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The relationship between serum miR-21 levels and left atrium dilation in elderly patients with essential hypertension

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Journal of Geriatric Cardiology 2022年第11期19卷 833-842页

作者： yan wang Guang-Ping FU qiu-yan wang Ting-Ting ZHANG Li-Li HE Qing-Juan ZUO Chang-Lei ZHANG Yi-Fang GUO Department of Geriatric Cardiology Hebei General HospitalShijiazhuangHebeiChina Hebei Key Laboratory of Forensic Medicine Department of Forensic MedicalHebei Medical UniversityShijiazhuangHebeiChina Hebei Medical University ShijiazhuangHebeiChina

BACKGROUND MicroRNA-21(miR-21)is related to hypertension and cardiac *** atrium(LA)dilation is highly sensitive to small haemodynamic changes in the left ventricle(LV)that are induced by *** study aimed to elucidate the relationship between miR-21 expression and LA dilation in elderly patients with essential hypertension(EH).METHODS In this cross-sectional study,one hundred elderly patients with EH were recruited for the *** to their left atrium diameters(LADs),the patients were divided into the LA dilation group[42 patients(42%)]and the no-LA dilation group[58 patients(58%)].The serum levels of miR-21 and chemical biomarkers used in the clinic,such as creatinine,blood urea nitrogen,uric acid,fasting blood glucose,total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDLC),low-density lipoprotein cholesterol(LDL-C),very-low-density lipoprotein cholesterol,Lp(a),apolipoprotein A1(apoA1),and apolipoprotein B,were *** the patients underwent echocardiographic examination,and the LAD,interventricular septum(IVS),right atrium diameter(RAD),right ventricle diameter(RVD),left ventricular end-systolic diameter(LVESD),left ventricular end-systolic diameter(LVEDD)and left ventricular ejection fraction(LVEF)were *** The levels of miR-21[8.02(5.21,14.39)vs.6.05(3.81,8.95),P=0.011]and LVEF(67.02±3.82 vs.64.14±4.43,P=0.001)were higher in the LA dilation *** levels of creatinine[70.40(64.45,80.15)vs.63.9(60.1,73.43)],P=0.020]were higher in the no-LA dilation *** levels of HDLC(r=-0.209,P=0.037),apoA1(r=-0.269,P=0.007)and RAD(r=0.203,P=0.043)were significantly correlated with miR-21 *** LAD was significantly correlated with the RAD(r=0.287,P=0.004),RVD(r=0.450,P<0.001),LVEDD(r=0.248,P=0.013)and LVEF(r=0.232,P=0.020).Multivariate logistic regression revealed that miR-21 significantly influenced LA dilation in elderly patients with EH(P<0.05).CONCLUSIONS Circulating serum levels o

关键词： patients hypertension atrium

Wavelength-dependent Photodissociation Dynamics of Benzaldehyde

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Chinese Journal of Chemical Physics 2009年第6期22卷 587-591,J0001页

作者： Ben-kang Liu Bing-xing wang yan-qiu wang Li wang State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Dalian115023 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

The ultrafast dynamics of benzaldehyde upon 260, 271, 284, and 287 nm excitations have been studied by femtosecond pinup-probe time-of-flight mass spectrometry. A bi-exponential decay component model was applied to fit the transient profiles of benzaldehyde ions and fragment ions. At the S2 origin, the first decay of the component was attributed to the internal conversion to the high vibrational levels of S1 state. Lifetimes of the first component decreased with increasing vibrational energy, due to the influence of high density of the vibrational levels. The second decay was assigned to the vibrational relaxation of the S1 whose lifetime was about 600 fs. Upon 287 nm excitation, the first decay became ultra-short （-56 fs） which was taken for the intersystem cross from S1 to T2, while the second decay component was attributed to the vibrational relaxation. The pump-probe transient of fragment was also studied with the different probe intensity at 284 nm pump.

关键词： Benzaldehyde Ultrafast process Femtosecond pump-probe

Silk damping in scalar-induced gravitational waves: a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng Yu Sai wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

An Artificial Intelligence‑Assisted Flexible and Wearable Mechanoluminescent Strain Sensor System

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Nano-Micro Letters 2025年第3期17卷 217-231页

作者： yan Dong Wenzheng An Zihu wang Dongzhi Zhang College of Control Science and Engineering China University of Petroleum(East China)Qingdao 266580People’s Republic of China

The complex wiring,bulky data collection devices,and difficulty in fast and on-site data interpretation significantly limit the practical application of flexible strain sensors as wearable *** tackle these challenges,this work develops an artificial intelligenceassisted,wireless,flexible,and wearable mechanoluminescent strain sensor system(AIFWMLS)by integration of deep learning neural network-based color data processing system(CDPS)with a sandwich-structured flexible mechanoluminescent sensor(SFLC)*** SFLC film shows remarkable and robust mechanoluminescent performance with a simple structure for easy *** CDPS system can rapidly and accurately extract and interpret the color of the SFLC film to strain values with auto-correction of errors caused by the varying color temperature,which significantly improves the accuracy of the predicted strain.A smart glove mechanoluminescent sensor system demonstrates the great potential of the AIFWMLS system in human gesture ***,the versatile SFLC film can also serve as a encryption *** integration of deep learning neural network-based artificial intelligence and SFLC film provides a promising strategy to break the“color to strain value”bottleneck that hinders the practical application of flexible colorimetric strain sensors,which could promote the development of wearable and flexible strain sensors from laboratory research to consumer markets.

关键词： Mechanoluminescent Strain sensor Flexible Deep learning Wireless

Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs

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World Journal of Gastroenterology 1998年第5期4卷 58-62页

作者： XIAO Bing, SHI Yong Quan, ZHAO yan qiu, YOU Han, wang Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming

AIM To compare the expression level of Fas gene and Bcl-2 gene in gastric cancer cells SGC7901 and gastric cancer MDR (multidrug resistant) cells SGC7901/VCR, to transduce Fas cDNA and Bcl-2 antisense nucleic acid into SGC7901/VCR cells respectively, and to observe the expression of two genes in transfectants and non-transfectants as well as their drug *** Eukaryotic expression vector pBK-Fas cDNA and pDOR-anti Bcl-2 were constructed and transfected into SGC7901/VCR cells by lipofectamine, respectively. Northern blot and Western blot were used to detect the expression of mRNA and protein in SGC7901/VCR and SGC7901 cells and transfectants, and drug sensitivity of transfectants for VCR, CDDP and 5-FU was analyzed with MTT *** After gene transfection, 80 for Fas and 120 for antisense Bcl-2 drug-resistant clones were selected from 2×105 cells, transfection rate being 0.04% and 0.06%. Two clones of SGC7901 Fas/VCR cells and SGC7901 anti Bcl-2/VCR cells were randomly selected for further incubation. Hybridization results showed that the expression level of Fas mRNA and protein in SGC7901/VCR cells was much lower, but that of Bcl-2 mRNA and protein was higher than that in SGC7901 cells. The expression of Fas mRNA and protein in SGC7901 Fas/VCR cells was higher, and of Bcl-2 mRNA and protein was lower in SGC7901 anti Bcl-2/VCR cells than that in non-transfectants. MTT assay showed that transfectants were more sensitive to VCR, CDDP, 5-FU than *** Bcl-2 gene displayed high expression while Fas gene had low expression in drug resistant gastric cancer cells. Expression of Bcl-2 protein was effectively blocked in SGC7901 anti Bcl-2/VCR cells by gene transfection. In contrast, the expression of Fas mRNA and protein in SGC7901 Fas/VCR cells increased. Fas gene and Bcl-2 antisense nucleic acid transfection sensitized drug resistant gastric cancer cells to chemotherapeutic drugs. These results suggest cell apoptosis plays an import

关键词： stomach neoplasms Fas gene Bcl 2 gene antisense nucleic acid drug resistance, multiple gene transduction apoptosis

Nanograting‑Based Dynamic Structural Colors Using Heterogeneous Materials

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Nano-Micro Letters 2025年第3期17卷 138-151页

作者： Jingang wang Haibo Yu Jianchen Zheng Yuzhao Zhang Hongji Guo Ye qiu Xiaoduo wang Yongliang yang Lianqing Liu State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China

Dynamic structuralcolors can change in response todifferent environmental *** ability remains effectiveeven when the size of the speciesresponsible for the structural coloris reduced to a few micrometers,providing a promising sensingmechanism for solving microenvironmentalsensing problems inmicro-robotics and ***, the lack of dynamicstructural colors that can encoderapidly, easily integrate, and accuratelyreflect changes in physical quantities hinders their use in microscale sensing applications. Herein, we present a 2.5-dimensionaldynamic structural color based on nanogratings of heterogeneous materials, which were obtained by interweaving a pH-responsive hydrogelwith an IP-L photoresist. Transverse gratings printed with pH-responsive hydrogels elongated the period of longitudinal grating in the swollenstate, resulting in pH-tuned structural colors at a 45° incidence. Moreover, the patterned encoding and array printing of dynamic structuralcolors were achieved using grayscale stripe images to accurately encode the periods and heights of the nanogrid structures. Overall, dynamicstructural color networks exhibit promising potential for applications in information encryption and in situ sensing for microfluidic chips.

关键词： Dynamic structural colors Four-dimensional printing pH-responsive Nanogrid Heterogeneous materials

Number rigid determinantal point processes induced by generalized Cantor sets

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Acta Mathematica Sinica,English Series 2025年

作者： Zhaofeng LIN yanqi qiu Kai wang School of Fundamental Physics and Mathematical Sciences HIAS University of Chinese Academy of Sciences School of Mathematical Sciences Fudan University

We consider the Ghosh-Peres number rigidity of translation-invariant determinantal point processes on the real line R, whose correlation kernels are induced by the Fourier transform of the indicators of generalized Cantor sets in the unit interval. Our main results show that for any givenθ∈(0, 1), there exists a generalized Cantor set with Lebesgue measure θ, such that the corresponding determinantal point process is Ghosh-Peres number rigid.

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Improved physicochemical and functional properties of dietary fiber from Rosa roxburghii pomace fermented by Bacillus natto

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Food Bioscience 2022年第6期50卷 902-910页

作者： yan-qiu wang Jian-Dong wang Zi-Hui Cai Han Huang Su Zhang Li-Na Fu Peng-Quan Zhao Xin-Yu yan Yu-Jie Fu The College of Forestry Beijing Forestry University100083BeijingPR China College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry University150040HarbinPR China

Rosa roxburghii juice is of increasing importance in recent years and has become a favorite fruit juice in the market due to its extremely high Vc ***,a large amount of pomace from juice process is usually treated as ***,the pomace still contains a lot of nutrients and has great reuse *** this study,the Rosa roxburghii pomace was fermented with Bacillus natto to develop a new healthy food ingredient rich in high quality dietary fiber(soluble dietary fiber,SDF).Under the optimal fermentation process conditions(inoculum concentration 4%,temperature 38.7°C,time 12 h,and pH 4.97),SDF content of *** pomace increased from 7.68%to 10.68%.SEM and FTIR analysis revealed that the fermentation can lead to degradation of cellulose and hemicellulose,resulting in the formation of more porous lax structure,the related functions such as water holding,oil holding,substance adsorption and cation exchange capacity were obviously *** addition,19 phytochemicals from *** pomace were quantified by UPLC-QqQ-MS/MS,which demonstrated the fruit pomace also could be used as a functional ingredient in food field.

关键词： Rosa roxburghii pomace Bacillus natto Fermentation Soluble dietary fiber Functional properties

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格栅颗粒复合堆积床内流动传热的实验研究

工程热物理学报 2017年第10期38卷 2225-2228页

作者：王晶钰杨剑胡映学刘衍王秋旺西安交通大学热流科学与工程教育部重点实验室西安710049

颗粒有序堆积床相比于颗粒无序堆积床具有压降较小的优点,但在实际操作中,有序堆积床的实现具有一定的难度,本文设计了一种可快速实现有序堆积的新结构,即带有格栅的复合颗粒堆积结构。采用萘升华热质比拟方法对格栅颗粒复合堆积结构中... 详细信息

颗粒有序堆积床相比于颗粒无序堆积床具有压降较小的优点,但在实际操作中,有序堆积床的实现具有一定的难度,本文设计了一种可快速实现有序堆积的新结构,即带有格栅的复合颗粒堆积结构。采用萘升华热质比拟方法对格栅颗粒复合堆积结构中的颗粒-流体对流传热系数进行了研究。结果表明,格栅复合堆积结构相比于简单立方堆积结构,压降略高,但传热系数也有大幅度提高;而相比于无序结构,在传热系数下降不多的情况下,压降大大减低。格栅颗粒复合堆积结构的综合传热系数最高,可为堆积床的设计提供一种新的思路。

关键词：格栅颗粒复合堆积颗粒有序堆积床热质比拟萘升华对流传热