School of Mathematics and Statistics Southwest UniversityChongqing400715P.R.China Department of Mathematics Changshu Institute of TechnologyChangshu215500P.R.China

For a characterχof a finite group G,the number cod(χ) := ∣G:ker(χ)∣/χ(1)is called the codegree ofχ.In this paper,we give a solvability criterion for a finite group G depending on the minimum of the ratioχ(1)^(... 详细信息

关键词： Finite group codegree degree simple group

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan Mo yan-Tong Zhou Dan lv Jing-Tong Zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

Inhalable metal–organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2281-2297页

作者： Chongzheng yan Ying Liu Guozhi Zhao Huatian yang Huaiyou lv Genju Li Yuhan Li Yaqing Fu Fengqin Sun Yafei Feng Yizhe Li Zhongxi Zhao Department of Pharmaceutics Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesCheelloo College of MedicineShandong UniversityJinan 250012China Key University Laboratory of Pharmaceutics&Drug Delivery Systems of Shandong Province School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China

Cuproptosis shows enormous application prospects in lung metastasis ***,the glycolysis,Cu^(+)efflux mechanisms,and insufficient lung drug accumulation severely restrict cuproptosis ***,an inhalable poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate)(OPDEA)-coated copper-based metal–organic framework encapsulating pyruvate dehydrogenase kinase 1 siRNA(siPDK)is constructed for mediating cuproptosis and subsequently promoting lung metastasis immunotherapy,namely *** inhalation,OMP shows highly efficient lung accumulation and long-term retention,ascribing to the OPDEA-mediated pulmonary mucosa *** tumor cells,OMP is degraded to release Cu2+under acidic condition,which will be reduced to toxic Cu^(+)to induce cuproptosis under glutathione(GSH)***,siPDK released from OMP inhibits intracellular glycolysis and adenosine-5ʹ-triphosphate(ATP)production,then blocking the Cu^(+)efflux protein ATP7B,thereby rendering tumor cells more sensitive to OMP-mediated ***,OMP-mediated cuproptosis triggers immunogenic cell death(ICD)to promote dendritic cells(DCs)maturation and CD8^(+)T cells ***,OMP-induced cuproptosis up-regulates membrane-associated programmed cell death-ligand 1(PD-L1)expression and induces soluble PD-L1 secretion,and thus synergizes with anti-PD-L1 antibodies(aPD-L1)to reprogram immunosuppressive tumor microenvironment,finally yielding improved immunotherapy ***,OMP may serve as an efficient inhalable nanoplatform and afford preferable efficacy against lung metastasis through inducing cuproptosis and combining with aPD-L1.

关键词： Cuproptosis Immunogenic cell death PD-L1 checkpoint blockade Copper-based metal-organic framework Immunotherapy Tumor microenvironment Transmucosal deliveryLung metastasis

Chlorajaponins A—Q,lindenane-Related Sesquiterpenoid Dimers from Chloranthus japonicus and Their Biological Activities

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Chinese Journal of Chemistry 2024年第11期42卷 1247-1259页

作者： Wei-Jiao Feng Yue Gu Pei-Zhi Huang Hong-Ying yang Rui Zhang Yi-lin He Ting-Hong lv Ya Li Kun Gao State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhouGansu730000 China Research Institute Lanzhou Jiaotong UniversityLanzhouGansu730070 China

Seventeen undescribed lindenane-related sesquiterpenoid dimers,chlorajaponins A—Q(1—17),and 13 reported analogs(18—30)were isolated from Chloranthus japonicus *** 1 possesses an unprecedented 3/5/7/5/5/6/5/3 fused octacyclic scaffold,featuring a 6(5→4)-abeo-lindenane monomer,while 2 exhibits a 3/5/6/6/5/6/5/3 fused octacyclic *** structures were determined through a combination of spectroscopic analyses and X-ray *** 1,2,and 18 demonstrated significant inhibitory effects on lipid accumulation and effectively reduced the levels of triglycerides and total cholesterol,as well as the levels of aspartate aminotransferase and alanine aminotransferase in a HepG2 cell *** addition,compounds 1,2,and 18 significantly suppressed the protein expression of the fatty acid synthase(FASN)and the sterol regulatory element-binding protein 1(SREBP1).Moreover,the anti-inflammatory assay showed that compounds 19—22 and 25 inhibited the NO production induced by lipopolysaccharide in RAW 264.7 macrophages with IC50 values of 7.89±0.44,6.25±0.46,2.98±0.29,10.77±0.60,and 3.60±0.28μmol/L.

关键词： Chloranthus japonicus lindenane-type sesquiterpenoid dimers Lipid-lowering activity Anti-inflammatory activity NMR spectroscopy Natural products X-ray diffraction