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Study on yan-xin wang’s medication experience and regularity in treating Insomnia from the liver based on data mining

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TMR Integrative Medicine 2023年第17期7卷 1-9页

作者： yan-yan Chen yan-xin wang Man Wen Zheng Yu Jing-Jing Wu First Clinical Medical College Anhui University of Chinese MedicineHefei 230031China Department of Neurology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China

Background:Professor yan-xin wang has been committed to the use of traditional Chinese medicine formulas to treat insomnia from the liver for many years,and has achieved excellent clinical *** order to better inherit yan-xin wang’s academic *** purpose of this study is to use clinical data to explore the clinical experience of ***-xin wang in the application of Chinese medicine to treat insomnia patients from the liver,explore the compatibility and medication rules of traditional Chinese medicine,and give more clinical treatment ideas for ***:The general data and prescription information of insomnia patients treated with Chinese herbal medicine by ***-xin wang from January 1,2021,to December 31,2021,were summarized according to the inclusion and exclusion criteria,and the data were subjected to frequency statistics and drug association rules,complex network diagram analysis and cluster ***:A total of 159 patients and prescriptions were included in the study,of which 81.1%were women and 18.9%were men,containing 128 herbs;the highest frequency of use was 91.8%for Bupleuri *** Chinese herbs were used more than 70%of the time,namely Bupleuri Radix,Scutellariae Radix,oyster shell,Glycyrrhizae Radix,Os Draconis,and Ziziphi Spinosae *** top 20 herbs in terms of frequency of use were analyzed in terms of the four Qi,five flavours,and their *** four Qi were mainly calm and warm,the five flavours were mainly bitter and acrid,followed by sweet,and the attributions were mainly to the liver,spleen,and heart *** Chinese medicine association rules set the confidence level>80%and the support level>10%,resulting in 10 two-herb and three-herb associations with the highest confidence level,such as Os Draconis is associated with oyster shell,Platycodonis Radix is associated with Achyranthis Bidentatae Radix,Scutellariae Radix is associated with Bupleuri Radix,Os Draconis,Bupleuri Radix is associated

关键词： data mining insomnia liver-based treatment medication patterns

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Minimalistic approach to left atrial appendage occlusion guided by cardiac computed tomography angiography

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Journal of Geriatric Cardiology 2024年第4期21卷 431-442页

作者： Xian-Sai MENG Qing-Song wang xin-yan wang Xu LU yang MU Jing wang Ting-Ting SONG Yun-Dai CHEN Tao CHEN Jun GUO Graduate School of Chinese PLA Medical College BeijingChina Senior Department of Cardiology the Sixth Med-ical CenterChinese PLA General HospitalBeijingChina

OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using *** A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months *** CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO.

关键词： anesthesia matched approach

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Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology,molecular docking,and in vitro validation

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3539-3558页

作者： Cheng-Lei wang Bing-Wei yang xin-yan wang Xue Chen Wei-Dong Li Hao-Yu Zhai Ying Wu Mu-YaoCui Jia-He Wu Qing-Hui Meng Nan Zhang Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Scientific Research Management Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China School of Clinical Medicine Qinghai University Xining 810000Qinghai ProvinceChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Herba Patriniae and Coix seed(HC)constitute a widely utilized drug combination in the clinical management of colorectal cancer(CRC)that is known for its diuretic,anti-inflammatory,and swelling-reducing *** its efficacy has been demonstrated in a clinical setting,the active compounds and their mechanisms of action in CRC treatment remain to be fully *** To identify the active,CRC-targeting components of HC and to elucidate the mechanisms of action *** Active HC components were identified and screened using *** for each component were ***-related targets were obtained from human gene *** targets between HC and CRC were identified.A“drug-ingredient-target”network was created to identify the core components and targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were conducted to elucidate the key pathways *** docking between core targets and key components was *** vitro experiments validated core *** Nineteen active components of HC were identified,with acacetin as the primary active *** predictive analysis identified 454 targets of the active compounds in *** mapping with 2685 CRC-related targets yielded 171 intervention targets,including 30 core *** and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase(PI3K)/Akt signaling *** docking showed that acacetin exhibited an optimal interaction with AKT1,identifying PI3K,AKT,and P53 as key genes likely targeted by HC during CRC *** inhibited HT-29 cell proliferation and migration,as well as promoted apoptosis,in *** blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K,p-Akt,and survivin,which likely contributed to CRC *** Acacetin,the principal active compound in the HC pair,inhibited the proliferati

关键词： Colorectal cancer Baijiangcao(Herba Patriniae) Yiyiren(Coix seed) Acacetin Proliferation Migration Apoptosis Network pharmacology

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Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

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Integrative Medicine Discovery 2024年第18期8卷 1-10页

作者： Dao-Xian Shu yan-yan Chen Jiao-Rong wang Ying wang Yong-Fang Gu yan-xin wang Department of Brain DiseaseⅡ The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031China

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo ***:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions *** constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***,molecular docking was performed and validated by in vivo *** vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of ***-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in ***:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and *** core targets and key active ingredients had better binding *** with the blank group,the number of head scratching in the model group *** with the model group,there was a significant reduction of the number of head scratching in the SGR *** comparison with the blank group,the protein level in the plasma in the model group was markedly *** with the model group,the protein level in the SGR group was significantly ***:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

关键词： migraine Smilacis Glabrae Rhizoma network pharmacology molecular docking mechanism of effect

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Hysteroscopic cervical biopsy for women with persistent human papillomavirus infection after loop electrosurgical excision procedure: A case report

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World Journal of Clinical Cases 2024年第21期12卷 4777-4782页

作者： Hui Li Shan-Shan Mei Pei-Yu Mao xin-yan wang Hua-Di yang Department of Gynecology and Obstetrics The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006Zhejiang ProvinceChina

BACKGROUNDAlmost all cases of cervical cancer can be attributed to human papillomavirus(HPV) infection. The loop electrosurgical excision procedure (LEEP) is widelyused to treat HPV-mediated disease;thus, cervical cancer is highly ***, LEEP does not necessarily clear HPV rapidly and may affect theaccuracy of the results of ThinPrep cytology test (TCT) and cervical biopsy due tothe formation of cervical *** SUMMARYA 40-year-old woman underwent LEEP for cervical intraepithelial neoplasia grade1 approximately 10 years ago. Subsequent standard cervical cancer screeningsuggested persistent HPV-52 infection, but TCT results were negative. Cervicalbiopsy under colposcopy was performed thrice over a 10-year period, yieldingnegative pathology results. She developed abnormal vaginal bleeding after sexualactivity, persisting for approximately 1 year, and underwent hysteroscopy in ourhospital. Histopathologic evaluation confirmed adenocarcinoma in situ of theuterine *** with long-term persistent, high-risk HPV infection and negative pathologyresults of cervical biopsy after LEEP are at risk of cervical cancer. Hysteroscopicresection of cervical canal tissue is recommended as a supplement tocervical biopsy because it helps define the lesion site and may yield a pathologicdiagnosis.

关键词： Loop electrosurgical excision procedure Persistent human papillomavirus

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CIDNP Study of Photoinduced [2+2] Cycloadditions (the Paterno- Büchi Coupling) of Arylacetylenes and Quinone

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Chinese Chemical Letters 2003年第3期14卷 270-273页

作者： xin yan wang Bao Zhen yan Ting wang Department of Applied Chemistry Beijing University of Chemical TechnologyBeijing 100029

CIDNP techniques were applied to study the mechanism of photocycloadditions of 2-chloro-5-methoxybenzoquinone 1 with arylacetylenes 2-5 in benzene-d6 and acetonitrile-d6 respectively.

关键词： Paterno-Büchi reaction 1, 4-biradicals photo-CIDNP arylacetylenes quinones.

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A Novel Method for Prediction of Protein Domain Using Distance-Based Maximal Entropy

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Journal of Bionic Engineering 2008年第3期5卷 215-223页

作者： Shu-xue Zou yan-xin Huang yan wang Chun-guang Zhou Key Laboratory of Symbol Computation and Knowledge Engineering of Ministry of Education College of Computer Science and Technology Jilin University Changchun 130012 P. R. China

Detecting the boundaries of protein domains is an important and challenging task in both experimental and computational structural biology. In this paper, a promising method for detecting the domain structure of a protein from sequence information alone is presented. The method is based on analyzing multiple sequence alignments derived from a database search. Multiple measures are defined to quantify the domain information content of each position along the sequence. Then they are combined into a single predictor using support vector machine. What is more important, the domain detection is first taken as an imbal- anced data learning problem. A novel undersampling method is proposed on distance-based maximal entropy in the feature space of Support Vector Machine （SVM）. The overall precision is about 80%. Simulation results demonstrate that the method can help not only in predicting the complete 3D structure of a protein but also in the machine learning system on general im- balanced datasets.

关键词： protein domain boundary SVM imbalanced data learning distance-based maximal entropy

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Thermal Shock Behavior Analysis of Tungsten-Armored Plasma-Facing Components for Future Fusion Reactor

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Acta Metallurgica Sinica(English Letters) 2018年第5期31卷 515-522页

作者： Shu-Ming wang Jiang-Shan Li yan-xin wang Xiao-Fang Zhang Qing Ye Department of Materials Science and Engineering University of Science and Technology Beijing

In a fusion reactor, plasma-facing components（PFCs） will suffer severe thermal shock; behavior and performance of PFCs under high heat flux（HHF） loads are of major importance for the long-term stable operation of the reactor. This work investigates the thermo-mechanical behaviors of tungsten armor under high heat loads by the method of finite element modeling and simulating. The temperature distribution and corresponding thermal stress changing rule under different HHF are analyzed and deduced. The Manson–Coffin equation is employed to evaluate the fatigue lifetime（cyclic times of HHF loading） of W-armored first wall under cyclic HHF load. The results are useful for the formulation design and structural optimization of tungsten-armored PFCs for the future demonstration fusion reactor and China fusion experimental thermal reactor.

关键词： Plasma-facing components Thermo-mechanical behavior High heat flux Tungsten armor-Fatigue lifetime Finite element method

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pH-Responsive Magnetic I-Motif Container Coupled with DNA Walker for Construction of Dual-Signal Electrochemical Biosensor

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Journal of Analysis and Testing 2022年第1期6卷 3-10页

作者： xin-yan wang Yuanfang Li Shuzhen Lv Sai Bi College of Materials Science and Engineering Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao 266071China College of Chemistry and Chemical Engineering Shandong Demonstration Center for Experimental Chemistry EducationQingdao UniversityQingdao 266071China

Herein,a dual-signal electrochemical biosensor has been developed by self-assembly of pH-activatable i-motif probes on magnetic microparticles(MMPs)coupled with DNA walker for signal *** this study,the cytosine(C)-rich single-stranded DNAs are hybridized with DNA initiators to obtain the long-nicked duplexes with repeated units,which are further captured on MMPs to form the magnetic i-motif *** resulting duplexes contain abundant G-C base pairs,thus providing extensive binding sites for doxorubicin(DOX).At acidic pH,the C-rich sequences are folded into i-motif structure,resulting in the release of DOX and walker *** this case,the liberated DOX is adsorbed on gra-phene quantum dots-modified glassy carbon electrode viaπ-πinteraction,while the walker initiators as a moving part can catalyze the hybridization between MB-modified fueler DNA and tracker DNA on electrode,contributing to the generation of dual electrochemical signals induced by MB and ***,the magnetic separation can effectively reduce the background,achieving sensitive biosensing of pH ranging from 4.0 to 7.4 with excellent ***,the proposed dual-signal electrochemical biosensor has been successfully applied for accurate monitoring of pH in human serum,which holds great potential in pH-dependent bioassays,especially in ultra-micro analysis for clinical applications.

关键词： Dual-signal electrochemical biosensor pH I-motif DNA walker Signal amplification

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Intraorbital wooden foreign bodies: case series and literature review

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1619-1627页

作者： Ya-yan You Bing-Jie Shi xin-yan wang Jin Chen Zheng-Rong wang xing-Hua wang Fa-Gang Jiang Department of Ophthalmology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

Intraorbital wooden foreign bodies(IOWFBs) constitute a relatively rare ocular trauma, which occupy a special type of intraorbital foreign bodies(IOFBs). Data regarding IOWFBs must be obtained from case reports or small case series due to their rarity. Here, we reported 5 cases of IOWFBs and reviewed the related literatures, which could provide comprehensive information regarding the clinical manifestations, diagnosis, and surgical treatment of IOWFBs. Combined with the published literature, a total of 51 independent cases were counted after we added 5 cases. Among them, the number of male and female patients was 35 and 16 respectively;the mean age was 27.3±18.2(range 1-66)y. Obviously, the disorder seemed to occur mainly in young and middle-aged people. Because of the diversity in the clinical manifestations and imaging characteristics of IOWFBs, misdiagnosis and missed diagnosis often occur during the initial visit. Delayed diagnosis may lead to a high risk of orbital infection caused by IOWFBs. Surgery is the treatment of choice for most patients;however, the missed diagnosis and residue of foreign bodies after previous surgery cannot be ignored. Therefore, an accurate diagnosis is governed by the detailed trauma history, careful ocular examination, close observation of clinical manifestations, correct imaging diagnosis [e.g., magnetic resonance imaging(MRI) or computerized tomography(CT)], and timely and completely elimination of IOWFBs.

关键词： orbit foreign body wooden trauma infection

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