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Immunological Effect of Subunit Influenza Vaccine Entrapped by Liposomes

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Biomedical and Environmental Sciences 2009年第5期22卷 388-393页

作者： shuI-HUA ZHANG JIA-XU LIANG shu-yan DAI XIAO-LIN QIU yan-RONG YI YUN pan College of Life Sciences and Technology Shanghai Jiao Tong University Shanghai 200240 China Shenzhen Neptunus Interlong Bio-technique Company Ltd Shenzhen 518054 Guangdong China

Objective To elevate the immunological effect of subunit influenza vaccine in infants and aged people （over 60） using liposomal adjuvant in the context of its relatively low immunity and to investigate the relation between vaccine antigens and liposomal characteristics. Methods Several formulations of liposomal subunit influenza vaccine were prepared. Their relevant characteristics were investigated to optimize the preparation method. Antisera obtained from immunizinged mice were used to evaluate the antibody titers of various samples by HI and EL1SA. Results Liposomal trivalent influenza vaccine prepared by film evaporation in combinedation with freeze-drying significantly increased its immunological effect in SPF Balb/e mice. Liposomal vaccine stimulated the antibody titer of H3N2, H1N1, and B much stronger than conventional influenza vaccine. As a result, liposomal vaccine （mean size： 4.5-5.5 pm, entrapment efficiency： 30%-40%） significantly increased the immunological effect of subunit influenza vaccine. Conclusion The immune effect of liposomal vaccine depends on different antigens, and enhanced immunity is not positively correlated with the mean size of liposome or its entrapped efficiency.

关键词： Liposome Subunit influenza vaccine Size distribution Mean size Entrapped efficiency

Soluble Two-dimensional Supramolecular Organic Frameworks(SOFs):An Emerging Class of 2D Supramolecular Polymers with Internal Longrange Orders

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Chinese Journal of Polymer Science 2019年第1期37卷 1-10页

作者： shu-yan Jiang Xin Zhao CAS Key Laboratory of Synthetic and Self-assembly Chemistry for Organic Functional Molecules Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Two-dimensional(2D) materials have been demonstrated to exhibit unique properties originating from its 2D nature. In recent years, the construction of 2D materials has become a topic of great interest. This article summarizes the recent advance of 2D supramolecular organic frameworks(SOFs) which are homogeneously constructed in solution phase through self-assembly of rationally designed building blocks. These 2D SOFs are soluble and still maintain stable network structures in solutions, which exhibit uniqueness not only in structures but also in properties. In this concise review, the SOFs-related background is briefly introduced firstly, followed by outlining the research progress of soluble 2D SOFs from the perspective of monomer design, assembly, and structural *** article ends with a personal outlook on the future development of this new class of supramolecular polymers.

关键词： Supramolecular organic frameworks(SOFs) Self-assembly Two-dimensional Supramolecular polymers

Systematic comparison of Kawasaki disease Z-score formulas:Enhancing diagnostic accuracy and clinical applicability across populations

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World Journal of Clinical Pediatrics 2025年第1期14卷 63-68页

作者： yan pan Fu-Yong Jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children's HospitalShaanxi Provincial People's Hospital of Xi'anJiaotong UniveristyXi'an 710000Shaanxi ProvinceChina

This study aims to evaluate the performance of six distinct Z-score formulas in diagnosing coronary artery dilation in Kawasaki disease(KD)patients,with a focus on their clinical applicability across diverse populations.A retrospective analysis was conducted using comparative statistical methods to assess the sensitivity and specificity of each *** Kobayashi and Dallaire formulas demonstrated the highest sensitivity in China,particularly in younger patients with prolonged fever *** findings provide evidence-based recommend-ations for selecting Z-score formulas to optimize diagnostic precision in KD patients.

关键词： Kawasaki disease Early diagnosis Z-score Children

A simple image-based method for online moisture content estimation of iron ore green pellets

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Journal of Iron and Steel Research International 2023年第5期30卷 851-863页

作者： shu-yi Zhou Xiao-yan Liu College of Electrical and Information Engineering Hunan UniversityChangsha 410082HunanChina Innovation Institute of Industrial Design and Machine Intelligence Quanzhou-Hunan University Quanzhou 362006FujianChina

Moisture content(MC)is an important quality metric of iron ore green pellets in pelletizing process in ironmaking *** image-based methods for MC estimation may result in big errors for gray-scale pellet images captured under various lighting *** proposed a simple image-based method to improve the MC estimation accuracy by illumination correction and linear regression ***,the illumination of the pellet image was transformed into the reference illumination by use of a color checker chart and piecewise linear interpolation,so that the influence of different illuminations could be greatly *** experimental analysis,it was found that MC is approximately adversely proportional to the average intensity of the transformed images.A simple model for MC prediction was then established by linear *** demonstrated that the proposed method has good robustness to different lighting conditions and achieves the best performance in metrics of mean square error,mean absolute error and maximum absolute error in comparison with five state-of-art MC estimating *** on a working disk pelletizer shows that the proposed method can predict well the change of moisture content with time,and its computing efficiency can satisfy the requirement for online MC monitoring during the pelletizing process.

关键词： Green pellet Moisture content Image processing Pelletizing process

Monitoring nearest neighbor queries with cache strategies

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第4期8卷 529-537页

作者： pan Peng LU yan-sheng College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

The problem of continuously monitoring multiple K-nearest neighbor (K-NN) queries with dynamic object and query dataset is valuable for many location-based applications. A practical method is to partition the data space into grid cells, with both object and query table being indexed by this grid structure, while solving the problem by periodically joining cells of objects with queries having their influence regions intersecting the cells. In the worst case, all cells of objects will be accessed once. Object and query cache strategies are proposed to further reduce the I/O cost. With object cache strategy, queries remaining static in current processing cycle seldom need I/O cost, they can be returned quickly. The main I/O cost comes from moving queries, the query cache strategy is used to restrict their search-regions, which uses current results of queries in the main memory buffer. The queries can share not only the accessing of object pages, but also their influence regions. Theoretical analysis of the expected I/O cost is presented, with the I/O cost being about 40% that of the SEA-CNN method in the experiment results.

关键词： K-nearest neighbors (K-NNs) Continuous query Object cache Query cache

数实融合下农业产业化价值创造机理:基于资源编排的案例研究

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世界农业 2025年第1期 92-102页

作者：张燕潘亚楠河北科技大学经济管理学院石家庄050091

党的二十大报告强调推进数字经济与实体经济深度融合。在农业企业数字化背景下,本文利用纵向案例方法剖析北大荒集团的“工具化—智能化—生态化”变革路径,提炼出“资源—能力—价值创造”的逻辑框架,研究数字时代农业产业化企业价值... 详细信息

党的二十大报告强调推进数字经济与实体经济深度融合。在农业企业数字化背景下,本文利用纵向案例方法剖析北大荒集团的“工具化—智能化—生态化”变革路径,提炼出“资源—能力—价值创造”的逻辑框架,研究数字时代农业产业化企业价值创造机理。其中在工具化向智能化转换的过程中,实现由生产流程标准化向产线自动化过渡,纳入人的主观价值,以积累式资源结构为主,通过丰富资源能力形成稳定性资源以实现资源调动,利用平台优势汇集流量,协同各利益相关者实现价值创造;由智能化向生态化转换的过程中,构建了全产业链数据平台、产业链智能化生态,以获取资源结构为主,通过开拓性资源形成协调能力,利用技术优势联结利益相关者参与价值创造过程,进而嵌入数字创新生态系统。

关键词：数实融合资源编排理论农业产业化企业价值创造

Diffusion and Relaxation Dynamics of Supercooled Polymer Melts

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Chinese Journal of Polymer Science 2018年第10期36卷 1187-1194页

作者： Deng pan Zhao-yan Sun State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China University of Chinese Academy of Sciences Beijing 100049 China Xinjiang Laboratory of Phase Transitions and Microstructures in Condensed Matters College of Physical Science and Technology Yili Normal University Yining 835000 China

The dynamic properties of polymer melts are investigated in the range of normal liquid regime to the supercooled liquid regime. The polymer is modeled as a coarse-grained bead-spring model with chain length ranging from 5 to 160. The mean squared displacement and non-Gaussian parameter are used to describe the self diffusion of polymer beads. We find slow dynamics with decreasing temperature and increasing chain length. The time evolution of non-Gaussian parameters shows two peaks （or one peak one shoulder） in the a-relaxation time, τa, regime and sub-diffusion time regime, respectively, where the first primary peak indicates the dynamic heterogeneity stemmed from the motion of beads, and the secondary peak is the result of correlated motion along a polymer chain. Moreover, the relaxation of polymer beads shows clear two-step decay in supercooled melts and the dynamics shows growing heterogeneity with decreasing temperature. As chain length is increased, a peak of the dynamic susceptibility occurs, and the peak height, x＊4, increases and then reaches a plateau. The curves of the height of the first peak of a2, a2＊, versus τa and the curves of x＊4 versus τa follow two master curves for different chain lengths. Our results indicate the similarity of dynamic heterogeneity dominated by the motion of single bead even the chain length is different. It is interesting to find that the Stokes-Einstein （SE） relation between ra and diffusion coefficient D, D-rq 1, is highly length-scale dependent. The SE relation breaks down in both normal melts regime and supercooled regime at large magnitude of wave vectors, attributed to the non-Brownian motion arising from the chain connectivity and growing heterogeneity due to supercooling. However, the SE relation is reconstructed when the probing length scale is large （at small magnitude of wave vectors）. Our results show a hierarchical physical picture of the supercooled polymeric dynamics.

关键词： Supercooled polymer melt Molecular dynamics simulation Diffusion Relaxation

The momentum distributions of triatomic molecular ion H_(3)^(2+) by intense laser pulses

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Communications in Theoretical Physics 2023年第6期75卷 112-119页

作者： Zhi-Xian Lei shu-Juan yan Xin-Yu Hao pan Ma Sheng-Peng Zhou Jing Guo Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

We investigate theoretically the photoionization of triatomic molecular ion H_(3)^(2+) by numerically solving the two-dimensional time-dependent Schrödinger equations under Bohn-Oppenheimer *** results show that the photoelectron momentum distributions(PMDs)of H_(3)^(2+) with different initial states are strongly dependent on the laser ellipticities and molecular orbital symmetry,and the PMDs of degenerate electronic states E^(±)are mirror ***,for degenerate electronic states E^(±),vortex structures appear in the PMDs by the counter-rotating circularly polarized laser pulses as the time delay between the two pulses increases,which can be explained by multicenter ionization and ultrafast photoionization model.

关键词： momentum distribution ringlike molecules intense laser fields

Characteristics of Mesoscale Vortices over China in 2015

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Journal of Meteorological Research 2017年第6期31卷 1149-1160页

作者： Yu shu Jisong SUN Yinong pan Nanjing Meteorological Bureau Nanjing 210019 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081 Institute of Earth Sciences University of Chinese Academy of SciencesBeijing 100049 School of Atmospheric Sciences Nanjing UniversityNanjing 210093 Key Laboratory for Mesoscale Severe Weather of Ministry of Education Nanjing UniversityNanjing 210093

Mesoscale vortices, which appear at middle and lower levels of rainstorms, are cyclonic circulations with a size ranging from tens of kilometers to several hundred kilometers. Mesoscale vortices often have close relationships with convective activities. The ERA-Interim dataset and an automatic vortex-searching method were used to identify the mesoscale vortices occurring over China in 2015 and their basic characteristics were analyzed. The mesoscale vortices are divided into three categories： mesoscale convective vortices, mesoscale stratiform vortices, and mesoscale dry vortices. The mesoscale convective vortices have the largest intensity, size, and duration, whereas the mesoscale dry vortices have the smallest. Mesoscale convective vortices are able to form in any direction of the parent mesoscale convective system, although the secondary convection tends to appear to the southeast of the parent vortices. The mesoscale vortices tend to generate in the transition area between high and low altitudes. The leeward side of the Tibetan Plateau is the main source region of mesoscale vortices in China. Most of vortices are generated at midday and midnight. The activities of mesoscale convective vortices and mesoscale stratiform vortices peak in summer, whereas those of the mesoscale dry vortices peak in winter.

关键词： mesoscale vortex mesoscale convective vortex mesoscale convective system