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Effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization in high myopia mice

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1034-1040页

作者： yan-yan ji Shi-Xi Zhang Ye Kang Song Chen Clinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China Tianjin Eye Hospital Tianjin 300020China Liaocheng Aier Eye Hospital Liaocheng 252100Shandong ProvinceChina Dezhou Aier Eye Hospital Dezhou 253000Shandong ProvinceChina yanTai Aier Eye Hospital Yantai 264000Shandong ProvinceChina

AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia ***:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm *** changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was ***:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant.

关键词： high myopia choroidal neovascularization low concentration atropine eye drops dopamine D1 receptor dopamine D2 receptor

Response-guided treatment of cirrhotic chronic hepatitis B patients: Multicenter prospective study

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World Journal of Gastroenterology 2015年第2期21卷 653-660页

作者： Er-Li Gu Yi-Qi Yu jia-Li Wang yan-yan ji Xiu-Yun Ma Qing Xie Hong-Ying Pan Shan-Min Wu Jun Li Cheng-Wei Chen Xiao-Wei Xu Yue-Er Wang Guang-Bi Yao Hong Wang Wen-Hong Zhang Department of Gastroenterology and Hepatology Jing’an District Central Hospital jing’an Branch of Huashan Hospital Fudan University Department of Infectious Diseases Huashan HospitalFudan University Department of Infectious Diseases Ditan Hospital Department of Hepatology Department of Infectious DiseasesRuijin HospitalSchool of MedicineShanghai Jiaotong University Department of Infectious Diseases The 6th People’s Hospital of Hangzhou Shanghai Public Health Clincal Center Department of Infectious Diseases Jiangsu Provincial Hospital Department of Hepatology Shanghai Liver Disease Research Center of Nanjing Military Area Department of Infectious Diseases The 1st Affiliated Hospital of Zhejiang University MOH and MOE Key Laboratory of Medical Molecular Virology Shanghai Medical CollegeFudan University Institutes of Biomedical Sciences Fudan University

AIM: To observe the effect of response-guided add-on therapy with adefovir(ADV) and lamivudine(LAM) in cirrhotic hepatitis B(CHB) ***: A total of 100 patients with CHB and cirrhosis were divided into three arms according to hepatitis B virus(HBV) DNA level after 24 wk LAM monotherapy: Arm A(complete response, HBV DNA ≤ 60 IU/m L, n = 49), Arm B(partial response, HBV DNA: 60-2000 IU/m L, n = 31) and Arm C(inadequate response, HBV DNA > 2000 IU/m L, n = 20). ADV was added to LAM at week 48 in Arms A and B, but at week 24 in Arm C. Virological response, YMDD mutations, biochemical response, and liver function were ***: Comparison of the three arms demonstrated that early complete virologic response at week 24was associated with maintained viral suppression(undetectable rate of HBV DNA at week 144 was 95.96%, 66.67% and 35.29%, respectively, P = 0.000) and reduced YMDD mutations(mutation rate at week 144 was 0%, 3.23% and 15%, respectively, P = 0.015) after 144 wk treatment. For patients who failed to achieve complete virological response at week 24, switching to combination therapy further decreased HBV DNA level by 1 log10 IU/m L. All three arms obtained biochemical benefits including decline of alanine aminotransferase and elevation of albumin. In patients who developed HBV DNA breakthrough for YMDD mutations, ADV add-on therapy did not induce further multiple drug resistance to LAM or ***: Optimized response-guided add-on therapy of ADV and LAM maintains long-term suppression of HBV DNA and improves liver function in CHB patients with compensated liver cirrhosis.

关键词： Hepatitis B Cirrhosis Adefovir dipivoxil Lamivudin

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第01期 8-9页

作者： yang Li Tianyu Li yan ji Baoguang Liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang yan Liu jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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种公禽繁殖系统对光要素的应答机制研究进展

中国畜牧兽医 2017年第9期44卷 2692-2698页

作者：孙研研陈继兰中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖(家禽)重点实验室北京100193

光照是生物体重要的生活环境因素之一。禽类具有优越的感光机能,光线通过其光感受器被感知,并转变为生物学信号,从而对生长发育、繁殖和行为等方面产生影响。在现代养禽业中,人工优化光照环境已成为提高动物生产性能的一项重要手段。近... 详细信息

光照是生物体重要的生活环境因素之一。禽类具有优越的感光机能,光线通过其光感受器被感知,并转变为生物学信号,从而对生长发育、繁殖和行为等方面产生影响。在现代养禽业中,人工优化光照环境已成为提高动物生产性能的一项重要手段。近年来,随着种用母鸡笼养、人工授精技术的广泛应用及精液处理、包装和存储技术的发展,在家禽养殖中,也逐步将种公禽单独饲养。研究光照对种公禽繁殖性能的影响,一方面可以进一步解析种公禽繁殖系统对光要素的生物应答机制,另一方面可为生产中采用精细化的光照条件提高种公禽繁殖效率提供科学依据。笔者就禽类的光感受器,参与光—性信号传导的激素,以及光照节律、光照强度和光波长对种公禽性成熟和繁殖性能的影响等方面的研究进展进行综述,以期为其在生产中的应用奠定基础。

关键词：种公禽光照繁殖激素

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基于造型美学的牙科椅意象造型设计

包装工程 2018年第6期39卷 181-186页

作者：陈艳艳董继先郭西雅陕西科技大学西安710021

目的提升牙科椅的情感价值,满足患者以及医护人员的感性诉求,提出基于造型美学的牙科椅意象造型设计方法。方法通过李克特量表对具有代表性的感性意象词汇对进行量化处理,采用形态分析法提取牙科椅的造型设计要素,并将提取的造型设计要... 详细信息

目的提升牙科椅的情感价值,满足患者以及医护人员的感性诉求,提出基于造型美学的牙科椅意象造型设计方法。方法通过李克特量表对具有代表性的感性意象词汇对进行量化处理,采用形态分析法提取牙科椅的造型设计要素,并将提取的造型设计要素分解为造型设计类目,结合SPSS软件,运用多元线性回归方法建立感性语义与造型设计类目的关联;分析整理得出造型设计类目得分,得分值的大小体现了造型设计要素对感性语义的贡献程度;在此基础上,运用造型美学设计的加法和减法对感性语义贡献最大的设计要素类目进一步分析研究,得出满足用户感性需求的牙科椅造型设计关键点。结论这些优化点有助于牙科椅造型的精准化设计,也为后续牙科椅造型设计系统的建立提供理论依据。

关键词：牙科椅感性意象造型要素造型美学设计

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亚抑菌浓度庆大霉素对铜绿假单胞菌的影响

中国现代医学杂志 2017年第26期27卷 35-39页

作者：杨正贵季艳艳何照庆贵州盘江投资控股(集团)有限公司总医院检验科贵州六盘水553536

目的探讨亚抑菌浓度庆大霉素(GEN)对铜绿假单胞菌(PAO1)浮游菌和生物膜的影响。方法采用微量肉汤稀释法检测PAO1对GEN的敏感性。采用96孔板比浊法检测亚抑菌浓度GEN对PAO1浮游菌生长的影响,并通过结晶紫染色法检测亚抑菌浓度GEN对PAO1... 详细信息

目的探讨亚抑菌浓度庆大霉素(GEN)对铜绿假单胞菌(PAO1)浮游菌和生物膜的影响。方法采用微量肉汤稀释法检测PAO1对GEN的敏感性。采用96孔板比浊法检测亚抑菌浓度GEN对PAO1浮游菌生长的影响,并通过结晶紫染色法检测亚抑菌浓度GEN对PAO1生物膜形成的影响。采用化学反应比色法测定亚抑菌浓度GEN对PAO1毒力因子表达的影响。结果 GEN对PAO1的最低抑菌浓度为2μg/ml;而当GEN浓度≤0.250μg/ml时,不影响PAO1浮游菌的增殖;当GEN为0.125μg/ml时,能促进PAO1生物膜的形成(P<0.05),且在一定范围内(0.125~0.250μg/ml)随着GEN浓度增高,其促进生物膜形成的能力越强;0.125和0.250μg/ml GEN能促进群体密度信号系统相关基因las I、las R、rhl I、rhl R、pqs C、pqs D和毒力因子青脓素、弹性蛋白酶、碱性蛋白酶的表达(P<0.05),且呈一定的剂量依赖性。结论亚抑菌浓度GEN在一定浓度范围内能促进PAO1生物膜的形成,并进一步促进群体密度信号系统相关基因和毒力因子的表达。

关键词：庆大霉素压抑菌浓度铜绿假单胞菌生物膜青脓素群体密度感应

Primary Studies on Burnup Estimation of Irradiated Uranium by Dtermining 236U/238U in Contaminated Environmental Samples jiANG Xiao-yan,ZHANG ji-long,ZOU Wei,Chang Zhi-yuan

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Primary Studies on Burnup Estimation of Irradiated Uranium b...