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Association between physical activity and risk of gastroesophageal reflux disease:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第5期13卷 687-698页

作者： Chuting Yu Tinglu Wang Ye Gao Yunfei jiao Huishan Jiang yan Bian Wei Wang Han Lin Lei Xin Luowei Wang Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases(Shanghai) Shanghai 200433China

Background:Lifestyle plays an important role in preventing and managing gastroesophageal reflux disease(GERD).In response to the conflicting results in previous studies,we performed a systematic review and meta-analysis to investigate this ***:Relevant studies published until January 2023 were retrieved from 6 databases,and the prevalence of symptomatic gastroesophageal reflux(GER)or GERD was determined from the original studies.A random effects model was employed to meta-analyze the association by computing the pooled relative risk(RR)with 95%confidence intervals(95%CIs).Furthermore,subgroup and dose-response analyses were performed to explore subgroup differences and the association between cumulative physical activity(PA)time and ***:This meta-analysis included 33 studies comprising 242,850 participants.A significant negative association was observed between PA and the prevalence of symptomatic GER(RR=0.74,95%CI:0.66-0.83;p<0.01)or GERD(RR=0.80,95%CI:0.76-0.84;p<0.01),suggesting that engaging in PA might confer a protective benefit against *** analyses consistently indicated the presence of this association across nearly all subgroups,particularly among the older individuals(RR_(<40 years):RR_(≥40 years)=0.85:0.69,p<0.01)and smokers(RR_(smoker):RR_(non-smoker)=0.67:0.82,p=0.03).Furthermore,a dose-response analysis revealed that individuals who engaged in 150 min of PA per week had a 72.09%lower risk of developing ***:Maintaining high levels of PA decreased the risk of GERD,particularly among older adults and *** the recommended PA level of 150 min per week may significantly decrease the prevalence of GERD.

关键词： Physical activity Gastroesophageal reflux disease Prevalence Systematic review

质子导体电解质钇掺杂锆酸铈钡微波烧结制备及其电化学和力学性能

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硅酸盐学报 2024年第7期52卷 2243-2253页

作者：秦嘉辰高燕焦震钧张进严资林哈尔滨工业大学(深圳)理学院广东深圳518055

质子陶瓷燃料电池(PCFC)是新一代固体氧化物燃料电池(SOFC)技术的重要发展方向。钇掺杂锆酸铈钡BaZr_(1–x–y)Ce_(x)Y_(y)O_(3–δ)(BZCY)是常用的质子导体电解质材料。然而,BZCY电解质致密化通常需要在超过1700℃的高温烧结5 h以上,... 详细信息

质子陶瓷燃料电池(PCFC)是新一代固体氧化物燃料电池(SOFC)技术的重要发展方向。钇掺杂锆酸铈钡BaZr_(1–x–y)Ce_(x)Y_(y)O_(3–δ)(BZCY)是常用的质子导体电解质材料。然而,BZCY电解质致密化通常需要在超过1700℃的高温烧结5 h以上,这不仅会消耗大量能源和时间成本,而且,由于制备温度高,当电解质冷却到室温时,残余应力可能会导致试样后期力学破坏,进而影响其力学性能。本研究探索了质子导体电解质BaZr_(0.7)Ce_(0.2)Y_(0.1)O_(3–δ)(BZCY721)的微波烧结工艺及研究了其电化学和力学性能。结果表明:相对于传统烧结方式,微波烧结可以将BZCY721烧结温度降低100~150℃。试样在1500℃微波烧结40 min,致密度可以达到97%以上。试样在650℃测试温度下,晶粒阻抗为34.81Ω·cm^(2),晶界阻抗为89.98Ω·cm^(2),电导率为6.41×10^(–4)S·cm^(–1)。力学性能测试结果表明,微波烧结的电解质具有与传统烧结结果相当的弹性模量(190.8 GPa),以及更优的硬度(12.379 GPa)和断裂韧性(0.359 MPa·m^(1/2))。本研究结果为在低温下制备致密BZCY721电解质的进一步研究提供了重要参考。

关键词：固体氧化物燃料电池质子导体电解质微波烧结电化学性能力学性能

Knock-in of exogenous sequences based on CRISPR/Cas9 targeting autosomal genes and sex chromosomes in the diamondback moth,Plutella xylostella

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Journal of Integrative Agriculture 2024年第9期23卷 3089-3103页

作者： Shanyu Li Guifang Lin Haoqi Wen Haiyan Lu Anyuan Yin Chanqin Zheng Feifei Li Qingxuan Qiao Lu jiao Ling Lin Yi yan Xiujuan Xiang Huang Liao Huiting Feng Yussuf Mohamed Salum Minsheng You Wei Chen Weiyi He State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops/Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops/International Joint Research Laboratory of Ecological Pest Control Ministry of EducationInstitute of Applied EcologyFujian Agriculture and Forestry UniversityFuzhou 350002China Ganzhou Key Laboratory of Greenhouse Vegetable Gannan Normal UniversityGanzhou 341000China

Genetic pest control strategies based on precise sex separation and only releasing sterile males can be accomplished by site-specific genome *** the current study,we showed that the mutation of single-allele Pxfl(2)d can significantly impair the normal mating behavior and testis development in male adults of the notorious cruciferous insect pest Plutella xylostella,in addition to its known functions in the ovarian development in female adults and egg *** CRISPR/Cas9-based knock-in experiments revealed that site-specific integration of an exogenous green fluorescent protein(GFP)gene into autosomal Pxfl(2)d for labelling mutants could be ***,this gene is not a suitable target for GFP insertion to establish a genetically stable knock-in strain because of the severe decline in reproductive *** further screened for the W-chromosome-linked and Z-chromosome-linked regions to test the knock-in efficiency mediated by CRISPR/*** results verified that both types of chromosomes can be targeted for the site-specific insertion of exogenous *** ultimately obtained a homozygous knock-in strain with the integration of both Cas9 and cyan fluorescent protein(CFP)expression cassettes on a Z-linked region in ***,which can also be used for early sex *** injecting the sgRNA targeting Pxfl(2)d alone into the eggs laid by female adults of the Z-Cas9-CFP strain,the gene editing efficiency reached 29.73%,confirming the success of expressing a functional Cas9 *** together,we demonstrated the feasibility of the knock-in of an exogenous gene to different genomic regions in ***,while the establishment of a heritable strain required the positioning of appropriate *** study provides an important working basis and technical support for further developing genetic strategies for insect pest control.

关键词： cruciferous specialist fl(2)d CRISPR/Cas9 knock-in sex chromosome

A near-infrared fluorescent probe for visualizing transformation pathway of Cys/Hcy and H2S and its applications in living system

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Chinese Chemical Letters 2024年第5期35卷 296-301页

作者： Yudi Cheng Xiao Wang jiao Chen Zihan Zhang Jiadong Ou Mengyao She Fulin Chen Jianli Li Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education Xi’an Key Laboratory of Functional Supramolecular Structure and MaterialsCollege of Chemistry&Materials ScienceNorthwest UniversityXi’an 710127China Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationBiomedicine Key Laboratory of Shaanxi ProvinceLab of Tissue Engineeringthe College of Life SciencesFaculty of Life Science&MedicineNorthwest UniversityXi’an 710069China

Sulfydryl-contained(-SH)substances including hydrogen sulfide(H_(2)S),cysteine(Cys),homocysteine(Hcy)and glutathione(GSH)play crucial roles in living systems,and their variations are closely associated with various ***,we developed a near-infrared intramolecular charge transfer(ICT)based fluorescent probe Y-NBD,achieving detection of Cys/Hcy and H_(2)S with different fluorescent signals(green-red for Cys/Hcy,red for H_(2)S),large Stokes shifts(∼100/105nm or 191 nm)and high signal-background-ratio,but not responding to GSH.Y-NBD was successfully applied to image exogenous/endogenous Cys/Hcy and H_(2)S in various living cancer cells(HeLa,A549,and HepG2)and in *** not only visualized the transformation pathway of several thiols in HepG2 cells but also verified that the intestine is the main site for the activation and metabolism of Y-NBD in zebrafish,as well as realized to evaluate the degree of drug-induced liver *** work provides a promising tool for imaging Cys/Hcy and H_(2)S in living systems and shows great potency in evaluating drug-induced liver injury and its treatment.

关键词： Fluorescent probe Near-infrared Hydrogen sulfide Cysteine/homocysteine Large Stokes shift Dicyanoisophorone Drug-induced liver injury

Infantile bacterial meningitis combined with sepsis caused by Streptococcus gallolyticus subspecies pasteurianus:A case report

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World Journal of Clinical Cases 2024年第31期12卷 6472-6478页

作者： Dan Zou Fen Li Shu-Li jiao Jin-Rong Dong Yao-Yao Xiao Xiao-Ling yan yan Li Dan Ren Department of Pediatrics Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina Department of Clinical Laboratory Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang 621000Sichuan ProvinceChina

BACKGROUND Streptococcus gallolyticus subspecies pasteurianus(SGSP)is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal ***,we present a case of SGSP-induced infant meningitis and sepsis,accompanied by bronchopneumonia induced by multidrug-resistant Staphylococcus aureus(MRSA),providing insights into the identification,management,and prognosis of this bacterial *** SUMMARY A 45-day-old female infant presented with two episodes of high fever(maximum temperature:39.5°C)and two generalized grand mal seizure episodes that lasted over ten seconds and self-resolved without concomitant ***,the patient’s C-reactive protein level was 40.73 mg/L,white blood cell count was 13.42×10^(9)/L,neutrophil ratio was 78.4%,procalcitonin level was 7.89μg/L,cerebrospinal fluid(CSF)white cell count was 36×10^(6)/L,multinucleated cell ratio was 95.2%,and protein concentration was 0.41 g/*** and CSF culture revealed that the pathogen was *** bacterium was sensitive to ampicillin,furazolidone,penicillin,lincomycin,moxifloxacin,rifampicin,vancomycin,and levofloxacin but resistant to clindamycin and *** culture revealed the presence of MRSA,which was sensitive to *** patient was diagnosed with meningitis and sepsis caused by SGSP,accompanied by bronchopneumonia induced by ***(100 mg/kg/d)combined with vancomycin(10 mg/kg/dose,q6h)was given as an anti-infective treatment *** 12 days of treatment,the infant was discharged from the hospital with normal CSF,blood culture,and routine blood test results,and no complications,such as subdural effusion,were observed on cranial computed *** growth retardation or neurological sequelae occurred during *** SGPSP-induced infant bacterial meningitis and sepsis should be treated with prompt blood and CSF cultures,and a sensitiv

关键词： Streptococcus gallolyticus subspecies pasteurianus Rare pathogen Bacterial meningitis Sepsis Multidrugresistant Staphylococcus aureus Bronchopneumonia Infant Case report

Velocity-Incorporated Wear Model of Rolling Guide Shoe Material Selection

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 118-135页

作者： Longye Chen Lingyu yan Chengliang Liu Zhinan Zhang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China

To ensure an accurate selection of rolling guide shoe materials,an analysis of the intricate relationship between linear speed and wear is *** element simulations and experimental measurements are employed to evaluate four distinct types of materials:polyurethane,rubber,polytetrafluoroethylene(PTFE),and *** speed-index of each material is measured,serving as a preparation for subsequent ***,the velocity-wear factor is determined,providing insights into the resilience and durability of the material across varying ***,a wear model tailored specifically for viscoelastic bodies is explored,which is pivotal in understanding the wear mechanisms within the *** this model,wear predictions are made under higher speed conditions,facilitating the choice of material for rolling guide *** validate the accuracy of the model,the predicted degree of wear is compared with experimental data,ensuring its alignment with both theoretical principles and real-world *** comprehensive analysis has verified the effectiveness of the model in the selection of materials under high-speed conditions,thereby offering confidence in its reliability and ensuring optimal performance.

关键词： Archard model Wear model Speed-index Wear prediction

Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng CUI Yao-Ming MA yan WANG Jian-Sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN jiao WANG Guo-Tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-Bo TANG Chao-Yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk

Chemoselective Transfer Hydrogenation of Nitroarenes with Ammonia Borane Catalyzed by Copper N-Heterocyclic Carbene Complexes

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Chinese Journal of Chemistry 2024年第15期42卷 1721-1726页

作者： Hui Zhou Hongmei jiao Xing Lu Yuanyuan Gao Zhiqiang Ren Haojie Ma Yuqi Zhang Bo Han Laboratory of New Energy&New Function Materials Shaanxi Key Laboratory of Chemical Reaction EngineeringCollege of Chemistry and Chemical EngineeringYan'an UniversityYan'anShaanxi 716000China

Herein,we present a method for the homogeneous hydrogenation of nitroarenes to produce anilines using low catalyst loading(1 mo%)of copper N-heterocyclic carbene complexes as the catalyst and ammonia borane as the source of hydrogen.A wide range of nitroarenes,featuring diverse functional groups,were selectively transformed into their corresponding primary aromatic amines with high *** process can be readily scaled up and exhibits compatibility with various sensitive functional groups,including halogen,trifluoromethyl,aminomethyl,alkenyl,cyano,ester,amide,and ***,this catalytic methodology finds application in the synthesis of essential drug *** investigations suggest that the in-situ-generated Cu-H species may serve as active intermediates,with reduction pathways involving species such as azobenzene,1,2-diphenylhydrazine,nitrosobenzene,and N-phenylhydroxylamine.

关键词： Homogeneous catalysis Hydrogenation N-Heterocyclic carbene complexes Nitroarenes Ammonia borane

s偏振激光斜入射诱导类“叶脉”状自组织条纹结构(特邀)

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激光与光电子学进展 2024年第3期61卷 55-60页

作者：耿娇严吉石理平西安电子科技大学杭州研究院浙江杭州311231 西安电子科技大学光电工程学院陕西西安710071 上海应用技术大学理学院上海201418

在金属铂和非晶硅构成的复合薄膜上,观察到了在斜入射条件下由s偏振激光诱导产生的、具有氧化周期性结构的、远离中轴线且外侧结构倾斜的周期性结构。首先,稳态照射下产生的条纹结构呈叶脉状,既不平行也不垂直于激光偏振方向;其次,动态... 详细信息

在金属铂和非晶硅构成的复合薄膜上,观察到了在斜入射条件下由s偏振激光诱导产生的、具有氧化周期性结构的、远离中轴线且外侧结构倾斜的周期性结构。首先,稳态照射下产生的条纹结构呈叶脉状,既不平行也不垂直于激光偏振方向;其次,动态扫描时产生的结构取向单一且与扫描方向有关;最后,结构周期随着入射角的增大而减小。这几个现象均与通常的激光烧蚀周期性结构不同。这些发现为调控激光诱导自组织提供了更多可能性。

关键词：激光诱导周期性表面结构斜入射纳米光栅金属-半导体复合薄膜