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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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GPU并行加速的边折叠简化算法

计算机工程与设计 2016年第11期37卷 3051-3057页

作者：范豪刘峻孙宇陆向艳刘艳广西大学计算机与电子信息学院广西南宁530004 广西信息科学实验中心广西桂林541004 广西大学广西多媒体通信与网络技术重点实验室培育基地广西南宁530004 国家气象中心北京100081

针对目前串行的网格简化算法速度过慢,忽略模型细节特征的问题,提出一种基于GPU的边折叠网格简化算法。将三角网格模型划分为一系列强独立区域,采用二次误差测度计算边折叠代价,将独立区域内的所有强独立边中的最小折叠代价作为强独立... 详细信息

针对目前串行的网格简化算法速度过慢,忽略模型细节特征的问题,提出一种基于GPU的边折叠网格简化算法。将三角网格模型划分为一系列强独立区域,采用二次误差测度计算边折叠代价,将独立区域内的所有强独立边中的最小折叠代价作为强独立区域排序值,取各个强独立区域中折叠代价最小的边并行地进行折叠操作。实验结果表明,该算法具有较快的简化速率,较好的细节特征保持能力,简化模型具有较好的拓扑连接关系和较小的几何误差。

关键词：网格简化边折叠强独立区域二次误差测度图形处理单元

Structure-based multi-ligand molecular modeling to predict the synergistic effects of limonin and obacunone from Simiao pill against nitric oxide synthase 3 associated with hyperuricemia

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Precision Medicine Research 2023年第3期5卷 11-15页

作者： Qing-Hong Chen Xiao-Mei Chen Xiao-Hu Chen yan-Ting You Shu-Xuan yang Chuang-Hai Wu Mei-Lin Chen Ming-Di Li Akari Komori yan-yan liu Andrew Hung Xiao-Shan Zhao Hong Li Department of Traditional Chinese Medicine Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China Centre of General Practice The Seventh Affiliated HospitalSouthern Medical UniversityFoshan 528244China Department of Preventive Health Care Qingdao Hiser Hospital Affiliated to Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Science STEM CollegeRMIT UniversityMelbourneVictoria 3000Australia

Hyperuricemia(HUA)mainly occurs because of purine metabolism *** recently proposed that limonin from Simiao pill may have therapeutic effects on nitric oxide synthase 3(NOS3)that is related to ***,our previous work employed a new method,structure-based multi-ligand molecular modeling,to identify potential agents from a herbal formula that may produce synergistic effects and may have the potential to develop combination ***,we employed multi-ligand modeling to seek compounds with potential synergistic effects with limonin against *** obtained 403 multi-ligand docking results between 403 compounds and the limonin-NOS3 complex(average affinity–8.297 kcal/mol).Then we selected the top 10 highest binding affinity compounds for virtual pharmacokinetic and toxicity screening and we found that only obacunone passed all *** further subjected obacunone,bound to limonin and NOS3,to molecular dynamics *** found that the NOS3-limonin-obacunone complex was more stable than the NOS3-limonin complex,based on the root mean square deviation of backbone Cαatoms and root mean square fluctuation,which suggests that synergistic effects may exist between limonin and *** cell and animal experimental research is required to verify our results.

关键词： hyperuricemia synergistic mechanism Chinese herbal medicine complementary and alternative medicine molecular docking molecular dynamics simulations in silico analysis

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轨道约束对铁路桥梁纵向地震反应特性的影响

铁道学报 2002年第5期24卷 124-128页

作者：黄艳阎贵平刘林北方交通大学土木建筑工程学院北京100044

采用非线性弹簧单元模拟道床的纵向位移阻力关系,建立了地震作用下桥梁与轨道共同作用的线桥一体化模型,分析轨道约束对铁路桥梁纵向抗震性能的影响。研究表明,在地震中当桥墩刚度相近时,轨道约束对桥墩是有利的;当桥墩刚度相差较大时,... 详细信息

采用非线性弹簧单元模拟道床的纵向位移阻力关系,建立了地震作用下桥梁与轨道共同作用的线桥一体化模型,分析轨道约束对铁路桥梁纵向抗震性能的影响。研究表明,在地震中当桥墩刚度相近时,轨道约束对桥墩是有利的;当桥墩刚度相差较大时,轨道约束对刚度较大桥墩有时是不利的。文章还分析了道床阻力、桥梁跨数等因素对桥梁抗震的影响。

关键词：影响铁路桥梁轨道约束纵向地震反应

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang yan Cheng Jianxun liu Yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

Investigation on the interaction of dispersed and elongated bubbles based on laser-induced fluorescence

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Optoelectronics Letters 2025年

作者： XUE Ting SHI Ruini liu Jinshun WANG Haixia WU yan School of Electrical and Information Engineering， Tianjin University

The purpose of this paper is to investigate the interaction between dispersed and elongated bubbles in horizontal slug flow utilizing the laser-induced fluorescence method. A Segmentation method based on the fuzzy C-mean (FCM) algorithm is proposed to effectively separate elongated bubbles from the liquid phase， and an extreme value extraction method is developed to calculate the number of dispersed bubbles in front of the nose of elongated bubbles. Moreover， the velocity offsets of elongated bubbles with and without dispersed bubbles are calculated separately based on contour extraction. In addition， the effect of dispersed bubbles on the fluctuating offsets of the nose tip position and velocity of elongated bubbles are statistically investigated under different flow velocities. The experimental results show that the increase of the gas-liquid flow velocity exacerbates the radial deviation of the nose tip and the fluctuation of axial velocity.

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牛舌草总黄酮通过ROS/TXNIP/NLRP3抑制炎症小体活化抗心肌缺血再灌注损伤

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中国药学杂志 2021年第14期56卷 1131-1137页

作者：阴苏月姜瑜王丹姝燕柳艳王守宝杜冠华中国医学科学院北京协和医学院药物研究所药物靶点研究与新药筛选北京市重点实验室北京100050

目的从炎症小体活化和活性氧/硫氧还蛋白互作蛋白/NOD样受体蛋白3(ROS/TXNIP/NLRP3)通路考察牛舌草总黄酮(total flavonoids of Anchusa italica Retz.,TF)抗心肌缺血再灌注损伤的作用机制。方法小鼠采用冠状动脉左前降支结扎模型模拟... 详细信息

目的从炎症小体活化和活性氧/硫氧还蛋白互作蛋白/NOD样受体蛋白3(ROS/TXNIP/NLRP3)通路考察牛舌草总黄酮(total flavonoids of Anchusa italica Retz.,TF)抗心肌缺血再灌注损伤的作用机制。方法小鼠采用冠状动脉左前降支结扎模型模拟心肌缺血再灌注(ischemia/reperfusion,I/R)损伤。将模型制备成功的30只小鼠随机分为模型组(I/R)、TF 30 mg·kg^(-1)处理组(I/R+TF30)和100 mg·kg^(-1)处理组(I/R+TF100),再灌同时给予生理盐水、TF。于再灌注24 h时,检测小鼠心功能,测定心肌梗死范围和血清心肌酶谱,心肌冰冻切片染色观察活性氧(ROS)水平,Western blotting分析NLRP3炎症小体活化以及TXNIP与NLRP3相互作用的变化。结果TF在剂量为30和100 mg·kg^(-1)时均可改善心功能,减少心肌梗死范围,降低血清心肌酶水平。另外,TF处理减少心肌炎症因子白细胞介素(IL)-1β、IL-6、肿瘤坏死因子(TNF)α含量,降低心肌ROS水平。TF在30和100 mg·kg^(-1)均显著降低TXNIP、NLRP3、cleaved caspase-1和cleaved IL-1β,并抑制TXNIP/NLRP3相互作用。结论牛舌草总黄酮通过抑制ROS/TXNIP/NLRP3通路,从而减轻NLRP3炎症小体活化,发挥抗心肌缺血再灌注损伤作用。

关键词：牛舌草总黄酮心肌缺血再灌注损伤 NOD样受体蛋白3炎症小体活性氧硫氧还蛋白互作蛋白/NOD样受体蛋白3相互作用

城市交通排放高分辨率分析方法研究——北京实证

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交通运输系统工程与信息 2018年第2期18卷 236-244页

作者：程颖陈艳艳刘莹吴克寒何巍楠赵晋北京工业大学城市交通学院北京100124 北京交通发展研究院北京100073

交通污染减排政策呈现多样化、精细化和差别化发展趋势,传统交通排放模型在评价范围、评价尺度上的分辨率存在局限性.本文基于实时监测数据的交通流仿真模型、视频检测方法的车队结构分析和本地化工况的速度排放因子修正关系,提出了城... 详细信息

交通污染减排政策呈现多样化、精细化和差别化发展趋势,传统交通排放模型在评价范围、评价尺度上的分辨率存在局限性.本文基于实时监测数据的交通流仿真模型、视频检测方法的车队结构分析和本地化工况的速度排放因子修正关系,提出了城市交通排放高分辨率分析方法,时空分辨率达到小时和路段级别,排放源可区分不同交通方式和本地外地.并以北京市机动车NO_x排放为例,对路网交通排放时空分布特征进行实证分析.北京市高峰时段路网交通排放量占全天排放的31.2%;高速路、快速路排放分别占路网排放总量的37.9%和38.8%;五环~六环间排放量占六环内排放总量的38.32%;货运车辆排放占路网排放比例达到47%.本文提出的城市交通排放高分辨率分析方法对精准定位交通污染治理时间、空间和对象,提升精细化决策水平具有一定意义.

关键词：城市交通污染排放高分辨率大数据

p38 MAPK-BCL-xL pathway was involved in HPC-induced neuroprotection in ischemic brain of mice

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p38 MAPK-BCL-xL pathway was involved in HPC-induced neuropro...