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Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization

CCS Chemistry 2024年第1期6卷 196-207页

作者： Liujun Xu Yawei Feng Tong Wang Shenhuan Li Kangli Xu Yue Sun Yi Luo Yishan Ye yan Miao yun Dong Zhenzhen Guo Qing Zhang Benshang Li He Huang Xue-Qiang Wang Liping Qiu Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of MedicineChinese Academy of SciencesHangzhouZhejiang 310022 Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 Institute of Hematology Zhejiang UniversityHangzhou 310003 Department of Hematology and Oncology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200127

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer *** mass cytometry(MC)enables synchronous detection of over 40 cellular parameters,its full potential in disease classification is challenged by the limited types of recognition probes currently *** this work,we synthesize a panel of heavy isotopeconjugated aptamers to profile cancer-associated signatures on the surface of hematological malignancy(HM)*** on 15 molecular signatures,we performed cell-surface profiling that allowed the precise classification of 8 HM cell *** with machine-learning technology,this aptamer-based MC platform also achieved multiclass identification of HM subtypes in clinical sampleswith 100%accuracy in the training cohort and 80%accuracy in the test ***,we report an effective and practical strategy for precise cancer classification at the singlecell level,paving the way for its clinical use in the near future.

关键词： molecular profiling cancer diagnosis mass cytometry aptamers machine learning

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石墨烯基材料在电磁屏蔽领域的研究进展

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新型炭材料（中英文） 2024年第2期39卷 223-239页

作者：杨赏娟曹赟贺艳兵吕伟清华大学深圳国际研究生院广东深圳518055

通信技术在为人类的生活带来便利的同时,其产生的电磁辐射对社会安全、人体健康产生的危害也受到了社会各界的广泛关注,宽屏蔽范围、高吸收效率和高稳定性的电磁屏蔽材料逐渐成为研究热点。石墨烯是一种导电性高、比表面积大且可调控性... 详细信息

通信技术在为人类的生活带来便利的同时,其产生的电磁辐射对社会安全、人体健康产生的危害也受到了社会各界的广泛关注,宽屏蔽范围、高吸收效率和高稳定性的电磁屏蔽材料逐渐成为研究热点。石墨烯是一种导电性高、比表面积大且可调控性高的轻质材料,可有效实现电磁衰减,保护精密电子设备和人体健康,在电磁屏蔽领域具有广阔的应用前景。本综述从电磁屏蔽的基本原理与石墨烯基材料的结构特性角度,阐述了石墨烯及其衍生物的电磁屏蔽特点,总结了结构调控以及表面异质化、复合化策略在电磁屏蔽领域的应用。结构调控有利于提高石墨烯基材料对电磁波的吸收损耗和多重反射损耗;表面异质化和复合化策略有利于提高石墨烯基材料的界面极化和磁特性,从而加强对电磁波的吸收损耗和磁损耗。总结了石墨烯基电磁屏蔽材料的改性方法,旨在为开发新一代绿色、轻薄、高屏蔽带宽的电磁屏蔽材料提供启发,指明石墨烯基电磁屏蔽材料的未来发展方向。

关键词：石墨烯电磁屏蔽结构调控异质掺杂复合材料

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Construction and performance test of charged particle detector array for MATE

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Nuclear Science and Techniques 2024年第8期35卷 92-100页

作者： Xiao‑Bin Li Long‑Hui Ru Zhi‑Chao Zhang Bing‑Feng Lv Ning‑Tao Zhang Jin‑Long Zhang Chen‑Gui Lu Bing‑Shui Gao Jun‑Bing Ma Fu‑Shuai Shi Satoru Terashima Xiao‑Dong Xu Zhen Bai Shi‑Wei Xu yan‑yun yang Hooi‑Jin Ong Xiao‑Dong Tang Institute of Modern Physics(IMP) Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Research Center for Nuclear Physics Osaka UniversityIbarakiOsaka 567‑0047Japan RIKEN Nishina Center WakoSaitama 351‑0198Japan Joint Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China

A charged particle array named MATE-PA,which serves as an auxiliary detector system for a Multi-purpose Active-target Time projection chamber used in nuclear astrophysical and exotic beam Experiments(MATE),was *** array comprised of 20 single-sided strip-silicon detectors covering approximately 10%of the solid *** detectors facilitated the detection of reaction-induced charged particles that penetrate the active volume of the *** performance of MATE-PA has been experimentally studied using an alpha source and a 36-MeV 14 N beam injected into the MATE chamber on the radioactive ion beam line in Lanzhou(RIBLL).The chamber was filled with a gas mixture of 95%4 He and 5%CO_(2) at a pressure of 500 *** results indicated good separation of light-charged particles using the forward double-layer silicon detectors of *** energy resolution of the Si detectors was deduced to be approximately 1%(σ)for an energy loss of approximately 10 MeV caused by theα*** inclusion of MATE-PA improves particle identification and increases the dynamic range of the kinetic energy of charged particles,particularly that of theαparticles,up to approximately 15 MeV.

关键词： Silicon detector array Active target Time projection chamber

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基于时频域融合和ECA-1DCNN的航空串联故障电弧检测

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科学技术与工程 2024年第5期24卷 1937-1945页

作者：闫锋苏忠允中国民用航空飞行学院航空工程学院广汉618307 南京航空航天大学民航学院南京211106

为了快速准确地检测航空交流线路中出现的串联故障电弧,提出了一种基于时频域融合和加入高效注意力机制(efficient channel attention, ECA)的一维卷积神经网络(one-dimensional convolutional neural network, 1DCNN)的故障检测算法。... 详细信息

为了快速准确地检测航空交流线路中出现的串联故障电弧,提出了一种基于时频域融合和加入高效注意力机制(efficient channel attention, ECA)的一维卷积神经网络(one-dimensional convolutional neural network, 1DCNN)的故障检测算法。首先,搭建航空交流电弧故障实验平台,负载选择多类型、多参数值进行电流信号的采集;其次,为了保留更多的故障信息,分析其特征频段,经过大量数据验证,航空串联电弧在发生时,1 000~4 000 Hz分量具有一定的占比,因此将原始信号与特征频段进行融合,融合后的一维数据作为模型输入;最后,搭建ECA-1DCNN检测模型,进行训练,并通过K折交叉验证模型的有效性,得到测试集平均准确率为97.96%。该方法网络层数较少,计算快速,避免了复杂时频域计算过程,较为智能,对航空串联电弧检测装置的研究提供了理论参考。

关键词：串联电弧高效注意力机制特征频段一维卷积神经网络 K折交叉验证

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下腔静脉变异率联合脉搏指示连续心排血量在心肌梗死后心源性休克容量管理中应用研究

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中国实用内科杂志 2024年第3期44卷 223-227页

作者：吕云玲卢娜张明明王妍张兴游道锋石家庄市第二医院急诊重症医学科河北石家庄050000 河北医科大学第一医院急诊重症医学科河北石家庄050000 河北医科大学第一医院重症医学一科河北石家庄050000 河北医科大学第一医院胃肠诊疗中心三科河北石家庄050000

目的探讨下腔静脉变异率(IVCV)与脉搏指示连续心排血量(PiCCO)监测对心肌梗死后心源性休克患者进行精细容量管理的价值。方法以2019年2月至2022年2月石家庄市第二医院收治的90例心肌梗死后心源性休克患者为研究对象,根据干预方法分组... 详细信息

目的探讨下腔静脉变异率(IVCV)与脉搏指示连续心排血量(PiCCO)监测对心肌梗死后心源性休克患者进行精细容量管理的价值。方法以2019年2月至2022年2月石家庄市第二医院收治的90例心肌梗死后心源性休克患者为研究对象,根据干预方法分组,对照组行常规干预,观察组在下腔静脉变异率与PiCCO监测下开展精细容量管理干预。结果 72 h治疗后,观察组N-末端脑钠肽前体(NT-proBNP)、乳酸(Lac)、氧合指数(PaO_(2)/FiO_(2))、24 h尿量、平均动脉压(MAP)、心指数(CI)、心功能指数(CFI)、每搏量指数(SVI)、全心射血分数(GEF)均明显优于对照组(P<0.05),且观察组下腔静脉变异率明显高于对照组(P<0.05)。72 h治疗后,观察组急性生理与慢性健康评分(APACHE-Ⅱ)明显低于对照组,治疗总有效率明显高于对照组(97.78%比77.78%,P<0.05)。结论在心肌梗死后心源性休克患者精细容量管理中实施下腔静脉变异率和PiCCO监测,可改善患者血流动力学与下腔静脉状况,提高临床治疗效果与患者健康管理质量,提升生存率,降低病死率。

关键词：容量管理心源性休克心肌梗死后心源性休克下腔静脉变异率脉搏指示连续心输出量血流动力学

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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng yang Xiao Xiao Hao yan Tian-Lan Lu Jun Li yun-Dan Liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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大型复杂锻件打磨路径的智能化规划方法

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机械工程学报 2024年第11期60卷 216-225页

作者：闫守鑫王伟苏鹏飞贠超北京航空航天大学机械工程及自动化学院北京100191

大型复杂锻件作为能源、船舶、交通等领域的主要承力构件,对后处理的尺寸精度和表面质量要求高,实现大型复杂锻件的自动化打磨是锻造行业亟待解决的共性难题。主要技术障碍之一是:大型复杂锻件存在较大的热变形、多种随机锻造缺陷,难以... 详细信息

大型复杂锻件作为能源、船舶、交通等领域的主要承力构件,对后处理的尺寸精度和表面质量要求高,实现大型复杂锻件的自动化打磨是锻造行业亟待解决的共性难题。主要技术障碍之一是:大型复杂锻件存在较大的热变形、多种随机锻造缺陷,难以自动生成打磨加工路径。首先提出了一种大型复杂锻件随机缺陷识别算法,通过随机采样一致性算法(Random sample consensus,RANSAC)与改进迭代最近点(Modified iterative closest point,M-ICP)算法相结合,对标准件点云与锻件点云进行配准,得到需要打磨的随机缺陷点云;接着,按照缺陷面积大小,对随机缺陷点云进行的分类,建立了打磨路径生成策略;然后,利用随机缺陷点云中的位置坐标信息,不需要CAD模型,直接生成了机器人打磨路径;最后,开展了大型复杂锻件的机器人打磨实验,实验结果表明:打磨路径智能化生成方法准确识别了随机锻造缺陷特征,正确规划了机器人打磨路径,提高了打磨效率和打磨质量,为大型复杂锻件后处理加工提供了技术方法。

关键词：缺陷识别智能化打磨路径规划大型复杂锻件

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Efficacy and safety of Tianqi Pingchan Granule, a compound Chinese herbal medicine, for levodopa-induced dyskinesia in Parkinson's disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： Yu Zhang Xiao-bo Zhu yang Zhao Gui-yun Cui Wen-tao Li Can-xing Yuan Jian-ping Huang Ying Wan Na Wu Lu Song Jia-hao Zhao yan Liang Chuan-ying Xu Mei-juan Liu Chen Gao Xin-xin Chen Zhen-guo Liu Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Parkinson's Disease Center the Affiliated Hospital of Xuzhou Medical University Department of Neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Department of Neurology Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Neurology Wenzhou Central Hospital

Background: Patients with Parkinson's disease(PD) undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(LID). Amantadine is the main drug recommended for the treatment of LID by current guidelines, but it is far from meeting clinical needs. Tianqi Pingchan Granule(TPG), a compound Chinese herbal medicine, has been developed to relieve symptom of ***: This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***, setting, participants and interventions: This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in Jiangsu, Zhejiang and Shanghai, China. One hundred PD patients with ≥ 0.5 h of LID were randomly assigned to either the TPG plus amantadine group(TPG group) or the placebo plus amantadine group(placebo group), and treated for a period of12 weeks. To ensure unbiased results, all study participants, investigators and sponsors were unaware of group allocations. Additionally, the data analysts remained blinded until the analysis was *** outcome measures: The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104). The key secondary end point was improvement of motor and non-motor symptoms. Safety analyses included all enrolled ***: One hundred patients were enrolled and randomized into the two treatment groups. The changes in UDysRS at week 12 were –11.02 for the TPG group and –4.19 for the placebo group(treatment difference –6.83 [–10.53 to –3.12]; P = 0.0004). Adverse events were reported for 2 of 50 patients(4.0%) in each of the ***: This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated, demonstrating the efficacy and safety of TPG for the treatment of LID in PD.

关键词： Levodopa-induced dyskinesia Parkinson’s disease Tianqi Pingchan Granule

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Optical PAM-4/PAM-8 generation via dual-Raman process in Rydberg atoms

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Chinese Physics B 2024年第6期33卷 383-388页

作者：宋晓云尹政任冠宇韩明志杨艾红祁义红彭延东 Qingdao Key Laboratory of Terahertz Technology College of Electronic and Information EngineeringShandong University of Science and TechnologyQingdao 266590China School of Physics East China University of Science and TechnologyShanghai 200237China MIIT Key Laboratory of Complex-field Intelligent Exploration Beijing Institute of TechnologyBeijing 100081China

A scheme of optical four-level pulse amplitude modulation(PAM-4) is proposed based on dual-Raman process in Rydberg atoms. A probe field counter-propagates with a dual-Raman field which drives the ground and the excited states transition, respectively, and the Rydberg transition is driven by a microwave(MW) field. A gain peak appears in the probe transmission and is sensitive to the MW field strength. Optical PAM-4 can be achieved by encoding an MW signal and decoding the magnitude of a probe signal. Simulation results show that the differential nonlinearity and the integral nonlinearity of the proposed scheme can be reduced by 5 times and 6 times, respectively, compared with the counterparts of previous scheme, and the ratio of level separation mismatch is close to the ideal value 1. Moreover, the scheme is extended to optical PAM-8 signal, which may further improve the spectral efficiency.

关键词： Rydberg atoms PAM-4/PAM-8 dual-Raman process

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Intramedullary nailing for irreducible spiral subtrochanteric fractures:A comparison of cerclage and non-cerclage wiring

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Chinese Journal of Traumatology 2024年第5期27卷 305-310页

作者： yan-Hui Guo Zhan-Lin Song Hua-Yong Zheng Jie Gao Yi-yun Lin Zhi Liu Lian-Hua Li Department of Orthopedics The Seventh Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China Department of Orthopedics The Fourth Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China

Purpose:Intramedullary nailing is the preferred internal fixation technique for the treatment of subtrochanteric fractures because of its biomechanical ***,no definitive conclusion has been reached regarding whether combined cable cerclage is required during intramedullary nailing *** study is performed to compare the clinical effects of intramedullary nailing with cerclage and non-cerclage wiring in the treatment of irreducible spiral subtrochanteric ***:Patients with subtrochanteric fractures admitted to our center from January 2013 to December 2021 were retrospectively *** patients were enrolled in the case-control study according to the inclusion and exclusion criteria and divided into the non-cerclage group and the cerclage *** patients'clinical data,including the operative time,intraoperative blood loss,hospital stay,reoperation rate,fracture union time,and Harris hip score,were compared between these 2 *** variables were compared using Chi-square or Fisher's exact *** variables with normal distribution were presented as mean±standard deviation and analyzed with Student's *** distributed variables were expressed as median(Q_(1),Q_(3))and assessed using the Mann-Whitney test.A p<0.05 was considered ***:In total,69 patients were included in the study(35 patients in the non-cerclage group and 34 patients in the cerclage group).The baseline data of the 2 groups were *** were no significant difference in the length of hospital stay(z=-0.391,p=0.696),operative time(z=-1.289,p=0.197),or intraoperative blood loss(z=-1.321,p=0.186).However,compared with non-cerclage group,the fracture union time was shorter(z=-5.587,p<0.001),the rate of nonunion was lower(χ^(2)=6.030,p=0.03),the anatomical reduction rate was higher(χ^(2)=5.449,p=0.03),and the Harris hip score was higher(z=-2.99,p=0.003)in the cerclage group,all with statistically significant dif

关键词： Hip fracture Subtrochanteric fracture Intramedullary nail Cerclage wiring

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