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I_(2)-DMSO mediated tetra-functionalization of enaminones for the construction of novel furo[2,3:4,5]pyrimido[1,2-b]indazole skeletons via in situ capture of ketenimine cations

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Chinese Chemical Letters 2025年第1期36卷 277-282页

作者： You Zhou Li-Sheng Wang Shuang-Gui Lei Bo-Cheng Tang Zhi-Cheng yu Xing Li yan-Dong Wu Kai-Lu Zheng An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs The First Dongguan Affiliated HospitalSchool of PharmacyGuangdong Medical UniversityDongguan 523808China State Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong Kong SAR 999077China

The first-ever synthesis of the unknown furo[2,3:4,5]pyrimido[1,2-b]indazole skeleton was demonstrated based on the undiscovered tetra-functionalization of enaminones,with simple substrates and reaction *** key to realizing this process lies in the multiple trapping of the in situ generated ketenimine cation by the 3-aminoindazole,which results in the formation of four new chemical bonds and two new rings in one ***,the products of this new reaction were found to exhibit aggregationinduced emission(AIE)without modification.

关键词： Unknown skeleton Tetra-functionalization Ketenimine cations Aggregation-induced emission

Precision storage lifetime measurements of highly charged heavy ions in the CSRe storage ring using a Schottky resonator

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Nuclear Science and Techniques 2025年第1期36卷 150-160页

作者： Qian Wang Xin-Liang yan Guang-yu Zhu Shahab Sanjari Li-Jun Mao He Zhao yuri ALitvinov Rui-Jiu Chen Meng Wang yu-Hu Zhang You-Jin yuan Jun-Xia Wu Hong-yang Jiao yue yu Zu-Yi Chen Yin-Fang Luo Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China GSI Helmholtzzentrum für Schwerionenforschung Planckstrasse 164291 DarmstadtGermany FH Aachen University of Applied Sciences Heinrich-Mussmann-Str.152428 JülichGermany

Schottky mass spectrometry utilizing heavy-ion storage rings is a powerful technique for the precise mass and decay half-life measurements of highly charged *** to the nondestructive ion detection features of Schottky noise detectors,the number of stored ions in the ring is determined by the peak area in the measured revolution frequency *** of their intrinsic amplitude-frequency characteristic(AFC),Schottky detector systems exhibit varying sensitivities at different *** low-energy electron-cooled stored ions,a new method is developed to calibrate the AFC curve of the Schottky detector system of the Experimental Cooler Storage Ring(CSRe)storage ring located in Lanzhou,*** the amplitude-calibrated frequency spectrum,a notable refinement was observed in the precision of both the peak position and peak *** a result,the storage lifetimes of the electron-cooled fully ionized^(56)Fe^(26+)ions were determined with high precision at beam energies of 13.7 and 116.4 MeV/u,despite of frequency drifts during the *** electron cooling was turned off,the effective vacuum condition experienced by the 116.4 MeV/u^(56)Fe^(26+)ions was determined using amplitude-calibrated spectra,revealing a value of 2×10^(−10)mbar,which is consistent with vacuum gauge readings along the CSRe *** method reported herein will be adapted for the next-generation storage ring of the HIAF facility under construction in Huizhou,*** can also be adapted to other storage ring facilities worldwide to improve precision and enhance lifetime measurements using many ions in the ring.

关键词： Lifetime measurement Schottky mass spectrometry Sensitivity response Highly charged heavy ion Resonator UH vacuum Nondestructive diagnostics

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin yan You Zheng Gong yangping Zhuang Jiali Wu yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan

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Science China(Life Sciences) 2025年第2期68卷 416-430页

作者： Jia-yu Liu Yao Wang yue Guo Run-Qi Zheng yun-Ying Wang yan-yan Shen yan-Hong Liu Ai-Ping Cao Rui-Bo Wang Bo-yang Xie Shuai Jiang Qiu-Ying Han Jing Chen Fang-Ting Dong Kun He Na Wang Xin Pan Tao Li Tao Zhou Ai-Ling Li Qing Xia Wei-Na Zhang Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100850China

As the elderly population expands,the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly *** an FDA-approved drug for chronic cholestatic liver diseases,tauroursodeoxycholic acid(TUDCA),a natural bile acid,offers additional health benefits beyond liver ***,we show that TUDCA extends the lifespan and healthspan of ***,oral supplementation of TUDCA improves fitness in old mice,including clinically relevant phenotypes,exercise capacity and cognitive ***,TUDCA treatment drives broad transcriptional changes correlated with anti-aging ***,we discover that TUDCA targets the chaperone HSP90 to promote its protein refolding *** collaboration further alleviates aging-induced endoplasmic reticulum(ER)stress and facilitates protein homeostasis,thus offering resistance to *** summary,our findings uncover new molecular links between an endogenous metabolite and protein homeostasis,and propose a novel anti-aging strategy that could improve both lifespan and healthspan.

关键词： tauroursodeoxycholic acid lifespan healthspan protein homeostasis

Fisetin micelles precisely exhibit a radiosensitization effect by inhibiting PDGFRβ/STAT1/STAT3/Bcl-2 signaling pathway in tumor

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Chinese Chemical Letters 2025年第2期36卷 262-269页

作者： yuanyuan Zeng Fang Liu Jun Wang Bianfei Shao Tao He Zhongzheng Xiang yan Wang Shunyao Zhu Tian yang Siting yu Changyang Gong Lei Liu Department of Radiation Oncology Cancer CenterState Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer Hospital Chongqing Key Laboratory of translational Research for Cancer Metastasis and individualized Treatment Chongqing University Cancer Hospital Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan University Department of Pharmacy The First Affiliated Hospital of Wannan Medical CollegeYijishan Hospital of Wannan Medical College Institute of Surgery Research Daping HospitalThird Military Medical University

It is of great significance to find safe and effective radiosensitizers. A primary investigation has been made on fisetin's modification of radiation effect, but its radiosensitization and related mechanisms still need to be deeply clarified. Furthermore, fisetin with high hydrophobicity is difficult to dissolve in water,severely limiting its research and application. In this study, we fabricated a safe and soluble radiosensitizer fisetin micelle for precisely enhancing radiotherapy by inhibiting platelet-derived growth factor receptor-β(PDGFRβ)/signal transducer and activator of transcription 1(STAT1)/signal transducer and activator of transcription 3(STAT3)/B cell lymphoma 2(Bcl-2) signaling pathway in the tumor. Systematic and detailed studies were performed to verify its radiosensitization effect in vitro and in vivo. On the cellular level, fisetin micelles selectively increased the radiosensitivity of tumor cells(CT26 and 4T1 cells)and had little effect on the sensitivity of normal mouse cells(L929 cells) to radiation. In the mouse models of colon and breast cancers, fisetin micelles showed an efficient radiosensitization capacity without apparent toxicity. Additionally, we first found that fisetin micelles played a radiotherapy sensitization role by inhibiting the PDGFRβ/STAT1/STAT3/Bcl-2 pathway activity. In general, this work not only confirmed that fisetin micelles precisely exhibit a radiosensitization effect in vitro and in vivo, but also profoundly explored its mechanisms underlying, to provide a theoretical and experimental basis for the clinical application of fisetin micelles.

关键词： Fisetin Platelet-derived growth factor receptor-β Polymetric micelles Radiosensitizer Radiotherapy

Network pharmacology and in vivo study:Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis

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World Journal of Gastroenterology 2025年第9期31卷 83-99页

作者： yan Qin Rui-Ya Zhang yu Zhang Yi-Qing Zhao Hai-Feng Hao Jun-Ping Wang Department of Gastroenterology Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current *** Chinese medicine(TCM),known for its multi-stage and multi-targeted approach,has a long history in treating gastrointestinal diseases and offering a promising alternative UC *** ginseng(***),a commonly used remedy for UC in TCM,exemplifies this potential,although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated,highlighting the need for further research to unlock its full potential as a treatment *** To investigate the key constituents and biological pathways through which *** exerts therapeutic effects on *** Network pharmacology investigated the UC-alleviating mechanism of ***,including“active ingredient-target-disease”network analysis,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment ***(PD;active ingredient of ***)was tested in a mouse model of 3%dextran sulfate sodium-induced UC,with assessments of body weight,Disease Activity Index scores,and colon *** and intestinal barrier integrity were analyzed via hematoxylin-eosin and Alcian blue and periodic acid-Schiff staining,immunohistochemistry,real time-quantitative PCR,and western *** By integrating and analyzing the targets of *** and UC,15 critical hub genes were *** Encyclopedia of Genes and Genomes pathway analysis revealed the mechanisms involved to be linked to MAPK and PI3K-Akt *** the 10 main active ingredients identified as potentially effective,PD was most abundant and was validated in vivo to mitigate weight loss,reduce Disease Activity Index scores,and prevent colon *** also reduced inflammation and suppressed expression of pro-inflammatory cytokines and me

关键词： Ulcerative colitis Panax ginseng Network pharmacology Panaxadiol MAPK NF-κB AMPK NRF2

Multiple pseudoprogressions during ongoing immunotherapy-based treatment of advanced gastric neuroendocrine carcinoma:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 431-442页

作者： yan-Hua Mou Juan Zhang Hui Shen Jing yu Lan Han Hui Li Qing-Feng Li Department of Oncology Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Institute of Oncology Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina

BACKGROUND Gastric neuroendocrine carcinomas(NECs)exhibit aggressive features,such as rapid growth,higher rate of metastasis,and a generally unfavorable prognosis compared to gastric *** a result,therapeutic options for NECs remain limited,contributing to the poor prognosis of *** has emerged as a promising treatment strategy and demonstrated the potential to partially improve the survival and prognosis of patients with ***,the unique clinical response termed pseudoprogression(PsP)has garnered considerable attention in the context of *** SUMMARY Presented here is a case of NEC recurrence five and a half months after radical gastric *** 45-year-old male patient underwent combination treatment involving a PD-1 blocker and tyrosine kinase inhibitors and encountered two instances of PsP during *** patient ultimately achieved a durable treatment response without altering his treatment regimens,resulting in a substantial therapeutic *** This case report aimed to provide the authors’experience with the diagnosis of PsP and treatment strategies for PsP in ongoing immunotherapy.

关键词： Gastric neuroendocrine carcinomas Pseudoprogression Immunotherapy Teprotumumab Case report

Alterations of interhemispheric functional connectivity in patients with hypertensive retinopathy using voxelmirrored homotopic connectivity:a resting state fMRI study

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 297-307页

作者： Xue-Lin Wang yu Chen Jin-yu Hu Hong Wei Qian Ling Liang-Qi He Cheng Chen Yi-Xin Wang yan-Mei Zeng Xiao-yu Wang Qian-Min Ge Xu Chen Yi Shao Department of Ophthalmology the First Affiliated Hospital of Jiangxi Medical CollegeShangrao Center HospitalEye Hospital of Shangrao CityShangrao 334000Jiangxi ProvinceChina Department of Traditional Chinese Medicine the Second Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110000Liaoning ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To analyze whether alterations of voxel mirror homology connectivity(VMHC)values,as determined by resting-state functional magnetic resonance imaging(rsfMRI),occur in cerebral regions of patients with hypertensive retinopathy(HR)and to determine the relationship between VMHC values and clinical characteristics in patients with ***:Twenty-one patients with HR and 21 agematched healthy controls(HCs)were assessed by rsfMRI *** functional connectivity between the hemispheres of the cerebrum was assessed by measuring VMHC,with the ability of VMHC to distinguish between the HR and HC groups assessed using receiver operating characteristic(ROC)curve *** in the demographic and clinical characteristics of the HR and HC groups were analyzed by independent sample *** relationship between average VMHC in several brain areas of HR patients and clinical features was determined using Pearson correlation ***:Mean VMHC values of the bilateral cuneus gyrus(BA19),bilateral middle orbitofrontal gyrus(BA47),bilateral middle temporal gyrus(BA39)and bilateral superior medial frontal gyrus(BA9)were lower in the HR than in the HC ***:VMHC values can predict the development of early HR,prevent the transformation of hypertensive microangiopathy,and provide useful information explaining the changes in neural mechanism associated with HR.

关键词： hypertensive retinopathy voxel-mirrored homotopic connectivity neuroimaging functional MRI resting state

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梭沙韭和昌都韭的遗传变异和生态位分化

生态学杂志 2018年第4期37卷 994-1002页

作者：钟燕余岩谢登峰谢川何兴金四川大学生命科学学院生物资源与生态环境教育部重点实验室成都610065

选取葱属(Allium L.)的两个近缘类群,梭沙韭(Allium forrestii Diels)和昌都韭(*** ***.)共16个居群232个个体,基于3个叶绿体基因片段序列(atp IatpH、trn L-trn F和ndh C-trn V)进行遗传变异和生态位分化研究。野外调查发现,两物种分... 详细信息

选取葱属(Allium L.)的两个近缘类群,梭沙韭(Allium forrestii Diels)和昌都韭(*** ***.)共16个居群232个个体,基于3个叶绿体基因片段序列(atp IatpH、trn L-trn F和ndh C-trn V)进行遗传变异和生态位分化研究。野外调查发现,两物种分布间断,生境有明显的差异;遗传变异分析结果表明,梭沙韭和昌都韭既没有共享单倍型,也不存在明显基因流,支持两个种是独立进化的观点;生态位分析显示,梭沙韭和昌都韭的最适生态位基本重叠,只有温度季节性变化和最冷季平均温度差别较大。推测,剧烈的温度变化和较低的冬季均温以及高度特异性的生境可能是昌都韭与梭沙韭分化的重要原因。

关键词：梭沙韭昌都韭遗传变异生态位分化