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The effect of fasting plasma glucose on in-hospital mortality after acute myocardial infarction in patients with and without diabetes:findings from a prospective,nationwide,and multicenter registry

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Journal of Geriatric Cardiology 2024年第5期21卷 523-533页

作者： Rui FU Ying-Xuan ZHU Kong-Yong CUI Jin-Gang yanG Hai-yan XU Dong YIN Wei-Hua SONG Hong-Jian WANG Cheng-Gang ZHU Lei FENG Wei WU Kai-HongCHEN yan-yan zhao Ye LU Ke-Fei DOU Yue-Jin yanG on behalf of the CAMI Registry Investigators Cardiometabolic Medicine Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Research&Biometrics Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Coronary Heart Disease Center Fuwai HospitalNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseNational Clinical Research Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Guangzhou Traditional Chinese Medical College First Affiliated HospitalGuangdong ProvinceChina Department of Cardiology Longyan Hospital First HospitalFujian ProvinceChina 不详

OBJECTIVES To evaluate the predictive value of fasting plasma glucose(FPG)for in-hospital mortality in patients with acute myocardial infarction(AMI)with different glucose metabolism *** We selected 5,308 participants with AMI from the prospective,nationwide,multicenter CAMI registry,of which 2,081 were diabetic and 3,227 were *** were divided into high FPG and low FPG groups according to the optim-al cutoff values of FPG to predict in-hospital mortality for diabetic and nondiabetic cohorts,*** primary endpoint was in-hospital *** Overall,94 diabetic patients(4.5%)and 131 nondiabetic patients(4.1%)died during hospitalization,and the optimal FPG thresholds for predicting in-hospital death of the two cohorts were 13.2 mmol/L and 6.4 mmol/L,*** with individuals who had low FPG,those with high FPG were significantly associated with higher in-hospital mortality in diabet-ic cohort(10.1%vs.2.8%;odds ratio[OR]=3.862,95%confidence interval[CI]:2.542-5.869)and nondiabetic cohort(7.4%vs.1.7%;HR=4.542,95%CI:3.041-6.782).After adjusting the potential confounders,this significant association was not ***-more,FPG as a continuous variable was positively associated with in-hospital mortality in single-variable and multivariable models regardless of diabetic *** FPG to the original model showed a significant improvement in C-statistic and net reclassification in diabetic and nondiabetic *** This large-scale registry indicated that there is a strong positive association between FPG and in-hospital mor-tality in AMI patients with and without *** might be useful to stratify patients with AMI.

关键词： patients fasting infarction

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UniBind:a novel artificial intelligence-based prediction model for SARS-CoV-2 infectivity and variant evolution

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Signal Transduction and Targeted Therapy 2024年第1期9卷 14-15页

作者： Qihong yan Jincun zhao State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

In a recent study published in Nature Medicine,Wang et *** an excellent framework called UniBind based on artificial intelligence(AI),which enables accurately predicting infectivity of SARS-CoV-2 variants and evolutionary trends of future viral variants.1 This computational method holds the possibility to not only serve as a valuable early-warning tool for monitoring potential pathogenic SARS-CoV-2 variants but also facilitate fundamental research on protein-protein interactions(PPIs).

关键词： artificial Bind prediction

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Proactive Resilience Enhancement of Power Systems with Link Transmission Model-based Dynamic Traffic Assignment Among Electric Vehicles

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1320-1330页

作者： Haoyuan yan Tianyang zhao Zhanglei Guan Energy Electricity Research Center Jinan UniversityGuangzhou 510632China Energy Research Institute Nanyang Technological UniversitySingapore IEEE

The rapid development of electric vehicles(EVs)is strengthening the bi-directional interactions between electric power networks(EPNs)and transportation networks(TNs)while providing opportunities to enhance the resilience of power systems towards extreme *** quantify the temporal and spatial flexibility of EVs for charging and discharging,a novel dynamic traffic assignment(DTA)problem is *** DTA problem is based on a link transmission model(LTM)with extended charging links,depicting the interaction between EVs and power *** models the charging rates as continuous variables by an energy boundary *** consider the evacuation requirements of TNs and the uncertainties of traffic conditions,the DTA problem is extended to a two-stage distributionally robust *** is further incorporated into a two-stage distributionally robust unit commitment problem to balance the enhancement of EPNs and the performance of *** problem is reformulated into a mixed-integer linear programming problem and solved by off-the-shelf commercial *** studies are performed on two test *** effectiveness is verified by the numerical results,e.g.,reducing the load shedding amount without increasing the unmet traffic demand.

关键词： Coupled transportation and power network link transmission model resilience enhancement

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Multi-blade rubbing characteristics of the shaft-disk-blade-casing system with large rotation

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Applied Mathematics and Mechanics(English Edition) 2024年第1期45卷 111-136页

作者： Zhiyuan WU Linchuan zhao Han yan Ge yan Ao CHEN Wenming ZHANG State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Aerospace Systems Engineering Shanghai 201108China

Blade rubbing faults cause detrimental impact on the operation of aeroengines. Most of the existing studies on blade rubbing in the shaft-disk-blade-casing(SDBC) system have overlooked the elastic deformation of the blade, while some only consider the whirl of the rotor, neglecting its spin. To address these limitations, this paper proposes a dynamic model with large rotation for the SDBC system. The model incorporates the spin and whirl of the rotor, enabling the realistic reproduction of multiblade rubbing faults. To verify the accuracy of the SDBC model with large rotation and demonstrate its capability to effectively consider the rotational effects such as the centrifugal stiffening and gyroscopic effects, the natural characteristics and dynamic responses of the proposed model are compared with those obtained from reported research and experimental results. Furthermore, the effects of the rotating speed, contact stiffness,and blade number on the dynamic characteristics of the SDBC system with multi-blade rubbing are investigated. The results indicate that the phase angle between the rotor deflection and the unbalance excitation force increases with the increasing rotating speed,which significantly influences the rubbing penetration of each blade. The natural frequency of the SDBC system with rubbing constrain can be observed in the acceleration response of the casing and the torsional response of the shaft, and the frequency is related to the contact stiffness. Moreover, the vibration amplitude increases significantly with the product of the blade number under rubbing, and the rotating frequency approaches the natural frequency of the SDBC system. The proposed model can provide valuable insight for the fault diagnosis of rubbing in bladed rotating machinery.

关键词： shaft-disk-blade-casing(SDBC) large rotation spin and whirl multi-blade rubbing rotational effect

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Integrated separation-electrochemical detection device based on wood column for online identification of enantiomer

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Nano Research 2024年第3期17卷 1893-1901页

作者： Junli Guo Yuanfei Xue Chenxi zhao Junjian zhao Zhida Gao Ye Mei yan-yan Song College of Sciences Northeastern UniversityShenyang 110004China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200062China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Chiral chemicals have attracted significant interest in the pharmaceutical industry,yet the separation methods to get pure enantiomers from racemic mixture are still *** date,the separation of enantiomers still mainly depends on chromatography using high-cost chiral stationary ***,wood channels were used as the handheld integrated device,and enantiomer separation was simultaneously detected using an electrochemical *** this method,a chiral UIO-66(L-UIO-66)modified enantiomer separation zone and carbonized wood based online detection zone are integrated along a single wood *** on the in situ separation results from the chronoamperometry data,the wood device shows excellent separation ability for a wide range of electrochemically active enantiomers,including 3,4-dihydroxyphenylalanine,amino acids,ascorbic acid,carnitine,and penicillamine with high chirality *** unbiased molecular dynamic simulations indicate that the excellent chiral recognition and separation are attributed to the different barriers from the bound states to the dissociated state of the enantiomers in the homochiral microenvironment of the *** integrated enantiomer separation-electrochemical detection device provides a novel,easy,and low-cost platform for the separation of pure enantiomer from racemic mixture.

关键词： wood column integrated separation-detection device enantioselectivity online sensing free energy barrier

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A calibration and compensation method for an industrial robot with high accuracy harmonic reducers

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Science China(Technological Sciences) 2024年第3期67卷 725-739页

作者： zhao Yiyang LIU Xun CAO JiaBin LIU JinYu XU yan yan WeiXin School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Computer and Control Engineering Northeast Forestry UniversityHarbin 150040China

Industrial serial robots need high stiffness to keep absolute pose accuracy and meet the requirements in practical applications. However, the weak stiffness feature of robot joints and the payloads affected on robot end-effector, which will also increase the pose error of robot. Especially, the existing calibration methods often consider under no-payload condition without discussing the payload state. In this paper, we report a new industrial serial robot composed by a new harmonic reducer: Model-Y, based on high accuracy and high stiffness, and a kinematic parameter calibration algorithm which is based on a harmonic reducer forcedeformation model. To decrease the accuracy effects of payload, an iterative calibration method for kinematic parameters with payload situation was proposed. Simulation and experiments are conducted to verify the effectiveness of the proposed calibration method using the self-developed industrial serial robot. The results show a remarkably improved accuracy in absolute position and orientation with the robot's payload range. The position mean error has 70% decreased to 0.1 mm and the orientation mean error diminished to less than 0.01° after calibration with compensation. Additionally, online linear and circular tests are carried out to evaluate the position error of the robot during large-scale spatial and low-speed continuous movement. The accuracy is consistent with the previous calibration results, indicating the effectiveness and advantages of the proposed strategy in this article.

关键词： industrial serial robot Model-Y harmonic calibration stiffness model online compensation

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Rotor cross-tilt optimization for yaw control improvement of multi-rotor eVTOL aircraft

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Chinese Journal of Aeronautics 2024年第3期37卷 153-167页

作者： Xufei yan Ye YUAN yanqin zhao Renliang CHEN Zhejiang Lab Hangzhou 311100China Department of Aerospace Engineering Swansea UniversitySwanseaWales SA28PPUK National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Manned multi-rotor electric Vertical Takeoff and Landing(eVTOL)aircraft is prone to actuator saturation due to its weak yaw control *** address this inherent problem,a rotor cross-tilt configuration is applied in this paper,with an optimization method proposed to improve the overall control efficiency of the ***,a flight dynamics model of a 500-kg manned multi-rotor eVTOL aircraft is *** accuracy of the co-axial rotor model is verified using a single arm test bench,and the accuracy of the flight dynamics model is verified by the flight test ***,an optimization method is designed based on the flight dynamics model to calculate an optimal rotor cross-tilt mounting angle,which not only improves the yaw control efficiency,but also basically maintains the efficiency of other control *** ideal rotor cross-tilt mounting angle for the prototype is determined by comprehensively considering the optimal results with different payloads,forward flight speeds,and rotor mounting angle ***,the feasibility of the rotor cross-tilt mounting angle is proved by analyzing the control derivatives of the flight dynamics model,the test data of a ground three Degree-of-Freedom(3DOF)platform,and the actual flight data of the *** results show that a fixed rotor cross-tilt mounting angle can achieve ideal yaw control effectiveness,improving yaw angle tracking and hold ability,increasing endurance time,and achieving good yaw control performance with different payloads and forward speeds.

关键词： Multi-rotor eVTOL Control efficiency Flight dynamics model Cross-tilt optimization Endurance time

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Kinetic model of vibration screening for granular materials based on biological neural network

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Particuology 2024年第5期88卷 98-106页

作者： Zhan zhao yan Zhang Fang Qin Mingzhi Jin School of Agricultural Engineering Jiangsu UniversityZhenjiang212013China Shandong Academy of Agricultural Machinery Sciences Ji'nan250100China

The kinetic model is the theoretical basis for optimizing the structure and operation performance of vibration screening *** this paper,a biological neurodynamic equation and neural connections were established according to the motion and interaction properties of the material under vibration *** material feeding to the screen and the material passing through apertures were considered as excitatory and inhibitory inputs,respectively,and the generated stable neural activity landscape was used to describe the material distribution on the 2D screen *** dynamic process of material vibration screening was simulated using discrete element method(DEM).By comparing the similarity between the material distribution established using biological neural network(BNN)and that obtained using DEM simulation,the optimum coefficients of BNN model under a certain screening parameter were determined,that is,one relationship between the BNN model coefficients and the screening operation parameters was *** screening parameters were randomly selected,and the corresponding relationships were established as a ***,with straw/grain ratio,aperture diameter,inclination angle,vibration strength in normal and tangential directions as inputs,five independent adaptive neuro-fuzzy inference systems(ANFIS)were established to predict the optimum BNN model coefficients,*** training results indicated that ANFIS models had good stability and *** flexibility and adaptability of the proposed BNN method was demonstrated by modeling material distribution under complex feeding conditions such as multiple regions and non-uniform rate.

关键词： Kinetic model Material distribution Vibration screening Biological neural network DEM simulation Adaptive neuro-fuzzy inference systems

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Composition optimization and performance prediction for ultra-stable water-based aerosol based on thermodynamic entropy theory

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Defence Technology（防务技术） 2024年第3期33卷 437-446页

作者： Tingting Kang Canjun yan Xinying zhao Jingru zhao Zixin Liu Chenggong Ju Xinyue Zhang Yun Zhang yan Wu College of Chemical Engineering and Materials Science Tianjin University of Science and TechnologyNo.29 13th AvenueEconomic and Technologic Development ZoneTianjin 300457China Tianjin Key Laboratory of Brine Chemical Engineering and Resource Eco-utilization Tianjin University of Science and TechnologyTianjin 300457China College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China

Water-based aerosol is widely used as an effective strategy in electro-optical countermeasure on the battlefield used to the preponderance of high efficiency,low cost and ***,the stability of the water-based aerosol is always unsatisfactory due to the rapid evaporation and sedimentation of the aerosol *** efforts have been devoted to improve the stability of water-based aerosol by using additives with different composition and ***,the lack of the criterion and principle for screening the effective additives results in excessive experimental time consumption and *** the stabilization time of the aerosol is still only 30 min,which could not meet the requirements of the perdurable ***,to improve the stability of water-based aerosol and optimize the complex formulation efficiently,a theoretical calculation method based on thermodynamic entropy theory is *** the factors that influence the shielding effect,including polyol,stabilizer,propellant,water and cosolvent,are considered within *** ultra-stable water-based aerosol with long duration over 120 min is obtained with the optimal fogging agent composition,providing enough time for fighting the electro-optic *** design guideline for choosing the additives with high phase transition temperature and low phase transition enthalpy is also proposed,which greatly improves the total entropy change and reduce the absolute entropy change of the aerosol cooling process,and gives rise to an enhanced stability of the water-based *** theoretical calculation methodology contributes to an abstemious time and space for sieving the water-based aerosol with desirable performance and stability,and provides the powerful guarantee to the homeland security.

关键词： Ultra-stable Water-based aerosol Thermodynamic entropy Composition optimization Performance prediction

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Application of ultrasonic fatigue technology in very-high-cycle fatigue testing of aviation gas turbine engine blade materials:A review

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Science China(Technological Sciences) 2024年第5期67卷 1317-1363页

作者： zhao JiuCheng WAN Jie ZHANG ShiZhong yan ChuLiang zhao HongWei Key Laboratory of CNC Equipment Reliability Ministry of Education Jilin UniversityChangchun 130025China School of Mechanical&Aerospace Engineering Jilin UniversityChangchun 130025China Chongqing Research Institute of Jilin University Chongqing401120China School of Aeronautic Science and Engineering Beihang UniversityBeijing 102206China

The need for very-high-cycle fatigue(VHCF)testing up to 1010cycles of aviation gas turbine engine blade materials under combined mechanical loads and complex environments has encouraged the development of VHCF testing instrumentation and *** article begins with a comprehensive review of the existing available techniques that enable VHCF *** advances in ultrasonic fatigue testing(UFT)techniques are highlighted,containing their new capabilities and methods for single load,multiaxial load,variable amplitude fatigue,and combined cycle *** techniques for conducting UFT in high-temperature,humid environments,and corrosive environments are *** developments in mechanical loading and environmental building techniques provide the possibility of laboratory construction for real service conditions of blade *** techniques that can be used for in situ monitoring of VHCF damage are *** issues in the UFT field are presented,and countermeasures are ***,the existing problems and future trends in the field are briefly described.

关键词： aviation gas turbine engine blade materials ultrasonic fatigue very-high-cycle fatigue high-temperature complex stress in situ testing

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