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Biomaterial‑based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration

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Military Medical Research 2025年第1期12卷 96-120页

作者： Ying-Ying Li Shuai-Fei Ji Xiao-Bing Fu yu-Feng Jiang Xiao-yan Sun Research Center for Tissue Repair and Regeneration Affiliated to the Medical Innovation Research Department Chinese PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048China 2Department of Tissue Regeneration and Wound RepairChinese PLA General HospitalBeijing 100853China

Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages,ultimately impairing its normal physiological *** evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration,promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic *** field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical ***,a comprehensive understanding of the underlying mechanisms remains somewhat elusive,limiting the broader application of these *** this review,we present two promising biomaterial-based mechanical approaches aimed at bolstering the regenerative capacity of compromised *** first approach involves leveraging biomaterials with specific biophysical properties to create an optimal scarless environment that supports cellular activities essential for *** second approach centers on harnessing mechanical forces exerted by biomaterials to enhance cellular plasticity,facilitating efficient cellular reprogramming and,consequently,promoting the regeneration of skin *** summary,the manipulation of mechanical cues using biomaterial-based strategies holds significant promise as a supplementary approach for achieving scarless wound healing,coupled with the restoration of multiple skin appendage functions.

关键词： Scarless Wound healing Biomaterials Mechanical cues Skin appendages

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Acupuncture Combined with Periocular Injection for Treatment of Hydroxychloroquine Retinopathy with Cystoid Macular Edema:A Case Report

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Chinese Journal of Integrative Medicine 2025年第1期31卷 68-72页

作者： LI Tian-tian WU yan yanG Ying-xin XUE yu-xin MA Chao-ting Department of Ophthalmology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China

Hydroxychloroquine(HCQ)is widely used in the treatment of autoimmune disorders such as systemic lupus erythematosus(SLE)and rheumatoid arthritis,and in recent years it has also been used in diseases such as cancer,neurodegenerative diseases,metabolic diseases,and microbial infections.(1)Due to the complex pharmacokinetic characteristics of HCQ,overdose or long-term use of the drug will lead to accumulation in the tissue of organism,and severe HCQ-related retinal toxicity may occur.A cohort study in America showes that after 10 and 15 years of HCQ use,the incidence of HCQ retinopathy will be 2.5%and 8.6%,respectively.(2)The clinical manifestations of HCQ retinopathy are various,mainly photoreceptor and retinal pigment epithelium(RPE)defects,some combined with cystoid macular edema(CME),and ireversible central vision loss.

关键词： Acupuncture diseases epithelium

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Advances in human umbilical cord mesenchymal stem cells-derived extracellular vesicles and biomaterial assemblies for endometrial injury treatment

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World Journal of Stem Cells 2025年第1期17卷 6-21页

作者： Wan-yu Zhang Han-Bi Wang Cheng-yan Deng Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Obstetrics and Gynecology Peking Union Medical College HospitalBeijing 100730China

Endometrial injury caused by repeated uterine procedures,infections,inflammation,or uterine artery dysfunction can deplete endometrial stem/progenitor cells and impair regeneration,thereby diminishing endometrial receptivity and evidently lowering the live birth,clinical pregnancy,and embryo implantation ***,safe and effective clinical treatment methods or gene-targeted therapies are unavailable,especially for severe endometrial *** cord mesenchymal stem cells and their extracellular vesicles are characterized by their simple collection,rapid proliferation,low immunogenicity,and tumorigenicity,along with their involvement in regulating angiogenesis,immune response,cell apoptosis and proliferation,inflammatory response,and fibrosis,Therefore,these cells and vesicles hold broad potential for application in endometrial *** article reviewed recent research on human umbilical cord mesenchymal stem cells as well as their extracellular vesicles in repairing endometrial injury.

关键词： Endometrial injury Umbilical cord mesenchymal stem cells Extracellular vesicles MicroRNA Biomaterial assemblies Regenerative repair

Mechanism and Application of Chinese Herb Medicine in Treatment of Peripheral Nerve Injury

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CHINESE JOURNAL OF INTEGRATIVE MEDICINE 2025年第3期31卷 270-280页

作者： Chen, yu-qing Zhang, yan-xian Zhang, Xu Lyu, Yong-mei Miao, Zeng-li Liu, Xiao-yu Duan, Xu-chu Nantong Univ Nantong Lab Dev & Dis Key Lab Neuroregenerat Jiangsu Sch Life SciAffiliated Hosp Nantong 226019 Jiangsu Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Minist Educ Nantong 226019 Jiangsu Peoples R China Nantong Univ Dept Pharm Dept Endocrine Affiliated Hosp Nantong 226006 Jiangsu Peoples R China Xuzhou Med Univ Jiangsu Key Lab New Drug Res & Clin Pharm Xuzhou 221004 Jiangsu Peoples R China Nantong Univ Affiliated Wuxi Clin Coll Wuxi 2 Peolpes Hosp Clin Med Res CtrMed CtrDept NeurosurgJiangnan U Wuxi 214002 Jiangsu Peoples R China yancheng Inst Technol Sch Marine & Bioengn Yancheng 224007 Jiangsu Peoples R China

Peripheral nerve injury (PNI) encompasses damage to nerves located outside the central nervous system, adversely affecting both motor and sensory functions. Although peripheral nerves possess an intrinsic capacity for self-repair, severe injuries frequently result in significant tissue loss and erroneous axonal junctions, thereby impeding complete recovery and potentially causing neuropathic pain. Various therapeutic strategies, including surgical interventions, biomaterials, and pharmacological agents, have been developed to enhance nerve repair processes. While preclinical studies in animal models have demonstrated the efficacy of certain pharmacological agents in promoting nerve regeneration and mitigating inflammation, only a limited number of these agents have been translated into clinical practice to expedite nerve regeneration. Chinese herb medicine (CHM) possesses a longstanding history in the treatment of various ailments and demonstrates potential efficacy in addressing PNI through its distinctive, cost-effective, and multifaceted methodologies. This review critically examines the advancements in the application of CHM for PNI treatment and nerve regeneration. In particular, we have summarized the most commonly employed and rigorously investigated CHM prescriptions, individual herbs, and natural products, elucidating their respective functions and underlying mechanisms in the context of PNI treatment. Furthermore, we have deliberated on the prospective development of CHM in both clinical practice and fundamental research.

关键词： peripheral nerve injury peripheral nerve regeneration Chinese herb medicine natural product mechanism

Failure mechanisms of AlGaN/GaN HEMTs irradiated by high-energy heavy ions with and without bias

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Nuclear Science and Techniques 2025年第1期36卷 49-58页

作者： Pei-Pei Hu Li-Jun Xu Sheng-Xia Zhang Peng-Fei Zhai Ling Lv Xiao-yu yan Zong-Zhen Li yan-Rong Cao Xue-Feng Zheng Jian Zeng yuan He Jie Liu Institute of Modern Physics Chinese Academy of Sciences(CAS)Lanzhou 730000China Key Laboratory of Wide Band‑gap Semiconductor Materials Ministry of EducationXidian UniversityXi’an 710071China University of Chinese Academy of Sciences(UCAS) Beijing 100049China

Gallium nitride(GaN)-based devices have significant potential for space ***,the mechanisms of radiation damage to the device,particularly from strong ionizing radiation,remains *** study investigates the effects of radiation on p-gate AlGaN/GaN high-electron-mobility transistors(HEMTs).Under a high voltage,the HEMT leakage current increased sharply and was accompanied by a rapid increase in power density that caused"thermal burnout"of the *** addition,a burnout signature appeared on the surface of the burned devices,proving that a single-event burnout effect ***,degradation,including an increase in the on-resistance and a decrease in the breakdown voltage,was observed in devices irradiated with high-energy heavy ions and without *** latent tracks induced by heavy ions penetrated the heterojunction interface and extended into the GaN ***,a new type of N_(2)bubble defect was discovered inside the tracks using Fresnel *** accumulation of N_(2)bubbles in the heterojunction and buffer layers is more likely to cause leakage and *** study indicates that electrical stress accelerates the failure rate and that improving heat dissipation is an effective reinforcement method for GaN-based devices.

关键词： GaN HEMTs Heavy ions Single-event burnout Latent tracks Degradation

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Thermo-Hydraulic Performances of Microchannel Heat Sinks with Different Types of Perforated Rectangular Blocks

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Fluid Dynamics & Materials Processing 2025年第1期21卷 87-105页

作者： Heng Zhao Honghua Ma Hui Liu Xiang yan Huaqing yu Yongjun Xiao Xiao Xiao School of Physics and Electronic Information Engineering Hubei Engineering UniversityXiaogan432000China Wuhan National Laboratory for Optoelectronics(WNLO) Huazhong University of Science and TechnologyWuhan430074China Institute of Engineering and Technology Hubei University of Science and TechnologyXianning437100China

The behavior of single-phase flow and conjugate heat transfer in micro-channel heat sinks(MCHS)subjected to auniform heat flux is investigated by means of numerical *** geometrical configurations areexamined,particularly,the combinations of rectangular solid and perforated blocks,used to create a disturbancein the *** analysis focuses on several key aspects and related metrics,including the temperature distribution,the mean Fanning friction factor,the pressure drop,the Nusselt number,and the overall heat transfer coefficientacross a range of Reynolds numbers(80–870).It is shown that the introduction of such blocks significantlyenhances the heat transfer performances of the MCHS compared to the straight-through flow ***,a case is found where the Nusselt number increases by 2.3 times relative to the reference *** integrationof perforated blocks facilitates the generation of vorticity within the channel,promoting the mixing of coldand hot ***,MCHS incorporating perforated rectangular blocks exhibit more pronounced heat transferbenefits at Reynolds numbers smaller than 400.

关键词： Micro-channel heat sink(MCHS) perforated rectangular blocks thermal performance convection heat transfer

Functional ternary salt construction enabling an in-situ Li3N/LiF-enriched interface for ultra-stable all-solid-state lithium metal batteries

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Journal of Energy Chemistry 2025年第2期101卷 68-75页

作者： Hong-yan Liu Xin-yu Liu Nan Zhang Peng-Fei Wang Zong-Lin Liu Jie Shu Ting-Feng Yi School of Materials Science and Engineering Northeastern University Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and Materials Northeastern University at Qinhuangdao Faculty of Materials Science and Chemical Engineering and Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo University

Poly（ethylene oxide）-based polymer all-solid-state lithium metal batteries（ASSLBs） have received widespread attention due to their low cost,good process ability,and high energy ***,the growth of Li dendrites within polymer solid-state electrolytes damages the reversibility of Li anodes and still impedes their widespread *** efficient strategy is to construct a superior solid electrolyte ***,a stable interface enriched with Li3N and LiF is in-situ formed between Li anode and a terna ry salt *** terna ry salt electrolyte is innovatively designed by introducing lithium bis（trifluoromethane sulfonyl）imide（LiTFSI）,lithium bis（fluorosulfonyl）imide（LiFSI）,and LiNO3to poly（ethylene oxide） *** characterization indicates that LiNO3and LiFSI contribute to forming a Li3N-LiF-enriched interface and meanwhile LiTFSI ensures excellent ***,among various Li compound components,Li3N has high ionic conductivity,which is beneficial for reducing overpotential,while LiF has high interfacial energy which can enhance nucleation energy and suppress the formation of Li *** experimental results show that ASSLBs coupled with LiFePO4cathode display extremely excellent cycle stability approximately 2200 cycles at 2 C,with a final and corresponding discharge specific capacity of 96.7 mA h g-1. Additionally,a schematic illustration of the working mechanism for the Li3N-LiF interface is proposed.

关键词： All-solid-state lithium metal batteries In-situ SEI Lithium dendrite PEO (LiTFSI) Solid electrolyte

Super-resolution microscopy: Shedding new light on blood cell imaging

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JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 2025年第1期18卷 29-53页

作者： Deng, Huan Ma, yan Zhang, yu-Hui Huazhong Univ Sci & Technol Britton Chance Ctr Biomed Photon Wuhan Natl Lab Optoelect MoEKey Lab Biomed Photon Adv Biomed Imaging Facil Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Inst Blood Transfus Hubei Prov Joint Wuhan Blood Ctr Hematol Opt Imaging Ctr Wuhan 430030 Peoples R China

Blood cells are the most integral part of the body, which are made up of erythrocytes, platelets and white blood cells. The examination of subcellular structures and proteins within blood cells at the nanoscale can provide valuable insights into the health status of an individual, accurate diagnosis, and efficient treatment strategies for diseases. Super-resolution microscopy (SRM) has recently emerged as a cutting-edge tool for the study of blood cells, providing numerous advantages over traditional methods for examining subcellular structures and proteins. In this paper, we focus on outlining the fundamental principles of various SRM techniques and their applications in both normal and diseased states of blood cells. Furthermore, future prospects of SRM techniques in the analysis of blood cells are also discussed.

关键词： Super-resolution imaging blood cells subcellular structure proteins

One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C

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World Journal of Clinical Cases 2022年第28期10卷 10085-10096页

作者： Jing-Hang Xu Sa Wang Da-Zhi Zhang yan-yan yu Chong-Wen Si Zheng Zeng Zhong-Nan Xu Jun Li Qing Mao Hong Tang Ji-Fang Sheng Xin-yue Chen Qin Ning Guang-Feng Shi Qing Xie Xi-Quan Zhang Jun Dai Department of Infectious Diseases Center for Liver DiseasesPeking University First HospitalBeijing 100094China Clinical and Research Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infectious Diseases The Second Affiliated Hospital with Chongqing Medical UniversityChongqing 400010China Jiangsu Chia-tai Tianqing Pharmaceutical Co. LtdNanjing 222006Jiangsu ProvinceChina Department of Infectious Diseases The First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Infectious Diseases Southwest China HospitalChongqing 400038China Department of Infectious Diseases West China HospitalChengdu 610041Sichuan ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310010Zhejiang ProvinceChina Department of International Medicine Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Department and Institute of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of Infectious Diseases Ruijin HospitalJiaotong University School of MedicineShanghai 200025China

BACKGROUND Entecavir(ETV)is a potent and selective nucleotide analog with significant activity against hepatitis B virus(HBV).ETV maleate is a derivative compound of ETV and was reported to have an efficacy and safety profile that is comparable to ETV(Baraclude)when used in Chinese patients with chronic hepatitis B(CHB)in phase III clinical trials(Clinical *** number,NCT-01926288)at weeks 48,96,and *** To investigate the antiviral potency and safety of ETV maleate at week 192 in Chinese CHB patients predominantly genotyped B or *** In this double-blind study,we randomly assigned patients to receive 0.5 mg/d ETV(Group A)or ETV maleate(Group B)(ratio,1:1),each with a placebo tablet for 48 ***,all patients received open-label treatment with 0.5 mg/d ETV maleate starting at week *** primary efficacy endpoint was the reduction in HBV DNA levels from *** endpoints included the proportion of patients with undetectable HBV DNA(0.05),viral suppression with HBV DNA0.05)and HBe Ag seroconversion(28.77%vs 20.00%,P>0.05)occurred similarly between Groups A and B at week ***,there was a significant difference in the proportion of patients with normal ALT levels(91.14%vs 78.38%,P0.05),percentages of patients who achieved undetectable HBV DNA(100%vs 100%,P>0.05)and rates of ALT normal

关键词： Chronic hepatitis B Entecavir maleate Randomized controlled trial Treatment outcome Mutation Genotype