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Fuzheng Huayu Formula(扶正化瘀方) Prevents Rat Renal Interstitial Fibrosis Induced by HgCl2 via Antioxidative Stress and Down-regulation of Nuclear Factor-Kappa B Activity

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Chinese Journal of Integrative Medicine 2017年第8期23卷 598-604页

作者： YUAN Ji-li TAO yan-yan WANG qing-lan SHEN Li LIU Cheng-hai Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shangha 201203 China Shanghai Key Laboratory of Traditiona Chinese Clinical Medicine Shanghai 201203 China E-Institute of TCM Internal Medicine Shanghai Municipa Education Commission Shanghai 201203 China

Objective：To investigate the mechanism of action of Fuzheng Huayu Formula（扶正化瘀方,FZHY）against renal interstitial fibrosis（RIF）relating to oxidative injury and nuclear factor-kappa B（NF-κB）***：Thirty-two Sprague-Dawley rats were randomly divided into 3 groups：normal group,model group and FZHY treatment *** RIF model was induced by oral administration of HgC l2 at a dose of 8 mg/kg body weight once a day for 9 ***,rats in FZHY treatment group orally took FZHY at a dose of4.0 g/kg rat weight for 9 *** content of hydroxyproline（Hyp）and collagen deposition in kidney were *** activities of superoxide dismutase（SOD）and glutathione peroxidase（GSH-Px）,the content of glutathione（GSH）and malondialdehyde（MDA）of kidney were *** expressions of inhibitor-κappa B（IκB）,phospho-IκB（p-IκB）,tumor necrosis factor-α（TNF-α）,matrix metalloproteinase-2（MMP-2）andα-smooth muscle actin（α-SMA）were analyzed by Western blot.α-SMA expression was also observed by immunofluorescent ***-2 activity was measured by gelatin ***-κB activation was determined by electrophoretic mobility shift ***：Renal interstitial fibrosis was induced by Hg Cl2,demonstrated by remarkably increased Hyp contents and excessive collagen deposition in kidney（P〈0.01）.FZHY significantly inhibited renal interstitial collagen deposition and reduced Hyp content of the Hg Cl2-treated rats（P〈0.01）.GSH content decreased obviously,and MDA content increased significantly in HgC l2-treated rats compared with that of normal rats（P〈0.01）.FZHY significantly increased GSH content and decreased MDA content in the model rats（P〈0.01）.The expressionα-SMA was increased in model rats compared with that of normal rats,FZHY significantly decreased its expression（P〈0.01）.The expressions of p-IκB and TNF-αand MMP-2,MMP-2 activity,and NF-κB activation were increased in model group compared with that in normal group（P〈0.01）,FZHY significantly decreased NF-κB activation,MMP-

关键词： Fuzheng Huayu Formula renal interstitial fibrosis mercuric chloride oxidative stress nuclearfactor-kappa B matrix metalloproteinase-2 tumor necrosis factor- α Chinese medicine

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不同混合回收模式和权力结构的逆向供应链决策分析

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中国管理科学 2020年第10期28卷 131-143页

作者：公彦德蒋雨薇达庆利南京审计大学商学院江苏南京211815 东南大学经济管理学院江苏南京210096

在制造商主导和销售商主导两种权力结构下,构建了制造商与销售商两者混合回收及制造商、销售商和第三方三者混合回收的四类逆向供应链模型,运用博弈理论求解,对四类逆向供应链进行比较发现:(1)回收竞争程度较高时,制造商的最优策略为制... 详细信息

在制造商主导和销售商主导两种权力结构下,构建了制造商与销售商两者混合回收及制造商、销售商和第三方三者混合回收的四类逆向供应链模型,运用博弈理论求解,对四类逆向供应链进行比较发现:(1)回收竞争程度较高时,制造商的最优策略为制造商主导且两者混合回收;回收竞争程度较低时,制造商的最优策略为制造商主导且三者混合回收。(2)销售商的最优决策始终为参与制造商主导且制造商和销售商混合回收的逆向供应链,最差决策始终为销售商主导且三者混合回收的逆向供应链。(3)逆向供应链系统的最优决策为制造商主导两者混合回收或三者混合回收。(4)针对最佳权力结构和混合回收方式,制造商和逆向供应链系统的最优决策基本一致,均为制造商主导的逆向供应链;制造商、销售商和逆向供应链系统的最差策略均为销售商主导的逆向供应链。

关键词：逆向供应链混合回收模式权力结构博弈论

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Distribution and release of 2,4,5-trichlorobiphenyl in ice

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Water Science and Engineering 2015年第2期8卷 132-138页

作者： Guo-xia Pei yan-hong Han Geng-yun Liu Qi Zhang Wei-juan Cao Qi Guo Zhen Han Le Wei Han-qing Li College of Water Conservancy and Civil Engineering Inner Mongolia Agricultural University

The distribution of persistent organic pollutants（POPs） in ice and the release of POPs from ice during ice melting have an important influence on the eco-environment and water quality of a river. Through laboratory simulation experiments, the distribution and release of 2,4,5-trichlorobiphenyl（PCB29） in ice and the partition coefficients of PCB29 in ice water at different temperatures, concentrations, and p H levels were studied. The results showed that, at different temperatures and concentrations, the concentration of PCB29 in ice increased progressively with depth. The modes of release of different concentrations of PCB29 from ice were obtained. A large amount of PCB29 was released rapidly in the first melting period, and then the remaining PCB29 was released uniformly. The p H value dominated both the distribution and late release of PCB29 in ice. In ice water, at different temperatures, concentrations, and p H levels, the majority of PCB29 entered the water, and a lesser amount remained in the ice. Finally, laboratory experiment results were verified with field investigations. A theoretical framework is provided by this research of the behavior of POPs in ice under different environmental conditions, but a more quantitative understanding of the behavior of POPs in ice will need to be developed through further laboratory studies combined with field investigations.

关键词： Persistent organic pollutants 2 4 5-trichlorobiphenyl Ice Distribution Release Partition coefficient

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Antenatal Diagnosis and Outcome of 12 Congenital Cystic Adenomatoid Malformation of Lung

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Journal of Reproduction and Contraception 2007年第4期18卷 289-295页

作者： Xue-lian LI Yu-qing ZHOU Jue-hua ZHANG Ying-liu yan Xiao-tian LI Obstetrics Department the Obstetrics ＆ Gynecology Hospital of FudanUniversity Shanghai 200011 China Ultrasonography Department the Obstetrics ＆ Gynecology Hospital of FudanUniversity Shanghai 200011 China

Objective To investigate the ultrasonic detection probability, type, prenatal diagnosis, and outcome of congenital cystic adenomatoid malformation of lung （CCAM）. Methods In this retrospective study, all 12 cases which were diagnosed with suspected prenatal CC,4M over the period in the hospital were analyzed. Information on diagnosis time, types and progression of the lesions during pregnancy, the additional abnormalities, and the outcome of pregnancies were recorded.Results The positive rate of ultrasonic detection of CCAM was about 1.01‰ （1/11 124） before 28 gestation weeks. There were 1 case of type Ⅰ （8%）, 2 cases of type Ⅱ （17%） and 9 cases of type Ⅲ （75%）. Nine pregnancies were terminated and 2 cases were confirmed by pathology. Three neonates were alive and without any symptom now. Conclusions Type Ⅲ is the major type. Ultrasound examination during 20-28 weeks and following up, prenatal consultation, chromosome examination offetus, delivery with a pediatrician standing by, and all suspected neonates being investigated are recommended.

关键词： congenital cystic adenomatoid malformation of lung ultrasonic detection type prenatal diagnosis outcome

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MAPKs signaling in 5-LOX pathway-associated inflammatory responses

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中国药理学与毒理学杂志 2019年第10期 912-913页

作者： yan Meng-die JIA Xiao-xia LI Cheng-tan QIU Ya-qing WANG yan-fang ZHANG Li-hui Department of Pharmacology Hangzhou Key Laboratory of Medical Neurobiology School of Medicine Hangzhou Normal University

5-Lipoxygenase(5-LOX) is a crucial enzyme catalyzing arachidonic acid to form cysteinyl leukotrienes(Cys LTs, including LTC4, LTD4, LTE4). Cys LTs are potent inflammatory mediators that mediate many pathophysiological responses by activating two distinct G-protein-coupled receptors(CysLT1R and CysLT2R). 5-LOX pathway is implicated in inflammatory pathological processes. Mitogenactivated protein kinases(MAPKs) are important signal transduction pathways of complex cellular *** MAPK families in mammalian cells include the P38 MAPK, extracellular signal-regulated kinases(ERK)and c-Jun amino N-terminal kinase(JNK). Increasing evidence has suggested that MAPKs signaling acts as key modulator in 5-LOX pathway-related pathological processes. It was reported that P38 MAPK and 5-LOX were dramatically activated to mediate neuronal injury in oxygen-glucose deprivation(OGD)-treated PC12 cells,which could be inhibited by P38 MAPK inhibitor SB203580 and nonselective 5-LOX inhibitor caffeic acid. In primary cultured rat astrocytes, OGD induced increased expression of CysLT2R and aquaporin 4, and ischemic astrocyte injury. Also, OGD increased phosphorylation of ERK and P38 MAPK. These astrocyte responses were attenuated by P38 MAPK inhibitor SB203580, ERK inhibitor U0126, CysLT2R antagonist Bay Cys LT2 and non-selective Cys LTR antagonist Bay u9773, but not by JNK inhibitor SP600125 and CysLT1R antagonist montelukast. These data demonstrate the roles of ERK and P38 MAPK signaling pathways in 5-LOX and CysLT2R-mediated ischemic-like injury in neuron-like PC12 cel s and rat astrocytes. Furthermore, CysLT1R and ERK signaling were found to be involved in regulation of LTD4-stimulated expression of glial fibrillary acidic protein and cell proliferation in astrocytes. ERK inhibitor PD98059 and CysLT1R antagonist montelukast, MK-571 abolished Cys LTs-induced astrocyte proliferation. Vascular endothelial cells play a pivotal role in maintaining brain homeostasis. Endothelial

关键词： mitogen-activated protein kinases cysteinylleukotrienes 5-lipoxygenase inflammation

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Bio-inspired synthesis of transition-metal oxide hybrid ultrathin nanosheets for enhancing the cycling stability in lithium-ion batteries

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Nano Research 2022年第6期15卷 5064-5071页

作者： yan-Ru Wang qing-Feng Zhuang Yi Li Ya-Lin Hu yang-Yi Liu Qiao-Bao Zhang Lei Shi Chuan-Xin He Xiao Zheng Shu-Hong Yu Department of Chemistry Institute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Laboratory for Physical Sciences at the MicroscaleInstitute of EnergyHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefei 230026China Division of Theoretical and Computational Sciences Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of Chemical PhysicsUniversity of Science and Technology of ChinaHefei 230026China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhenGuangdong 518060China Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamenFujian 361005China

Constructing two-dimensional(2D)structures for transition-metal oxides(TMOs)can optimize their electronic structures and enable high specific surface areas,thereby offering routes to enhancing the performance of TMOs in energy storage and ***,most 2D TMOs,e.g.,Fe_(2)O^(3),remain so far synthetically challenging due to their intrinsic non-layered ***,inspired by the mechanism of biomineralization,we report the synthesis of CuO/Fe_(2)O^(3)hybrid ultrathin nanosheets by using polyvinylpyrrolidone-decorated CuO nanosheets as growth modifiers to modulate the hydrolysis process of Fe^(2+).The formulated“absorption-and-crystallization”two-step formation processes of such 2D hybrid structures accorded well with the biomineralization scheme in *** the in-situ transmission electron microscopy(TEM)study,theoretical calculation,and control experiments,we validated that the large density of 2D/2D interfaces enabled by this bio-inspired synthesis process can overcome the self-stacking phenomenon during lithium-ion battery cycling,leading to their high operation *** work emphasizes the bio-inspired synthesis of 2D TMOs as a promising pathway toward material design and performance optimization.

关键词： bio-inspired synthesis two-dimensional transition-metal oxides hybrid nanosheets interfaces lithium-ion batteries

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Ethylene and Spermidine in Wheat Grains in Relation to Starch Content and Granule Size Distribution Under Water Deficit

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Journal of Integrative Agriculture 2014年第10期13卷 2141-2153页

作者： yanG Wei-bing LI Yong YIN yan-ping JIANG Wen-wen PENG Dian-liang CUI Zheng-yong yanG Dong-qing WANG Zhen-lin National Key Laboratory of Crop Biology Ministry of Science and Technology/Agronomy CollegeShandong Agricultural University

Two wheat cultivars （Triticum aestivum L.） were used to evaluate the effects ofpost-anthesis severe water deficit （SD） on starch content and granule size distribution and their relations with ethylene and spermidine （Spd）. Comparison to the well-watered （WW） treatment, SD led to lower Spd and higher 1-aminocylopropane-l-carboxylic acid （ACC） concentrations and ethylene evolution rate （EER） in grains at the critical stage of forming starch granules. Application of Spd or aminoethoxyvinylglycine （AVG） significantly reduced ACC concentration and EER and increased Spd concentration, while ethephon or methylglyoxal-bis （MGBG） had an opposite impact. The volume and surface area distribution of starch granules showed a bimodal curve, while the number distribution exhibited a unimodal curve. SD caused a marked drop in grain weight, grain number and starch content, also led to a significant reduction in the proportion （both by volume and by surface area） of B-type starch granules （〈10 Ixm）, with an increase in those of A-type starch granules （〉10 ~tm）. Application of Spd or AVG increased the proportion （both by volume and by surface area） of B-type starch granules under SD. Correlation analysis suggested that ethylene and Spd showed an antagonism relation in the formation of B-type granules. These results suggested that it would be good for the formation of B-type starch granules to have the physiological traits of higher Spd and lower ACC concentrations and ethylene emission under SD.

关键词： ethylene evolution rate 1-aminocylopropane-1-carboxylic acid spermidine severe water deficit wheat (Triticumaestivum L.)

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Exosomes Derived from Hydroquinone-transformed Human Bronchial Epithelial Cells Inhibited Recipient Cell Apoptosis by transferring miR-221

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Biomedical and Environmental Sciences 2021年第7期34卷 520-527页

作者： XIAN Hong Yi CHEN Ying ZHANG Jia Ying TANG Mei Lin LIAN Zhen Wei JIANG Ran HU Zu qing LI yan Feng HU Da Lin Department of Environmental Health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Grade 2017 Undergraduate Student Majoring in Preventive Medicine School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Grade 2018 Undergraduate Student Majoring in Clinical Medicine Department of Clinical MedicineJiamusi UniversityJiamusi 154007HeilongjiangChina

Objective Although benzene is a confirmed environmental carcinogen,the mechanism of its carcinogenicity remains largely *** suggested oncogene,miR-221,is elevated and plays important roles in various tumors,but its role in benzene-induced carcinogenesis remains *** In the present study,we constructed hydroquinone(HQ,a representative metabolite of benzene with biological activity)-transformed malignant cell line(16 HBE-t)and analyzed the level of miR-221 in it with *** from 16 HBE-t cells incubated with or without an miR-221 inhibitor were isolated by ultracentrifugation,characterized by transmission electron microscopy and laser scanning confocal microscope,and then transfected into 16 HBE *** effects of exosomal miR-221 on apoptosis induced by HQ in recipient cells were determined using flow *** The amount of miR-221 in 16 HBE-t was significantly increased compared with *** recipient cells ingested exosomes derived from 16 HBE-t,miR-221 was increased,and apoptosis induced by HQ was *** miR-221 in 16 HBE-t using an inhibitor did not significantly alter miR-221 or apoptosis in recipient *** Exosomal miR-221 secreted by 16 HBE-t inhibits apoptosis induced by HQ in normal recipient cells.

关键词： Benzene Toxic mechanism Apoptosis Exosomes miR-221 Intercellular communications

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Management and implementation strategies of pre-screening triage in children during coronavirus disease 2019 pandemic in Guangzhou, China

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World Journal of Clinical Cases 2021年第12期9卷 2731-2738页

作者： Xuan Shi Yu-Tao Cai Xian Cai Xiu-Lan Wen Jing-yan Wang Wen-Cheng Ma Jun Shen Jin-Xia Wu Hai-yan Liu Jing Sun Pei-Qin He yan Lin Dan-yang Zhao Pei-qing Li Department of Pediatric Emergency Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Outpatient Department of Pediatrics Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Emergency General Ward Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Nursing Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Disease Control and Prevention Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Emerging infectious diseases are a constant threat to the public’s health and health care systems around the *** disease 2019(COVID-2019),which was defined by the World Health Organization as pandemic,has rapidly emerged as a global health *** evolution and prevention of international implications require substantial flexibility of frontline health care facilities in their *** To explore the effect of the implementation and management strategy of prescreening triage in children during *** The standardized triage screening procedures included a standardized triage screening questionnaire,setup of pre-screening triage station,multi-point temperature monitoring,extensive screenings,and two-way *** order to ensure the implementation of the pre-screening triage,the prevention and control management strategies included training,emergency exercise,and staff *** analysis was performed on the data from all the children hospitalized from January 20,2020 to March 20,2020 at solstice during the pandemic *** were obtained from questionnaires and electronic medical record *** A total of 17561 children,including 2652 who met the criteria for screening,192 suspected cases,and two confirmed cases without omission,were screened from January 20,2020 to March 20,2020 at solstice during the pandemic *** was zero transmission of the infection to any medical *** The effective strategies for pre-screening triage have an essential role in the prevention and control of hospital infection.

关键词： COVID-19 Pre-screening triage Management Implementation Strategies Pandemic

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Controllable optofluidic assembly of biological cells using an all-dielectric one-dimensional photonic crystal

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Photonics Research 2022年第1期10卷 14-20页

作者： FENGYA LU LEI gong yan KUAI XI TANG YIFENG XIANG PEI WANG DOUGUO ZHANG Advanced Laser Technology Laboratory of Anhui Province Department of Optics and Optical EngineeringUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Fujian Provincial Key Laboratory of Photonics Technology College of Photonic and Electronic EngineeringFujian Normal UniversityFuzhou 350117China

Opto-thermophoretic manipulation is emerging as an effective way for versatile trapping,guiding,and assembly of biological nanoparticles and *** we report a new opto-thermophoretic tweezer based on an all-dielectric one-dimensional photonic crystal(1 DPC)for reversible assembly of biological cells with a controllable *** reveal its ability of long-range optofluidic manipulation,we demonstrate the reversible assembly of many yeast cells as well as *** cells that are dispersed in water *** 1 DPC-based tweezer can also exert short-range optical gradient forces associated with focused Bloch surface waves excited on the 1 DPC,which can optically trap single *** combining both the optical and thermophoretic manipulation,the optically trapped single polystyrene particle can work as a controllable origin of the reversible cellular *** simulations are performed to calculate the temperature distribution and convective flow velocity on the 1 DPC,which are consistent with the experimental observations and theoretically confirm the long-range manipulations on the alldielectric 1 DPC *** opto-thermophoretic tweezers based on all-dielectric 1 DPC endow the microma-nipulation toolbox for potential applications in biomedical sciences.

关键词： solution dielectric reversible

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