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Cutaneous metastasis from esophageal squamous cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4676-4683页

作者： rui-yan zhang Shi-Jie Zhu Peng Xue Sheng-Qi He Department of Oncology Wangjing HospitalChina Academy of Chinese Medicine SciencesBeijing 100102China

BACKGROUND Esophageal cancer is a common cause of cancer-related death *** metastasis of esophageal squamous cell carcinoma is rare,particularly in diffuse skin *** SUMMARY In this case report,we describe an 82-year-old male who was diagnosed with esophageal squamous cell *** tumor was staged as T4N3M1(Stage IVB).The pathological findings revealed poorly differentiated squamous cell carcinoma of the *** months after diagnosis,the patient began chemotherapy,and symptoms were relieved after four cycles of *** that,the patient returned home without a systematic physical *** year after diagnosis,the patient realized that the skin of the abdominal wall was hard and rough without pain,and the color became darker than normal *** months after diagnosis,a biopsy of the patient’s abdominal lesion revealed that the skin metastasis was derived from the *** the patient received two cycles of apatinib combined with docetaxel,but the abdominal lesion *** cycles of nivolumab were administered,but the patient eventually died of multiple organ *** This report highlights cutaneous metastasis as a late and untreatable metastasis of esophageal cancer.

关键词： Esophageal carcinoma Squamous cell carcinoma Cutaneous metastasis Immunological checkpoint inhibitor Chemotherapy Case report

Hierarchical Crystalline Structures Induced by Temperature Profile in HDPE Bars during Melt Penetration Process

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Chinese Journal of Polymer Science 2017年第1期35卷 108-122页

作者： chun-xia zhu rui-yan zhang yan-hao huang wei yang zheng-ying liu jian-ming feng 杨鸣波 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

The hierarchical crystalline morphologies and orientation structures across the thickness direction in high-density polyethylene （HDPE） molded bars were investigated via a novel melt-penetrating processing method named multi-melt multi-injection molding （M3IM）. The samples with various mold temperatures （20, 40 and 60 ℃） were prepared, and the effects of the external temperature profile on the evolution of crystalline microstructures were studied. With scanning electron microscopy （SEM）, the transition of crystalline morphology from ring-banded structure to oriented lamellae was observed with decreasing mold temperature, and the oriented lamellae were formed at the sub-skin layer of the samples at the lowest mold temperature, which was further testified by differential scanning calorimetry （DSC）. With the decline of mold temperature, the degree of orientation, obtained from two-dimensional small angle X-ray scattering （2D-SAXS）, was increased and long periods rose a little. Thus, decreasing mold temperature was beneficial to the formation of orientation structures because the relaxation of chains was weakened.

关键词： Hierarchical structures Orientation Multi-melt multi-injection molding Mold temperature

Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 631-637页

作者： Li-jin PU Ying SHEN rui-yan zhang Qi zhang Lin LU Feng-hua DING Jian HU Zheng-kun yanG Wei-feng SHEN Department of Cardiology Ruijin Hospital Shanghai Jiao Tong Uniwzrsity School of MedicineShanghai 200025China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention.

关键词： Renal artery stenosis Transradial coronary angiography Resistant hypertension

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 705-712页

作者： Zhen SUN Ying SHEN Lin LU rui-yan zhang Li-jin PU Qi zhang Zheng-kun yanG Jian HU Qiu-jing CHEN Wei-feng SHEN Department of Cardiology Shanghai Ruijin Hospital Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine

Objective： Coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods： Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results： Low （Rentrop score of 0 or 1） and high （Rentrop score of 2 or 3） coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high coUateralization （for all comparisons, P〈0.05）. In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein （hsCRP） compared with those with high col- lateralization. Multivariate analysis revealed that age of 〉65 years, female gender, diabetes, no history of hypertension dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were inde- pendently associated with low coronary collateralization. Conclusions： Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation.

关键词： Stable angina Coronary collateral circulation Risk factors Angiography Chronic total coronary occlusion

Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis

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World Journal of Gastroenterology 2014年第26期20卷 8660-8666页

作者： yang-Qiu Bai Yu-Xiu yang Ya-Ge yang Song-Ze Ding Fang-Li Jin Ming-Bo Cao yan-rui zhang Bing-Yong zhang Department of Gastroenterology and Hepatology Zhengzhou University People’s Hospital Department of Gastroenterology and Hepatology The First Affiliated Hospital of Zhengzhou University The Seventh People’s Hospital of Zhengzhou City

AIM: To determine the long-term efficacy of autologous bone marrow mononuclear cells (BM-MNCs) transplantation in terms of improving liver function and reducing complications in patients with decompensated cirrhosis.

关键词： Autologous Bone marrow mononuclear cells Transplantation Liver cirrhosis Hepatitis B virus

Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

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World Journal of Gastroenterology 2020年第25期26卷 3673-3685页

作者： Lin Yuan Jun-Bo Zhao Ying-Lei Zhou Ya-Bin Qi Qiong-Ya Guo Hai-Hui zhang Muhammad Noman Khan Ling Lan Chang-He Jia yan-rui zhang Song-Ze Ding Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou UniversityHenan ProvinceChina Henan Provincial People’s Hospital Henan ProvinceChina Henan University School of Medicine Zhengzhou 450003Henan ProvinceChina

BACKGROUND Type I Helicobacter pylori(***)infection causes severe gastric inflammation and is a predisposing factor for gastric ***,its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated;it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17(G-17)and pepsinogens(PGs)during clinical *** To explore the prevalence of type I and type II *** infection status and their impact on G-17 and PG levels in clinical *** Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined,and 523 patients were enrolled in this *** infection was confirmed by both 13C-urea breath test and serological *** were divided into non-atrophic gastritis(NAG),nonatrophic gastritis with erosion(NAGE),chronic atrophic gastritis(CAG),peptic ulcers(PU)and gastric cancer(GC)*** serological G-17,PG I and PG II values and PG I/PG II ratio were also *** A total *** infection rate of 3572 examined patients was 75.9%,the infection rate of 523 enrolled patients was 76.9%,among which type I *** infection accounted for 72.4%(291/402)and type II was 27.6%;88.4%of GC patients were *** positive,and 84.2%of them were type I infection,only 11.6%of GC patients were *** *** rates of type I *** in NAG,NAGE,CAG,PU and GC groups were 67.9%,62.7%,79.7%,77.6%and 84.2%,*** infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II *** types of *** induced higher G-17 level,but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG,NAGE and CAG groups over uninfected *** PG I levels showed no difference among all disease groups and in the presence or absence of ***;in stratified analysis,its level w

关键词： Helicobacter pylori Chronic gastric diseases Gastrin-17 Pepsinogen Gastric cancer

Unveiling solid-solid contact states in all-solid-state lithium batteries:An electrochemical impedance spectroscopy viewpoint

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Journal of Energy Chemistry 2025年第2期101卷 16-22页

作者： Jin-Liang Li Liang Shen Zi-Ning Cheng Jun-Dong zhang Ling-Xuan Li Yu-Tong zhang yan-Bin Gao Chunli Guo Xiang Chen Chen-Zi Zhao rui zhang Qiang zhang Tsinghua Center for Green Chemical Engineering Electrification Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical Engineering Tsinghua University College of Materials Science and Engineering Taiyuan University of Technology Advanced Research Institute of Multidisciplinary Science School of Materials Science and Engineering Beijing Institute of Technology Beijing Huairou Laboratory Institute for Carbon Neutrality Tsinghua University Shanxi Research Institute for Clean Energy Tsinghua University

All-solid-state lithium batteries（ASSLBs） are strongly considered as the next-generation energy storage devices for their high energy density and intrinsic *** solid-solid contact between lithium metal and solid electrolyte plays a vital role in the performance of working ASSLBs,which is challenging to investigate quantitatively by experimental *** work proposed a quantitative model based on the finite element method for electrochemical impedance spectroscopy simulation of different solid-solid contact states in *** the assistance of an equivalent circuit model and distribution of relaxation times,it is discovered that as the number of voids and the sharpness of cracks increase,the contact resistance Rcgrows and ultimately dominates the battery *** accurate fitting,inverse proportional relations between contact resistance Rcand（1-porosity） as well as crack angle was *** contribution affords a fresh insight into clarifying solid-solid contact states in ASSLBs.

关键词： All-solid-state lithium batteries Distribution of relaxation times Electrochemical impedance spectroscopy Equivalent circuit model Finite element method Solid-solid contacts

Advances in origin of high oxidation state of magmas associated with porphyry Cu-(Mo-Au) deposits

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Science China Earth Sciences 2025年第3期68卷 953-956页

作者： rui WANG Jingbo zhang State Key Laboratory of Geological Processes and Mineral Resources Frontiers Science Center for Deep-time Digital Earth Institute of Earth Sciences China University of Geosciences School of Earth Sciences and Resources China University of Geosciences

1. Introduction Porphyry Cu-(Mo-Au) deposits, hereafter termed as porphyry Cu deposits, are typical magmatic-hydrothermal systems spatially and genetically associated with shallow,intermediate to felsic porphyritic intrusions. These deposits exhibit well-developed alteration zoning and are characterized by veinlet-disseminated mineralization.

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Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults

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World Journal of Emergency Medicine 2025年第1期16卷 35-42页

作者： Tianpeng Hu yan Li Shengtao yan Lichao Sun rui Lian Jieqiong Yu Jie Chen Xiaoyu Liu Guoqiang zhang Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND: Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A(MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of Mx A to distinguish viral from bacterial ***: We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic(ROC) curve analysis were used to determine the diagnostic value of Mx A, either alone or in combination with C-reactive protein(CRP) or procalcitonin(PCT), in patients with viral, bacterial, or ***: The value of MxA(ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections(82.3 [24.5–182.9] vs. 16.4 [10.8–26.5], P<0.0001)(82.3 [24.5–182.9] vs. 28.5 [10.2–106.8], P=0.0237). The area under the curve(AUC) of the ROC curve for distinguishing between viral and bacterial infections was 0.799(95% confidence interval [95% CI] 0.696–0.903), with a sensitivity of 68.9%(95% CI 54.3%–80.5%) and specificity of 90.0%(95% CI 74.4%–96.5%) at the threshold of 50.3 ng/mL. Combining the MxA level with the CRP or PCT level improved its ability. MxA expression was low in cytomegalovirus(15.8 [9.6–47.6] ng/mL) and Epstein-Barr virus(12.9 [8.5–21.0] ng/mL) ***: Our study showed the diagnostic efficacy of Mx A in distinguishing between viral and bacterial infections, with further enhancement when it was combined with CRP or PCT. Moreover, EpsteinBarr virus and human cytomegalovirus infections did not elicit elevated Mx A expression.

关键词： Myxovirus resistance protein A Viral infections C-reactive protein Procalcitonin Biomarker