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Shape Discrimination Analysis of Rolled Strip Based on Strip Element Method

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Journal of Iron and Steel Research International 2004年第1期11卷 29-32页

作者： PENG yan CHU Yu-peng liu Hong-min yanshan University

Based on load-oriented manufacturing control theory, different combining modes and slab storage calculation method for continuous casting and hot rolling were discussed. The buffer capacity index of continuous casting-rolling was introduced, and the reasonable slab storage under different combining modes was calculated with buffer capacity index of 120.00 h for CCR, 79.20 h for HCR, 19.68 h for DHCR and 3.84 h for DR. Thin slab is 1.20 h, and the strip is zero. Theory gist was provided for steel enterprise to decrease storage.

关键词： continuous casting hot rolling production control slab storage

间充质干细胞治疗再生障碍性贫血:抑制或激活其病理演变过程中的相关靶点

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中国组织工程研究 2025年第31期29卷 6800-6810页

作者：张溥链刘宝茹杨敏遵义医科大学附属医院血液内科贵州省遵义市563000

背景:目前再生障碍性贫血的主要治疗方法是进行造血干细胞移植和免疫抑制治疗。然而,治疗后的并发症和不良反应严重影响了再生障碍性贫血患者的预后和生活质量。间充质干细胞有着独特的低免疫原性,可抑制T淋巴细胞、B淋巴细胞、树突细... 详细信息

背景:目前再生障碍性贫血的主要治疗方法是进行造血干细胞移植和免疫抑制治疗。然而,治疗后的并发症和不良反应严重影响了再生障碍性贫血患者的预后和生活质量。间充质干细胞有着独特的低免疫原性,可抑制T淋巴细胞、B淋巴细胞、树突细胞、自然杀伤细胞的增殖与活化,调节机体免疫,为再生障碍性贫血和移植物抗宿主病带来了良好的细胞治疗前景。目的:综述近几年间充质干细胞在再生障碍性贫血中的应用进展,以及间充质干细胞与再生障碍性贫血发病机制之间的相关性,为再生障碍性贫血患者提供新的治疗理论基础和更有效的治疗方案。方法:检索2003年1月至2024年2月中国知网和PubMed数据库,中文检索词为“再生障碍性贫血,间充质干细胞,造血干细胞,造血,造血微环境,造血干细胞移植,生物学,免疫,移植物抗宿主病”;英文检索词为“aplastic anemia,mesenchymal stem cell,hematopoietic stem cell,hematopoiesis,hematopoietic microenvironment,hematopoietic stem cell transplantation,biology,immuno-modulatory,immune regulation,graft-versus-host disease,chronic graft-versus-host disease,acute graft-versus-host disease”。排除低质量、重复、内容陈旧的文献,最终纳入88篇文献进行综述分析。结果与结论:①间充质干细胞作为一种多能干细胞,可通过细胞间直接接触、分泌多种造血相关因子、参与造血相关通路来重塑造血功能;②与间充质干细胞联合免疫抑制剂输注、单纯间充质干细胞输注相比,间充质干细胞联合造血干细胞移植治疗再生障碍性贫血患者更能发挥两种干细胞的疗效,显著降低慢性和Ⅲ-Ⅳ度急性移植物抗宿主病的发生率,提高患者的总生存期;③使用脐带来源和传代次数<6次的间充质干细胞,并且在造血干细胞移植前输注的方案可能是更有效的治疗选择;④间充质干细胞与再生障碍性贫血发病机制之间存在密切联系,通过抑制或激活再生障碍性贫血病理演变过程中相关的靶点,可能为再生障碍性贫血带来新的治疗方案。

关键词：再生障碍性贫血间充质干细胞造血干细胞移植细胞治疗造血微环境移植物抗宿主病发病机制综述

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Inclusion variations and calcium treatment optimization in pipeline steel production

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International Journal of minerals,Metallurgy and Materials 2011年第5期18卷 527-534页

作者： Jian-hua liu Hua-jie Wu yan-ping Bao min Wang Research Institute of Metallurgy Engineering University of Science and Technology Beijing Beijing 100083 China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

SiCa line and SiCaBaFe alloy were injected into liquid pipeline steel at the end of LF refining as calcium treatment,and samples were taken from the ladles,mould,and *** of Ca content and inclusions shows that Ca content in steel decreases obviously in the following process after calcium treatment;the compositions,morphology,and sizes of inclusions also vary much in the production;primary inclusions in the ladles prior to calcium treatment are mainly Al2O3 inclusions,but they turn to fine irregular CaS-CaO-Al2O3 compound inclusions after the treatment,then become fine globular CaO-Al2O3 inclusions in the mould,and finally change to a few larger irregular CaS-CaO-Al2O3 complex inclusions in the *** study reveals that inclusion variations are related with the preferential reactions among Ca,Al2O3,and S and the precipitation of S in CaO-Al2O3 inclusions with high sulfur *** evaluation standards for calcium treatment in high-grade pipeline steel were put forward according to the inclusion variations and requirements of pipeline steel on inclusion controlling,and the calcium process was studied and optimized.

关键词： pipeline steel refining inclusions calcium treatment thermodynamics precipitation

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蓝刺头多糖体外抗氧化及抗菌活性的研究

华北农学报 2016年第4期31卷 233-238页

作者：杨斌萨茹丽张月梅达来宝力格宋越宋爱军陈伟卢岩刘敏杨英赵世华内蒙古农牧业科学院兽医研究所内蒙古呼和浩特010031 内蒙古农业大学动物科学学院内蒙古呼和浩特010018 内蒙古农业大学兽医学院内蒙古呼和浩特010018

通过研究蓝刺头粗多糖及其洗脱纯化组分蓝刺头多糖A、B、C的体外抗氧化和抗菌作用,初步确定蓝刺头多糖的生物活性。结果显示,添加浓度相同时,蓝刺头粗多糖的总还原能力以及清除DPPH有机自由基能力最强,显著高于蓝刺头多糖A,极显著高于... 详细信息

通过研究蓝刺头粗多糖及其洗脱纯化组分蓝刺头多糖A、B、C的体外抗氧化和抗菌作用,初步确定蓝刺头多糖的生物活性。结果显示,添加浓度相同时,蓝刺头粗多糖的总还原能力以及清除DPPH有机自由基能力最强,显著高于蓝刺头多糖A,极显著高于蓝刺头多糖B、C。当添加浓度为0.1～0.3 mg/m L时,蓝刺头粗多糖清除羟基自由基的能力略高于蓝刺头多糖A,但差异不显著;当添加浓度为0.4 mg/m L时,蓝刺头粗多糖清除羟基自由基的能力略高于蓝刺头多糖A,蓝刺头多糖A略高于蓝刺头多糖B,三者差异不显著,但均极显著高于蓝刺头多糖C,当添加浓度为0.5 mg/m L时,蓝刺头粗多糖清除羟基自由基的能力显著高于蓝刺头多糖A、B,极显著高于蓝刺头多糖C。试验条件下,蓝刺头粗多糖和蓝刺头多糖A对大肠杆菌为低度敏感,最低抑菌浓度均为0.62 mg/m L,蓝刺头多糖B和C对大肠杆菌不敏感,最小抑菌浓度均为1.25 mg/m L;蓝刺头粗多糖、蓝刺头多糖A、B和C对金黄色葡萄球菌为不敏感,最低抑菌浓度分别为1.25,2.50,2.50,2.50 mg/m L;蓝刺头粗多糖、蓝刺头多糖B、C对铜绿假单胞菌为不敏感,最低抑菌浓度均为5.00 mg/m L,蓝刺头多糖A对铜绿假单胞菌无抑制作用;蓝刺头粗多糖和蓝刺头多糖A、B、C对沙门氏菌均为不敏感,最低抑菌浓度分别为2.50,2.50,1.25,5.00 mg/m L。说明蓝刺头粗多糖的抗氧化能力最强,其次为蓝刺头多糖A,而蓝刺头多糖B和C的抗氧化能力较弱。蓝刺头粗多糖和蓝刺头多糖A具有一定的抗大肠杆菌活性,蓝刺头粗多糖和蓝刺头多糖A、B、C均无抗金黄色葡萄球菌、铜绿假单胞菌以及沙门氏菌活性。

关键词：蓝刺头多糖抗氧化活性抗菌活性

Study of steam heat transfer enhanced by CO_(2) and chemical agents: In heavy oil production

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Petroleum Science 2023年第2期20卷 1030-1043页

作者： Ya-Li liu Chao Zhang Song-yan Li Zhao-min Li Key Laboratory of Unconventional Oil&Gas Development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Steam flooding with the assistance of carbon dioxide (CO_(2)) and chemicals is an effective approach for enhancing super heavy oil recovery. However, the promotion and application of CO_(2) and chemical agent-assisted steam flooding technology have been restricted by the current lack of research on the synergistic effect of CO_(2) and chemical agents on enhanced steam flooding heat transfer. The novel experiments on CO_(2)–chemicals cooperate affected steam condensation and seepage were conducted by adding CO_(2) and two chemicals (sodium dodecyl sulfate (SDS) and the betaine temperature-salt resistant foaming agent ZK-05200).According to the experimental findings, a “film” formed on the heat-transfer medium surface following the co-injection of CO_(2) and the chemical to impede the steam heat transfer, reducing the heat transfer efficiency of steam, heat flux and condensation heat transfer coefficient. The steam seepage experiment revealed that the temperature at the back end of the sandpack model was dramatically raised by 3.5–12.8 °C by adding CO_(2) and chemical agents, achieving the goal of driving deep-formation heavy oil. The combined effect of CO_(2) and SDS was the most effective for improving steam heat transfer, the steam heat loss was reduced by 6.2%, the steam condensation cycle was prolonged by 1.3 times, the condensation heat transfer coefficient was decreased by 15.5%, and the heavy oil recovery was enhanced by 9.82%. Theoretical recommendations are offered in this study for improving the CO_(2)–chemical-assisted steam flooding technique.

关键词： Steam flooding Heavy oil Carbon dioxide Chemical agent Enhanced oil recovery(EOR) Heat transfer

Candidate genes involved in the biosynthesis of lignan in Schisandra chinensis fruit based on transcriptome and metabolomes analysis

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Chinese Journal of Natural Medicines 2020年第9期18卷 684-695页

作者： CHEN Chun-Yu liu Shu-Ying yan yan YIN Le DI Peng liu Hui-min liu Hong-Zhang College of life Science Jilin Agricultural UniversityChangchun 130118China College of Chinese Medicinal Materials Jilin Agricultural UniversityChangchun 130118China

Schisandra chinensis Turcz.(Baill.) is a plant species with fruits that have been well known in Far Eastern medicine for a long time. It has traditionally been used as a stimulating and fortifying agent in cases of physical exhaustion and to inhibit *** major bioactive compounds found in S. chinensis are lignans with a dibenzocyclooctadiene skeleton, but little is known about their biosynthesis in plants. S. chinensis is the ideal medicinal plant for studying the biosynthesis of lignans, especially the dibenzocyclooctadiene skeleton. Genomic information for this important herbal plant is unavailable. To better understand the lignan biosynthesis pathway, we generated transcriptome sequences from the fruit during ripening and performed de novo sequence assembly, yielding136 843 unique transcripts with N50 of 1778 bp. Putative functions could be assigned to 41 824 transcripts(51.57%) based on BLAST searches against annotation databases including GO(Gene ontology) and KEGG(Kyoto Encyclopedia of Genes and Genomes). Furthermore, 22 candidate cytochrome P450 genes and 15 candidate dirigent proteins genes that were most likely involved in the lignan biosynthesis pathway were discovered based on transcriptome sequencing of S. chinensis. The genomic data obtained from S. chinensis, especially the identification of putative genes involved in the lignan biosynthesis pathway, will facilitate our understanding of lignan biosynthesis at the molecular level. The lignan metabolite profiles were analyzed by metabolomes, the accumulation patterns of 30 metabolites involved in the lignan pathway were studied. Co-expression network of lignan contents and transcriptional changes showed355 strong correlations(correlation coefficient, R^2 > 0.9) between 21 compounds and 153 transcripts. Furthermore, the comprehensive analysis and characterization of the genes involved in lignan pathways and the metabolite profiles of lignans are expected to provide better insight regarding the dive

关键词： Schisandra chinensis Transcriptome Metabolome Biosynthetic pathways Lignan

Enabling Efficient Caching in High Mobility UAV Communications Network under Limited Backhaul

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China Communications 2022年第10期19卷 207-219页

作者： yan Wu Jiandong Li Junyu liu min Sheng Chenxi Zhao State Key Laboratory of Integrated Service Networks Xidian UniversityXi'anShaanxi 710071China

Due to flexible deployment,unmanned aerial vehicle(UAV)mounted aerial access points are capable of expanding the coverage capabilities of existing terrestrial base stations(TBSs).Different from TBSs,however,UAV access points(UAPs)are of high mobility in horizontal and vertical dimensions,which may deteriorate the coverage ***,the mobility of UAPs would as well increase the pressure of wireless *** this light,we investigate the performance of the cache-enabled UAV communications network(CUCN)in terms of network spatial throughput(ST)by analyzing the line of sight(LoS)connections and non-line of sight(NLoS)*** is found that the network ST is exponentially decreased with the square of UAP ***,contrary to intuition,a large cache size may deteriorate the network ST when UAPs are *** reason is that a large cache size increases the hit probability,which may increase the activation of UAPs and consequently result in complicated *** to maximize the network ST,we optimize the cache strategy under limited ***,the results show that network ST could be substantially improved by the optimized cache strategy and the performance degeneration brought by UAP high mobility could be even eliminated especially when the UAP altitude is high.

关键词： caching optimization UAV communications network spatial throughput stochastic geometry aerial access point

Effects of chromium on the corrosion and electrochemical behaviors of ultra high strength steels

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International Journal of minerals,Metallurgy and Materials 2010年第3期17卷 282-289页

作者： Jin-yan Zhong min Sun Da-bo liu Xiao-gang Li Tian-qi liu School of Chemistry and Environmental Engineering China University of Mining and Technology （Beijing） Beijing 100083 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Beijing Institute of Aeronautical Materials Beijing 100095 China

The effects of chromium on the corrosion and the electrochemical behaviors of ultra high strength steels were studied by the salt spray test and electrochemical methods. The results show that ultra high strength steels remain martensite structures and have anodic dissolution characteristic with an increase of chromium content. There is no typical passive region on the polarization curves of an ultra high strength stainless steel, AerMet 100 steel, and 300M steel. However, chromium improves the corrosion resistance of the stainless steel remarkably. It has the slowest corrosion rate in the salt spray test, one order of magnitude less than that of AerMet 100 and 300M steels. With the increase of chromium content, the polarization resistance becomes larger, the corrosion potential shifts towards the positive direction with a value of 545 mV, and the corrosion current density decreases in electrochemical measures in 3.5wt% NaCl solutions. Because of the higher content of chromium, the ultra high strength stainless steel has a better corrosion resistance than AerMet 100 and 300M steels.

关键词： ultra high strength steel corrosion rate chromium electrochemical behavior