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Chinese herbal formula Tongluo Jiunao injection protects against cerebral ischemia by activating neurotrophin 3/tropomyosin-related kinase C pathway

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Neural Regeneration Research 2015年第3期10卷 445-450页

作者： Peiman Alesheikh Arezou Mashoufi Hui-ling Tang Wei Zhang Bo Di yang-yang yan Peng-tao Li yan-shu pan Research Center of Natural Product Health North Khorasan University of Medical Science Department of Pathology Preclinical Medical SchoolBeijing University of Chinese Medicine Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

The Chinese herbal formula Tongluo fiunao, containing the active components panax notogin- seng and Gardenia jasminoides, has recently been patented and is in use clinically. It is known to be neuroprotective in cerebral ischemia, but the underlying pathway remains poorly understood. In the present study, we established a rat model of cerebral ischemia by occlusion of the middle cerebral artery, and administered Tongluo Jiunao, a positive control （Xuesai Tong, containing panax notoginseng） or saline intraperitoneally to investigate the pathway involved in the action of TongIuo fiunao injection. 2,3,5-Triphenyltetrazolium chloride （TTC） staining showed that the cerebral infarct area was significantly smaller in model rats that received Tongluo fiunao than in those that received saline. Enzyme-linked immunosorbent assay revealed significantly greater expression of neurotrophin 3 and growth-associated protein 43 in ischemic cerebral tissue, and serum levels of neurotrophin 3, in the Tongluo Jiunao group than in the saline group. The reverse transcription polymerase chain reaction and immunohistochemical staining showed that after treatment with Tongluo fiunao or Xuesai Tong, tropomyosin-related kinase C gene expression and immunoreactivity were significantly elevated compared with saline, with the greatest expression observed after Tongluo Jiunao treatment. These findings suggest that Tongluo Jiunao injection exerts a neuroprotective effect in rats with cerebral ischemia by activating the neurotrophin 3/ tropomyosin-related kinase C pathway.

关键词： neural regeneration cerebral ischemia Chinese herbal formula Tneurotrophic factor ongluo Jiunao injection nerve growth factor receptor Xuesai Tong neuroprotection NSFC grant neuroprotection neural regeneration

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Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期68卷 157-162页

作者： Rong-De He Yun-Lei Luo Qiu-Quan pan Qi-Wei Yao Xing-Zhong shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes

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Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期68卷 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang Li-shuo Zheng Yu-Tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

关键词： host-guest interaction hydrophobic effect endo-functionalized cavity mutation pyridine

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Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： yan pan Fu-Yong Jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care

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Broadband low-frequency sound absorption of multifunctional composite metastructure

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Science China Technological Sciences 2025年

作者： Yilong yanG Shanshan LIU yan LI Tong GAO Yongdong pan Yong LI Yabin JIN School of Aerospace Engineering and Applied Mechanics Tongji University Institute of Acoustics School of Physics Science and Engineering Tongji University Shanghai Institute of Aircraft Mechanics and Control State International Joint Research Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical University Shanghai Key Laboratory of Intelligent Sensing and Detection Technology School of Mechanical and Power Engineering East China University of Science and Technology

In this study, we fabricated multifunctional metastructures from carbon fiber-reinforced plastic composites using additive manufacturing technology. These metastructures are characterized by their lightweight, load-bearing capacity, and broadband low-frequency sound absorption properties. The metastructure consists of 36 unit cells, and non-local coupling mechanism was considered for designing the sound absorption performance. We developed an acoustic impedance theory tailored for the metastructure, facilitating an analysis of thermal and viscous dissipation mechanisms. It is proven theoretically and experimentally that the proposed composite metastructure can achieve a noise reduction with an average sound absorption coefficient greater than 0.9 across frequencies in the rage of 330–1500 Hz. We also studied the metastructure’s quasi-static and cyclic compression performance, confirming its efficient absorption capabilities after cyclic compression. The proposed design and additive manufacturing method for composite metastructures provides a novel pathway for creating lightweight, multifunctional structures with diverse applications, such as aerospace engineering.

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo yan pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi Lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： Long pan Guoqiang Li Xiaoyan Wang Ming Jin Xinrong He Luo Qin Zhong Wang Wenwei Zhao Chunzhu Chen Yuanlu Liu Jin yang Lele shu Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Lanzhou University College of Earth Sciences， Chengdu University of Technology School of Geographic Science， Nantong University Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the Late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi Lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi Lake salinity varied between 2 g/L and 47 g/L during the Late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the Late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi Lake has a low salinity of average value of ～15 g/L. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and Little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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蓬莱气候舒适度与旅客网络关注度相关研究

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西南师范大学学报（自然科学版） 2018年第5期43卷 57-63页

作者：刘璐王一然于言衣淑玉潘仕梅王学芬中国农业大学烟台研究院山东烟台264670

利用蓬莱市地面气象站观测的1961-2015年的气温、降水、相对湿度等气候资料,采用滑动平均法、线性倾向估计法和气候舒适度评价方法分析蓬莱市的气候特征,评价蓬莱市的气候舒适度;利用蓬莱市2012年至2015年旅客网络关注度的统计资料,运用... 详细信息

利用蓬莱市地面气象站观测的1961-2015年的气温、降水、相对湿度等气候资料,采用滑动平均法、线性倾向估计法和气候舒适度评价方法分析蓬莱市的气候特征,评价蓬莱市的气候舒适度;利用蓬莱市2012年至2015年旅客网络关注度的统计资料,运用OLS方法分析蓬莱市旅游气候舒适度与旅客网络关注度的关联性.结果表明:蓬莱市近年的年降水量和气温分别以倾向率0.644 5mm/a,0.032 1℃/a上升,21世纪以来的降水和温度波动变化较大;蓬莱市全年最宜旅行的月份为5,6,9和10月份,最不宜旅行的月份是冬季3个月;旅客网络关注度与旅游气候舒适度相关性系数是0.978,旅客网络关注度月份指数的气候弹性系数是0.156,说明旅客网络关注度年内改变在一定程度上受气候影响,旅游气候舒适度综合指数每改变一个单位,蓬莱市的旅客网络关注度月份指数会随之变化0.156%.

关键词：气候舒适度网络关注度相关性蓬莱

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Sugarcane derived carbon@CuS-octadecanol composite phase change materials for efficient solar thermal storage

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Progress in Natural Science:Materials International 2024年第4期34卷 803-813页

作者： shu-Yao Li Ying-Jie Huo Ting yan Wei-Guo pan College of Energy and Mechanical Engineering Shanghai University of Electric Power Key Laboratory of Clean Power Generation and Environmental Protection Technology in Mechanical Industry

Biomass carbon has the advantage of a wide spectral absorption range, which makes it great potential for solar thermal utilization. In this study, porous skeleton support materials of sugarcane-derived carbon were prepared by freeze-drying-high-temperature carbonization method using natural sugarcane as raw material, and the characterization results demonstrate that the porous skeleton of sugarcane-derived carbon has outstanding porous support properties. By combining CuS with sugarcane-derived carbon, a porous material with outstanding photothermal conversion performance was synthesized. Four photo-thermal composite phase change materials（CPCMs） were prepared, the maximum loading mass of the support material C600 to the phase change materials（PCMs） reached 79.77 %. The C600-CuS-OC had excellent thermal storage properties with an enthalpy of melting of 276.3 J/g and a thermal conductivity of 0.61 W·m-1·K-1. The photo-thermal conversion efficiency of C600-CuS-OC was 83.2 %. Sugarcane carbon-based CPCMs are a low-cost and high-efficiency solar thermal storage material, which has great potential for applications in solar thermal storage, biomass utilization, and thermal management.

关键词： Biomass carbon Phase change materials Photo-thermal conversion Solar energy Thermal management Thermal storage

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Effect of Sorbents Added on Adsorption Capability of Soil for Nano-TiO_2

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Chemical Research in Chinese Universities 2009年第4期25卷 446-450页

作者： pan shu-ying GAO Bao-yu YUE Qin-yan School of Environmental Science and Engineering Shandong University Jinan 250100 P. R. China

The adsorption capability of loam soil for nano-TiO2 affected by the amount and intensity of leached water has been investigated by simulating the natural rainfall process under the leaching *** results show that the amount and the intensity of leached water are two important factors affecting the adsorption capability of loam soil for *** results indicate that the depth of the loam soil containing a maximal amount of nano-TiO2 is proportional to the amount of leached water,while it is inversely proportional to the intensity of leached water,at a constant amount of the leached *** was also found that the adsorption capability of soils for nano-TiO2 can be improved by adding other materials,such as dissolved organic matter（DOM）,bentonite and *** was found that DOM is the best sorbent for improving the adsorption capability of loam soil for nano-TiO2,followed by bentonite,while straw is not suitable for the modification of loam *** improvement of adsorption capability of loam soil depends on the amount of these ***-TiO2 can be effectively adsorbed on the surface layer of loam soil containing an appropriate amount of additive.

关键词： Nano-TiO2 DOM Bentonite Adsorption Eluviations

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