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XOR spin logic operated by unipolar current based on field-free spin-orbit torque switching induced by a lateral interface

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Rare Metals 2024年第8期43卷 3868-3875页

作者： yan-ru li Mei-Yin yang Guo-Qiang Yu Bao-Shan Cui Jin-Biao liu Yong-liang li Qi-Ming Shao Jun Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences(IMECAS)Beijing 100029China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Spin logics have emerged as a promising avenue for the development of logic-in-memory *** particular,the realization of XOR spin logic gates using a single spin-orbit torque device shows great potential for low-power stateful logic circuits in the next *** this study,we successfully obtained the XOR logic gate by utilizing a spin-orbit torque device with a lateral interface,which was created by local ion implantation in the Ta/Pt/Co/Ta Hall device exhibiting perpendicular magnetic *** angle of the lateral interface is set at 45°relative to the current direction,leading to the competition between symmetry breaking and current-driven Néel-type domain wall ***,the field-free magnetic switching reversed is realized by the same sign of current amplitude at this *** on this field-free magnetic switching behavior,we successfully proposed an XOR logic gate that could be implemented using only a single spin-orbit torque Hall *** study provides a potentially viable approach toward efficient spin logics and in-memory computing architectures.

关键词： Filed-free magnetic switching Spin-orbit torque XOR logic gate Lateral interface

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高背压+引射器+抽汽供热方式下热网调节特性分析

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汽轮机技术 2024年第2期66卷 133-137页

作者：武云跃马素霞闫利如太原理工大学电气与动力工程学院太原030024

分析一次热网调节方式的调节特性并获得最佳的一次热网调节方式在供热期对能源节约利用至关重要。基于某2×350MW热电机组高背压+引射器+抽汽梯级供热系统,研究比较了供热初末寒期与寒期各3种调节方式的经济特性,给出了不同环境温度下... 详细信息

分析一次热网调节方式的调节特性并获得最佳的一次热网调节方式在供热期对能源节约利用至关重要。基于某2×350MW热电机组高背压+引射器+抽汽梯级供热系统,研究比较了供热初末寒期与寒期各3种调节方式的经济特性,给出了不同环境温度下所需要乏汽量及抽汽量;并以机组发电量与循环泵耗电量的净电量最佳为目标量化了不同环境温度段的最优供热调节方式。结果表明:整个供热期调节方式的相对流量比越大,总乏汽量利用越多,抽汽总量越少;初末寒期:环境温度为-3℃~1℃、2℃~3℃、4℃~5℃3个阶段对应的最优热网调节方式分别为相对流量比为1、0.84、0.7的质调节。寒期:环境温度为-11℃~-4℃,质调节最优且平均净电量优于质量综合调节约3.087MW、优于量调+质调约4.75MW,-14℃~-12℃3种调节方式净电量几乎相同。

关键词：热电机组高背压+引射器+抽汽调节特性相对流量比净电量

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High-Performance ruCl3 Catalyst Systems for Hydro-Esterification of Methyl Formate and Ethylene

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Chinese Journal of Chemistry 2019年第8期37卷 769-774页

作者： yan-ru li Zhong-Ning Xu Bing Bai Zhi-Qiao Wang Guo-Cong Guo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China

Summary of main observation and conclusion ruCl3 catalyst system has many advantages for the hydro-esterification of methyl formate and ethylene to methyl ***,the unsatisfied performance restricts the development of this *** this work,high-performance ruCl3 catalyst systems (ruCl3-[PPN]Cl-Et4NI and ruCl3-Nal) are firstly reported for this *** ruCl3-[PPN]Cl-Et4NI catalyst system,the conversion of methyl formate and the selectivity to methyl propionate are 93.9% and 90.9% at mild reaction conditions (165 ℃,2.5 MPa),***,a simple inorganic ruCl3-Nal catalyst system achieves 88.8% conversion of methyl formate and 97.6% selectivity to methyl propionate (86.7% yield) at same ***,as a promoter,may inhibit the decomposition of methyl formate and be conducive to the formation of methyl *** effects of solvents and promoters are investigated in *** addition,the reaction mechanism has been also *** is hoped to lay a certain foundation for further industrial application.

关键词： ruCl3 Catalyst Systems Hydro-Esterification Methyl Formate Ethylene

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Coated sodium butyrate ameliorates high‑energy and low‑protein diet induced hepatic dysfunction via modulating mitochondrial dynamics, autophagy and apoptosis in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1190-1206页

作者： Sasa Miao Tianming Mu ru li yan li Wenyan Zhao Jiankui li Xinyang Dong Xiaoting Zou Key Laboratory of Animal Feed and Nutrition of Zhejiang Province Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)Ministry of Agriculture and Rural AffairsThe Key Laboratory of Molecular Animal NutritionMinistry of EducationCollege of Animal SciencesZhejiang UniversityHangzhou 310058China.

Background Fatty liver hemorrhagic syndrome(FLHS),a fatty liver disease in laying hens,poses a grave threat to the layer industry,stemming from its ability to trigger an alarming plummet in egg production and usher in acute mortality among laying *** evidence suggests that the onset and progression of fatty liver was closely related to mitochondria *** butyrate was demonstrated to modulate hepatic lipid metabolism,alle-viate oxidative stress and improve mitochondrial dysfunction in vitro and mice ***,there is limited existing research on coated sodium butyrate(CSB)to prevent FLHS in laying hens,and whether and how CSB exerts the anti-FLHS effect still needs to be *** this experiment,the FLHS model was induced by administering a high-energy low-protein(HELP)diet in laying *** objective was to investigate the effects of CSB on alleviating FLHS with a focus on the role of CSB in modulating mitochondrial *** A total of 288 healthy 28-week-old Huafeng laying hens were arbitrarily allocated into 4 groups with 6 replicates each,namely,the CON group(normal diet),HELP group(HELP diet),CH500 group(500 mg/kg CSB added to HELP diet)and CH750 group(750 mg/kg CSB added to HELP diet).The duration of the trial encompassed a period of 10 *** The result revealed that CSB ameliorated the HELP-induced FLHS by improving hepatic steatosis and patho-logical damage,reducing the gene levels of fatty acid synthesis,and promoting the mRNA levels of key enzymes of fatty acid *** reduced oxidative stress induced by the HELP diet,upregulated the activity of GSH-Px and SOD,and decreased the content of MDA and *** also mitigated the HELP diet-induced inflammatory response by blocking TNF-α,IL-1β,and F4/*** addition,dietary CSB supplementation attenuated HELP-induced activation of the mitochondrial unfolded protein response(UPRmt),mitochondrial damage,and decline of ATPase *** diet decreased th

关键词： Autophagy Coated sodium butyrate Laying hens lipid metabolism Mitochondria

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Evaluating new biomarkers for diabetic nephropathy:Role ofα2-macroglobulin,podocalyxin,α-L-fucosidase,retinol-binding protein-4,and cystatin C

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World Journal of Diabetes 2024年第6期15卷 1212-1225页

作者： Jing-Jing li ru-La Sa Yu Zhang Zhao-li yan Department of Infectious Diseases Inner Mongolia Medical UniversityHohhot First HospitalHohhot 010000Inner Mongolia Autonomous RegionChina Department of Endocrinology The Affiliated Hospital of Inner Mongolia Medical UniversityHohhot 010000Inner Mongolia Autonomous RegionChina Department of Dermatology Inner Mongolia Autonomous Region People’s HospitalHohhot 010000Inner Mongolia Autonomous RegionChina

BACKGROUND The intricate relationship between type 2 diabetes mellitus(T2DM)and diabetic nephropathy(DN)presents a challenge in understanding the significance of various biomarkers in *** To elucidate the roles and diagnostic values ofα2-macroglobulin(α2-MG),podocalyxin(PCX),α-L-fucosidase(AFU),retinol-binding protein-4(RBP-4),and cystatin C(CysC)in *** From December 2018 to December 2020,203 T2DM patients were enrolled in the *** these,115 were diagnosed with DN(115 patients),while the remaining 88 patients were classified as *** urinary levels ofα2-MG,PCX,and AFU and the serum concentrations RBP-4 and CysC were measured in conjunction with other relevant clinical indicators to evaluate their potential correlations and diagnostic *** After adjustments for age and gender,significant positive correlations were observed between the biomarkers CysC,RBP-4,α2-MG/urinary creatinine(UCr),PCX/UCr,and AFU/UCr,and clinical indicators such as urinary albumin-to-creatinine ratio(UACR),serum creatinine,urea,24-h total urine protein,and neutrophil-to-lymphocyte ratio(NLR).Conversely,these biomarkers exhibited negative correlations with the estimated glomerular filtration rate(P<0.05).Receiver operating characteristic(ROC)curve analysis further demonstrated the diagnostic performance of these biomarkers,with UACR showcasing the highest area under the ROC curve(AUC^(ROC))at *** This study underscores the diagnostic significance ofα2-MG,PCX,and AFU in the development of *** biomarkers RBP-4,CysC,PCX,AFU,andα2-MG provide promising diagnostic insights,while UACR is the most potent diagnostic biomarker in assessing DN.

关键词： α2-macroglobulin Podocalysin α-L-fucosidase Retinol binding protein-4 Cystatin C Diabetic nephropathy

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Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao ru Wu yan‑yan Gao yang Zhou Jun‑Jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

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Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

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Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： Qidi Zhao Tian Wei ru Ma Yubin Fu rui yang yandong Su yang Yu Bing li yan li School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Surgical Oncology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Peritoneal Cancer Surgery Bejing Shijitan HospitalCapital Medical UniversityBejing 100038China

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation

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NODULATION TRIO in Medicago truncatula:Unveiling the redundant roles of MtLYK2,MtLYK3,and MtLYK2bis

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Journal of Integrative Plant Biology 2024年第8期66卷 1553-1556页

作者： Yaohua li yanwen Zhao Ziang yan ru Dong Haixiang Yu Hui Zhu yangrong Cao National Key Lab of Agricultural Microbiology Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China

The legume–rhizobial symbiosis is a distinctive model in plant–microbe *** being foreign invaders,rhizobia are acknowledged as“friends”by compatible host plants,leading to mutualistic endosymbiosis(Cao et al.,2017).

关键词： mutual spite redundant

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Mitophagy in neurodegenerative disease pathogenesis

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Neural Regeneration Research 2024年第5期19卷 998-1005页

作者： Kan yang Yuqing yan Anni Yu ru Zhang Yuefang Zhang Zilong Qiu Zhengyi li Qianlong Zhang Shihao Wu Fei li Department of Developmental and Behavioural Pediatric&Child Primary Care Brain and Behavioural Research Unit of Shanghai Institute for Pediatric Research and MOE-Shanghai Key Laboratory for Children’s Environmental HealthXinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology Institute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghaiChina College of Materials and Chemical Engineering Hunan Institute of EngineeringXiangtanHunan ProvinceChina School of Medicine Yunnan UniversityKunmingYunnan ProvinceChina Songjiang Research Institute Shanghai Jiao Tong University School of MedicineShanghaiChina Neurosurgery Department Kunming Yenan HospitalKunmingYunnan ProvinceChina

Mitochondria are critical cellular energy resources and are central to the life of the *** selectively clears damaged or dysfunctional mitochondria through autophagic machinery to maintain mitochondrial quality control and *** neurons are postmitotic and consume substantial energy,thus require highly efficient mitophagy pathways to turn over damaged or dysfunctional *** evidence indicates that mitophagy is pivotal to the pathogenesis of neurological ***,more work is needed to study mitophagy pathway components as potential therapeutic *** this review,we briefly discuss the characteristics of nonselective autophagy and selective autophagy,including ERphagy,aggrephagy,and *** then introduce the mechanisms of Parkin-dependent and Parkin-independent mitophagy pathways under physiological ***,we summarize the diverse repertoire of mitochondrial membrane receptors and phospholipids that mediate ***,we review the critical role of mitophagy in the pathogenesis of neurodegenerative diseases including Alzheimer’s disease,Parkinson’s disease,and amyotrophic lateral ***,we discuss recent studies considering mitophagy as a potential therapeutic target for treating neurodegenerative ***,our review may provide novel views to better understand the roles of mitophagy in neurodegenerative disease pathogenesis.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis autophagy mitochondria mitophagy mitophagy receptor Parkin Parkinson’s disease PINK1

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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu yan Jing-ru Ma Dong-Fu li Jun-ling yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease *** review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and *** delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive *** factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are ***,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease *** reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is *** strategies,including anti-viral and immunomodulatory approaches,are critically *** role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent *** conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV *** a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge *** more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient *** dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory *** role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

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