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Intrauterine Infections and Birth Defects

Biomedical and Environmental Sciences 2004年第4期17卷 476-491页

作者： XIAO-YING ZHENG TING ZHANG YI-FEI WANG CHEN XU GONG CHEN RuO-LEI XIN JIA-PENG CHEN XU-MEI HU QING yanG XIN-MING SONG LI-HUA PANG YING JI HONG-MEI SUN LEI ZHANG JU-FEN LIU yan-ling guo yan ZHANG Institute of Population Research／WHO Collaborating Centeron Reproductive Health and Population Science Beijing 100871China Department of Infection and Immunity Capitallnstimte of PediatricsBeijing 100020China Medical School of Shanghai Jiatong University No.1954Huashan RoadShanghai 200030China Department of Embryology the Second Medical UniversityNo.280Chongqing NanluShanghai 200025China

Intrauterine infection is an important cause of some birth defects worldwide. The most common pathogens include rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. General information about these pathogens in epidemiology, consequence of birth defects, and the possible mechanisms in the progress of birth defects, and the interventions to prevent or treat these pathogens?infections are described. The infections caused by rubella virus, cytomegaloviurs, ureaplasma urealyticum, toxoplasma, etc. are common, yet they are proved to be fatal during the pregnant period, especially during the first trimester. These infections may cause sterility, abortion, stillbirth, low birth weight, and affect multiple organs that may induce loss of hearing and vision, even fetal deformity and the long-term effects. These pathogens?infections may influence the microenvironment of placenta, including levels of enzymes and cytokines, and affect chondriosome that may induce the progress of birth defect. Early diagnosis of infections during pregnancy should be strengthened. There are still many things to be settled, such as the molecular mechanisms of birth defects, the effective vaccines to certain pathogens. Birth defect researches in terms of etiology and the development of applicable and sensitive pathogen detection technology and methods are imperative.

关键词： Intrauterine infections Birth defects Rubella virus Ureaplasma urealyticum Toxoplasma

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Three types of promising functional building units for designing metal halide nonlinear optical crystals

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Chinese Journal of Structural Chemistry 2024年第6期43卷 8-11页

作者： Jiajing Wu Ru-ling Tang Sheng-Ping guo School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002PR China Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Material and EnergyYunnan UniversityKunming650000PR China

Nonlinear optical(NLO)crystal materials greatly extend the tunable range of laser by frequency conversion,which promotes the rapid development of laser technology and plays an important role in many civil and military *** excellent and famous NLO crystals from the ultraviolet(UV)to visible to near infrared(NIR)regions have been developed,such as borates(KBe_(2)BO_(3)F_(2),β-BaB_(2)O_(4)),phosphates(KH_(2)PO_(4),KTiOPO_(4)),chalcogenides(AgGaS_(2),AgGaSe_(2))and so on[1,2].

关键词： optical tunable designing

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A vector sum analysis method for stability evolution of expansive soil slope considering shear zone damage softening

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3746-3759页

作者： Junbiao yan lingwei Kong Cheng Chen Mingwei guo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Slope stability analysis is a classical mechanical problem in geotechnical engineering and engineering *** is of great significance to study the stability evolution of expansive soil slopes for engineering construction in expansive soil *** of the existing studies evaluate the slope stability by analyzing the limit equilibrium state of the slope,and the analysis method for the stability evolution considering the damage softening of the shear zone is *** this study,the large deformation shear mechanical behavior of expansive soil was investigated by ring shear *** damage softening characteristic of expansive soil in the shear zone was analyzed,and a shear damage model reflecting the damage softening behavior of expansive soil was derived based on the damage ***,by skillfully combining the vector sum method and the shear damage model,an analysis method for the stability evolution of the expansive soil slope considering the shear zone damage softening was *** results show that the shear zone subjected to large displacement shear deformation exhibits an obvious damage softening *** damage variable equation based on the logistic function can be well used to describe the shear damage characteristics of expansive soil,and the proposed shear damage model is in good agreement with the ring shear test *** vector sum method considering the damage softening behavior of the shear zone can be well applied to analyze the stability evolution characteristics of the expansive soil *** stability factor of the expansive soil slope decreases with the increase of shear displacement,showing an obvious progressive failure behavior.

关键词： Expansive soil slope Stability analysis Ring shear test Vector sum method Damage model Strain softening

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Glacial-interglacial cycles recorded in clay minerals from the eastern Tibetan Plateau over the last 800 ka and their indications

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Science China Earth Sciences 2024年第7期67卷 2162-2177页

作者： Xiaoyan ZHANG Chunxia ZHANG yan ZHAO Bin HU Zhengtang guo Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Clay mineral proxies have been widely used to reconstruct changes in provenance and the ***,high-altitude clay mineral indications and long-term and orbital variations have not been fully ***,we present an800-ka clay-mineral record from a lacustrine sediment core(ZB13-C2)from the Zoige Basin on the eastern Tibetan Plateau(TP).X-ray diffraction and scanning electron microscopy were used to identify the clay mineral assemblages and their micromorphological characteristics of core *** results revealed that the clay minerals in core ZB13-C2 are mainly illite,with small amounts of chlorite,kaolinite,and smectite(including irregular mixed-layers of illite-smectite(I/S)and chloritesmectite(C/S)).The clay mineral assemblages and proxies exhibit three stages of change,which are mainly controlled by the Zoige watershed range under different climate *** watershed was limited to the southeastern region with altitudes ranging from~3500 to~4200 meters above sea level(m a.s.l.),and glacial-interglacial hydraulic erosion controlled the input of bedrock debris during 800-621 ka *** expanded to higher altitudes(~4200 to~4700 m a.s.l.)due to stronger seasonal freezethaw weathering without significant glacial-interglacial variations under a cooling and drying climate during 621-100 ka ***,it expanded to its highest altitudes of~4700 to~5200 m *** of the watershed after 100 ka BP,and hydraulic erosion increased obviously under a warm climate of the interstadial MIS 3 on the *** watershed underwent two major expansions under different climatic conditions at~621 ka and 100 ka BP,with the wet/dry alternation became strong at~621 ka *** results reveal that long-term temperature changes and the wet/dry alternation at high altitudes controlled the watershed range and degree of the physical erosion,and that the indications of clay minerals should be carefully clarified before they are used as climate indicators,especi

关键词： Quaternary Zoige Basin Lacustrine sediments Paleoenvironment Weathering

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Integrated separation-electrochemical detection device based on wood column for online identification of enantiomer

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Nano Research 2024年第3期17卷 1893-1901页

作者： Junli guo Yuanfei Xue Chenxi Zhao Junjian Zhao Zhida Gao Ye Mei yan-yan Song College of Sciences Northeastern UniversityShenyang 110004China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200062China NYU-ECNU Center for Computational Chemistry at NYU Shanghai Shanghai 200062China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Chiral chemicals have attracted significant interest in the pharmaceutical industry,yet the separation methods to get pure enantiomers from racemic mixture are still *** date,the separation of enantiomers still mainly depends on chromatography using high-cost chiral stationary ***,wood channels were used as the handheld integrated device,and enantiomer separation was simultaneously detected using an electrochemical *** this method,a chiral UIO-66(L-UIO-66)modified enantiomer separation zone and carbonized wood based online detection zone are integrated along a single wood *** on the in situ separation results from the chronoamperometry data,the wood device shows excellent separation ability for a wide range of electrochemically active enantiomers,including 3,4-dihydroxyphenylalanine,amino acids,ascorbic acid,carnitine,and penicillamine with high chirality *** unbiased molecular dynamic simulations indicate that the excellent chiral recognition and separation are attributed to the different barriers from the bound states to the dissociated state of the enantiomers in the homochiral microenvironment of the *** integrated enantiomer separation-electrochemical detection device provides a novel,easy,and low-cost platform for the separation of pure enantiomer from racemic mixture.

关键词： wood column integrated separation-detection device enantioselectivity online sensing free energy barrier

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Phosphotungstic acid immobilized on amino-functionalized TS-1 zeolite as a solid acid catalyst for the synthesis of tributyl citrate

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Chinese Journal of Chemical Engineering 2024年第6期70卷 199-210页

作者： Pei Li Bianfang Shi Junyao Shen Ran Cui Wenze guo ling Zhao Zhenhao Xi State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of EducationEast China University of Science and TechnologyShanghai 200237China

The amino-functionalization of TS-1 zeolite followed by immobilization of phosphotungstic acid(HPW)was presented to prepare a strong solid acid catalyst for the synthesis of bio-based tributyl citrate from the esterification of citric acid and n-butanol.γ-Aminopropyltriethoxysilane(APTES)was first grafted on the TS-1 zeolite via the condensation reactions with surface hydroxyl groups,and subsequently the HPW was immobilized via the reaction between the amino groups and the protons from HPW-forming strong ionic *** Keggin structure of HPW and MFI topology of TS-1 zeolite were well maintained after the *** amino-functionalization generated abundant uniformly distributed active sites on TS-1 for HPW immobilization,which promoted the dispersity,abundance,as well as the stability of the acid *** tetrahedrally coordinated framework titanium and non-framework titania behaved as weak Lewis acid sites,and the protons from the immobilized HPW acted as the moderate or strong Brønsted acid *** optimized TBC yield of 96.2%(mol)with a conversion of-COOH of 98.1%(mol)was achieved at 150℃for 6 h over the HPW immobilized on amino-functionalized *** catalyst exhibited good stability after four consecutive reaction runs,where the activity leveled off at still a relatively high level after somewhat deactivation possibly caused by the leaching of a small portion of weakly anchored APTES or HPW.

关键词： Amino-functionalization Phosphotungstic acid TS-1 zeolite Esterification Tributyl citrate

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NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation

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Zoological Research 2024年第4期45卷 857-874页

作者： Na Zhao Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fan Geng Meng-Meng Zhu Fu-ling yan Zhi-Jun Zhang Qing-guo Ren Department of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indicates that sleep deprivation(SD)can lead to Alzheimer’s disease(AD)-related pathological changes and cognitive ***,the underlying mechanisms remain *** the present study,we identified the existence of a microbiota-gut-brain axis in cognitive deficits resulting from chronic SD and revealed a potential pathway by which gut microbiota affects cognitive functioning in chronic *** findings demonstrated that chronic SD in mice not only led to cognitive decline but also induced gut microbiota dysbiosis,elevated NLRP3 inflammasome expression,GSK-3βactivation,autophagy dysfunction,and tau hyperphosphorylation in the *** with the“SD microbiota”replicated the pathological and behavioral abnormalities observed in chronic sleep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice and specific knockdown of NLRP3 in the hippocampus restored autophagic flux,suppressed tau hyperphosphorylation,and ameliorated cognitive deficits induced by chronic SD,while GSK-3βactivity was not regulated by the NLRP3 inflammasome in chronic ***,deletion of NLRP3 reversed NLRP3 inflammasome activation,autophagy deficits,and tau hyperphosphorylation induced by GSK-3βactivation in primary hippocampal neurons,suggesting that GSK-3β,as a regulator of NLRP3-mediated autophagy dysfunction,plays a significant role in promoting tau ***,gut microbiota dysbiosis was identified as a contributor to chronic SD-induced tau pathology via NLRP3-mediated autophagy dysfunction,ultimately leading to cognitive ***,these findings highlight GSK-3βas a regulator of NLRP3-mediated autophagy dysfunction,playing a critical role in promoting tau hyperphosphorylation.

关键词： Chronic sleep deprivation Tau pathology NLRP3 inflammasome Autophagy GSK-3β Microbiota-gut-brain axis

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A Novel Analysis Approach of Uniform Persistence for an Epidemic Model with Quarantine and Standard Incidence Rate

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 695-707页

作者： Song-bai guo Yu-ling XUE Xi-liang LI Zuo-huan ZHENG School of Science Beijing University of Civil Engineering and ArchitectureBeijing 102616China School of Mathematics and Statistics Hainan Normal UniversityHaikou 571158China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China School of Mathematics and Information Science Shandong Technology and Business UniversityYantai 264005China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Inspired by the transmission characteristics of the coronavirus disease 2019(COVID-19),an epidemic model with quarantine and standard incidence rate is first developed,then a novel analysis approach is proposed for finding the ultimate lower bound of the number of infected individuals,which means that the epidemic is uniformly persistent if the control reproduction number R_(c)>*** approach can be applied to the related biomat hem at ical models,and some existing works can be improved by using *** addition,the infection-free equilibrium V^(0)of the model is locally asymptotically stable(LAS)if R_(c)1.

关键词： uniform persistence epidemic model control reproduction number quarantine standard incidence rate

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Mechanism of action of the bile acid receptor TGR5 in obesity

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Acta Pharmaceutica Sinica B 2024年第2期14卷 468-491页

作者： Weijun Lun Qihao yan Xinghua guo Minchuan Zhou yan Bai Jincan He Hua Cao Qishi Che Jiao guo Zhengquan Su Guangdong Engineering Research Center of Natural Products and New Drugs Guangdong Provincial University Engineering Technology Research Center of Natural Products and DrugsGuangdong Pharmaceutical UniversityGuangzhou 510006China Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine Key Laboratory of Glucolipid Metabolic DisorderMinistry of Education of ChinaGuangdong TCM Key Laboratory for Metabolic DiseasesGuangdong Pharmaceutical UniversityGuangzhou 510006China School of Public Health Guangdong Pharmaceutical UniversityGuangzhou 510310China School of Chemistry and Chemical Engineering Guangdong Pharmaceutical UniversityZhongshan 528458China Guangzhou Rainhome Pharm&Tech Co. Ltd.Science CityGuangzhou 510663China

G protein-coupled receptors(GPCRs)are a large family of membrane protein receptors,and Takeda G protein-coupled receptor 5(TGR5)is a member of this *** a membrane receptor,TGR5 is widely distributed in different parts of the human body and plays a vital role in regulating metabolism,including the processes of energy consumption,weight loss and blood glucose *** studies have shown that TGR5 plays an important role in glucose and lipid metabolism disorders such as fatty liver,obesity and *** the global obesity situation becoming more and more serious,a comprehensive explanation of the mechanism of TGR5 and filling the gaps in knowledge concerning clinical ligand drugs are urgently *** this review,we mainly explain the anti-obesity mechanism of TGR5 to promote the further study of this target,and show the electron microscope structure of TGR5 and review recent studies on TGR5 ligands to illustrate the specific binding between TGR5 receptor binding sites and ligands,which can effectively provide new ideas for ligand research and promote drug research.

关键词： Obesity TGR5 Bile acids Ligand Appetite Metabolism GLP-1 Inflammation

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Innovations in metallurgical and materials processes:advancing liquid theory and honoring ***-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research International 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,***-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of *** under the assumption that molecul... 详细信息

关键词： chemistry liquid complexes

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