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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

Science China(Life Sciences) 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye yan Sun Jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care HospitalDongguan 523000China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People’s HospitalSouthern University of Science and TechnologyShenzhen 518020China State Key Laboratory for Quality Ensurance andSustainable Use of Dao-di Herbs Artemisinin Research CenterandInstitute of Chinese Materia MedicaChina Academyof Chinese Medical SciencesBeijing 100700China State Key Laboratory of Antiviral Drugs School of PharmacyHenan UniversityKaifeng 475004China Reproductive Medicine Center Foshan Women and Children HospitalFoshan 528000China

Ovarian endometrioma(OE),also known as“chocolate cysts,”is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus,leading to symptoms such as dysmenorrhea,pelvic pain,and ***,the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown,posing challenges for diagnosis and ***,we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell *** identified notable alterations in cell type-specific proportions and molecular signatures associated with ***,the activation of IGFBP5^(+) macrophages with pro-inflammatory properties,NK cell exhaustion,and aberrant proliferation of IQCG^(+) and KLF2^(+) epithelium are key features and may be the potential mechanisms underlying the pathogenesis of ***,our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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论晚清四大词人与光宣吴中词坛

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泰山学院学报 2019年第1期41卷 66-71页

作者：闫毓燕苏州大学文学院江苏苏州215123

晚清四大词人王鹏运、朱祖谋、郑文焯以及况周颐创作成就卓著,词学理论、词集校勘以及词学活动等方面在晚清词坛上均具有举足轻重的地位。四位词人在光宣年间主导和参与了吴中词坛一系列的词学交游活动,对此时期该词坛的发展做出了贡献... 详细信息

晚清四大词人王鹏运、朱祖谋、郑文焯以及况周颐创作成就卓著,词学理论、词集校勘以及词学活动等方面在晚清词坛上均具有举足轻重的地位。四位词人在光宣年间主导和参与了吴中词坛一系列的词学交游活动,对此时期该词坛的发展做出了贡献。通过对这些形式多样的词学交游唱和活动的考察,有助于更好地认识四位词人对于光宣吴中词坛产生的深远影响,也有助于了解这一时期吴中词坛的词学风貌。

关键词：晚清四大词人吴中词坛光宣

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Scaled non-passive environmental interaction force tracking for telerobotic manufacturing system with variable time delay

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Science China Technological Sciences 2025年第3期68卷 171-182页

作者： yukui ZHANG Fangyu PENG Yiming WAN Chen CHEN Zhitao GAO Haoyan LIU yu WANG Rong yan Xiaowei TANG School of Mechanical Science and Engineering Huazhong University of Science and Technology School of Artificial Intelligence and Automation Huazhong University of Science and Technology Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and Technology

Robot teleoperation plays an important role in industrial manufacturing in unknown and dangerous environments beyond human reach. In telerobotic manufacturing tasks, environmental interaction forces may vary significantly from task to ***, it is crucial to provide operators with the specific proportional feedback of environmental interaction forces to enhance their environmental awareness and manipulation capabilities. However, variable time delays and various scales of environmental interaction force feedback seriously affect the system stability, which should be rigorously addressed when designing control parameters. To cope with these difficulties, a position and scaled force tracking control framework is proposed and the LyapunovKrasovskii theory is used to obtain a simple algebraic stability criterion with the scaling factor of the environmental interaction force feedback. In addition, a low-pass filter-based radial basis function neural network is designed to avoid the effect of the measurement noise and the sudden change of the non-passive environmental interaction force on the system stability. Compared with different controllers in various telerobotic manufacturing tasks such as heavy lifting, cutting, and polishing, our proposed method achieves better position and scaled force tracking performance.

关键词： non-passive interaction force position tracking scaled force tracking stability analysis telerobotic manufacturing system variable time delay

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CT-based radiomics-deep learning model predicts occult lymph node metastasis in early-stage lung adenocarcinoma patients:A multicenter study

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Chinese Journal of Cancer Research 2025年第01期 12-30页

作者： Xiaoyan Yin Yao Lu Yongbin Cui Zichun Zhou Junxu Wen Zhaoqin Huang yuanyuan yan Jinming yu Xiangjiao Meng Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Science School of Computer Science and Engineering Sun Yat-sen University Department of Radiology Shandong Provincial Hospital Shandong First Medical University Department of Radiology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Science

Objective: The neglect of occult lymph nodes metastasis(OLNM) is one of the pivotal causes of early non-small cell lung cancer(NSCLC) recurrence after local treatments such as stereotactic body radiotherapy(SBRT) or surgery. This study aimed to develop and validate a computed tomography(CT)-based radiomics and deep learning(DL) fusion model for predicting non-invasive ***: Patients with radiologically node-negative lung adenocarcinoma from two centers were retrospectively analyzed. We developed clinical, radiomics, and radiomics-clinical models using logistic regression. A DL model was established using a three-dimensional squeeze-and-excitation residual network-34(3D SE-ResNet34) and a fusion model was created by integrating seleted clinical, radiomics features and DL features. Model performance was assessed using the area under the curve(AUC) of the receiver operating characteristic(ROC) curve, calibration curves, and decision curve analysis(DCA). Five predictive models were compared; SHapley Additive exPlanations(SHAP) and Gradient-weighted Class Activation Mapping(Grad-CAM) were employed for visualization and ***: Overall, 358 patients were included: 186 in the training cohort, 48 in the internal validation cohort, and 124 in the external testing cohort. The DL fusion model incorporating 3D SE-Resnet 34 achieved the highest AUC of 0.947 in the training dataset, with strong performance in internal and external cohorts(AUCs of 0.903 and 0.907, respectively), outperforming single-modal DL models, clinical models, radiomics models, and radiomicsclinical combined models(DeLong test: P<0.05). DCA confirmed its clinical utility, and calibration curves demonstrated excellent agreement between predicted and observed OLNM probabilities. Features interpretation highlighted the importance of textural characteristics and the surrounding tumor regions in stratifying OLNM ***: The DL fusion model reliably and accurately predicts OLNM in

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The miR172a–SNB module orchestrates both induced and adult-plant resistance to multiple diseases via MYB30-mediated lignin accumulation in rice

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Molecular Plant 2025年第1期18卷 59-75页

作者： He Wang Zhe-Xu Wang Hong-yuan Tian yu-Long Zeng Hao Xue Wan-Ting Mao Lu-yue Zhang Jun-Ni Chen Xiang Lu Yong Zhu Guo-Bang Li Zhi-Xue Zhao Ji-Wei Zhang yan-yan Huang Jing Fan Pei-Zhou Xu Xiao-Qiong Chen Wei-Tao Li Xian-Jun Wu Wen-Ming Wang yan Li State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute and Key Lab for Major Crop Diseases Sichuan Agricultural UniversityChengduChina

Plants mount induced resistance and adult-plant resistance against different pathogens throughout the whole growth *** production faces threats from multiple major diseases,including rice blast,sheath blight,and bacterial leaf ***,we report that the miR172a–SNB–MYB30 module regulates both induced and adult-plant resistance to these three major diseases via lignification in ***,pathogen infections induce the expression of miR172a,which downregulates the transcription factor SNB to release its suppression of MYB30,leading to an increase in lignin biosynthesis and disease resistance throughout the whole growth ***,expression levels of miR172a and MYB30 gradually increase and are consistently correlated with lignin contents and disease resistance during rice development,reaching a peak at full maturity,whereas SNB RNA levels are negatively correlated with lignin contents and disease resistance,indicating the involvement of the miR172a–SNB–MYB30 module in adult-plant *** functional domain of SNB protein and its binding sites in the MYB30 promoter are highly conserved among more than 4000 rice accessions,while abnormal expression of miR172a,SNB,or MYB30 compromises yield traits,suggesting artificial selection of the miR172a–SNB–MYB30 module during rice *** together,these results reveal a novel role for a conserved miRNA-regulated module that contributes significantly to induced and adult-plant resistance against multiple pathogens by increasing lignin accumulation,deepening our understanding of broad-spectrum resistance and adult-plant resistance.

关键词： miR172a SNB MYB30 lignin induced resistance adult-plant resistance

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Alpiniae oxyphyllae Fructus ameliorates renal lipid accumulation in diabetic kidney disease via activating PPARα

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Asian Pacific Journal of Tropical Biomedicine 2025年第1期15卷 11-23,I0008-I0012页

作者： Zi-Jie yan Lin Zhang Xin-Yao Han yu Kang Shu-Man Liu Tian-Peng Ma Man Xiao Yi-Qiang Xie College of Traditional Chinese Medicine Hainan Medical UniversityHaikou 571199China First Clinical College of Medicine of Guizhou University of Traditional Chinese Medicine Guiyang 550002China Heilongjiang Academy of Traditional Chinese Medicine Harbin 150001China Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Basic Medicine and Life SciencesHainan Medical UniversityHaikou 571199China

Objective:To investigate the effects of Alpiniae oxyphyllae Fructus(AOF)on renal lipid deposition in diabetic kidney disease(DKD)and elucidate its molecular ***:The mechanism of AOF in treating DKD was explored by network pharmacological enrichment analysis,molecular docking,and molecular dynamics *** effects of AOF on renal function and lipid deposition were assessed in a mouse model of DKD and high glucose-stressed HK-2 *** viability and lipid accumulation were detected by CCK8 and oil red O *** expressions of PPARαand fatty acid oxidation-related genes(ACOX1 and CPT1A)were detected by quantitative RT-PCR,Western blot,and ***,PPARαknockdown was performed to examine the molecular mechanism of AOF in treating ***:Network pharmacological enrichment analysis,molecular docking,and molecular dynamics simulation showed that the active compounds in AOF targeted PPARαand thus transcriptionally regulated ACOX1 and *** lowered blood glucose,improved dyslipidemia,and attenuated renal injury in DKD ***-containing serum accentuated high glucose-induced decrease in cell viability and ameliorated lipid ***,it significantly upregulated the expression of PPARα,ACOX1,and CPT1A in both in vivo and in vitro experiments,which was reversed by PPARα***:AOF may promote fatty acid oxidation via PPARαto ameliorate renal lipid deposition in DKD.

关键词： Diabetic kidney disease Alpiniae oxyphyllae Fructus Natural medicine Lipid accumulation PPARα Fatty acid oxidation

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong Hong-Jie Zhang yan Cheng Jianxun Liu yuhan Ai Yaqin Li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao yuan-yuan Zhu Liang-Jin Xu yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of TechnologyHefei 230009China State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic MaterialsWuhan UniversityWuhan 430072China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Key Laboratory of Photochemical Conversion and Optoelectronic Materials&CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Photoactive complexes of nonprecious transition metals,mainly including those in the first-row and partially the second-row of the Periodic table of elements,have received increasing attention in view of their low cost and long-term *** are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices,artificial photosynthesis,photocatalysis,biodiagnostics,and therapeutics,*** review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes,including photoactive Zr,V,Cr,Mo,and W complexes,Mn complexes and hybrids,Fe,Co,Ni,and Cu complexes,and Zn and Cd complexes and hybrids.A particular focus is given on the molecular design,modulation of photophysical and photochemical properties,and applications of the representative and lately-developed nonprecious metal *** addition,a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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Quantitative Separation of Spatiotemporal Patterns and Driving Factors of Carbon Sequestration Benefits in the Beijing-Tianjin-Hebei Region

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Huanjing Kexue/Environmental Science 2025年第3期46卷 1666-1678页

作者： Pang, Jiao Shan, Jing yan, yu-yue Miao, Zi-Han Tian, Shi-yu Guo, Xin-yu Ren, Han-Qi Lü, Tian-Le yan, Feng Bohai College Hebei Agricultural University Cangzhou061100 China College of Modern Science and Technology Hebei Agricultural University Baoding071000 China College of Economics and Management Hebei Agricultural University Baoding071000 China College of Land and Resources Hebei Agricultural University Baoding071000 China College of Natural Resources and Environment Northwest A&F University Yangling712100 China

Net ecosystem productivity(NEP)is an important indicator for evaluating carbon sources and sinks in regional ecosystems. Clarifying its spatiotemporal differentiation pattern and driving mechanisms is crucial for precise protection and restoration of the Beijing-Tianjin-Hebei ecosystem. We estimated the net ecosystem productivity(NEP)based on MODIS remote sensing data and explored the spatial and temporal patterns of carbon sequestration benefits and succession patterns in the Beijing-Tianjin-Hebei Region from 2002 to 2020 by using Sen’s trend + MK test,Hurst index,and center of gravity shift and quantitatively separated the relative contributions of carbon sequestration benefits driven by human activities and climate change by using bias correlation,complex correlation,and residual analysis. The relative contributions of anthropogenic activities and climate change in driving the spatial and temporal changes in carbon sequestration were quantitatively separated using partial correlation and residual analysis. The results showed that:① NEP in the Beijing-Tianjin-Hebei Region showed an increasing trend year by year over the past 20 years,with a growth rate(in terms of C)of 3.066 4 g·(m2·a)-1,and the spatial manifestation was high in the northwest and low in the southeast;the areas with strong carbon sink capacity were mainly concentrated in the periphery of Zhangjiakou City and Chengde City,and those with a strong carbon source effect were distributed in the regions of Tianjin and Handan. More than 80% of the regional carbon sink capacity was on the rise,with 47.45% and 8.29% of the regions showing very significant and significant increases,respectively,especially in Zhangjiakou and Chengde;however,the future growth trend was gradually slowing down. The center of gravity of carbon sources was gradually shifting to the southeastern plains,while the center of gravity of carbon sinks was shifting from the northeast to the southwest. ② More than 50% of the regions showed

关键词： Anthropogenic

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气相色谱-质谱分析新种海绵Reniochalina sp.中的低极性组分

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色谱 2004年第6期22卷 652-654页

作者：闫小燕靳艳虞星炬张卫金美芳中国科学院大连化学物理研究所辽宁大连116023

采用气相色谱质谱联用技术(GC MS)与核磁共振氢谱(1H NMR)相结合的方法,对中国黄海肾指海绵属新种海绵Reniochalinasp.中的低极性组分进行了研究。实验首先采用环己烷对海绵进行提取,然后将提取液浓缩,用硅胶柱对其进行柱色谱分离。取... 详细信息

采用气相色谱质谱联用技术(GC MS)与核磁共振氢谱(1H NMR)相结合的方法,对中国黄海肾指海绵属新种海绵Reniochalinasp.中的低极性组分进行了研究。实验首先采用环己烷对海绵进行提取,然后将提取液浓缩,用硅胶柱对其进行柱色谱分离。取乙酸乙酯环己烷(体积比为1∶9)混合液梯度洗脱所得油状物用于连续两次制备色谱分离,得到两个样品,对其进行1H NMR及GC MS分析。此次实验共从该海绵中分离鉴定出10种链烃、2种脂肪酸、2种脂肪酸酯、邻苯二甲酸以及3种邻苯二甲酸二酯共18种化学成分。该研究对肾指海绵属的化学分类具有一定的意义,并为进一步开发利用此种海绵提供了依据。

关键词：气相色谱-质谱核磁共振氢谱低极性组分肾指海绵属

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian yu Jane Howe Kaiwen Chen Ning yan Hao Ren Huamin Zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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